POFUT1 (protein O-fucosyltransferase 1) - Rat Genome Database

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Gene: POFUT1 (protein O-fucosyltransferase 1) Canis lupus familiaris
Analyze
Symbol: POFUT1
Name: protein O-fucosyltransferase 1
RGD ID: 12285354
Description: ENCODES a protein that exhibits fucosyltransferase activity (ortholog); INVOLVED IN angiogenesis (ortholog); heart development (ortholog); nervous system development (ortholog); PARTICIPATES IN Notch signaling pathway; ASSOCIATED WITH Dowling-Degos disease (ortholog); Dowling-Degos Disease 2 (ortholog); genetic disease (ortholog); FOUND IN endoplasmic reticulum (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GDP-fucose protein O-fucosyltransferase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,608,905 - 21,636,084 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,608,899 - 21,632,979 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,255,008 - 21,280,646 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,295,373 - 22,325,022 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,295,367 - 22,325,465 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,573,904 - 21,599,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,679,257 - 21,705,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,110,055 - 22,136,141 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
endoplasmic reticulum  (IBA,IEA) membrane  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16679357   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
POFUT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12421,608,905 - 21,636,084 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2421,608,899 - 21,632,979 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2421,255,008 - 21,280,646 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02422,295,373 - 22,325,022 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2422,295,367 - 22,325,465 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12421,573,904 - 21,599,988 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02421,679,257 - 21,705,352 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02422,110,055 - 22,136,141 (+)NCBIUU_Cfam_GSD_1.0
POFUT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382032,207,880 - 32,238,658 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2032,207,855 - 32,238,658 (+)EnsemblGRCh38hg38GRCh38
GRCh372030,795,683 - 30,826,461 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362030,259,357 - 30,290,128 (+)NCBINCBI36Build 36hg18NCBI36
Build 342030,259,356 - 30,269,386NCBI
Celera2027,552,048 - 27,582,816 (+)NCBICelera
Cytogenetic Map20q11.21NCBI
HuRef2027,584,207 - 27,614,126 (+)NCBIHuRef
CHM1_12030,699,542 - 30,730,309 (+)NCBICHM1_1
T2T-CHM13v2.02033,931,803 - 33,962,575 (+)NCBIT2T-CHM13v2.0
Pofut1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392153,083,435 - 153,114,862 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2153,083,453 - 153,112,167 (+)EnsemblGRCm39 Ensembl
GRCm382153,241,532 - 153,271,029 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2153,241,533 - 153,270,247 (+)EnsemblGRCm38mm10GRCm38
MGSCv372153,067,268 - 153,095,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362152,932,973 - 152,961,694 (+)NCBIMGSCv36mm8
Celera2159,069,104 - 159,097,829 (+)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.41NCBI
Pofut1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83162,168,855 - 162,195,798 (+)NCBIGRCr8
mRatBN7.23141,708,618 - 141,735,558 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3141,708,644 - 141,734,786 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3145,613,393 - 145,633,308 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03154,197,190 - 154,217,106 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,936,320 - 151,958,399 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03148,722,864 - 148,749,743 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3148,722,955 - 148,747,208 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03155,347,854 - 155,374,715 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43143,592,269 - 143,614,466 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13143,497,890 - 143,520,088 (+)NCBI
Celera3140,454,947 - 140,477,055 (+)NCBICelera
Cytogenetic Map3q41NCBI
Pofut1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542228,809,901 - 28,833,186 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542228,809,901 - 28,833,186 (-)NCBIChiLan1.0ChiLan1.0
POFUT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22137,900,199 - 37,931,013 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12037,893,296 - 37,924,248 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02028,496,987 - 28,527,817 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12029,625,481 - 29,655,722 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2029,625,481 - 29,655,722 (+)Ensemblpanpan1.1panPan2
Pofut1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640170,680,317 - 170,706,325 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648519,111,675 - 19,137,611 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648519,111,704 - 19,137,689 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
POFUT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1735,856,575 - 35,882,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11735,856,557 - 35,883,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,857,249 - 40,880,949 (+)NCBISscrofa10.2Sscrofa10.2susScr3
POFUT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,590,905 - 36,622,788 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,591,038 - 36,622,568 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605090,291,033 - 90,322,472 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pofut1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624741337,148 - 364,301 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624741338,028 - 364,414 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.
Variants

.
Variants in POFUT1
220 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000011540   ⟹   ENSCAFP00000010693
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2421,608,899 - 21,632,979 (+)Ensembl
Ensembl Acc Id: ENSCAFT00000072807   ⟹   ENSCAFP00000048684
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2421,608,899 - 21,618,268 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845036817   ⟹   ENSCAFP00845028826
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2422,295,367 - 22,325,465 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845036878   ⟹   ENSCAFP00845028873
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2422,295,367 - 22,304,737 (+)Ensembl
RefSeq Acc Id: NM_001077357   ⟹   NP_001070825
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,608,905 - 21,632,857 (+)NCBI
Dog10K_Boxer_Tasha2421,255,008 - 21,280,646 (+)NCBI
ROS_Cfam_1.02422,295,373 - 22,321,482 (+)NCBI
UMICH_Zoey_3.12421,573,904 - 21,599,988 (+)NCBI
UNSW_CanFamBas_1.02421,679,257 - 21,705,352 (+)NCBI
UU_Cfam_GSD_1.02422,110,055 - 22,136,141 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038432840   ⟹   XP_038288768
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02422,296,540 - 22,325,022 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001070825 (Get FASTA)   NCBI Sequence Viewer  
  XP_038288768 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABA29461 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCAFP00000010693.2
  ENSCAFP00000048684.1
  ENSCAFP00845028826
  ENSCAFP00845028826.1
  ENSCAFP00845028873.1
RefSeq Acc Id: NP_001070825   ⟸   NM_001077357
- Peptide Label: precursor
- UniProtKB: Q00P48 (UniProtKB/TrEMBL),   A0A8P0SCM8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000010693   ⟸   ENSCAFT00000011540
Ensembl Acc Id: ENSCAFP00000048684   ⟸   ENSCAFT00000072807
RefSeq Acc Id: XP_038288768   ⟸   XM_038432840
- Peptide Label: isoform X1
- UniProtKB: A0A8P0SCM8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845028826   ⟸   ENSCAFT00845036817
Ensembl Acc Id: ENSCAFP00845028873   ⟸   ENSCAFT00845036878

Promoters
RGD ID:13687564
Promoter ID:EPDNEW_C5634
Type:initiation region
Name:POFUT1_1
Description:protein O-fucosyltransferase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12421,608,856 - 21,608,916EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007186 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00845020869 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011540.4 UniProtKB/TrEMBL
  ENSCAFT00000072807.2 UniProtKB/TrEMBL
  ENSCAFT00845036817 ENTREZGENE
  ENSCAFT00845036817.1 UniProtKB/TrEMBL
  ENSCAFT00845036878.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.11340 UniProtKB/TrEMBL
  3.40.50.11350 UniProtKB/TrEMBL
InterPro GDP-Fuc_O-FucTrfase UniProtKB/TrEMBL
  POFUT1 UniProtKB/TrEMBL
KEGG Report cfa:609881 UniProtKB/TrEMBL
NCBI Gene POFUT1 ENTREZGENE
PANTHER GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 1 UniProtKB/TrEMBL
  PTHR21420 UniProtKB/TrEMBL
Pfam O-FucT UniProtKB/TrEMBL
UniProt A0A8I3PBD6_CANLF UniProtKB/TrEMBL
  A0A8I3S4M0_CANLF UniProtKB/TrEMBL
  A0A8P0SCM8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8P0T1H3_CANLF UniProtKB/TrEMBL
  Q00P48 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:44767 ENTREZGENE