Rangrf (RAN guanine nucleotide release factor)

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Gene: Rangrf (RAN guanine nucleotide release factor) Ictidomys tridecemlineatus

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Symbol:

Rangrf

Name:

RAN guanine nucleotide release factor

RGD ID:

12441952

Description:

ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (inferred); small GTPase binding (inferred); sodium channel regulator activity (inferred); INVOLVED IN regulation of sodium ion transmembrane transporter activity (ortholog); ASSOCIATED WITH Animal Disease Models (ortholog); Cardiac Arrhythmias (ortholog); Diamond-Blackfan anemia (ortholog); FOUND IN caveola (inferred); cytoplasm (inferred); cytosol (inferred)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	48,039,669 - 48,041,112 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	1,513,180 - 1,517,270 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	1,513,855 - 1,515,300 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

Cardiac Arrhythmias (ISO)

Diamond-Blackfan anemia (ISO)

dyskeratosis congenita (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Li-Fraumeni syndrome (ISO)

lung adenocarcinoma (ISO)

very long chain acyl-CoA dehydrogenase deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

endoplasmic reticulum to Golgi vesicle-mediated transport (IEA)

heart contraction (IEA)

mitotic spindle assembly (IEA)

positive regulation of protein localization to cell surface (IEA)

positive regulation of protein localization to plasma membrane (IEA)

protein exit from endoplasmic reticulum (IEA)

protein import into nucleus (IEA)

protein transport (IEA)

regulation of bundle of His cell action potential (IEA)

regulation of cardiac muscle cell action potential involved in regulation of contraction (IEA)

regulation of membrane depolarization (IEA)

regulation of membrane depolarization during cardiac muscle cell action potential (IEA)

regulation of membrane potential (IEA)

regulation of sodium ion transmembrane transport (IEA)

regulation of sodium ion transmembrane transporter activity (ISO)

Cellular Component

caveola (IEA)

cytoplasm (IEA)

cytosol (IEA)

intercalated disc (IEA)

nucleoplasm (IEA)

nucleus (IEA)

rough endoplasmic reticulum (IEA)

Molecular Function

guanyl-nucleotide exchange factor activity (IEA)

protein binding (ISO)

small GTPase binding (IEA)

sodium channel regulator activity (IEA)

transmembrane transporter binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Rangrf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	48,039,669 - 48,041,112 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936595	1,513,180 - 1,517,270 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936595	1,513,855 - 1,515,300 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RANGRF
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	8,288,670 - 8,290,087 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	8,288,654 - 8,290,092 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	8,191,988 - 8,193,405 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	8,132,714 - 8,134,130 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	8,220,823 - 8,222,263 (+)	NCBI		Celera
Cytogenetic Map	17	p13.1	NCBI
HuRef	17	8,087,401 - 8,088,841 (+)	NCBI		HuRef
CHM1_1	17	8,200,890 - 8,202,330 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	8,194,912 - 8,196,329 (+)	NCBI		T2T-CHM13v2.0

Rangrf
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	68,863,310 - 68,866,011 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	68,863,310 - 68,866,011 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	68,972,484 - 68,975,185 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	68,972,484 - 68,975,185 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	68,785,989 - 68,787,322 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	68,788,682 - 68,790,015 (-)	NCBI		MGSCv36	mm8
Celera	11	75,915,300 - 75,916,633 (-)	NCBI		Celera
Cytogenetic Map	11	B3	NCBI
cM Map	11	42.24	NCBI

Rangrf
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	54,176,325 - 54,177,696 (-)	NCBI		GRCr8
mRatBN7.2	10	53,677,467 - 53,678,880 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	53,677,467 - 53,678,840 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	58,338,539 - 58,339,910 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	57,827,138 - 57,828,509 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	53,336,169 - 53,337,540 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	55,559,049 - 55,560,420 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	55,559,041 - 55,560,422 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	55,301,089 - 55,302,460 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	55,731,343 - 55,732,714 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	52,843,782 - 52,845,153 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Rangrf
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	8,622,843 - 8,624,401 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	8,622,843 - 8,624,401 (-)	NCBI	ChiLan1.0	ChiLan1.0

RANGRF
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	65,464,267 - 65,465,922 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	70,273,759 - 70,275,232 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	43,369,556 - 43,371,025 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	48,101,744 - 48,103,394 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	48,101,744 - 48,103,394 (-)	Ensembl	panpan1.1		panPan2

RANGRF
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	33,084,355 - 33,085,810 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	33,084,397 - 33,085,812 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	33,220,241 - 33,221,698 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	33,187,232 - 33,188,689 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	33,187,276 - 33,188,691 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	33,153,967 - 33,155,423 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	33,109,932 - 33,111,388 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	33,289,666 - 33,291,122 (+)	NCBI		UU_Cfam_GSD_1.0

RANGRF
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	53,485,265 - 53,486,713 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	53,484,584 - 53,486,716 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	55,960,779 - 55,962,215 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RANGRF
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	7,654,235 - 7,655,851 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	7,654,439 - 7,655,703 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	13,744,846 - 13,746,467 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rangrf
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	10,866,834 - 10,867,983 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	10,866,724 - 10,868,136 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332851	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040269429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_040269430	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000005532 ⟹ ENSSTOP00000004948

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936595	1,513,180 - 1,517,270 (+)	Ensembl

RefSeq Acc Id:

XM_005332851 ⟹ XP_005332908

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	48,039,669 - 48,041,112 (+)	NCBI
SpeTri2.0	NW_004936595	1,513,855 - 1,515,300 (+)	NCBI

Sequence:

show sequence

CAAACCTTAAAGGGTCCAGAAACTAAGCTAGTAGAGAAGAGGCTGTGGCGGCTGTGAAAGCCGG
GGAGGTGATGCCACGTGTGCCCATATGGATTTCTTTTAAATCTCTCTAGGGCCCATACCCTCGT
CCTAGGCCCATGGAGCCCTCAAGAAACTATCCACTGTTCGGGGGCGCCTTCTCCTCCATCCTCC
CCCCTGGGGCCATTGATGTAAGTGACCTCCGACCAGTCCCAGACAACCAAGAAGTTTTCTGCCA
TCCAGTGACTGACCAGAGCCTGATCGTGGAACTTCTGGAGTTCCAGGCTCACGTGCTGGGTGAA
GCGGCGGCGCGGTACCATTTTGAGGACGTTGGTGGGGTGCAGGGGGCTAGGGCTGTGCAAGTGG
AGTCTGTGCAGCCTCTCAATGTAGAGAACCTGGCCCTGAGGGGCTACTGTCAAGAAGCCTGGGT
CCTCTCTGGCAAGCAGCAGGTAGCTAAGGAAAACCAGCAGGTAGCAAAGGATGTGACACTGAAC
CTGGCCTTGCTGAGGCTGCCCCAGTACCAGACTGATCTCTTGCTCACCTTCAGTCAGCCCCCCC
CTGACAACAGGCCATCTCTTGGACCTGGAAATGTGCCACCTCCACCGTGGAACCTGGGTGACTT
TGAACAGCTAGTGACCAGTCTGACACTTCATGATCCCAACATCTTTGGTCCCCAGTAAAAATGC
TAAAGCACTGTATGATACTACTGAAGACTTAGAGACCTGGGTCTGGGAGGGGAGAAAAAGAGTT
TGAATACCACCTGGTTTTCTCTTCTTTCTTTCCTGTGCATAAACACAAGACACACCTTCTCTGC
AGAAATAAACTTGCTTTATAACCAA

hide sequence

RefSeq Acc Id:

XM_040269429 ⟹ XP_040125363

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	48,039,739 - 48,041,112 (+)	NCBI

RefSeq Acc Id:

XM_040269430 ⟹ XP_040125364

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	48,039,739 - 48,041,112 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_005332908	(Get FASTA)	NCBI Sequence Viewer
	XP_040125363	(Get FASTA)	NCBI Sequence Viewer
	XP_040125364	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000004948.2
GenBank Protein	KAG3269936	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005332908 ⟸ XM_005332851
- Peptide Label:	isoform X1
- UniProtKB:	I3M683 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEPSRNYPLFGGAFSSILPPGAIDVSDLRPVPDNQEVFCHPVTDQSLIVELLEFQAHVLGEAAA RYHFEDVGGVQGARAVQVESVQPLNVENLALRGYCQEAWVLSGKQQVAKENQQVAKDVTLNLAL LRLPQYQTDLLLTFSQPPPDNRPSLGPGNVPPPPWNLGDFEQLVTSLTLHDPNIFGPQ hide sequence

RefSeq Acc Id:	XP_040125363 ⟸ XM_040269429
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_040125364 ⟸ XM_040269430
- Peptide Label:	isoform X3

Ensembl Acc Id:

ENSSTOP00000004948 ⟸ ENSSTOT00000005532

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000005541	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000005532.3	UniProtKB/TrEMBL
Gene3D-CATH	Mog1/PsbP, alpha/beta/alpha sandwich	UniProtKB/TrEMBL
InterPro	Mog1	UniProtKB/TrEMBL
	Mog1/PsbP_a/b/a-sand	UniProtKB/TrEMBL
NCBI Gene	Rangrf	ENTREZGENE
PANTHER	PTHR15837	UniProtKB/TrEMBL
	RAN GUANINE NUCLEOTIDE RELEASE FACTOR	UniProtKB/TrEMBL
Pfam	Mog1	UniProtKB/TrEMBL
Superfamily-SCOP	SSF55724	UniProtKB/TrEMBL
UniProt	I3M683	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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