Pou5f1 (POU class 5 homeobox 1) - Rat Genome Database

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Gene: Pou5f1 (POU class 5 homeobox 1) Ictidomys tridecemlineatus
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Symbol: Pou5f1
Name: POU class 5 homeobox 1
RGD ID: 12518313
Description: ENCODES a protein that exhibits chromatin binding (ortholog); chromatin DNA binding (ortholog); cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN blastocyst development (ortholog); blastocyst growth (ortholog); BMP signaling pathway involved in heart induction (ortholog); PARTICIPATES IN hypoxia inducible factor pathway; ASSOCIATED WITH amphetamine abuse (ortholog); congenital heart disease (ortholog); dysgerminoma (ortholog); FOUND IN chromatin (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: POU domain, class 5, transcription factor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,462,312 - 34,467,659 (-)NCBI
SpeTri2.0NW_004936837827,568 - 838,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blastocyst development  (ISO)
blastocyst growth  (ISO)
BMP signaling pathway involved in heart induction  (ISO)
cardiac cell fate determination  (ISO)
cell fate commitment  (ISO)
cell fate commitment involved in formation of primary germ layer  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
ectodermal cell fate commitment  (ISO)
endodermal cell fate commitment  (ISO)
endodermal cell fate specification  (ISO)
germ-line stem cell population maintenance  (ISO)
mesodermal cell fate commitment  (ISO)
negative regulation of calcium ion-dependent exocytosis  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of gene silencing by miRNA  (ISO)
negative regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation from RNA polymerase II promoter  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
regulation of asymmetric cell division  (ISO)
regulation of DNA methylation-dependent heterochromatin assembly  (ISO)
regulation of gene expression  (ISO)
regulation of heart induction by regulation of canonical Wnt signaling pathway  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (ISO)
response to cytokine  (ISO)
response to organic substance  (ISO)
response to retinoic acid  (ISO)
response to wounding  (ISO)
somatic stem cell population maintenance  (ISO)
stem cell differentiation  (ISO)
stem cell population maintenance  (ISO)
transcription by RNA polymerase II  (ISO)
trophectodermal cell differentiation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Pou5f1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494634,462,312 - 34,467,659 (-)NCBI
SpeTri2.0NW_004936837827,568 - 838,933 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POU5F1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,164,337 - 31,180,731 (-)EnsemblGRCh38hg38GRCh38
GRCh38631,164,337 - 31,170,682 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,132,114 - 31,138,459 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,240,093 - 31,246,430 (-)NCBINCBI36hg18NCBI36
Build 34631,240,107 - 31,242,024NCBI
Celera632,732,336 - 32,738,691 (-)NCBI
Cytogenetic Map6p21.33NCBI
HuRef630,934,532 - 30,940,887 (-)NCBIHuRef
CHM1_1631,134,214 - 31,140,570 (-)NCBICHM1_1
Pou5f1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,816,929 - 35,821,674 (+)NCBIGRCm39mm39
GRCm39 Ensembl1735,816,915 - 35,821,669 (+)Ensembl
GRCm381735,506,032 - 35,510,777 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,506,018 - 35,510,772 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,642,984 - 35,647,722 (+)NCBIGRCm37mm9NCBIm37
MGSCv361735,114,104 - 35,118,822 (+)NCBImm8
Celera1739,020,984 - 39,025,724 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.69NCBI
Pou5f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,223,128 - 3,227,891 (-)NCBI
Rnor_6.0 Ensembl203,747,221 - 3,751,994 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0203,747,231 - 3,751,994 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0205,833,973 - 5,838,736 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera20650,325 - 655,095 (-)NCBICelera
Cytogenetic Map20p12NCBI
Pou5f1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955583995,707 - 1,003,202 (-)NCBIChiLan1.0ChiLan1.0
POU5F1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1631,775,343 - 31,781,426 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,775,343 - 31,781,426 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0630,910,421 - 30,916,465 (-)NCBIMhudiblu_PPA_v0panPan3
POU5F1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1723,564,654 - 23,570,691 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,262,690 - 27,268,388 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap7p1.1NCBI
POU5F1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11741,306,523 - 41,313,065 (+)NCBI
Pou5f1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,758,055 - 24,764,723 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_005341057   ⟹   XP_005341114
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440494634,462,312 - 34,467,659 (-)NCBI
SpeTri2.0NW_004936837827,568 - 832,976 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013365565   ⟹   XP_013221019
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936837827,581 - 838,933 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013365566   ⟹   XP_013221020
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0NW_004936837827,766 - 832,904 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005341114 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005341114   ⟸   XM_005341057
- UniProtKB: I3MW67 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013221019   ⟸   XM_013365565
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013221020   ⟸   XM_013365566
- Peptide Label: isoform X2
- Sequence:
Protein Domains
Homeobox   POU-specific


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026103 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000016362 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000030103 UniProtKB/TrEMBL
Gene3D-CATH 1.10.260.40 UniProtKB/TrEMBL
InterPro Homeobox-like UniProtKB/TrEMBL
  Homeobox_CS UniProtKB/TrEMBL
  Homeobox_dom UniProtKB/TrEMBL
  Lambda_DNA-bd_dom UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
  POU_dom UniProtKB/TrEMBL
  POU_dom_5 UniProtKB/TrEMBL
NCBI Gene Pou5f1 ENTREZGENE
PANTHER PTHR11636:SF86 UniProtKB/TrEMBL
Pfam Homeobox UniProtKB/TrEMBL
  Pou UniProtKB/TrEMBL
PRINTS POUDOMAIN UniProtKB/TrEMBL
PROSITE HOMEOBOX_1 UniProtKB/TrEMBL
  HOMEOBOX_2 UniProtKB/TrEMBL
  POU_1 UniProtKB/TrEMBL
  POU_2 UniProtKB/TrEMBL
  POU_3 UniProtKB/TrEMBL
SMART HOX UniProtKB/TrEMBL
  POU UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF47413 UniProtKB/TrEMBL
UniProt I3MW67 ENTREZGENE, UniProtKB/TrEMBL