COX6A2 (cytochrome c oxidase subunit 6A2) - Rat Genome Database

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Gene: COX6A2 (cytochrome c oxidase subunit 6A2) Canis lupus familiaris
Analyze
Symbol: COX6A2
Name: cytochrome c oxidase subunit 6A2
RGD ID: 12367857
Description: ENCODES a protein that exhibits oxidoreductase activity (inferred); INVOLVED IN oxidative phosphorylation (inferred); ASSOCIATED WITH branched-chain keto acid dehydrogenase kinase deficiency (ortholog); mitochondrial complex IV deficiency nuclear type 18 (ortholog); FOUND IN mitochondrial inner membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: COXVIAH; Cytochrome c oxidase polypeptide VIa-heart; Cytochrome c oxidase subunit 6A2, mitochondrial; cytochrome c oxidase subunit VIa polypeptide 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,807,094 - 16,807,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
COX6A2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1616,807,094 - 16,807,763 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBIUU_Cfam_GSD_1.0
COX6A2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381631,427,731 - 31,428,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1631,427,731 - 31,428,360 (-)EnsemblGRCh38hg38GRCh38
GRCh371631,439,052 - 31,439,681 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361631,346,556 - 31,347,222 (-)NCBINCBI36Build 36hg18NCBI36
Build 341631,346,555 - 31,347,222NCBI
Celera1628,868,661 - 28,869,331 (+)NCBICelera
Cytogenetic Map16p11.2NCBI
HuRef1628,999,436 - 29,000,138 (-)NCBIHuRef
CHM1_11632,757,735 - 32,758,378 (-)NCBICHM1_1
T2T-CHM13v2.01631,815,129 - 31,815,775 (-)NCBIT2T-CHM13v2.0
Cox6a2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397127,804,607 - 127,805,538 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7127,804,607 - 127,805,559 (-)EnsemblGRCm39 Ensembl
GRCm387128,205,435 - 128,206,366 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7128,205,435 - 128,206,387 (-)EnsemblGRCm38mm10GRCm38
MGSCv377135,348,949 - 135,349,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367127,996,583 - 127,997,514 (-)NCBIMGSCv36mm8
Celera7128,041,090 - 128,042,021 (-)NCBICelera
Cytogenetic Map7F3NCBI
cM Map770.04NCBI
Cox6a2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81192,218,970 - 192,221,188 (-)NCBIGRCr8
mRatBN7.21182,788,528 - 182,790,746 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1182,788,528 - 182,789,274 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1191,139,022 - 191,139,768 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01198,325,117 - 198,325,863 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01190,995,578 - 190,996,324 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01199,624,037 - 199,626,255 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1199,624,037 - 199,624,783 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01206,669,984 - 206,672,202 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,464,579 - 187,465,301 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11187,614,459 - 187,615,127 (-)NCBI
Celera1180,434,507 - 180,435,253 (-)NCBICelera
Cytogenetic Map1q37NCBI
LOC102006357
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554938,261,043 - 8,262,368 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554938,261,297 - 8,261,961 (-)NCBIChiLan1.0ChiLan1.0
LOC100974033
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21834,636,222 - 34,643,840 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11639,437,647 - 39,438,587 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01623,537,864 - 23,538,675 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11631,797,168 - 31,798,674 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC101956567
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344125,654,132 - 125,655,462 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365438,380,896 - 8,381,991 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365438,381,115 - 8,402,935 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
COX6A2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl317,133,476 - 17,135,104 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1317,108,623 - 17,135,108 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2317,362,408 - 17,370,106 (-)NCBISscrofa10.2Sscrofa10.2susScr3
COX6A2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1528,129,377 - 28,136,258 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl528,129,419 - 28,129,946 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660681,309,374 - 1,311,584 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101720122
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478214,432,226 - 14,432,814 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478214,432,226 - 14,432,818 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in COX6A2
6 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 21 15 5 6 5 6 32 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000026740   ⟹   ENSCAFP00000024845
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl616,807,150 - 16,809,998 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845019142   ⟹   ENSCAFP00845014953
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl616,931,872 - 16,934,720 (+)Ensembl
RefSeq Acc Id: XM_038478477   ⟹   XP_038334405
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1616,735,351 - 16,736,048 (+)NCBI
RefSeq Acc Id: XM_038539729   ⟹   XP_038395657
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0616,966,382 - 16,967,079 (+)NCBI
RefSeq Acc Id: XM_038603814   ⟹   XP_038459742
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0616,654,687 - 16,655,384 (+)NCBI
RefSeq Acc Id: XM_038668532   ⟹   XP_038524460
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0616,931,788 - 16,932,485 (+)NCBI
RefSeq Acc Id: XM_536907   ⟹   XP_536907
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,807,094 - 16,807,763 (+)NCBI
Dog10K_Boxer_Tasha618,358,170 - 18,358,867 (-)NCBI
Sequence:
RefSeq Acc Id: XP_536907   ⟸   XM_536907
- UniProtKB: A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000024845   ⟸   ENSCAFT00000026740
RefSeq Acc Id: XP_038334405   ⟸   XM_038478477
RefSeq Acc Id: XP_038459742   ⟸   XM_038603814
RefSeq Acc Id: XP_038524460   ⟸   XM_038668532
- UniProtKB: A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395657   ⟸   XM_038539729
- UniProtKB: A0A8C0R4Q7 (UniProtKB/TrEMBL),   A0A8C0RC68 (UniProtKB/TrEMBL),   A0A8I3NIL8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845014953   ⟸   ENSCAFT00845019142

Promoters
RGD ID:13683601
Promoter ID:EPDNEW_C1668
Type:multiple initiation site
Name:COX6A2_1
Description:cytochrome c oxidase subunit 6A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1616,807,123 - 16,807,183EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016887 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030003965 UniProtKB/TrEMBL
  ENSCAFG00040009763 UniProtKB/TrEMBL
  ENSCAFG00845010848 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000026740.5 UniProtKB/TrEMBL
  ENSCAFT00030007320.1 UniProtKB/TrEMBL
  ENSCAFT00040018119.1 UniProtKB/TrEMBL
  ENSCAFT00845019142 ENTREZGENE
  ENSCAFT00845019142.1 UniProtKB/TrEMBL
Gene3D-CATH 4.10.95.10 UniProtKB/TrEMBL
InterPro Cyt_c_oxidase_su6a UniProtKB/TrEMBL
  Cyt_c_oxidase_su6a_sf UniProtKB/TrEMBL
KEGG Report cfa:479780 UniProtKB/TrEMBL
NCBI Gene COX6A2 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 6A2, MITOCHONDRIAL UniProtKB/TrEMBL
  PTHR11504 UniProtKB/TrEMBL
Pfam COX6A UniProtKB/TrEMBL
PIRSF COX6A1 UniProtKB/TrEMBL
Superfamily-SCOP SSF81411 UniProtKB/TrEMBL
UniProt A0A8C0R4Q7 ENTREZGENE
  A0A8C0RC68 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NIL8 ENTREZGENE, UniProtKB/TrEMBL
  CX6A2_CANLF UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9TR31 UniProtKB/Swiss-Prot
VGNC ID VGNC:54936 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-06-05 COX6A2  cytochrome c oxidase subunit 6A2    cytochrome c oxidase subunit VIa polypeptide 2  Symbol and/or name change 5135510 APPROVED