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Gene: GAB2 (GRB2 associated binding protein 2) Homo sapiens
Symbol: GAB2
Name: GRB2 associated binding protein 2
Description: Exhibits transmembrane receptor protein tyrosine kinase adaptor activity. Involved in osteoclast differentiation and positive regulation of cell population proliferation. Localizes to the cytoplasm and plasma membrane. Biomarker of chronic myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Grb2-associated binder 2; GRB2-associated binding protein 2; GRB2-associated-binding protein 2; growth factor receptor bound protein 2-associated protein 2; KIAA0571; pp100
Mus musculus (house mouse) : Gab2 (growth factor receptor bound protein 2-associated protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gab2 (GRB2-associated binding protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gab2 (GRB2 associated binding protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GAB2 (GRB2 associated binding protein 2)
Canis lupus familiaris (dog) : GAB2 (GRB2 associated binding protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gab2 (GRB2 associated binding protein 2)
Sus scrofa (pig) : GAB2 (GRB2 associated binding protein 2)
Chlorocebus sabaeus (African green monkey) : GAB2 (GRB2 associated binding protein 2)
Heterocephalus glaber (naked mole-rat) : Gab2 (GRB2 associated binding protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1178,215,293 - 78,418,348 (-)Ensembl
GRCh381178,215,290 - 78,417,820 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371177,926,336 - 78,128,868 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,603,990 - 77,806,414 (-)NCBINCBI36hg18NCBI36
Build 341177,603,989 - 77,806,414NCBI
Celera1175,234,820 - 75,437,334 (-)NCBI
Cytogenetic Map11q14.1NCBI
HuRef1174,223,774 - 74,350,451 (-)NCBIHuRef
CHM1_11177,809,494 - 78,012,010 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GAB2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737428
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.