Snai1 (snail family transcriptional repressor 1)

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Gene: Snai1 (snail family transcriptional repressor 1) Ictidomys tridecemlineatus

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Symbol:

Snai1

Name:

snail family transcriptional repressor 1

RGD ID:

12531972

Description:

ENCODES a protein that exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific (inferred); E-box binding (inferred); kinase binding (inferred); INVOLVED IN cartilage morphogenesis (ortholog); epithelial cell migration (ortholog); hair follicle morphogenesis (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 1 (ortholog); Breast Neoplasms (ortholog); cholestasis (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); fibrillar center (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

zinc finger protein SNAI1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	189,002,837 - 189,012,567 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	4,456,484 - 4,462,987 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	4,456,498 - 4,462,436 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis type 1 (ISO)

Breast Neoplasms (ISO)

cholestasis (ISO)

colorectal cancer (ISO)

dilated cardiomyopathy (ISO)

hepatocellular carcinoma (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Neoplastic Cell Transformation (ISO)

oral mucosa leukoplakia (ISO)

papillary thyroid carcinoma (ISO)

rheumatic heart disease (ISO)

skin cancer (ISO)

Stomach Neoplasms (ISO)

ureteral obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical Wnt signaling pathway (IEA)

cartilage morphogenesis (IEA,ISO)

epithelial cell migration (IEA,ISO)

epithelial to mesenchymal transition (IEA)

epithelial to mesenchymal transition involved in endocardial cushion formation (IEA)

hair follicle morphogenesis (IEA,ISO)

heterochromatin organization (IEA)

left/right pattern formation (IEA,ISO)

mesoderm development (IEA,ISO)

mesoderm formation (IEA)

negative regulation of cell differentiation involved in embryonic placenta development (IEA,ISO)

negative regulation of DNA damage response, signal transduction by p53 class mediator (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage (IEA)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

negative regulation of vitamin D biosynthetic process (IEA)

Notch signaling pathway (IEA)

osteoblast differentiation (IEA)

positive regulation of cell migration (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of epithelial to mesenchymal transition (IEA)

regulation of bicellular tight junction assembly (IEA)

regulation of DNA-templated transcription (IEA)

regulation of transcription by RNA polymerase II (IEA,ISO)

roof of mouth development (IEA,ISO)

trophoblast giant cell differentiation (IEA,ISO)

Cellular Component

cytoplasm (IEA)

cytosol (IEA)

fibrillar center (IEA)

intracellular membrane-bounded organelle (IEA)

nucleoplasm (IEA)

nucleus (IEA)

pericentric heterochromatin (IEA)

Molecular Function

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

E-box binding (IEA)

kinase binding (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Snai1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	189,002,837 - 189,012,567 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	4,456,484 - 4,462,987 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936514	4,456,498 - 4,462,436 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SNAI1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	49,982,980 - 49,988,886 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	20	49,982,980 - 49,988,886 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	48,599,517 - 48,605,423 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	48,032,934 - 48,038,830 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	48,032,933 - 48,038,825	NCBI
Celera	20	45,304,074 - 45,309,984 (+)	NCBI		Celera
Cytogenetic Map	20	q13.13	NCBI
HuRef	20	45,348,282 - 45,354,192 (+)	NCBI		HuRef
CHM1_1	20	48,504,120 - 48,510,030 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	20	51,752,473 - 51,758,373 (+)	NCBI		T2T-CHM13v2.0

Snai1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	167,380,115 - 167,384,734 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	167,380,115 - 167,384,734 (+)	Ensembl		GRCm39 Ensembl
GRCm38	2	167,538,195 - 167,542,814 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	167,538,195 - 167,542,814 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	167,363,727 - 167,368,314 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	167,229,432 - 167,234,019 (+)	NCBI		MGSCv36	mm8
Celera	2	173,478,489 - 173,483,072 (+)	NCBI		Celera
Cytogenetic Map	2	H3	NCBI
cM Map	2	87.33	NCBI

Snai1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	176,667,476 - 176,671,965 (+)	NCBI		GRCr8
mRatBN7.2	3	156,248,479 - 156,252,969 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	156,248,485 - 156,252,969 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	160,043,780 - 160,048,265 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	168,542,842 - 168,547,327 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	166,284,546 - 166,289,031 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	164,274,710 - 164,279,199 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	164,274,710 - 164,279,378 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	170,425,898 - 170,430,387 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	158,676,980 - 158,681,471 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	158,583,924 - 158,586,727 (+)	NCBI
Celera	3	154,827,543 - 154,832,032 (+)	NCBI		Celera
Cytogenetic Map	3	q42	NCBI

Snai1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955445	8,231,924 - 8,237,996 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955445	8,232,084 - 8,237,893 (-)	NCBI	ChiLan1.0	ChiLan1.0

SNAI1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	21	55,722,221 - 55,732,559 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	20	55,715,326 - 55,725,666 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	20	46,321,075 - 46,328,865 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	20	47,384,818 - 47,390,738 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	47,384,818 - 47,390,733 (+)	Ensembl	panpan1.1		panPan2

SNAI1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	36,498,343 - 36,503,623 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	24	36,498,062 - 36,503,628 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	35,741,546 - 35,747,503 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	37,204,007 - 37,209,960 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	24	37,204,036 - 37,209,945 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	24	36,445,442 - 36,451,401 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	24	36,578,693 - 36,584,651 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	37,122,272 - 37,128,230 (+)	NCBI		UU_Cfam_GSD_1.0

SNAI1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	51,546,477 - 51,552,499 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	51,546,446 - 51,552,498 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SNAI1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	13,988,059 - 13,993,780 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	13,988,024 - 13,993,746 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	62,416,997 - 62,422,718 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Snai1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624790	5,509,311 - 5,515,266 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624790	5,509,541 - 5,515,240 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005325218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010003700	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000005855 ⟹ ENSSTOP00000005237

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936514	4,456,484 - 4,462,987 (-)	Ensembl

RefSeq Acc Id:

XM_005325218 ⟹ XP_005325275

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024408640	189,002,837 - 189,012,567 (-)	NCBI
SpeTri2.0	NW_004936514	4,456,498 - 4,462,436 (-)	NCBI

Sequence:

show sequence

CTGCTTGGGGCGTGGCCTTTGGCGGACGCGCGCCTCCGATTGGTGCGGCGTTGACAAAGGGGCG
TGGCGCTCATGGCCCCGCCCCGAGGCTGGGGTATTTAAAGGAGGCAGCGGGCTTCTTCACTCAC
AGCGCCGCTGCACGGCCTCGCGGGTGGTGTTCCCTGCGGCCCCTGCGCGACCCGGCGACCCCGG
CTGCTTCAGCCACCATGCCGCGCTCTTTCCTCGTCAGGAAGCCCTCGGTCCCTCGCCGGAAGCC
CAATTACAGCGAGCTGCAAGACTCTTCTCCCGAGTTCACCTTCCAGCAGCCCTACGACCAGGCC
CACCTGCTGGCTGCCATCCCGCCTCCTGAGGTCCTCAACCCCACCGCCTCGCTGCCCACCCTCA
TCTGGGACTGTCTCCTAGCGCCCCACACGCAGCCCATTGGCTGGGCCTCCCTGCAGCCCCAGGA
GAACCCCCAGGCAGCAGAGCTGACCTCCCTGTCGGATGAGGACAGCGGGAAGGGCTCGCAGCCC
CCCAGCCCACCCTCTCCAGCTCCTTCCTCCTTCTCTTCCACCTCCGCTTCTTCCCTGGAGGCTG
AGGCCTACATTGCCTTCCCAGGCTTGGGCCAACTGCCCAAGCAACTGGCTCTGCTCTCCGTGGC
CAAGGACCCCCAATCTCGCAAGGCTTTCAACTGCAAGTACTGCAACAAGGAATACCTCAGCCTG
GGCGCCCTCAAGATGCACATTCGGAGCCACACTCTCCCCTGTGTCTGCGCAACCTGTGGGAAGG
CCTTCTCCAGGCCCTGGCTGCTGCAGGGCCATGTCCGGACCCACACTGGTGAGAAGCCCTTCTC
CTGCCCCCACTGCAGCCGGGCCTTCGCTGACCGCTCCAACCTGCGCGCCCACCTGCAGACCCAC
TCGGACGTGAAGAAGTACCAGTGCCCGAGGTGCGCCCGCACCTTCTCCCGCATGTCCCTGCTGC
ACAAGCACCAGGAGTCGGGCTGCTCGGGTGGCCCCCGCTGAGCCTGCCACCACCCCAGCTGCCT
CCCCCATCCAGGAGGAAGGCGCCCCGTCCGTCGCCCCGCCACGGAAGCCACCGATGCCTGGCTG
CGTGGCCCCGTGGACGTTGCAGGCTGCTGACTGGTGTCGCGCCCCGGGGGCCTCATGGGCTTTG
AAGGAGCCTCTCGGGCCTCCCTGTGGACAGTGGACGGAAGGTGGCCTTGGAGCTGCTTCCTGGC
TTCCCGAGTTGGCCTCTGGGCTCGCGTCTCCAGGGCTGAGTGGATGCAGCTGCTGAGCAACAGG
ACAGAGCGGACAGATGAATGGGAGCTCCCCCACCCCACTTAGGACACTGCTCCCCTCCCTGTGC
TCCCACAAGGAACCCTCCGCCACCTTCCAGAGGTGTGACCAACTATGCAACAATCCCGCCCCCA
CGCGCATCTGTGGGGCACTGGAGGGCGGCTTCGAGCACAAGGATGGACCGGAGGATGCCCCTGG
CCCTGGGCAGCTCTTTAGCCTCCTGTTTGTCCTGGTGACACCTGTTTCACGGGCAACTTAACAA
TGTCTCCAAAGGGACTGTGAGTTATGGCCTTGCCTGTTGGGCTGAGTGGGGTGCTTCGGCCTGA
CCAGTTTGTCTCCCAGAGTGTTCCGGGGCCCTGACAGGCAGGCCTACAAGGACGACGTTTACAT
TTTTAAAGGTACACTGGTGTGTATATTGCAAGTGACATCTTGTATTACGGAAACATTTTGTATA
GTTATATATACAGTTTATTGATGTTCAATAAAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005325275	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000005237.2
GenBank Protein	KAG3263450	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005325275 ⟸ XM_005325218

- UniProtKB:

I3M6T1 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRSFLVRKPSVPRRKPNYSELQDSSPEFTFQQPYDQAHLLAAIPPPEVLNPTASLPTLIWDCL
LAPHTQPIGWASLQPQENPQAAELTSLSDEDSGKGSQPPSPPSPAPSSFSSTSASSLEAEAYIA
FPGLGQLPKQLALLSVAKDPQSRKAFNCKYCNKEYLSLGALKMHIRSHTLPCVCATCGKAFSRP
WLLQGHVRTHTGEKPFSCPHCSRAFADRSNLRAHLQTHSDVKKYQCPRCARTFSRMSLLHKHQE
SGCSGGPR

hide sequence

Ensembl Acc Id:

ENSSTOP00000005237 ⟸ ENSSTOT00000005855

Protein Domains

C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005866	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005855.3	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Snail/Krueppel_Znf	UniProtKB/TrEMBL
	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	Snai1	ENTREZGENE
PANTHER	ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	ZINC FINGER PROTEIN SNAI1	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_6	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	I3M6T1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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