MYO15A (myosin XVA) - Rat Genome Database

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Gene: MYO15A (myosin XVA) Canis lupus familiaris
Analyze
Symbol: MYO15A
Name: myosin XVA
RGD ID: 12354057
Description: ENCODES a protein that exhibits actin binding (inferred); ATP binding (inferred); INVOLVED IN inner ear morphogenesis (ortholog); locomotory behavior (ortholog); response to light stimulus (ortholog); PARTICIPATES IN auditory mechanotransduction pathway; ASSOCIATED WITH Alport syndrome (ortholog); autistic disorder (ortholog); autosomal recessive nonsyndromic deafness (ortholog); FOUND IN stereocilium (ortholog); stereocilium bundle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: myosin-XV; unconventional myosin-XV
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,369,484 - 41,421,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,370,509 - 41,392,881 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,507,455 - 41,559,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,474,709 - 41,526,462 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1541,442,539 - 41,494,282 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,389,966 - 41,441,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,581,821 - 41,633,567 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
MYO15A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1541,369,484 - 41,421,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl541,370,509 - 41,392,881 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha541,507,455 - 41,559,211 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0541,474,709 - 41,526,462 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1541,442,539 - 41,494,282 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0541,389,966 - 41,441,709 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0541,581,821 - 41,633,567 (-)NCBIUU_Cfam_GSD_1.0
MYO15A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381718,108,756 - 18,179,800 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1718,108,756 - 18,179,802 (+)EnsemblGRCh38hg38GRCh38
GRCh371718,012,070 - 18,083,114 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361717,952,745 - 18,023,841 (+)NCBINCBI36Build 36hg18NCBI36
Build 341717,952,744 - 18,023,840NCBI
Celera1718,953,160 - 19,024,251 (+)NCBICelera
Cytogenetic Map17p11.2NCBI
HuRef1717,765,392 - 17,836,464 (+)NCBIHuRef
CHM1_11718,020,789 - 18,091,861 (+)NCBICHM1_1
T2T-CHM13v2.01718,055,569 - 18,126,619 (+)NCBIT2T-CHM13v2.0
Myo15a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391160,360,165 - 60,419,195 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1160,360,165 - 60,419,195 (+)EnsemblGRCm39 Ensembl
GRCm381160,469,339 - 60,528,369 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1160,469,339 - 60,528,369 (+)EnsemblGRCm38mm10GRCm38
MGSCv371160,282,841 - 60,341,871 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361161,007,838 - 61,067,005 (+)NCBIMGSCv36mm8
MGSCv361160,285,534 - 60,344,564 (+)NCBIMGSCv36mm8
Celera1164,710,231 - 64,711,213 (-)NCBICelera
Cytogenetic Map11B2NCBI
cM Map1137.81NCBI
Myo15a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81045,776,907 - 45,835,473 (+)NCBIGRCr8
mRatBN7.21045,277,619 - 45,335,953 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1045,278,737 - 45,335,340 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01046,840,098 - 46,897,362 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1046,840,113 - 46,896,054 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01046,595,676 - 46,660,835 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41046,742,535 - 46,798,928 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1044,535,548 - 44,591,592 (+)NCBICelera
Cytogenetic Map10q22NCBI
Myo15a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547811,132,719 - 11,186,378 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547811,131,908 - 11,186,465 (-)NCBIChiLan1.0ChiLan1.0
LOC100971960
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21953,085,248 - 53,159,407 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11757,796,388 - 57,870,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01732,661,499 - 32,723,320 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11738,033,646 - 38,091,376 (-)NCBIpanpan1.1PanPan1.1panPan2
Myo15a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560261,142,863 - 61,197,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367411,669,680 - 1,723,891 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367411,669,680 - 1,724,929 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MYO15A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11260,533,502 - 60,582,645 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MYO15A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11617,157,275 - 17,217,609 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1617,157,490 - 17,218,009 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660593,687,568 - 3,750,880 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Myo15a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248493,284,085 - 3,344,759 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248493,283,180 - 3,345,456 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MYO15A
480 total Variants

Expression

RNA-SEQ Expression

adipose tissue
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 2 18 18 9 2 3 2 4 13 11 9 14 7

Sequence


Ensembl Acc Id: ENSCAFT00000029106   ⟹   ENSCAFP00000027065
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl541,370,509 - 41,392,881 (-)Ensembl
RefSeq Acc Id: XM_038475906   ⟹   XP_038331834
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1541,442,539 - 41,494,282 (-)NCBI
RefSeq Acc Id: XM_038518203   ⟹   XP_038374131
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
Dog10K_Boxer_Tasha541,507,455 - 41,559,211 (-)NCBI
RefSeq Acc Id: XM_038537096   ⟹   XP_038393024
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0541,581,821 - 41,633,567 (-)NCBI
RefSeq Acc Id: XM_038601227   ⟹   XP_038457155
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0541,389,966 - 41,441,709 (-)NCBI
RefSeq Acc Id: XM_038665789   ⟹   XP_038521717
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0541,474,709 - 41,526,462 (-)NCBI
Ensembl Acc Id: ENSCAFP00000027065   ⟸   ENSCAFT00000029106
RefSeq Acc Id: XP_038331834   ⟸   XM_038475906
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038457155   ⟸   XM_038601227
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038521717   ⟸   XM_038665789
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L9X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038374131   ⟸   XM_038518203
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L9X0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038393024   ⟸   XM_038537096
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L9X0 (UniProtKB/TrEMBL)
Protein Domains
FERM   MyTH4   SH3

Promoters
RGD ID:13683280
Promoter ID:EPDNEW_C1348
Type:single initiation site
Name:MYO15A_1
Description:myosin XVA
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1541,419,668 - 41,419,728EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000018319 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030001251 UniProtKB/TrEMBL
  ENSCAFG00040003040 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000029106.7 UniProtKB/TrEMBL
  ENSCAFT00030002266.1 UniProtKB/TrEMBL
  ENSCAFT00040005807.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.530 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_central UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  MyTH4_dom UniProtKB/TrEMBL
  MyTH4_dom_sf UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Unconventional_Myosin_ATPase UniProtKB/TrEMBL
NCBI Gene MYO15A ENTREZGENE
PANTHER MYOSIN VII, XV UniProtKB/TrEMBL
  PTHR22692:SF21 UniProtKB/TrEMBL
Pfam FERM_M UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SH3_2 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  MYTH4 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  MyTH4 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
Superfamily-SCOP SSF47031 UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A8C0L9X0 ENTREZGENE
  A0A8C0Q080_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43555 ENTREZGENE