Twist2 (twist family bHLH transcription factor 2) - Rat Genome Database

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Gene: Twist2 (twist family bHLH transcription factor 2) Ictidomys tridecemlineatus
Analyze
Symbol: Twist2
Name: twist family bHLH transcription factor 2
RGD ID: 12607943
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA-binding transcription factor activity (ortholog); protein domain specific binding (ortholog); INVOLVED IN cell population proliferation (ortholog); cornea development in camera-type eye (ortholog); embryonic cranial skeleton morphogenesis (ortholog); ASSOCIATED WITH ablepharon macrostomia syndrome (ortholog); Barber-Say syndrome (ortholog); Bethlem Myopathy 1A (ortholog); FOUND IN transcription regulator complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: twist basic helix-loop-helix transcription factor 2; twist-related protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303191,151,472 - 191,191,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367452,028,286 - 2,067,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367452,067,272 - 2,067,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2Squirrelablepharon macrostomia syndrome  ISORGD:7354688554872ClinVar Annotator: match by term: Ablepharon macrostomia syndromeClinVarPMID:11038439|PMID:11807864|PMID:15103726|PMID:2036354|PMID:21595001|PMID:25741868|PMID:26119818|PMID:8746822
Twist2SquirrelBarber-Say syndrome  ISORGD:7354688554872ClinVar Annotator: match by term: Barber-Say syndromeClinVarPMID:16650233|PMID:1867254|PMID:19760652|PMID:20799330|PMID:20830793|PMID:25741868|PMID:26119818|PMID:27092433|PMID:28680619|PMID:8368246|PMID:9674915
Twist2SquirrelBethlem Myopathy 1A  ISORGD:7354688554872ClinVar Annotator: match by term: Bethlem myopathy 1AClinVarPMID:26004199|PMID:28492532
Twist2Squirrelchromosome 2q37 deletion syndrome  ISORGD:7354688554872ClinVar Annotator: match by term: Chromosome 2q37 deletion syndromeClinVarPMID:25741868
Twist2SquirrelD-2-hydroxyglutaric aciduria 1  ISORGD:7354688554872ClinVar Annotator: match by term: D-2-hydroxyglutaric aciduria 1ClinVarPMID:16081310|PMID:20020533|PMID:20691407|PMID:21384162|PMID:21820098|PMID:24715439|PMID:28492532|PMID:30848064|PMID:31488895
Twist2SquirrelFocal Facial Dermal Dysplasia 3  ISORGD:7354688554872ClinVar Annotator: match by term: Focal facial dermal dysplasia 3, Setleis typeClinVarPMID:14069095|PMID:20691403|PMID:21931173|PMID:8818454
Twist2Squirrelgenetic disease  ISORGD:7354688554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:11038439|PMID:11807864|PMID:15103726|PMID:2036354|PMID:21595001|PMID:25741868|PMID:26119818|PMID:8746822
Twist2Squirrelhereditary spastic paraplegia 30  ISORGD:7354688554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 30ClinVarPMID:16081310|PMID:20020533|PMID:20691407|PMID:21384162|PMID:21820098|PMID:24715439|PMID:28492532|PMID:30848064|PMID:31488895
Twist2Squirrelintellectual disability  ISORGD:7354688554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2SquirrelFocal Facial Dermal Dysplasia  ISORGD:7354689068941CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2Squirrelablepharon macrostomia syndrome  ISORGD:7354687240710 OMIM 
Twist2SquirrelBarber-Say syndrome  ISORGD:7354687240710 OMIM 
Twist2SquirrelFocal Facial Dermal Dysplasia 3  ISORGD:7354687240710 OMIM 


Biological Process
1 to 20 of 26 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2Squirrelcell population proliferation acts_upstream_ofISOMGI:30444129068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelcornea development in camera-type eye acts_upstream_of_or_withinISOMGI:30444129068941 PMID:20574024MGIPMID:20574024
Twist2Squirreldevelopmental process involved_inIEAPANTHER:PTN000598549150520179 TreeGrafterGO_REF:0000118
Twist2Squirrelembryonic cranial skeleton morphogenesis acts_upstream_of_or_withinISOMGI:998299068941 PMID:15030764MGIPMID:15030764
Twist2Squirrelface morphogenesis acts_upstream_of_or_withinISOMGI:30444129068941 PMID:20574024, PMID:20691403MGIPMID:20574024|PMID:20691403
Twist2Squirrelkeratinocyte proliferation acts_upstream_ofISOMGI:30444129068941 PMID:20574024MGIPMID:20574024
Twist2Squirrelmyeloid cell differentiation acts_upstream_ofISOMGI:30444129068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelnegative regulation of apoptotic process  ISORGD:6212869068941 RGDPMID:10485844|REF_RGD_ID:634726
Twist2Squirrelnegative regulation of cell population proliferation acts_upstream_of_or_withinISOMGI:30444129068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelnegative regulation of DNA-templated transcription involved_inISORGD:7354699068941 PMID:7589808UniProtPMID:7589808
Twist2Squirrelnegative regulation of macrophage cytokine production acts_upstream_of_or_withinISOMGI:988729068941 PMID:16831897MGIPMID:16831897
Twist2Squirrelnegative regulation of macrophage cytokine production acts_upstream_of_or_withinISOMGI:30444129068941 PMID:16831897MGIPMID:16831897
Twist2Squirrelnegative regulation of myeloid cell differentiation acts_upstream_of_or_withinISOMGI:30444129068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelnegative regulation of osteoblast differentiation involved_inIEAUniProtKB:Q8WVJ9|ensembl:ENSP00000482581150520179 EnsemblGO_REF:0000107
Twist2Squirrelnegative regulation of osteoblast differentiation acts_upstream_of_or_withinISOMGI:30444129068941 PMID:15030764MGIPMID:15030764
Twist2Squirrelnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:107606|MGI:1080869068941 PMID:14654692MGIPMID:14654692
Twist2Squirrelnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOMGI:99480|MGI:998529068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISORGD:7354699068941 PMID:16831897MGIPMID:16831897
Twist2Squirrelnegative regulation of tumor necrosis factor production acts_upstream_of_or_withinISOMGI:988729068941 PMID:16831897MGIPMID:16831897
Twist2Squirrelnegative regulation of tumor necrosis factor production acts_upstream_of_or_withinISOMGI:30444129068941 PMID:16831897MGIPMID:16831897
1 to 20 of 26 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2Squirrelcytoplasm located_inIEAUniProtKB:Q8WVJ9|ensembl:ENSP00000482581150520179 EnsemblGO_REF:0000107
Twist2Squirrelnucleolus located_inIEAUniProtKB:Q8WVJ9|ensembl:ENSP00000482581150520179 EnsemblGO_REF:0000107
Twist2Squirrelnucleoplasm located_inIEAUniProtKB:Q8WVJ9|ensembl:ENSP00000482581150520179 EnsemblGO_REF:0000107
Twist2Squirrelnucleus located_inIEAUniProtKB:Q8WVJ9|ensembl:ENSP00000482581150520179 EnsemblGO_REF:0000107
Twist2Squirreltranscription regulator complex part_ofISOPR:P158069068941 PMID:7589808MGIPMID:7589808

Molecular Function
1 to 16 of 16 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Twist2Squirrelchromatin binding enablesISORGD:7354699068941 PMID:16831897MGIPMID:16831897
Twist2SquirrelDNA-binding transcription factor activity enablesISORGD:7354699068941 PMID:7589808MGIPMID:7589808
Twist2SquirrelDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAPANTHER:PTN000598549150520179 TreeGrafterGO_REF:0000118
Twist2Squirrelprotein binding enablesISOUniProtKB:A0A6Q8PF08|UniProtKB:P01023|UniProtKB:P37840|UniProtKB:P42858|UniProtKB:P54253|UniProtKB:Q14203-5|UniProtKB:Q9UBB49068941 PMID:32814053IntActPMID:32814053
Twist2Squirrelprotein binding enablesISOPR:Q9WTN39068941 PMID:14654692MGIPMID:14654692
Twist2Squirrelprotein binding enablesISOUniProtKB:P15923-3|UniProtKB:Q99081-3|UniProtKB:Q9BZE09068941 PMID:32296183IntActPMID:32296183
Twist2Squirrelprotein binding enablesISOUniProtKB:P158849068941 PMID:28514442IntActPMID:28514442
Twist2Squirrelprotein binding enablesISOPR:Q033479068941 PMID:19090621MGIPMID:19090621
Twist2Squirrelprotein binding enablesISOUniProtKB:Q087759068941 PMID:20655471IntActPMID:20655471
Twist2Squirrelprotein binding enablesISOUniProtKB:P15884|UniProtKB:Q990819068941 PMID:25416956, PMID:33961781IntActPMID:25416956|PMID:33961781
Twist2Squirrelprotein binding enablesISOUniProtKB:P150369068941 PMID:18598946IntActPMID:18598946
Twist2Squirrelprotein binding enablesISOUniProtKB:Q9BSQ59068941 PMID:25814554IntActPMID:25814554
Twist2Squirrelprotein dimerization activity enablesIEAInterPro:IPR011598|InterPro:IPR036638150520179 InterProGO_REF:0000002
Twist2Squirrelprotein domain specific binding enablesISOPR:Q087759068941 PMID:15030764MGIPMID:15030764
Twist2SquirrelRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIEAPANTHER:PTN000598549150520179 TreeGrafterGO_REF:0000118
Twist2SquirrelRNA polymerase II transcription regulatory region sequence-specific DNA binding enablesIEAInterPro:IPR047094150520179 InterProGO_REF:0000002
1 to 16 of 16 rows

PMID:22301074   PMID:30032202  



Twist2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303191,151,472 - 191,191,746 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367452,028,286 - 2,067,948 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367452,067,272 - 2,067,948 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWIST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,848,085 - 238,910,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,848,032 - 238,910,534 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,756,726 - 239,832,230 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362239,496,916 - 239,497,176 (+)NCBINCBI36Build 36hg18NCBI36
Build 342239,568,232 - 239,568,491NCBI
Celera2233,470,842 - 233,508,585 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2231,547,793 - 231,586,033 (+)NCBIHuRef
HuRef2231,602,511 - 231,603,214 (+)NCBIHuRef
CHM1_12239,838,012 - 239,838,268 (+)NCBICHM1_1
CHM1_12239,763,040 - 239,801,929 (+)NCBICHM1_1
T2T-CHM13v2.02239,335,184 - 239,402,179 (+)NCBIT2T-CHM13v2.0
Twist2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39191,729,183 - 91,775,756 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl191,729,183 - 91,775,750 (+)EnsemblGRCm39 Ensembl
GRCm38191,801,461 - 91,848,034 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl191,801,461 - 91,848,028 (+)EnsemblGRCm38mm10GRCm38
MGSCv37193,698,054 - 93,744,604 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36193,631,883 - 93,678,433 (+)NCBIMGSCv36mm8
Celera194,738,169 - 94,784,976 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map146.24NCBI
Twist2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8999,822,242 - 99,866,722 (+)NCBIGRCr8
mRatBN7.2992,374,740 - 92,419,222 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl992,374,574 - 92,419,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9100,809,039 - 100,853,482 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09105,944,804 - 105,989,247 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09104,302,463 - 104,346,934 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0998,924,134 - 98,968,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl998,924,134 - 98,968,510 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0998,599,201 - 98,642,827 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4991,016,450 - 91,058,863 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1991,221,218 - 91,263,067 (+)NCBI
Celera989,915,377 - 89,958,630 (+)NCBICelera
Cytogenetic Map9q36NCBI
Twist2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555421,959,765 - 2,000,665 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555421,959,765 - 2,000,665 (-)NCBIChiLan1.0ChiLan1.0
TWIST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213141,482,546 - 141,549,418 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B141,499,450 - 141,564,099 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B126,080,684 - 126,143,677 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B244,921,429 - 244,982,136 (+)NCBIpanpan1.1PanPan1.1panPan2
TWIST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12549,165,450 - 49,216,545 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2549,165,641 - 49,166,123 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2549,660,979 - 49,712,121 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02549,552,697 - 49,603,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2549,552,774 - 49,553,256 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12549,426,770 - 49,477,881 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02549,215,467 - 49,266,628 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02549,447,550 - 49,498,775 (+)NCBIUU_Cfam_GSD_1.0
TWIST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15138,228,807 - 138,229,289 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115138,228,640 - 138,276,341 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215152,586,205 - 152,633,994 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TWIST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110124,889,954 - 124,953,135 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10124,890,134 - 124,890,613 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604074,468,298 - 74,529,773 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twist2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248473,730,291 - 3,773,773 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248473,730,126 - 3,774,338 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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RefSeq Transcripts XM_021719641 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005725937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSSTOT00000004618   ⟹   ENSSTOP00000004144
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367452,028,286 - 2,067,948 (-)Ensembl
RefSeq Acc Id: XM_021719641   ⟹   XP_021575316
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303191,151,472 - 191,191,746 (+)NCBI
SpeTri2.0NW_0049367452,067,272 - 2,067,948 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005725937
Type: NON-CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_024405303191,151,472 - 191,191,746 (+)NCBI
Protein RefSeqs XP_021575316 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000004144.1
GenBank Protein KAG3275661 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021575316   ⟸   XM_021719641
- UniProtKB: I3M4K6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000004144   ⟸   ENSSTOT00000004618
bHLH



1 to 15 of 15 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSSTOG00000004633 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004618.2 UniProtKB/TrEMBL
Gene3D-CATH 4.10.280.10 UniProtKB/TrEMBL
InterPro bHLH_dom UniProtKB/TrEMBL
  E-box_TF_Regulators UniProtKB/TrEMBL
  HLH_DNA-bd_sf UniProtKB/TrEMBL
  Twist2_bHLH UniProtKB/TrEMBL
NCBI Gene Twist2 ENTREZGENE
PANTHER BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTOR, TWIST UniProtKB/TrEMBL
  PTHR23349:SF70 UniProtKB/TrEMBL
Pfam HLH UniProtKB/TrEMBL
PROSITE BHLH UniProtKB/TrEMBL
SMART HLH UniProtKB/TrEMBL
Superfamily-SCOP SSF47459 UniProtKB/TrEMBL
UniProt I3M4K6 ENTREZGENE, UniProtKB/TrEMBL
1 to 15 of 15 rows