NT5C (5', 3'-nucleotidase, cytosolic) - Rat Genome Database

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Gene: NT5C (5', 3'-nucleotidase, cytosolic) Canis lupus familiaris
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Symbol: NT5C
Name: 5', 3'-nucleotidase, cytosolic
RGD ID: 12271106
Description: ENCODES a protein that exhibits 5'-nucleotidase activity (inferred); identical protein binding (inferred); IMP 5'-nucleotidase activity (inferred); INVOLVED IN deoxyribonucleotide catabolic process (ortholog); dephosphorylation (ortholog); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); FOUND IN cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 5'(3')-deoxyribonucleotidase, cytosolic type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,342,793 - 5,344,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,013,114 - 6,014,835 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA,ISO)
mitochondrion  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NT5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,342,793 - 5,344,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl96,013,114 - 6,014,835 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBIUU_Cfam_GSD_1.0
NT5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381775,130,228 - 75,131,742 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1775,130,225 - 75,131,757 (-)EnsemblGRCh38hg38GRCh38
GRCh371773,126,323 - 73,127,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,637,918 - 70,639,472 (-)NCBINCBI36Build 36hg18NCBI36
Build 341770,637,918 - 70,639,472NCBI
Celera1769,718,700 - 69,720,253 (-)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1768,536,008 - 68,537,577 (-)NCBIHuRef
CHM1_11773,190,820 - 73,192,389 (-)NCBICHM1_1
T2T-CHM13v2.01776,021,691 - 76,023,204 (-)NCBIT2T-CHM13v2.0
Nt5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,381,251 - 115,382,659 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11115,381,246 - 115,382,688 (-)EnsemblGRCm39 Ensembl
GRCm3811115,490,420 - 115,492,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,490,420 - 115,491,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,351,739 - 115,353,128 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611115,306,515 - 115,307,904 (-)NCBIMGSCv36mm8
Celera11127,257,296 - 127,258,685 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1180.84NCBI
Nt5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810101,238,552 - 101,240,666 (-)NCBIGRCr8
mRatBN7.210100,739,591 - 100,742,276 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10100,739,588 - 100,741,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10105,799,983 - 105,801,929 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010105,263,054 - 105,264,998 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010100,660,564 - 100,662,519 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010104,052,807 - 104,054,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,052,831 - 104,054,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,225,988 - 104,227,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,574,754 - 105,576,848 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1099,314,518 - 99,316,243 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Nt5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,011,738 - 2,013,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,011,549 - 2,014,209 (-)NCBIChiLan1.0ChiLan1.0
NT5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21991,169,491 - 91,171,558 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11795,992,532 - 95,994,620 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01769,077,021 - 69,078,998 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11774,632,846 - 74,634,136 (-)NCBIpanpan1.1PanPan1.1panPan2
Nt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,979,933 - 5,981,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936594430,506 - 432,095 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936594430,274 - 432,027 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,162,243 - 6,164,140 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,162,420 - 6,164,143 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,124,412 - 6,126,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,531,820 - 46,533,763 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1646,532,216 - 46,535,736 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607717,309,387 - 17,311,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nt5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248014,952,736 - 4,954,639 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248014,952,736 - 4,954,660 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in NT5C
15 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000039741   ⟹   ENSCAFP00000035634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845048809   ⟹   ENSCAFP00845038295
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl96,013,114 - 6,014,835 (+)Ensembl
RefSeq Acc Id: XM_038484945   ⟹   XP_038340873
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBI
RefSeq Acc Id: XM_038546635   ⟹   XP_038402563
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBI
RefSeq Acc Id: XM_038610626   ⟹   XP_038466554
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBI
RefSeq Acc Id: XM_038675755   ⟹   XP_038531683
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBI
RefSeq Acc Id: XM_540428   ⟹   XP_540428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.195,342,793 - 5,344,432 (+)NCBI
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBI
Sequence:
RefSeq Acc Id: XP_540428   ⟸   XM_540428
- UniProtKB: A0A8C0L6Y6 (UniProtKB/TrEMBL),   A0A8C0RX55 (UniProtKB/TrEMBL),   A0A8I3QEE9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000035634   ⟸   ENSCAFT00000039741
RefSeq Acc Id: XP_038340873   ⟸   XM_038484945
RefSeq Acc Id: XP_038466554   ⟸   XM_038610626
RefSeq Acc Id: XP_038531683   ⟸   XM_038675755
- UniProtKB: A0A8C0L6Y6 (UniProtKB/TrEMBL),   A0A8C0RX55 (UniProtKB/TrEMBL),   A0A8I3QEE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038402563   ⟸   XM_038546635
- UniProtKB: A0A8C0L6Y6 (UniProtKB/TrEMBL),   A0A8C0RX55 (UniProtKB/TrEMBL),   A0A8I3QEE9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845038295   ⟸   ENSCAFT00845048809


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025532 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00040003478 UniProtKB/TrEMBL
  ENSCAFG00845027674 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039741.3 UniProtKB/TrEMBL
  ENSCAFT00040006608.1 UniProtKB/TrEMBL
  ENSCAFT00845048809 ENTREZGENE
  ENSCAFT00845048809.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1000 UniProtKB/TrEMBL
InterPro 5'(3')-deoxyribonucleotidase UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
NCBI Gene NT5C ENTREZGENE
PANTHER 5'(3')-DEOXYRIBONUCLEOTIDASE UniProtKB/TrEMBL
  5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE UniProtKB/TrEMBL
Pfam NT5C UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
UniProt A0A8C0L6Y6 ENTREZGENE
  A0A8C0RX55 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3QEE9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43994 ENTREZGENE