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Gene: Arhgap35 (Rho GTPase activating protein 35) Ictidomys tridecemlineatus

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Symbol:

Arhgap35

Name:

Rho GTPase activating protein 35

RGD ID:

12636039

Description:

ENCODES a protein that exhibits GTPase activating protein binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN positive regulation of GTPase activity (ortholog); positive regulation of neuron projection development (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Anophthalmia (ortholog); lung adenocarcinoma (ortholog); Martsolf syndrome 1 (ortholog); FOUND IN actin cytoskeleton (inferred); cell projection (inferred); ciliary basal body (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

rho GTPase-activating protein 35

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	19,095,903 - 19,170,964 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	713,984 - 789,344 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	714,036 - 788,584 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	Anophthalmia		ISO	ARHGAP35 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Anophthalmia	ClinVar	PMID:25741868 and PMID:36450800
Arhgap35	Squirrel	Martsolf syndrome 1		ISO	ARHGAP35 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Martsolf syndrome 1	ClinVar	PMID:25741868
Arhgap35	Squirrel	microphthalmia		ISO	ARHGAP35 (Homo sapiens)	8554872	ClinVar more ...	ClinVar	PMID:25741868 and PMID:36450800
Arhgap35	Squirrel	Neurodevelopmental Disorders		ISO	ARHGAP35 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Neurodevelopmental disorder	ClinVar	PMID:25741868 and PMID:33057194
Arhgap35	Squirrel	Peters anomaly		ISO	ARHGAP35 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Irido-corneo-trabecular dysgenesis	ClinVar	PMID:25741868 and PMID:36450800

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	lung adenocarcinoma		ISO	ARHGAP35 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:27158780

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	axon guidance	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	axonal fasciculation	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	camera-type eye development	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	cell migration	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	central nervous system neuron axonogenesis	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	establishment or maintenance of actin cytoskeleton polarity	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	forebrain development	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	mammary gland development	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	negative regulation of Rho protein signal transduction	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	negative regulation of vascular permeability	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	neural tube closure	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	neuron projection guidance	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	positive regulation of cilium assembly	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	positive regulation of GTPase activity	involved_in	ISO	Arhgap35 (Rattus norvegicus)	9068941	PMID:9852136	UniProt	PMID:9852136 and REF_RGD_ID:11535110
Arhgap35	Squirrel	positive regulation of neuron projection development	acts_upstream_of_or_within	ISO	MGI:87860	9068941	PMID:15084284	MGI	PMID:15084284
Arhgap35	Squirrel	positive regulation of neuron projection development	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	regulation of actin cytoskeleton organization	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	regulation of actin polymerization or depolymerization	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	regulation of axonogenesis	involved_in	IEA	PANTHER:PTN000571609	150520179		TreeGrafter	GO_REF:0000118
Arhgap35	Squirrel	regulation of axonogenesis	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	regulation of cell shape	acts_upstream_of_or_within	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	regulation of cell size	involved_in	IEA	PANTHER:PTN000571609	150520179		TreeGrafter	GO_REF:0000118
Arhgap35	Squirrel	Rho protein signal transduction	involved_in	IEA	PANTHER:PTN000571609	150520179		TreeGrafter	GO_REF:0000118
Arhgap35	Squirrel	Rho protein signal transduction	acts_upstream_of	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	signal transduction	involved_in	IEA	InterPro:IPR000198	150520179		InterPro	GO_REF:0000002
Arhgap35	Squirrel	wound healing, spreading of cells	involved_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	actin cytoskeleton	located_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	cell projection	located_in	IEA	UniProtKB-KW:KW-0966	150520179		UniProt	GO_REF:0000043
Arhgap35	Squirrel	ciliary basal body	located_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	cytoplasm	located_in	IEA	UniProtKB:Q91YM2 and ensembl:ENSMUSP00000075242	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	150520179		UniProt	GO_REF:0000043
Arhgap35	Squirrel	cytosol	located_in	IEA	PANTHER:PTN000571609	150520179		TreeGrafter	GO_REF:0000118
Arhgap35	Squirrel	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	150520179		UniProt	GO_REF:0000044
Arhgap35	Squirrel	plasma membrane	located_in	IEA	UniProtKB-SubCell:SL-0039	150520179		UniProt	GO_REF:0000044
Arhgap35	Squirrel	plasma membrane	located_in	IEA	UniProtKB-KW:KW-1003	150520179		UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	GTP binding	enables	IEA	InterPro:IPR001806	150520179		InterPro	GO_REF:0000002
Arhgap35	Squirrel	GTP binding	enables	IEA	UniProtKB-KW:KW-0342	150520179		UniProt	GO_REF:0000043
Arhgap35	Squirrel	GTPase activating protein binding		ISO	Rasa1 (Rattus norvegicus)	9068941		RGD	PMID:2005883 and REF_RGD_ID:10002731
Arhgap35	Squirrel	GTPase activator activity	enables	IEA	PANTHER:PTN000571609	150520179		TreeGrafter	GO_REF:0000118
Arhgap35	Squirrel	GTPase activator activity	enables	IEA	UniProtKB-KW:KW-0343	150520179		UniProt	GO_REF:0000043
Arhgap35	Squirrel	GTPase activator activity	enables	IEA	UniProtKB:Q91YM2 more ...	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	GTPase activity	enables	IEA	InterPro:IPR001806	150520179		InterPro	GO_REF:0000002
Arhgap35	Squirrel	lipid binding	enables	IEA	UniProtKB-KW:KW-0446	150520179		UniProt	GO_REF:0000043
Arhgap35	Squirrel	phospholipid binding	enables	IEA	UniProtKB:Q9NRY4 and ensembl:ENSP00000500409	150520179		Ensembl	GO_REF:0000107
Arhgap35	Squirrel	protein-containing complex binding		ISO	Arhgap35 (Rattus norvegicus)	9068941		RGD	PMID:2005883 and REF_RGD_ID:10002731

Imported Annotations - PID (archival)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Arhgap35	Squirrel	ephrin - ephrin receptor bidirectional signaling axis		ISO	ARHGAP35 (Homo sapiens)	9068941		PID	PID:200216
Arhgap35	Squirrel	platelet-derived growth factor signaling pathway		ISO	ARHGAP35 (Homo sapiens)	9068941		PID	PID:200149

PMID:22301074

Arhgap35
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	19,095,903 - 19,170,964 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936664	713,984 - 789,344 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936664	714,036 - 788,584 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARHGAP35
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	46,860,997 - 47,005,077 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	46,860,997 - 47,005,077 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	47,364,254 - 47,508,334 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	52,113,773 - 52,200,174 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	44,226,291 - 44,312,689 (+)	NCBI		Celera
Cytogenetic Map	19	q13.32	NCBI
HuRef	19	43,846,727 - 43,932,756 (+)	NCBI		HuRef
CHM1_1	19	47,423,799 - 47,510,216 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	49,686,835 - 49,830,977 (+)	NCBI		T2T-CHM13v2.0

Arhgap35
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	16,228,398 - 16,349,313 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	16,227,644 - 16,348,918 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	16,494,473 - 16,614,993 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	16,493,719 - 16,614,993 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	17,079,822 - 17,200,342 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	15,653,561 - 15,773,515 (-)	NCBI		MGSCv36	mm8
Celera	7	13,691,036 - 13,812,194 (-)	NCBI		Celera
Cytogenetic Map	7	A2	NCBI
cM Map	7	9.15	NCBI

Arhgap35
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	86,330,566 - 86,447,414 (-)	NCBI		GRCr8
mRatBN7.2	1	77,202,436 - 77,319,298 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	77,202,436 - 77,319,298 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	82,576,527 - 82,693,394 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	91,140,568 - 91,257,426 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	84,331,623 - 84,448,478 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	78,456,409 - 78,573,374 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	78,456,409 - 78,573,374 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	79,703,650 - 79,820,568 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	76,757,031 - 76,824,155 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	28,093,164 - 28,259,729 (+)	NCBI
Celera	1	71,687,713 - 71,804,603 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Arhgap35
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955574	915,325 - 984,744 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955574	915,604 - 984,744 (+)	NCBI	ChiLan1.0	ChiLan1.0

ARHGAP35
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	53,006,784 - 53,151,982 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	54,878,676 - 55,023,271 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	43,850,692 - 43,994,487 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	52,435,379 - 52,521,104 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	52,435,379 - 52,521,104 (+)	Ensembl	panpan1.1		panPan2

ARHGAP35
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	108,952,836 - 109,034,329 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	108,952,562 - 109,034,337 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	108,432,475 - 108,561,300 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	109,473,916 - 109,607,035 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	109,476,089 - 109,607,038 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	109,144,987 - 109,284,705 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	108,789,454 - 108,918,490 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	109,657,989 - 109,786,942 (-)	NCBI		UU_Cfam_GSD_1.0

ARHGAP35
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	52,711,901 - 52,841,288 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	52,711,463 - 52,841,295 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	48,200,461 - 48,215,323 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARHGAP35
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	40,264,466 - 40,353,157 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	40,205,892 - 40,353,280 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	19,911,593 - 20,059,133 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arhgap35
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624832	6,650,383 - 6,719,786 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624832	6,650,383 - 6,773,828 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_005336571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010004409	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000011410 ⟹ ENSSTOP00000010240

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936664	713,984 - 789,344 (+)	Ensembl

RefSeq Acc Id:

XM_005336571 ⟹ XP_005336628

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024409349	19,095,903 - 19,170,964 (+)	NCBI
SpeTri2.0	NW_004936664	714,036 - 788,584 (+)	NCBI

Sequence:

show sequence

AAATGTTGGCAATTTGGCGATGAGAAGTTGTGAAAACTGACCTCATAGTGGTACACAAGCACTATGGGACCTGGCACTCATGCTTATTGGGCAGCCATTCTCCACTGGTAATGTTGAGAAGCCCTCCA
CTCTACTGGAAAACACTAATCTGATCTTGGAAGTGGCTGTTTGTGGCAGGATGTGTCGACGATGATGATGGCAAGAAAGCAAGATGTCCGCATTCCCACCTACAACATCAGTGTGGTGGGATTGTCTG
GGACCGAGAAGGAGAAAGGCCAGTGTGGCATTGGGAAGTCTTGTCTCTGTAACCGCTTTGTGCGCCCAAGTGCTGATGAGTTTCACTTGGACCATACCTCTGTCCTCAGCACCAGTGACTTTGGTGGG
CGAGTGGTCAATAATGACCACTTTCTCTACTGGGGAGAAGTTGGCCGCTCCCTGGAGGATTGTGTGGAATGTAAGATGCACATTGTGGAACAGACTGAATTTATTGATGATCAGACTTTTCAACCTCA
TCGAAGCACGGCCCTGCAGCCCTACATCAAGAGAGCTGCTGCAACCAAGCTTGCATCAGCTGAAAAACTCATGTACTTTTGCACTGACCAGCTGGGGCTGGAACAGGACTTTGAGCAGAAACAAATGC
CAGATGGAAAGCTGCTGGTGGATGGTTTTCTTCTTGGTATTGATGTTAGCAGGGGCATGAATAGGAACTTTGATGACCAGCTCAAGTTTGTCTCTAATCTCTACAATCAGCTTGCAAAAACAAAAAAG
CCCATCGTGGTGGTCCTGACCAAGTGTGATGAGGGTGTCGAGCGGTACATTAGAGATGCACATACTTTTGCCTTAAGCAAAAAGAACCTTCAGGTTGTAGAGACCTCAGCAAGATCCAATGTAAATGT
GGATTTGGCTTTCAGCACCTTAGTGCAACTCATTGATAAAAGTCGGGGGAAAACAAAAATTATTCCTTATTTTGAAGCTCTCAAACAACAAAGCCAGCAGATAGCTACAGCAAAAGACAAATATGAGT
GGCTGGTGAGTCGCATTGTGAAAAATCACAATGAGAATTGGTTGAGTGTCAGCCGAAAGATGCAGGCCTCCCCAGAGTACCAGGACTATGTCTACCTGGAAGGGACTCAGAAGGCCAAGAAGCTGTTT
CTACAGCACATCCATCGCCTCAAGCATGAGCACATTGAGCGCAGGAGAAAGCTGTACCTAGCTGCCCTGCCATTAGCTTTTGAAGCTCTTATTCCTAATCTAGATGAAATAGACCACCTAAGCTGCAT
AAAAGCCAAAAAACTATTAGAGACTAAGCCAGAATTCTTGAAGTGGTTTGTTGTGCTTGAAGAGACACCATGGGATGCCACCAGCCACATTGACAACATGGAAAATGAACGGATTCCCTTTGACTTAA
TGGATACTGTCCCTGCCGAGCAGCTCTACGAGGCCCACTTAGAGAAGCTGAGGAATGAGAGGAAGAGAGCTGAGATGAGAAGGGCATTCAAGGAAAACCTGGAGACCTCGCCTTTCATAACTCCTGGA
AAACCTTGGGAAGAGGCCCGTAGTTTTATTATGAATGAAGATTTCTATCAGTGGCTGGAAGAATCTGTATACATGGATATTTATGGCAAACATCAAAAGCAGATTATAGACAAAGCAAAGGAAGAATT
TCAAGAGTTACTTTTGGAATATTCAGAATTGTTTTATGAGCTGGAGCTGGATGCTAAGCCCAGCAAGGAAAAGATGGGCGTCATTCAGGATGTCTTGGGGGAAGAACAGCGATTTAAAGCACTACAAA
AGCTCCAGGCAGAGCGGGATGCCCTCATTCTGAAGCACATTCACTTTGTGTACCACCCAACAAAAGAGACCTGCCCCAGCTGCCCAGCATGTGTGGATGCTAAGATTGAGCACTTGATTAGTTCTCGG
TTTATCCGACCATCTGACCGGAATCAGAAAAATTCACTTTCTGACCCCAACATTGATAGGATCAACTTGGTTATCTTGGGCAAAGATGGCCTCGCCCGAGAGTTGGCCAATGAGATTCGAGCTCTTTG
TACTAATGATGACAAGTATGTGATAGATGGTAAAATGTATGAACTTTCCCTGAGGCCAATAGAGGGGAATGTCAGGCTTCCTGTGAACTCTTTCCAGACACCAACCTTTCAGCCCCACGGCTGTCTCT
GCCTTTACAATTCAAAGGAATCACTATCCTACGTAGTAGAGAGTATAGAAAAAAGCAGAGAGTCCACACTGGGCCGGCGGGATAATCATTTAGTCCACCTCCCCCTGACATTAATTTTGGTTAACAAG
AGAGGAGATACCAGTGGAGAGACCCTGCATAGCTTAATACAACAAGGTCAGCAAATTGCTAGCAAACTTCAGTGTGTCTTTCTAGACCCAGCTTCTGCTGGCATCGGTTATGGACGGAACATTAACGA
GAAGCAAATCAGTCAAGTTTTAAAAGGACTGCTAGACTCAAAGCGAAACTTAAACCTGGTCAGTTCTACTGCTAGCATCAAAGATTTGGCCGATGTCGATCTGCGAATTGTTATGTGTCTGATGTGTG
GGGATCCTTTTAGTGCGGACGATATACTCTTTCCTGTCCTTCAGTCCCAAACCTGTAAGTCTTCCCATTGTGGGAGCAACAACTCTGTTTTACTTGAACTTCCAATTGGACTACACAAAAAGCGCATT
GAACTGTCTATTCTCTCATACCATTCCTCGTTTAGCATCAGAAAGAGCCGGTTGGTTCATGGGTACATTGTTTTTTATTCAGCCAAACGCAAGGCCTCCTTGGCTATGTTATGTGCCTTTCTTTGTGA
AGTGCAGGATATTATCCCTATCCAGCTTGTAGCACTCACTGATGGCGCCATAGACGTCCTGGACAATGACTTAAGTCGGGAACAGCTGTCAGAGGGGGAGGAGATCGCTCAAGAGATTGATGGAAGGT
TCACAAGTATCCCCTGTAGCCAACCCCAGCACAAACTTGAGATCTTTCACCCATTTTTTAAAGATGTGGTGGAGAAAAAGAACATAATTGAGGCCACTCATATGTACGATAATGCTGCTGAGGCCTGT
AGCACCACTGAGGAGGTCTTTAACTCCCCCCGGGCCGGCTCACCACTCTGCAACTCAAACCTGCAGGATTCAGAAGAGGATATCGAGCCCCCATCTTACACCCTGTTCCGAGAAGATACATCACTGCC
CTCTCTGTCCAAAGACCATTCCAAACTTTCTATGGAACTGGAGGGAAATGACGGGCTGTCTTTCATCATGAGCAATTTTGAGAGTAAACTGAACAACAAAGTACCTCCACCAGTCAAACCAAAGCCCC
CTGTCCATTTTGAAATCACGAAGGGAGATCTGTCTTATTTAGACCAAGGCCATAGGGATGGACAGAGGAAGTCTGTGTCCTCTAGTCCCTGGCTGCCTCAGGATGGCTTTGATCCTTCTGACTATGCT
GAACCCATGGATGCTGTGGTGAAGCCGAGGAATGAAGAAGAAAATATATACTCTGTGCCCCATGACAGCACCCAAGGCAAAATCATCACCATTCGGAACATCAACAAAGCCCAATCCAATGGCAGTGG
CAATGGTTCCGACAGTGAGATGGACACCAGTTCTCTAGAGCGAGGCCGCAAGGTATCCATTGTGAGCAAGCCTGTGCTATACAGGACGAGATGCACCCGGCTGGGGCGGTTTGCTAGTTACCGAACCA
GTTTCAGCGTGGGGAGTGATGATGAGCTGGGGCCCATTCGGAAGAAAGAGGAGGATCAGGCATCCCAGGGCTATAAAGGGGACAATGCTGTCATTCCATATGAAACCGATGAAGACCCGAGGAGGAGG
AATATCCTTCGCAGTCTAAGGAGGAACACTAAGAAACCAAAGCCCAAACCTCGACCGTCCATCACAAAGGCAACCTGGGAGAGTAACTACTTTGGGGTGCCCTTAACAACTGTCGTAACTCCAGAGAA
GCCGATCCCCATTTTTATTGAAAGGTGCATTGAGTACATTGAAGCTACAGGTCTGAGCACTGAAGGCATCTACCGGGTCAGTGGGAACAAGTCAGAGATGGAGAGTCTGCAGAGACAGTTTGATCAAG
ACCACAATCTGGACTTGGCAGAGAAAGACTTCACGGTGAACACTGTGGCAGGCGCCATGAAGAGCTTCTTCTCAGAACTGCCAGACCCCCTGGTCCCCTACAATATGCAGATCGACTTGGTGGAGGCG
CACAAGATCAACGACCGGGAGCAGAAATTACATGCCCTTAAGGAGGTATTAAAGAAATTCCCAAAGGAAAACCATGAAGTCTTCAAATACGTCATCTCTCACCTAAACAAAGTCAGCCACAACAACAA
GGTGAACCTCATGACCAGCGAGAACCTCTCCATCTGCTTCTGGCCCACCTTGATGAGGCCCGACTTCAGCACCATGGACGCGCTCACGGCCACGCGCACCTACCAGACAATCATCGAGCTCTTCATCC
AGCAGTGCCCCTTCTTCTTCTACAACCGCCCCATCAGCGAGCCCCCAGGTGCCGTGCCCAGCTCCCCCTCGGCTGTGGCTGCCACCGTCCCCTTCCTCACCTCCACGCCTGTCACCAGTCAGCCGTCA
CCCCCCCAGTCACCACCACCCACCCCACAGTCCCCCATGCAGCCACTGCTCCCCTCCCAGCTTCAAGCCGAACACACGTTGTGAGCCATCAGGGCCTGGGGCAACGGGGAACTGGTCTTCTCTTAAAC
AGCGTGGCACTCAGCCTTGAACACAACCACAGCTTCTGGGGCAGGGGCCAAAGCCAAGTGCCCCTCTTCCCTGTCAGTTCTCAAGACCTCAGCGCGGGGACCAGCTCGTGTCCTCCACAAGCTAGGCT
GTCAGGCACCCAAGCCCAGCAGCAGCAGTGGGGCCCTGCCCTTCGACTCGGACCACTTTAATGACTGACCTAGTCAGGCAGCAGCCCCAAGTGCTCTTCCGCTGCTCCCTGGACCACCTCGCCCAGCT
GTGCACACCAGCCTCAGGGTGTCTCCCTGCTTGTGCAGACCCCAGTACTGGGCCAGAACCCTGGCCTCTGCCAGAGGAGGACATTCTGAATGCAGGCCTGCCCCGGGCAGGGCTGGCACCCCTTTTGT
CTCTTCCCACCTTCATTGTCTGCCCACACATACCTGCCCTGGGGGTCCTCAGGAACATGTAGGTCTCAGTTCTGCCAACCCAAGGTACATATGGGGGCGTCTGCCCAGCTGATGAGAACCAGGGGAGG
ATAGCTTTGTGCCTGGACCGAAGAGAGTGTGACTTCTCCATCCCAGATCCCCGCTTCACAGGCTTCTGGACACACCTGTAGGAACACTGGAAGAGGGTGAAGGCTCCGCCCACGAGTCAACCGCAGGA
GGAAGAAACCGCAGACCTCGAGATTCCACCGTCTTCCACCTCTGCGGGCAGGTGGACAGATGGAGGTGGCCCCGAAGGCTCAGAGCAAAATAAGGATGTCCGGAGCAGAGGCCTGTGAGCCTTTTGGG
TCCCACTTAGGTCCTTTCAGCAAATCCCCTCTCCCCAAGATGGTTGCAGCCCCTGGTGGGAGAGCTGCAGGTGGGACCAGCCTGGCCCCGCTGCCAACACACTACACTGCTAAGGAAACACTACTTGT
GCACATGGGGTGAGGTGGGCACCTGGGGCCTGGGTTGGTGCGTTTGGTGTTAAAGTGGAATGACACCAGCAGGCGTGTCTGGGATGTGGGCAGGCAGGGTTGTCTGCTGGGGCCCTCACAGGAGCACA
CAGCTCAAGACACAGGCATTTTGCCTTCCTGTCATCACCACCCTGGCCCTGCCAGGTCTTTCCACCCGCCCCAAGAGCCATTTCCACCCCCTACCTCTACTGGAAGGGCCACTACCCTATCCCCCAAG
TTTTCATTTTCATGGTGGCATCACGGCCTCCGCAGCCCTGGGTGTAGGGGAGGGGCAGAGAGGCTCCTCACTTGTCATTGCACTTTAGAAACAGCTTTTGCATGGTAGGTTCCCAGGGCCTCCCCATC
ACAGGGCACCGCACCGCACCGCACTGCAGGAGAGGCCTCCAGGTGAGCAGTGCTGCCACCTGCTGGTAGAGGCGGGCACTGTGCCCACTAGGTCCTTTGGGTAAACCAGCTGTCGAGTTCTTGATGGC
AAAATAAGGTGCTTAGAAACACTAAATTACCCCCAAGAGTTTTGTGACTTTACTTTTTTTTTTTTTTTTTTTTTTACAGTGCTGGGGGTTAACCCAGGGCCTTTTGTCAGGCCACTGAGCTACACCCC
AGCCCATTATATTACCTAAGAACATAAAACCAAACCCAAGGTACAGACGCGTTGTGTGTGGGTGCTGGGTGCTGGTTTCCTCCCCTCTAGTGGGTCTGTAACACCTGGAGCTGTAGGTCTGGGTGGCT
GGAGGGGTAGTGCTGCTGGATTCGGTTGAGGCTGGTGGTCTGTCCTCTAGCCCTCCAGTCCCCACAGCCCTGAGCCATAGGCAGATGGGGAAGAGGCTTCATTTACCCCTCTACTTTATCTACATCTT
GCTCTCCCAGTTGGCTTTTCAAGGAGTTGGGGCTGCAGGGAAACCATGTTGGTGGAGTCCCTTGTTTGTACCAAGGGTAAAGGCAACCAATTCCCACACTGGCCAGCCGTTTCCACAAGTTCTGCTGC
TATGCTCTGTGGGGACAGGAGGGTGGCTGTGGGAGGCGCTGCCTTGCACCCTAACCCTTGCACAAGTACCAGAAGCCAGGCTGGGGCCTCCTGCCCACTGCCCCCAGGGCACCGGAGTTGGGCAGTGG
GCACTGACGCCCGGGTCCCAGGAGAGCCTGAGCGTGCAGGGAGCTACAGGTTCCCCTTGCCCTGACTCCTCAGCCTTCAAGTCCTGCTTCCCAGGACCCAGGGGATCAAGGACACTTCGTCGGGCATG
GCAGGGGTGGCAGTCAGGACAGCAATCAGATCTGAAAGGGAGAGCACCTAGGGCTTCACTAGGACACGCTGGCCTTGCACAGAACCCTGCCACCCTTCCCCTGTCCAGGACCGTCAGCTCTAGAACGT
TCTCGCCTGGTCCCTGGGTGGGCTGCACATCATTCGGATCCGGGTGGCAGCCAGTGCTCTTGCCCAAAGCAGGAGAGCAGGCCAGCTGCCGCCCCTGGCTGTTCTTGGTGGGCATAGCCTGATGGCAC
CGCTCGGCAGTACCCCAGGGTTGCCCTGCACAGAGACCCAGGCAGGCTGCAGGCCTGGGAACATTGGAACTCCTGACTTGTGTCACTGTTGGGCGTCTGCACACGCTCTGCATCGCCTGCCCTTCCCA
TCCCTCAACATTTTAAGGAGGAGTGTGAAGGGAGCCTGCCCCTCCCCCTTGGTTTTCCCTGCTTATGAGGCTTCTGGCAGAATTTGCCTTTGCCACTGCATTTGAGGGTGACATCACTTGTAAGAGCA
GCTTGCTGGCCGGAAGGTTTTGGGACAGAGCCCTCCCTCCCCAGACTAGGCTTCAGCCCCTTGTCTGTGGGACTGGGTTCCGTGGAAGCCAGTGTCCCCTTGATAGATGGTCCTAGGCCACTAGGCAC
CCTGGCCTCAACTCCAAATATGGCAGTGGGCTGGCTAGCTGCAGCATATTGTCACCAAATGTGATTTTTGCTTGTGCTGCTTCCTGTCCTGTGAGCAGAAGGCTTACTGTGCAGGTGGGGGGCCAGGT
CTGCTCCCCAAAAGAGTAGACCTGCTTGGGGCTGCGGGCTGTGCAGATCATGTGGCAGGGGAAGCAGGAGCAGCGCTCCTCGCCAGGCGGGCTTGACCGCGCGTCTGCACCTAGGGAGAAGGTGACCT
CGTCACTCGAGGACCCTGGGGATGGGTGCGGGGCGGCCCCAACACCTGGCAGCCTGTTTCCCTGTGCCCCTCCTGACAGCAGCGATGCCACTTGCTATCCATGTAGTTGAGACAGGGCGTAAGTTATT
GTTTGCATTTAAAAAAAAATCATGTTCCCTGTGTACATTTTTTTTAAAAAAAAGGAAATGTCTTGGAAATGTATGGGAATAAAACTGTTTGAAAAATT

hide sequence


Protein RefSeqs	XP_005336628	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000010240.3
GenBank Protein	KAG3256319	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005336628 ⟸ XM_005336571

- UniProtKB:

I3MHA2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVGRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASA
EKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKFVSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKI
IPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDHLSCIKAKKLLETKPEFLKWFVVLE
ETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRAEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKP
SKEKMGVIQDVLGEEQRFKALQKLQAERDALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPI
EGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQGQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLV
SSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSILSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLCAFLCEVQDIIPIQLVALTDGAIDVL
DNDLSREQLSEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPPSYTLFREDTSLPSLSKDHSKLSMELEGNDGLS
FIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQDGFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSI
VSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLST
EGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRP
DFSTMDALTATRTYQTIIELFIQQCPFFFYNRPISEPPGAVPSSPSAVAATVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQAEHTL

hide sequence

Ensembl Acc Id:

ENSSTOP00000010240 ⟸ ENSSTOT00000011410

Protein Domains

FF pG1 pseudoGTPase pG2 pseudoGTPase Rho-GAP

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000011409	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000011410.3	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.440	UniProtKB/TrEMBL
	1.10.555.10	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
InterPro	FF_domain	UniProtKB/TrEMBL
	FF_domain_sf	UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	pG1	UniProtKB/TrEMBL
	Rho-GAP_domain	UniProtKB/TrEMBL
	Rho_GTPase_activation_prot	UniProtKB/TrEMBL
	RhoGAP-FF1	UniProtKB/TrEMBL
	RhoGAP_dom	UniProtKB/TrEMBL
	RhoGAP_pG1_pG2	UniProtKB/TrEMBL
	RhoGAP_pG2	UniProtKB/TrEMBL
	Small_GTPase	UniProtKB/TrEMBL
NCBI Gene	Arhgap35	ENTREZGENE
PANTHER	RHO GTPASE-ACTIVATING PROTEIN 190	UniProtKB/TrEMBL
	RHO GTPASE-ACTIVATING PROTEIN 35	UniProtKB/TrEMBL
Pfam	Ras	UniProtKB/TrEMBL
	RhoGAP	UniProtKB/TrEMBL
	RhoGAP-FF1	UniProtKB/TrEMBL
	RhoGAP_pG1_pG2	UniProtKB/TrEMBL
PROSITE	PG1	UniProtKB/TrEMBL
	PG2	UniProtKB/TrEMBL
	PS51676	UniProtKB/TrEMBL
	RHOGAP	UniProtKB/TrEMBL
SMART	RhoGAP	UniProtKB/TrEMBL
	SM00441	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48350	UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
	SSF81698	UniProtKB/TrEMBL
UniProt	I3MHA2	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)