Stc2 (stanniocalcin 2) - Rat Genome Database

Name: Stc2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Stc2 (stanniocalcin 2) Ictidomys tridecemlineatus

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Symbol:

Stc2

Name:

stanniocalcin 2

RGD ID:

12618817

Description:

ENCODES a protein that exhibits enzyme binding (inferred); heme binding (inferred); hormone activity (inferred); INVOLVED IN calcium ion homeostasis (ortholog); cellular response to hypoxia (ortholog); decidualization (ortholog); ASSOCIATED WITH atrial heart septal defect 7 (ortholog); Atrial Septal Defect with Atrioventricular Conduction Defects (ortholog); Breast Neoplasms (ortholog); FOUND IN endoplasmic reticulum (inferred); extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

stanniocalcin-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	STC2 (stanniocalcin 2)	NCBI	Ortholog
Mus musculus (house mouse):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	STC2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Stc2 (stanniocalcin 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	93,596,596 - 93,607,949 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	2,319,111 - 2,332,988 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936609	2,319,546 - 2,331,049 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

atrial heart septal defect 7 (ISO)

Atrial Septal Defect with Atrioventricular Conduction Defects (ISO)

Breast Neoplasms (ISO)

endometriosis (ISO)

Experimental Mammary Neoplasms (ISO)

hepatocellular carcinoma (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Reperfusion Injury (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion homeostasis (IEA,ISO)

cellular response to hypoxia (ISO)

decidualization (ISO)

embryo implantation (ISO)

endoplasmic reticulum unfolded protein response (IEA,ISO)

intracellular calcium ion homeostasis (IEA,ISO)

negative regulation of gene expression (IEA)

negative regulation of multicellular organism growth (IEA,ISO)

regulation of hormone biosynthetic process (IEA)

regulation of store-operated calcium entry (IEA,ISO)

response to endoplasmic reticulum stress (IEA,ISO)

response to oxidative stress (IEA,ISO)

response to peptide hormone (ISO)

response to vitamin D (ISO)

Cellular Component

endoplasmic reticulum (IEA)

extracellular region (IEA)

extracellular space (IEA)

Golgi apparatus (IEA)

perinuclear region of cytoplasm (IEA)

Molecular Function

enzyme binding (IEA)

heme binding (IEA)

hormone activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Stc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	93,596,596 - 93,607,949 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936609	2,319,111 - 2,332,988 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936609	2,319,546 - 2,331,049 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	5	173,314,723 - 173,328,414 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	5	173,314,723 - 173,328,447 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	5	172,741,726 - 172,755,417 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	172,674,332 - 172,689,112 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	5	172,660,711 - 172,687,936	NCBI
Celera	5	168,774,827 - 168,789,607 (-)	NCBI		Celera
Cytogenetic Map	5	q35.2	NCBI
HuRef	5	167,836,956 - 167,851,740 (-)	NCBI		HuRef
CHM1_1	5	172,174,113 - 172,188,892 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	5	173,854,781 - 173,868,472 (-)	NCBI		T2T-CHM13v2.0

Stc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	31,309,441 - 31,320,061 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	31,307,307 - 31,320,074 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	31,359,441 - 31,370,061 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	31,357,307 - 31,370,074 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	31,259,441 - 31,270,061 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	31,259,441 - 31,270,061 (-)	NCBI		MGSCv36	mm8
Celera	11	33,778,331 - 33,788,980 (-)	NCBI		Celera
Cytogenetic Map	11	A4	NCBI
cM Map	11	18.4	NCBI

Stc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	16,755,508 - 16,765,275 (+)	NCBI		GRCr8
mRatBN7.2	10	16,251,046 - 16,260,815 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	16,250,853 - 16,262,973 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	20,999,993 - 21,009,760 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	20,488,943 - 20,498,710 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	15,978,545 - 15,988,328 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	16,542,909 - 16,552,675 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	16,542,882 - 16,553,295 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	16,432,189 - 16,441,955 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	16,514,603 - 16,524,369 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	16,515,651 - 16,525,418 (+)	NCBI
Celera	10	15,912,872 - 15,922,638 (+)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Stc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955408	25,934,932 - 25,949,399 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955408	25,937,174 - 25,950,221 (-)	NCBI	ChiLan1.0	ChiLan1.0

STC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	4	168,451,252 - 168,463,400 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	5	166,588,413 - 166,603,171 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	5	168,668,851 - 168,681,274 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	5	175,575,412 - 175,587,832 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	175,575,419 - 175,587,832 (-)	Ensembl	panpan1.1		panPan2

STC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	39,151,951 - 39,165,514 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	39,152,503 - 39,162,343 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	39,097,951 - 39,109,709 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	39,523,070 - 39,537,223 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	39,524,206 - 39,534,846 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	39,341,084 - 39,355,222 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	39,529,915 - 39,543,843 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	40,038,732 - 40,052,874 (+)	NCBI		UU_Cfam_GSD_1.0

STC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	16	50,989,433 - 51,004,481 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	16	50,989,676 - 51,001,412 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	16	55,330,021 - 55,341,757 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	23	75,475,020 - 75,489,727 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	23	75,475,022 - 75,488,678 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666034	3,118,074 - 3,132,787 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624733	16,773,644 - 16,785,214 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624733	16,773,422 - 16,787,475 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005334113	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010002273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000004407 ⟹ ENSSTOP00000003951

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936609	2,319,111 - 2,332,988 (+)	Ensembl

RefSeq Acc Id:

XM_005334113 ⟹ XP_005334170

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024407213	93,596,596 - 93,607,949 (+)	NCBI
SpeTri2.0	NW_004936609	2,319,546 - 2,331,049 (+)	NCBI

Sequence:

show sequence

GGGAGGAGGAGGGGAAGCTGCGGAGGAGGAGGAGGAAGAGGAGGAGGAGAGGAGCACAAAGAAC
CCAGGTCTCCAGGCGGGAGGTTTATACCAAGAACCATGTGTGCTGAGCGTCTTGGTCAGTTTGT
GACCCTGGCTTTGGTGTTGGCCACCTTCGACCTGGCGCGAGGGACCGACGCCACCTACCCTCCC
GAAGGTCCTCAAGACAGGGGCTCCCAACAGAAAGGCCGCCTGTCTCTGCAGAACACAGCGGAGA
TCCAACACTGTTTGGTCAACGCTGGCGATGTGGGGTGTGGCGTGTTTGAATGTTTCGAGAACAA
CTCTTGTGAGATTCGGGGCTTACATGGGATTTGCATGACTTTTCTGCACAACGCTGGAAAATTT
GATGCCCAGGGCAAGTCGTTCATCAAAGATGCCTTGAAGTGCAAGGCCCACGCTCTGCGGCACA
GGTTCGGCTGCATAAGCCGGAAGTGCCCGGCCATTAAGGAAATGGTGTCCCAGCTGCAGCGGGA
ATGCTACCTCAGGCACGGGCTGTGCGCCGCGGCGCAGGAGAACATCCGGGTGATGGTGGAGATG
ATCCACTTCAAGGACCTGCTGCTGCACGAACCCTACGTGGACCTGGTGAACCTGCTGCTTACCT
GCGGGGAGGAGGTGAAGGAGGCTGTCACCCACAGTGTCCAGGCCCAGTGTGAACAGAACTTGGG
AGGGCTGTGCTCCATCCTGAGTTTCTGCACCTCAGCCATCCAGAGGCCCCCCACGGCATCCCCT
GAGCACCAGCTCCAAGGGGACAGAGCCAGGCTCTCCAGGATCCACCGCGGGGAAGCCAGCCTGC
ACTTCTCAGAGCCCAGCAGCAGGGAGGCTGTCAGAGGCTCCAGGGGCGAGCGAGGCAGCAGGAG
CCACCCACATGCCCAGGCCCGGGGCCGAGCGGGGAGCCAGGGGACCCAGGGACCTTCTGGAAGC
AGCGAGTGGGAGGACGAACAGTCTGAGTACTCTGACATCCGGAGGTGAAATCAAAGACCAGCCA
TGAAATCTTTCCTCCACGCCGTCCATTTTCTTATCTATGGACATTCCAAAACATTTGCCATTAA
AGAGGGGGGATGTCACACGCAGGATTTTGTGGGATTGTGGACTTCATGACGGTGTGTGAACAGG
TGAGATGGAGGCTCCTGGGGCAGCGGGGTCTCAGCGGGCCTGGTGAGCTGGGCACCTGCATGTG
CTCAAGGGCATCCCGCGACCTCCTTGTATCTCTGTCTTCTTCCCATAGTGGGCCAGTGAGTGGT
GGGCTGCCGTGTACCCTGCTCTGGGGGAGGTGAATACCCACCTGCGCTGGGCCAAGCACGGGGG
CTAGACCCTGCAGCCTCTGGCACTGTGGGAGGGCAAGGCGGGGCCAGAGGGGAGAGAGGATGTC
CCCGGAGGCACAGGGGCTGGTGCACAGGAGCCGCACAGTGCTCTGCGGAACCCGAATTCAGTTT
CCTGCATGGGGCCTCTTGGTTCAGAGCTGCTTGAGGGAGCGAGGGCAGAGTCATTTCCATGTGT
GATTTCTGAGCCATTGTTCTGCCCGGGGGACACAGTCCGAGGGAGTGACCCCTGTGTGTTTATA
CTTTAACCACTGCTTCCAATCTCGATTTCACTTTTTTTATTTATCCAGTTACATCTATATATCT
GTTGTCTAAATAAATGCCTTTCAAACAAAGCAACTGGTTCATTAAAACCAGCTCAAAGTGGGAG
GAAAAACAGCCCCGGCCCACCCTTTGGGGCCCAATTTTTTAAAGTGCAATTTTTAAAAGAATCC
AACAGCCCAACAGCACTGTGCCTGGCCTGGGCTCACATTCACCTGGGACAGACCTCATACCTGG
AGGGAAACGCACACAGGGAGGCCATCAGGCAGCTCACCTTGACCCATCGCCAGGTCCCAGCAAG
CCCTATACCCACCACCCTGCGAGGCCGAGCAGGAAACCTGGCTTCCCCATGCTGGAGGGGAAAA
AAGGGGAGAAGAGAAGGAGATTGCTGAGGCCACCCATCGAGAGGCCCACCAGTGGTGCCCACCT
GCAATCCCAGCAGCTCAGGAGGCTGAGACAGGAGGATCACATGTTTGAAGCCAGCCTTAGCAAC
TT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005334170	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000003951.3
GenBank Protein	KAG3265245	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005334170 ⟸ XM_005334113

- UniProtKB:

I3M465 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MCAERLGQFVTLALVLATFDLARGTDATYPPEGPQDRGSQQKGRLSLQNTAEIQHCLVNAGDVG
CGVFECFENNSCEIRGLHGICMTFLHNAGKFDAQGKSFIKDALKCKAHALRHRFGCISRKCPAI
KEMVSQLQRECYLRHGLCAAAQENIRVMVEMIHFKDLLLHEPYVDLVNLLLTCGEEVKEAVTHS
VQAQCEQNLGGLCSILSFCTSAIQRPPTASPEHQLQGDRARLSRIHRGEASLHFSEPSSREAVR
GSRGERGSRSHPHAQARGRAGSQGTQGPSGSSEWEDEQSEYSDIRR

hide sequence

Ensembl Acc Id:

ENSSTOP00000003951 ⟸ ENSSTOT00000004407

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000004413	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000004407.3	UniProtKB/TrEMBL
InterPro	Stanniocalcin	UniProtKB/TrEMBL
NCBI Gene	Stc2	ENTREZGENE
PANTHER	PTHR11245	UniProtKB/TrEMBL
	STANNIOCALCIN-2	UniProtKB/TrEMBL
Pfam	Stanniocalcin	UniProtKB/TrEMBL
UniProt	I3M465	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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