POLB (DNA polymerase beta) - Rat Genome Database

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Advanced Search (OLGA)
Gene: POLB (DNA polymerase beta) Canis lupus familiaris
Analyze
Symbol: POLB
Name: DNA polymerase beta
RGD ID: 12406908
Description: ENCODES a protein that exhibits damaged DNA binding (ortholog); DNA-directed DNA polymerase activity (ortholog); INVOLVED IN apoptotic process (ortholog); base-excision repair, gap-filling (ortholog); homeostasis of number of cells (ortholog); ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); Breast Cancer, Familial (ortholog); cervical cancer (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); microtubule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: polymerase (DNA directed), beta
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,306,359 - 23,335,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,306,367 - 23,335,322 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1623,810,815 - 23,839,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01625,054,877 - 25,083,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,054,893 - 25,083,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,426,046 - 23,455,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,988,955 - 24,018,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,039,745 - 24,068,768 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POLB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,306,359 - 23,335,352 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,306,367 - 23,335,322 (-)EnsemblCanFam3.1 EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1623,810,815 - 23,839,790 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01625,054,877 - 25,083,907 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,054,893 - 25,083,884 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,426,046 - 23,455,070 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01623,988,955 - 24,018,019 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,039,745 - 24,068,768 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
POLB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,338,494 - 42,371,808 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,338,454 - 42,373,513 (+)EnsemblGRCh38.p14 Ensemblhg38GRCh38
GRCh37842,196,012 - 42,229,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,315,187 - 42,348,470 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34842,315,186 - 42,348,470NCBI
Celera841,140,732 - 41,174,028 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,719,534 - 40,752,550 (+)NCBIHuRef
CHM1_1842,242,875 - 42,276,239 (+)NCBICHM1_1
T2T-CHM13v2.0842,608,570 - 42,642,104 (+)NCBIT2T-CHM13v2.0
Polb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,118,135 - 23,143,482 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,117,532 - 23,143,575 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38822,628,119 - 22,653,464 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,628,126 - 22,653,435 (-)EnsemblGRCm38.p6 Ensemblmm10GRCm38
MGSCv37823,738,591 - 23,763,909 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36824,093,810 - 24,118,959 (-)NCBIMGSCv36mm8
Celera824,118,302 - 24,143,706 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Polb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,081,903 - 76,105,174 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1676,081,864 - 76,108,180 (+)EnsemblGRCr8
mRatBN7.21669,379,438 - 69,402,710 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,379,400 - 69,404,812 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1674,653,139 - 74,676,411 (+)NCBIUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,084,728 - 78,107,983 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,333,927 - 73,357,182 (+)NCBIUTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd1676,014,909 - 76,038,213 (+)NCBI
Lyon_Normotensive1677,388,061 - 77,411,366 (+)NCBI
Lyon_Hypertensive1677,889,022 - 77,912,324 (+)NCBI
F344_StmMcwi1674,044,663 - 74,067,925 (+)NCBI
Rnor_6.01674,237,001 - 74,260,272 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,237,001 - 74,260,271 (+)EnsemblRnor_6.0 Ensemblrn6Rnor6.0
Rnor_5.01673,869,828 - 73,893,106 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41673,864,702 - 73,888,011 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1667,272,411 - 67,295,648 (+)NCBICelera
RGSC_v3.11673,864,971 - 73,890,378 (+)NCBI
Cytogenetic Map16q12.5NCBI
Polb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536540,836 - 595,198 (-)EnsemblChiLan1.0 Ensembl
ChiLan1.0NW_004955536542,179 - 595,198 (-)NCBIChiLan1.0ChiLan1.0
POLB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,790,457 - 60,824,468 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,507,601 - 36,541,429 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,582,370 - 41,615,950 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1839,026,991 - 39,060,464 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl839,026,991 - 39,060,464 (+)EnsemblPanPan1.1 EnsemblpanPan2panpan1.1
Polb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mIctTri1.hap11466,894,163 - 66,920,024 (+)NCBImIctTri1.hap1
HiC_Itri_2NW_02440494346,368,259 - 46,394,119 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785323,941 - 350,539 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936785324,655 - 350,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POLB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,356,129 - 11,388,821 (+)EnsemblSscrofa11.1 EnsemblsusScr11Sscrofa11.1
Sscrofa11.11711,356,130 - 11,388,122 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,109,577 - 13,131,807 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POLB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mChlSab1.0.hap1842,146,359 - 42,185,976 (+)NCBImChlSab1.0.hap1
Vero_WHO_p1.0NW_0236660521,415,871 - 1,455,483 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
ChlSab1.1840,332,165 - 40,368,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,332,208 - 40,372,582 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Polb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624780884,896 - 941,587 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Naked mole-rat maternal Ensembl663,055,270 - 63,085,895 (+)Ensembl
Polb
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11363,779,772 - 63,803,237 (+)NCBIRrattus_CSIRO_v1Rrattus_CSIRO_v1

Variants

.
Variants in POLB
289 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005629802 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038497485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559933 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038559934 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038623971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038689730 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_532790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY705788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000016 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000008893   ⟹   ENSCAFP00000008250
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1623,306,367 - 23,335,322 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845010836   ⟹   ENSCAFP00845008457
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1625,054,893 - 25,083,884 (-)Ensembl
RefSeq Acc Id: XM_005629802   ⟹   XP_005629859
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11623,306,359 - 23,335,352 (-)NCBI
Dog10K_Boxer_Tasha1623,810,815 - 23,839,790 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038497484   ⟹   XP_038353412
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11623,426,049 - 23,455,067 (-)NCBI
RefSeq Acc Id: XM_038497485   ⟹   XP_038353413
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11623,426,046 - 23,455,070 (-)NCBI
RefSeq Acc Id: XM_038559933   ⟹   XP_038415861
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01624,039,748 - 24,068,765 (-)NCBI
RefSeq Acc Id: XM_038559934   ⟹   XP_038415862
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01624,039,745 - 24,068,768 (-)NCBI
RefSeq Acc Id: XM_038623970   ⟹   XP_038479898
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01623,988,958 - 24,018,016 (-)NCBI
RefSeq Acc Id: XM_038623971   ⟹   XP_038479899
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01623,988,955 - 24,018,019 (-)NCBI
RefSeq Acc Id: XM_038689729   ⟹   XP_038545657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01625,054,880 - 25,083,904 (-)NCBI
RefSeq Acc Id: XM_038689730   ⟹   XP_038545658
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01625,054,877 - 25,083,907 (-)NCBI
RefSeq Acc Id: XM_532790   ⟹   XP_532790
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11623,306,362 - 23,335,352 (-)NCBI
Dog10K_Boxer_Tasha1623,810,818 - 23,839,787 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005629859   ⟸   XM_005629802
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_532790   ⟸   XM_532790
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JPP0 (UniProtKB/TrEMBL),   A0A8I3NDB6 (UniProtKB/TrEMBL),   Q5SBJ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000008250   ⟸   ENSCAFT00000008893
RefSeq Acc Id: XP_038353413   ⟸   XM_038497485
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038353412   ⟸   XM_038497484
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038479899   ⟸   XM_038623971
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038479898   ⟸   XM_038623970
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038545658   ⟸   XM_038689730
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038545657   ⟸   XM_038689729
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JPP0 (UniProtKB/TrEMBL),   A0A8I3NDB6 (UniProtKB/TrEMBL),   Q5SBJ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038415862   ⟸   XM_038559934
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038415861   ⟸   XM_038559933
- Peptide Label: isoform X1
- UniProtKB: A0A8C0JPP0 (UniProtKB/TrEMBL),   A0A8I3NDB6 (UniProtKB/TrEMBL),   Q5SBJ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845008457   ⟸   ENSCAFT00845010836
Protein Domains
DNA-directed DNA polymerase X   Helix-hairpin-helix DNA-binding motif class

Promoters
RGD ID:13686087
Promoter ID:EPDNEW_C4154
Type:single initiation site
Name:POLB_1
Description:DNA polymerase beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11623,335,365 - 23,335,425EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000005517 Ensembl
  ENSCAFG00845006104 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00845010836 ENTREZGENE
  ENSCAFT00845010836.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.110 UniProtKB/TrEMBL
  3.30.210.10 UniProtKB/TrEMBL
  3.30.460.10 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro DNA-dir_DNA_pol_X UniProtKB/TrEMBL
  DNA_pol-X_BS UniProtKB/TrEMBL
  DNA_pol_b-like_N UniProtKB/TrEMBL
  DNA_pol_B_palm_palm UniProtKB/TrEMBL
  DNA_pol_lambd_fingers_domain UniProtKB/TrEMBL
  DNA_pol_lamdba_lyase_dom_sf UniProtKB/TrEMBL
  DNA_Pol_thumb_sf UniProtKB/TrEMBL
  DNA_pol_X UniProtKB/TrEMBL
  DNA_pol_X_beta-like UniProtKB/TrEMBL
  Hlx-hairpin-Hlx_DNA-bd_motif UniProtKB/TrEMBL
  NT_sf UniProtKB/TrEMBL
  PolB_thumb UniProtKB/TrEMBL
NCBI Gene POLB ENTREZGENE
PANTHER DNA POLYMERASE BETA UniProtKB/TrEMBL
  PTHR11276 UniProtKB/TrEMBL
Pfam DNA_pol_B_palm UniProtKB/TrEMBL
  DNA_pol_B_thumb UniProtKB/TrEMBL
  DNA_pol_lambd_f UniProtKB/TrEMBL
  HHH_8 UniProtKB/TrEMBL
PRINTS DNAPOLX UniProtKB/TrEMBL
  DNAPOLXBETA UniProtKB/TrEMBL
PROSITE DNA_POLYMERASE_X UniProtKB/TrEMBL
SMART HhH1 UniProtKB/TrEMBL
  POLXc UniProtKB/TrEMBL
Superfamily-SCOP PsbU/PolX domain-like UniProtKB/TrEMBL
  SSF47802 UniProtKB/TrEMBL
  SSF81301 UniProtKB/TrEMBL
UniProt A0A8C0JPP0 ENTREZGENE
  A0A8I3NDB6 ENTREZGENE, UniProtKB/TrEMBL
  Q5SBJ1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44773 ENTREZGENE