ASRGL1 (asparaginase and isoaspartyl peptidase 1) - Rat Genome Database

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Gene: ASRGL1 (asparaginase and isoaspartyl peptidase 1) Canis lupus familiaris
Analyze
Symbol: ASRGL1
Name: asparaginase and isoaspartyl peptidase 1
RGD ID: 12423979
Description: ENCODES a protein that exhibits N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity (ortholog); INVOLVED IN asparagine catabolic process via L-aspartate (ortholog); PARTICIPATES IN Canavan disease pathway; ASSOCIATED WITH allergic contact dermatitis (ortholog); fundus dystrophy (ortholog); intellectual disability (ortholog); FOUND IN cytoplasm (inferred); extracellular region (inferred); photoreceptor inner segment (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: asparaginase like 1; isoaspartyl peptidase/L-asparaginase; L-asparaginase
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,215,920 - 54,238,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,216,926 - 54,238,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,821,517 - 52,843,789 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,269,510 - 55,291,720 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,366,156 - 54,388,161 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,939,643 - 53,961,840 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,736,115 - 54,758,461 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
ASRGL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11854,215,920 - 54,238,094 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1854,216,926 - 54,238,059 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1852,821,517 - 52,843,789 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01855,269,510 - 55,291,720 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11854,366,156 - 54,388,161 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,939,643 - 53,961,840 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,736,115 - 54,758,461 (-)NCBIUU_Cfam_GSD_1.0
ASRGL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,337,448 - 62,401,431 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,337,448 - 62,393,412 (+)EnsemblGRCh38hg38GRCh38
GRCh371162,104,920 - 62,160,884 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,861,350 - 61,917,463 (+)NCBINCBI36Build 36hg18NCBI36
Build 341161,861,540 - 61,916,616NCBI
Celera1159,434,150 - 59,490,290 (+)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1158,433,119 - 58,488,977 (+)NCBIHuRef
CHM1_11161,987,987 - 62,043,930 (+)NCBICHM1_1
T2T-CHM13v2.01162,326,729 - 62,390,808 (+)NCBIT2T-CHM13v2.0
Asrgl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39199,089,083 - 9,112,930 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl199,087,232 - 9,113,000 (-)EnsemblGRCm39 Ensembl
GRCm38199,111,719 - 9,135,566 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl199,109,868 - 9,135,636 (-)EnsemblGRCm38mm10GRCm38
MGSCv37199,186,209 - 9,210,056 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36199,178,764 - 9,202,611 (-)NCBIMGSCv36mm8
Celera198,872,234 - 8,896,083 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map196.06NCBI
Asrgl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81215,436,180 - 215,456,188 (-)NCBIGRCr8
mRatBN7.21206,006,103 - 206,027,115 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1206,006,109 - 206,027,108 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1214,424,837 - 214,444,989 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01221,450,459 - 221,470,476 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,139,868 - 214,159,873 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01225,309,737 - 225,329,743 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1225,309,246 - 225,329,770 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01232,247,185 - 232,267,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,788,145 - 211,808,943 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,945,611 - 211,967,379 (-)NCBI
Celera1203,517,344 - 203,537,342 (-)NCBICelera
Cytogenetic Map1q43NCBI
ASRGL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2963,569,499 - 63,620,018 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11164,612,245 - 64,662,759 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01157,700,104 - 57,750,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,056,817 - 61,107,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,056,817 - 61,107,485 (+)Ensemblpanpan1.1panPan2
Asrgl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,709,837 - 10,733,792 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581821,771 - 847,704 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936581823,665 - 847,579 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ASRGL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl29,328,269 - 9,353,340 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.129,328,260 - 9,353,384 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,651,527 - 8,675,547 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ASRGL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1111,503,137 - 11,529,745 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl111,502,578 - 11,529,598 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038108,849,009 - 108,884,156 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Asrgl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,010,069 - 1,020,159 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249261,009,865 - 1,018,538 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in ASRGL1
404 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005631627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005631628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038425342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038501604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038564294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038628433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038628434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038628435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_540910 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000025143   ⟹   ENSCAFP00000023340
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1854,216,926 - 54,238,059 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017377   ⟹   ENSCAFP00845013531
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,241,056 - 55,291,719 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017460   ⟹   ENSCAFP00845013588
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,241,059 - 55,245,064 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845017474   ⟹   ENSCAFP00845013599
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1855,269,077 - 55,291,693 (-)Ensembl
RefSeq Acc Id: XM_005631627   ⟹   XP_005631684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,215,920 - 54,237,759 (-)NCBI
Dog10K_Boxer_Tasha1852,821,517 - 52,843,458 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005631628   ⟹   XP_005631685
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,215,920 - 54,237,758 (-)NCBI
Dog10K_Boxer_Tasha1852,821,517 - 52,843,457 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038425340   ⟹   XP_038281268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01855,269,510 - 55,291,389 (-)NCBI
RefSeq Acc Id: XM_038425341   ⟹   XP_038281269
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01855,269,510 - 55,291,388 (-)NCBI
RefSeq Acc Id: XM_038425342   ⟹   XP_038281270
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01855,269,510 - 55,291,720 (-)NCBI
RefSeq Acc Id: XM_038501604   ⟹   XP_038357532
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11854,366,156 - 54,388,161 (-)NCBI
RefSeq Acc Id: XM_038564292   ⟹   XP_038420220
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01854,736,115 - 54,758,131 (-)NCBI
RefSeq Acc Id: XM_038564293   ⟹   XP_038420221
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01854,736,115 - 54,758,130 (-)NCBI
RefSeq Acc Id: XM_038564294   ⟹   XP_038420222
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01854,736,115 - 54,758,461 (-)NCBI
RefSeq Acc Id: XM_038628433   ⟹   XP_038484361
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01853,939,643 - 53,961,506 (-)NCBI
RefSeq Acc Id: XM_038628434   ⟹   XP_038484362
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01853,939,643 - 53,961,840 (-)NCBI
RefSeq Acc Id: XM_038628435   ⟹   XP_038484363
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01853,939,643 - 53,961,506 (-)NCBI
RefSeq Acc Id: XM_540910   ⟹   XP_540910
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,215,920 - 54,238,094 (-)NCBI
Dog10K_Boxer_Tasha1852,821,517 - 52,843,789 (-)NCBI
Sequence:
RefSeq Acc Id: XP_540910   ⟸   XM_540910
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KJ03 (UniProtKB/TrEMBL),   A0A8I3ND47 (UniProtKB/TrEMBL),   A0A8P0PNX2 (UniProtKB/TrEMBL),   A0A8C0M7R9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005631684   ⟸   XM_005631627
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M7R9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005631685   ⟸   XM_005631628
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KJ03 (UniProtKB/TrEMBL),   A0A8I3ND47 (UniProtKB/TrEMBL),   A0A8P0PNX2 (UniProtKB/TrEMBL),   A0A8C0M7R9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000023340   ⟸   ENSCAFT00000025143
RefSeq Acc Id: XP_038357532   ⟸   XM_038501604
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038484362   ⟸   XM_038628434
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038484363   ⟸   XM_038628435
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038484361   ⟸   XM_038628433
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038281270   ⟸   XM_038425342
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KJ03 (UniProtKB/TrEMBL),   A0A8I3ND47 (UniProtKB/TrEMBL),   A0A8P0PNX2 (UniProtKB/TrEMBL),   A0A8C0M7R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281268   ⟸   XM_038425340
- Peptide Label: isoform X1
- UniProtKB: A0A8C0M7R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038281269   ⟸   XM_038425341
- Peptide Label: isoform X2
- UniProtKB: A0A8C0KJ03 (UniProtKB/TrEMBL),   A0A8I3ND47 (UniProtKB/TrEMBL),   A0A8P0PNX2 (UniProtKB/TrEMBL),   A0A8C0M7R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420222   ⟸   XM_038564294
- Peptide Label: isoform X5
- UniProtKB: A0A8C0M7R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420220   ⟸   XM_038564292
- Peptide Label: isoform X4
- UniProtKB: A0A8C0M7R9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038420221   ⟸   XM_038564293
- Peptide Label: isoform X5
- UniProtKB: A0A8C0M7R9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845013531   ⟸   ENSCAFT00845017377
Ensembl Acc Id: ENSCAFP00845013588   ⟸   ENSCAFT00845017460
Ensembl Acc Id: ENSCAFP00845013599   ⟸   ENSCAFT00845017474

Promoters
RGD ID:13686661
Promoter ID:EPDNEW_C4727
Type:initiation region
Name:ASRGL1_1
Description:asparaginase like 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11854,238,059 - 54,238,119EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015868 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030004711 UniProtKB/TrEMBL
  ENSCAFG00845009877 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025143.5 UniProtKB/TrEMBL
  ENSCAFT00000108043.1 UniProtKB/TrEMBL
  ENSCAFT00030008656.1 UniProtKB/TrEMBL
  ENSCAFT00845017377.1 UniProtKB/TrEMBL
  ENSCAFT00845017474 ENTREZGENE
  ENSCAFT00845017474.1 UniProtKB/TrEMBL
Gene3D-CATH (Glycosyl)asparaginase UniProtKB/TrEMBL
  Secretoglobin UniProtKB/TrEMBL
InterPro ASRGL1_meta UniProtKB/TrEMBL
  Ntn_hydrolases_N UniProtKB/TrEMBL
  Peptidase_T2 UniProtKB/TrEMBL
  Secretoglobin UniProtKB/TrEMBL
  Secretoglobin_sf UniProtKB/TrEMBL
  Uteroglobin UniProtKB/TrEMBL
NCBI Gene ASRGL1 ENTREZGENE
PANTHER ISOASPARTYL PEPTIDASE/L-ASPARAGINASE UniProtKB/TrEMBL
  PTHR10188 UniProtKB/TrEMBL
Pfam Asparaginase_2 UniProtKB/TrEMBL
  Uteroglobin UniProtKB/TrEMBL
PRINTS UTEROGLOBIN UniProtKB/TrEMBL
PROSITE SCGB UniProtKB/TrEMBL
SMART UTG UniProtKB/TrEMBL
Superfamily-SCOP SSF48201 UniProtKB/TrEMBL
  SSF56235 UniProtKB/TrEMBL
UniProt A0A8C0KJ03 ENTREZGENE
  A0A8C0M7R9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N2M1_CANLF UniProtKB/TrEMBL
  A0A8I3ND47 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0NHG7_CANLF UniProtKB/TrEMBL
  A0A8P0PNX2 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:38192 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-06 ASRGL1  asparaginase and isoaspartyl peptidase 1  ASRGL1  asparaginase like 1  Symbol and/or name change 5135510 APPROVED