Wdr74 (WD repeat domain 74) - Rat Genome Database

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Gene: Wdr74 (WD repeat domain 74) Ictidomys tridecemlineatus
Analyze
Symbol: Wdr74
Name: WD repeat domain 74
RGD ID: 12621955
Description: INVOLVED IN blastocyst formation (ortholog); RNA metabolic process (ortholog); ASSOCIATED WITH COVID-19 (ortholog); disease of cellular proliferation (ortholog); intellectual disability (ortholog); FOUND IN nuclear exosome (RNase complex) (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: WD repeat domain 74, transcript variant X1; WD repeat domain 74, transcript variant X2; WD repeat-containing protein 74
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,342,627 - 10,347,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581455,606 - 461,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581456,354 - 461,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Wdr74
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,342,627 - 10,347,864 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581455,606 - 461,635 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581456,354 - 461,610 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR74
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,832,905 - 62,841,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,832,342 - 62,841,809 (-)EnsemblGRCh38hg38GRCh38
GRCh371162,600,377 - 62,609,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,356,960 - 62,364,204 (-)NCBINCBI36Build 36hg18NCBI36
Celera1159,929,980 - 59,931,022 (-)NCBICelera
Celera1151,134,558 - 51,137,689 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,929,412 - 58,936,657 (-)NCBIHuRef
CHM1_11162,483,425 - 62,490,670 (-)NCBICHM1_1
T2T-CHM13v2.01162,822,302 - 62,831,206 (-)NCBIT2T-CHM13v2.0
Wdr74
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,713,159 - 8,717,988 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,713,191 - 8,717,988 (+)EnsemblGRCm39 Ensembl
GRCm38198,735,795 - 8,740,624 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,735,827 - 8,740,624 (+)EnsemblGRCm38mm10GRCm38
MGSCv37198,810,329 - 8,815,114 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36198,802,884 - 8,807,669 (+)NCBIMGSCv36mm8
Celera198,495,912 - 8,500,697 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.44NCBI
Wdr74
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,060,901 - 215,065,687 (+)NCBIGRCr8
mRatBN7.21205,631,769 - 205,636,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,631,824 - 205,636,563 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,037,784 - 214,042,502 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,075,396 - 221,080,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,768,103 - 213,772,821 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,933,906 - 224,938,659 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,933,529 - 224,938,662 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01231,871,371 - 231,876,117 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,403,239 - 211,407,978 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1203,144,719 - 203,149,458 (+)NCBICelera
Cytogenetic Map1q43NCBI
Wdr74
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599407,207 - 413,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955599408,076 - 413,770 (+)NCBIChiLan1.0ChiLan1.0
WDR74
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,057,943 - 64,066,700 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,100,637 - 65,108,112 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,188,230 - 58,195,538 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,542,300 - 61,549,754 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,542,300 - 61,549,426 (-)Ensemblpanpan1.1panPan2
WDR74
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,855,207 - 53,861,700 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,855,282 - 53,861,698 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,461,069 - 52,467,744 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01854,907,385 - 54,914,153 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,907,414 - 54,914,149 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,004,274 - 54,010,799 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,578,697 - 53,585,230 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,374,793 - 54,381,506 (+)NCBIUU_Cfam_GSD_1.0
WDR74
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,931,495 - 8,936,906 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.128,931,530 - 8,936,908 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,276,762 - 8,282,140 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WDR74
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,063,294 - 11,070,215 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,063,265 - 11,070,218 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,405,836 - 108,412,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wdr74
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,287,012 - 1,301,658 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,287,012 - 1,291,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000025779   ⟹   ENSSTOP00000022780
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936581455,606 - 461,635 (+)Ensembl
RefSeq Acc Id: XM_005331470   ⟹   XP_005331527
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494710,342,641 - 10,347,864 (+)NCBI
SpeTri2.0NW_004936581456,356 - 461,610 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361262   ⟹   XP_013216716
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494710,342,627 - 10,347,864 (+)NCBI
SpeTri2.0NW_004936581456,354 - 461,610 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040284209   ⟹   XP_040140143
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494710,342,632 - 10,347,786 (+)NCBI
RefSeq Acc Id: XM_040284210   ⟹   XP_040140144
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494710,343,167 - 10,347,864 (+)NCBI
Protein Sequences
Protein RefSeqs XP_005331527 (Get FASTA)   NCBI Sequence Viewer  
  XP_013216716 (Get FASTA)   NCBI Sequence Viewer  
  XP_040140143 (Get FASTA)   NCBI Sequence Viewer  
  XP_040140144 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000022780.1
GenBank Protein KAG3284836 (Get FASTA)   NCBI Sequence Viewer  
  KAG3284837 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_005331527   ⟸   XM_005331470
- Peptide Label: isoform X1
- UniProtKB: I3NEI3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013216716   ⟸   XM_013361262
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_040140143   ⟸   XM_040284209
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040140144   ⟸   XM_040284210
- Peptide Label: isoform X4
Ensembl Acc Id: ENSSTOP00000022780   ⟸   ENSSTOT00000025779


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000028814 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000025779.2 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
  WDR74/Nsa1 UniProtKB/TrEMBL
NCBI Gene Wdr74 ENTREZGENE
PANTHER PTHR16038 UniProtKB/TrEMBL
  WD REPEAT-CONTAINING PROTEIN 74 UniProtKB/TrEMBL
Pfam WD40 UniProtKB/TrEMBL
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
UniProt I3NEI3 ENTREZGENE, UniProtKB/TrEMBL