RGD Reference Report - Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray irradiation. - Rat Genome Database

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Age-related changes in the induction of DNA polymerases in rat liver by gamma-ray irradiation.

Authors: Kaneko, T  Tahara, S  Tanno, M  Taguchi, T 
Citation: Kaneko T, etal., Mech Ageing Dev. 2002 Sep;123(11):1521-8.
RGD ID: 8694104
Pubmed: PMID:12425958   (View Abstract at PubMed)

DNA polymerase activities related to DNA repair were examined in the livers of young (6-month-old) and aged (27-month-old) rats irradiated with gamma-rays. The activity of DNA polymerase alpha was little changed in the livers of gamma-ray-irradiated rats, while DNA polymerases beta and gamma were induced in the livers of young and aged rats exposed by gamma-ray irradiation. These enzymes were induced from 2 to 6 h after irradiation of young and aged rats, respectively, although the induction in aged rats was weak. DNA polymerase beta activity in the livers of young rats irradiated with gamma-rays was 2-fold that in aged rats. Similarly, DNA polymerase gamma activity in the livers of young rats subjected to gamma-ray irradiation was 3-fold that in aged rats. The induction of proliferating cell nuclear antigen (PCNA) in the livers of aged rats irradiated with gamma-rays was also delayed compared with young rats. These results indicate that the decline in repair activity in aged rats leads to the accumulation of oxidative damage and DNA mutations in aged tissues.




Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
PolbRatresponse to gamma radiation  IEP  RGD 
PolgRatresponse to gamma radiation  IEP  RGD 


Genes (Rattus norvegicus)
Polb  (DNA polymerase beta) Polg  (DNA polymerase gamma, catalytic subunit)