COX6A2 (cytochrome c oxidase subunit 6A2) - Rat Genome Database

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Gene: COX6A2 (cytochrome c oxidase subunit 6A2) Canis lupus familiaris
Analyze
Symbol: COX6A2
Name: cytochrome c oxidase subunit 6A2
RGD ID: 12367857
Description: ENCODES a protein that exhibits enzyme regulator activity (inferred); oxidoreductase activity (inferred); INVOLVED IN mitochondrial electron transport, cytochrome c to oxygen (inferred); oxidative phosphorylation (inferred); ASSOCIATED WITH branched-chain keto acid dehydrogenase kinase deficiency (ortholog); genetic disease (ortholog); mitochondrial complex IV deficiency nuclear type 18 (ortholog); FOUND IN membrane (inferred); mitochondrial inner membrane (inferred); mitochondrial respiratory chain complex IV (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COXVIAH; Cytochrome c oxidase polypeptide VIa-heart; Cytochrome c oxidase subunit 6A2, mitochondrial; cytochrome c oxidase subunit VIa polypeptide 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,807,094 - 16,807,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX6A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,807,094 - 16,807,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBIUU_Cfam_GSD_1.0
COX6A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,427,731 - 31,428,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,427,731 - 31,428,360 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,439,052 - 31,439,681 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,346,556 - 31,347,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 341631,346,555 - 31,347,222NCBI
Celera1628,868,661 - 28,869,331 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,999,436 - 29,000,138 (-)NCBIHuRef
CHM1_11632,757,735 - 32,758,378 (-)NCBICHM1_1
T2T-CHM13v2.01631,815,129 - 31,815,775 (-)NCBIT2T-CHM13v2.0
Cox6a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,804,607 - 127,805,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,804,607 - 127,805,559 (-)EnsemblGRCm39 Ensembl
GRCm387128,205,435 - 128,206,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,205,435 - 128,206,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,348,949 - 135,349,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,996,583 - 127,997,514 (-)NCBIMGSCv36mm8
Celera7128,041,090 - 128,042,021 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.04NCBI
Cox6a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,218,970 - 192,221,188 (-)NCBIGRCr8
mRatBN7.21182,788,528 - 182,790,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,788,528 - 182,789,274 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,139,022 - 191,139,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,325,117 - 198,325,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,995,578 - 190,996,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,624,037 - 199,626,255 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,624,037 - 199,624,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,669,984 - 206,672,202 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,464,579 - 187,465,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,614,459 - 187,615,127 (-)NCBI
Celera1180,434,507 - 180,435,253 (-)NCBICelera
Cytogenetic Map1q37NCBI
LOC102006357
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,261,043 - 8,262,368 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,261,297 - 8,261,961 (-)NCBIChiLan1.0ChiLan1.0
LOC100974033
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,636,222 - 34,643,840 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,437,647 - 39,438,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,537,864 - 23,538,675 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,797,168 - 31,798,674 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC101956567
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,654,132 - 125,655,462 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,380,896 - 8,381,991 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,381,115 - 8,402,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX6A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,133,476 - 17,135,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,108,623 - 17,135,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,362,408 - 17,370,106 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COX6A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1528,129,377 - 28,136,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl528,129,419 - 28,129,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,309,374 - 1,311,584 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101720122
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,432,226 - 14,432,814 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,432,226 - 14,432,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX6A2
6 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High 5 6
Medium 3 3
Low 4 15 3 6 3 6 12 8 7 6
Below cutoff 1 3 2 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000026740   ⟹   ENSCAFP00000024845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845019142   ⟹   ENSCAFP00845014953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)Ensembl
RefSeq Acc Id: XM_038478477   ⟹   XP_038334405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBI
RefSeq Acc Id: XM_038539729   ⟹   XP_038395657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBI
RefSeq Acc Id: XM_038603814   ⟹   XP_038459742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBI
RefSeq Acc Id: XM_038668532   ⟹   XP_038524460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBI
RefSeq Acc Id: XM_536907   ⟹   XP_536907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,807,094 - 16,807,763 (+)NCBI
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: XP_536907   ⟸   XM_536907
- UniProtKB: A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000024845   ⟸   ENSCAFT00000026740
RefSeq Acc Id: XP_038334405   ⟸   XM_038478477
RefSeq Acc Id: XP_038459742   ⟸   XM_038603814
RefSeq Acc Id: XP_038524460   ⟸   XM_038668532
- UniProtKB: A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395657   ⟸   XM_038539729
- UniProtKB: A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845014953   ⟸   ENSCAFT00845019142

Promoters
RGD ID:13683601
Promoter ID:EPDNEW_C1668
Type:multiple initiation site
Name:COX6A2_1
Description:cytochrome c oxidase subunit 6A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,807,123 - 16,807,183EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016887 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003965 UniProtKB/TrEMBL
  ENSCAFG00040009763 UniProtKB/TrEMBL
  ENSCAFG00845010848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026740.5 UniProtKB/TrEMBL
  ENSCAFT00030007320.1 UniProtKB/TrEMBL
  ENSCAFT00040018119.1 UniProtKB/TrEMBL
  ENSCAFT00845019142 ENTREZGENE
  ENSCAFT00845019142.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.95.10 UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_su6a UniProtKB/TrEMBL
  Cyt_c_oxidase_su6a_sf UniProtKB/TrEMBL
KEGG Report cfa:479780 UniProtKB/TrEMBL
NCBI Gene COX6A2 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11504 UniProtKB/TrEMBL
Pfam COX6A UniProtKB/TrEMBL
PIRSF COX6A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF81411 UniProtKB/TrEMBL
UniProt A0A8C0R4Q7 ENTREZGENE
  A0A8C0RC68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NIL8 ENTREZGENE, UniProtKB/TrEMBL
  CX6A2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9TR31 UniProtKB/Swiss-Prot
VGNC ID VGNC:54936 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 COX6A2  cytochrome c oxidase subunit 6A2    cytochrome c oxidase subunit VIa polypeptide 2  Symbol and/or name change 5135510 APPROVED