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Gene: Arx (aristaless related homeobox) Ictidomys tridecemlineatus

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Symbol:

Arx

Name:

aristaless related homeobox

RGD ID:

12444459

Description:

ENCODES a protein that exhibits chromatin binding (inferred); DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); INVOLVED IN axon guidance (ortholog); cell proliferation in forebrain (ortholog); cerebral cortex GABAergic interneuron migration (ortholog); ASSOCIATED WITH Agenesis of Corpus Callosum (ortholog); Aicardi syndrome (ortholog); autistic disorder (ortholog); FOUND IN nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

homeobox protein ARX

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	13,532,367 - 13,551,810 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936836	295,664 - 306,756 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936836	295,090 - 306,756 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axon guidance (IEA,ISO)

cell proliferation in forebrain (IEA,ISO)

cerebral cortex GABAergic interneuron migration (IEA,ISO)

cerebral cortex tangential migration (IEA,ISO)

embryonic olfactory bulb interneuron precursor migration (IEA,ISO)

epithelial cell fate commitment (IEA,ISO)

forebrain development (IEA,ISO)

globus pallidus development (IEA,ISO)

interneuron migration (IEA,ISO)

lipid digestion (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA)

neuron development (ISO)

neuron fate commitment (ISO)

neuron migration (IEA,ISO)

olfactory bulb development (IEA,ISO)

organ growth (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of organ growth (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of DNA-templated transcription (IEA)

regulation of epithelial cell proliferation (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA)

Cellular Component

nucleus (IEA)

Molecular Function

chromatin binding (IEA)

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

RNA polymerase II transcription regulatory region sequence-specific DNA binding (IEA)

sequence-specific double-stranded DNA binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Arx
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	13,532,367 - 13,551,810 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936836	295,664 - 306,756 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936836	295,090 - 306,756 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ARX
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	25,003,694 - 25,015,965 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	25,003,694 - 25,016,420 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	25,021,811 - 25,034,082 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	24,932,213 - 24,943,775 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	24,781,948 - 24,793,511	NCBI
Celera	X	29,145,744 - 29,157,998 (-)	NCBI		Celera
Cytogenetic Map	X	p21.3	NCBI
HuRef	X	22,763,568 - 22,793,924 (-)	NCBI		HuRef
CHM1_1	X	25,053,346 - 25,065,599 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	X	24,587,932 - 24,600,202 (-)	NCBI		T2T-CHM13v2.0

Arx
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	92,330,113 - 92,341,963 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	92,330,051 - 92,341,963 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	93,286,507 - 93,298,357 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	93,286,445 - 93,298,357 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	90,531,985 - 90,543,696 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	89,539,365 - 89,551,076 (+)	NCBI		MGSCv36	mm8
Celera	X	80,208,596 - 80,220,179 (+)	NCBI		Celera
Cytogenetic Map	X	C3	NCBI
cM Map	X	41.05	NCBI

Arx
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	62,010,097 - 62,022,009 (+)	NCBI		GRCr8
mRatBN7.2	X	58,016,233 - 58,028,149 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	58,016,233 - 58,028,142 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	59,442,698 - 59,454,605 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	62,943,813 - 62,955,718 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	60,501,842 - 60,513,757 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	62,363,757 - 62,376,139 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	62,363,757 - 62,376,143 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	62,957,562 - 62,969,944 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	80,631,375 - 80,643,989 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	X	58,455,664 - 58,467,636 (+)	NCBI		Celera
Cytogenetic Map	X	q22	NCBI

Arx
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955509	5,326,145 - 5,338,250 (-)	NCBI	ChiLan1.0	ChiLan1.0

ARX
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	26,800,416 - 26,814,128 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	26,803,792 - 26,817,510 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	17,598,858 - 17,612,544 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	X	24,965,203 - 24,977,939 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

ARX
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	20,545,346 - 20,556,206 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	20,545,346 - 20,556,206 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
ROS_Cfam_1.0	X	20,498,344 - 20,511,419 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	20,499,238 - 20,510,100 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	20,538,249 - 20,549,126 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	20,571,748 - 20,582,617 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	20,628,835 - 20,639,715 (-)	NCBI		UU_Cfam_GSD_1.0

ARX
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	21,067,621 - 21,079,723 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	21,067,631 - 21,079,850 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	22,463,824 - 22,474,788 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ARX
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	23,499,791 - 23,518,333 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	23,500,454 - 23,511,524 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666056	25,363,945 - 25,376,208 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Arx
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624897	1,279,138 - 1,303,210 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005341015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000614	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000028025 ⟹ ENSSTOP00000022400

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936836	295,664 - 306,756 (-)	Ensembl

RefSeq Acc Id:

XM_005341015 ⟹ XP_005341072

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	X	13,532,367 - 13,551,810 (-)	NCBI
SpeTri2.0	NW_004936836	295,090 - 306,756 (-)	NCBI

Sequence:

show sequence

ATGAGCAATCAGTACCAGGAGGAGGGCTGCTCCGAGAGGCCCGAGTGCAAAAGTAAATCTCCAA
CTTTACTATCCTCCTACTGCATCGACAGCATCCTGGGCCGGAGAAGCCCGTGCAAAATGCGGCT
GCTGGGAGCCGCGCAGAGCTTGCCTGCCCCGCTGGCCAGCCGCGCTGACCAGGAAAAGGCCGTG
CAAGGCTCCCCCAAGGGCAGCGGTGCCCCGTTCGAGGCAGAGCTGCACCTGCCGCCCAAGCTGC
GGCGCCTCTATGCGCTGGACGAGCTGGGCGGCCCGGGGGGTGTTGCGCACCCTGACGAGCGCCT
TGGCGCGGCCGGCGGACCCGGCAGTGCCCCAGCGGCGGGTGGCGGCGCGGGCGCTGAGGACGAT
GAGGAGGAGCTGCTGGAGGATGAGGAGGATGAGGAGGAGGAAGAGGAGCTGCTGGAGGATGATG
AGGAGGAGCTGCTGGAGGACGATGCCCGCGCGCTGCTCAAGGAGCCCCGGCGCTGCGCAGTGGC
CGCTACCGGTGCCGTGGCCACAGCTGCTGCCGCCGCTGTGGCCACCGAGGGCGGGGAGCTGTCG
CCCAAGGAAGAGCTGCTACTGCATCCAGAGGACGCTGAGGGCAAGGACGGCGAGGACAGCGTTT
GCCTGTCCGCGGGCAGCGACTCGGAGGAGGGGCTGCTGAAGCGCAAGCAGAGGCGCTACCGCAC
CACGTTCACCAGCTACCAGCTGGAGGAACTGGAGCGAGCCTTCCAGAAGACGCACTATCCGGAC
GTCTTCACCAGGGAGGAACTGGCCATGAGACTGGACTTGACTGAGGCCCGAGTCCAGGTCTGGT
TCCAAAACCGTCGCGCTAAGTGGCGCAAGCGGGAGAAGGCTGGTGCGCAGACCCATCCCCCGGG
GTTGCCTTTCCCCGGGCCGCTCTCGGCCACCCACCCGCTCAGTCCCTACCTGGATGCCAGCCCC
TTTCCCCCGCACCATCCTGCGCTAGACTCAGCTTGGACGGCTGCTGCCGCTGCCGCCGCCGCCG
CCTTCCCGAGCCTACCTCCGCCTCCTGGCTCGGCCAGCCTGCCGCCCAGCGGGGCGCCGCTGGG
CCTGAGCACTTTCCTGGGAGCCGCCGTGTTCCGGCACCCGGCATTCATCAGCCCAGCGTTCGGC
AGGCTCTTTTCCACCATGGCCCCCCTGACCAGCGCGTCGACTGCGGCCGCGCTCCTGCGACAGC
CCACACCCGCGGTGGAGGGCGCGGTGGCATCGGGTGCGCTGGCTGATCCGGCCACTGCAGCCGC
AGACAGACGCGCCTCTAGCATAGCGGCTCTGAGGCTCAAGGCCAAGGAGCACGCGGCGCAGCTC
ACGCAGCTCAACATCCTGCCGGGCACCAGCACGGGCAAGGAGGTGTGCTAAAGGCTGCCTTCCA
CCCTCGCGCCTCCAGGCGCGTCCCGAAAGGTCACCTCACTCAGCACCACTCAAGACCAAATGGA
AACAGAGGACCAGCACACTCCCGAGACGGCACTGAGAGAGCGCAGCCGCCTTCGCAGCAGCCTG
GACGCGGGCAAGGCAGCCCTCGGCGCTTACGGACGTGGCACCTCCTCGGCTGGCTCTCCACCCG
CCCCCGCCCCCGCCCCTGCCCCTGCCACTGCCAACCTCGCTCCAACTCGAACGTCCATTCTCTC
CCATTCTTTGCTGAAAATATCGGGGAAGTTTTCTCCCCAAGACGCCTGGTATTGAAGTTAAAAT
GTTAAAAAGCCCAATCTCTTCTCCTGACACCCCACTTAGCTTTTTTTTTTTTTTTAATAGCATT
TTTGCGCTCTAAGTTCATCTCCCCAGCGCGGGCCCGGCGTGAAGCCAGGGCCAGGGAAGCGAAT
GCGAGTCTGTAAGATAGTTAACAGTGCACTTAAAGGAAAGGGGCGTCTTGTTCTTGTTCTCTTC
TTTATCATACACCAACCAAGGTTTTTATATCAAACCAAAGGGAAATACT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005341072	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000022400.2
GenBank Protein	KAG3271859	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005341072 ⟸ XM_005341015

- Sequence:

show sequence

MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRADQEKAV
QGSPKGSGAPFEAELHLPPKLRRLYALDELGGPGGVAHPDERLGAAGGPGSAPAAGGGAGAEDD
EEELLEDEEDEEEEEELLEDDEEELLEDDARALLKEPRRCAVAATGAVATAAAAAVATEGGELS
PKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPD
VFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASP
FPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFG
RLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQL
TQLNILPGTSTGKEVC

hide sequence

Ensembl Acc Id:

ENSSTOP00000022400 ⟸ ENSSTOT00000028025

Protein Domains

Homeobox OAR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000024095	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000028025.2	UniProtKB/TrEMBL
Gene3D-CATH	Homeodomain-like	UniProtKB/TrEMBL
InterPro	Homeobox-like_sf	UniProtKB/TrEMBL
	Homeobox_CS	UniProtKB/TrEMBL
	Homeobox_dom	UniProtKB/TrEMBL
	OAR_dom	UniProtKB/TrEMBL
	Paired_Homeobox_TFs	UniProtKB/TrEMBL
NCBI Gene	Arx	ENTREZGENE
PANTHER	ARISTALESS-RELATED HOMEOBOX PROTEIN-RELATED	UniProtKB/TrEMBL
	HOMEOBOX PROTEIN ARISTALESS	UniProtKB/TrEMBL
Pfam	Homeodomain	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
PROSITE	HOMEOBOX_1	UniProtKB/TrEMBL
	HOMEOBOX_2	UniProtKB/TrEMBL
	OAR	UniProtKB/TrEMBL
SMART	HOX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46689	UniProtKB/TrEMBL
UniProt	I3NDF3_ICTTR	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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