Gab2 (GRB2 associated binding protein 2) - Rat Genome Database

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Gene: Gab2 (GRB2 associated binding protein 2) Ictidomys tridecemlineatus
Analyze
Symbol: Gab2
Name: GRB2 associated binding protein 2
RGD ID: 12545209
Description: ENCODES a protein that exhibits phosphatidylinositol-3,4,5-trisphosphate binding (ortholog); phosphatidylinositol-3,4-bisphosphate binding (ortholog); protein domain specific binding (ortholog); INVOLVED IN cell migration (ortholog); integrin-mediated signaling pathway (ortholog); intracellular signal transduction (ortholog); PARTICIPATES IN Fc epsilon receptor mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-2 signaling pathway; ASSOCIATED WITH chronic myeloid leukemia (ortholog); intellectual disability (ortholog); melanoma (ortholog); FOUND IN membrane raft (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: GRB2-associated-binding protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,175,561 - 65,236,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,778,462 - 6,835,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,775,170 - 6,835,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
Gab2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494765,175,561 - 65,236,040 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364986,778,462 - 6,835,643 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364986,775,170 - 6,835,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GAB2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381178,215,293 - 78,417,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1178,215,293 - 78,418,348 (-)EnsemblGRCh38hg38GRCh38
GRCh371177,926,339 - 78,128,866 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,603,990 - 77,806,414 (-)NCBINCBI36Build 36hg18NCBI36
Build 341177,603,989 - 77,806,414NCBI
Celera1175,234,820 - 75,437,334 (-)NCBICelera
Cytogenetic Map11q14.1NCBI
HuRef1174,223,774 - 74,350,451 (-)NCBIHuRef
CHM1_11177,809,494 - 78,012,010 (-)NCBICHM1_1
T2T-CHM13v2.01178,148,579 - 78,351,115 (-)NCBIT2T-CHM13v2.0
Gab2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39796,730,958 - 96,958,158 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl796,730,793 - 96,958,153 (+)EnsemblGRCm39 Ensembl
GRCm38797,081,751 - 97,308,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl797,081,586 - 97,308,946 (+)EnsemblGRCm38mm10GRCm38
MGSCv377104,230,261 - 104,457,461 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36786,817,681 - 87,047,535 (+)NCBIMGSCv36mm8
MGSCv36796,956,943 - 97,180,228 (+)NCBIMGSCv36mm8
Cytogenetic Map7E1NCBI
cM Map753.39NCBI
Gab2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81160,841,066 - 161,036,940 (+)NCBIGRCr8
mRatBN7.21151,429,844 - 151,625,708 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1151,429,695 - 151,625,031 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1159,415,950 - 159,614,017 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01166,596,124 - 166,794,193 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01159,469,621 - 159,667,696 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01162,082,876 - 162,283,379 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1162,083,030 - 162,279,727 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01168,423,264 - 168,486,051 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41154,348,777 - 154,544,906 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11154,427,186 - 154,623,310 (+)NCBI
Celera1149,534,433 - 149,721,184 (+)NCBICelera
Cytogenetic Map1q32NCBI
Gab2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541413,679,588 - 13,751,079 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541413,640,713 - 13,754,401 (+)NCBIChiLan1.0ChiLan1.0
GAB2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2979,148,122 - 79,351,393 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,192,030 - 80,395,201 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01173,275,360 - 73,478,272 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11176,896,691 - 76,965,955 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1176,896,691 - 76,967,007 (-)Ensemblpanpan1.1panPan2
NARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12120,277,707 - 20,413,624 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2120,277,507 - 20,606,736 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2120,172,632 - 20,308,737 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02120,480,690 - 20,616,549 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2120,480,413 - 20,624,453 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12120,258,355 - 20,393,504 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02120,472,646 - 20,608,490 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02120,396,339 - 20,532,773 (+)NCBIUU_Cfam_GSD_1.0
GAB2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl912,663,657 - 12,851,342 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1912,663,658 - 12,851,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2913,937,322 - 14,135,579 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GAB2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1169,422,517 - 69,624,411 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl169,424,100 - 69,624,279 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604356,115,569 - 56,326,011 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gab2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248631,219,866 - 1,281,847 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248631,216,664 - 1,410,934 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000003169   ⟹   ENSSTOP00000002830
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364986,778,462 - 6,835,643 (-)Ensembl
RefSeq Acc Id: XM_021725131   ⟹   XP_021580806
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494765,175,779 - 65,236,040 (-)NCBI
SpeTri2.0NW_0049364986,775,170 - 6,835,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040284996   ⟹   XP_040140930
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494765,175,561 - 65,236,040 (-)NCBI
RefSeq Acc Id: XM_040284997   ⟹   XP_040140931
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494765,175,779 - 65,235,879 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021580806 (Get FASTA)   NCBI Sequence Viewer  
  XP_040140930 (Get FASTA)   NCBI Sequence Viewer  
  XP_040140931 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000002830.3
GenBank Protein KAG3286226 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021580806   ⟸   XM_021725131
- Peptide Label: isoform X1
- UniProtKB: I3M1S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040140930   ⟸   XM_040284996
- Peptide Label: isoform X2
- UniProtKB: I3M1S9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040140931   ⟸   XM_040284997
- Peptide Label: isoform X3
- UniProtKB: I3M1S9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSSTOP00000002830   ⟸   ENSSTOT00000003169
Protein Domains
PH


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000003173 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000003169.3 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro Gab1-4-like UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
NCBI Gene Gab2 ENTREZGENE
PANTHER GRB2-ASSOCIATED-BINDING PROTEIN 2 UniProtKB/TrEMBL
  PTHR45960 UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
SMART SM00233 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
UniProt I3M1S9 ENTREZGENE, UniProtKB/TrEMBL