NT5C (5', 3'-nucleotidase, cytosolic) - Rat Genome Database

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Gene: NT5C (5', 3'-nucleotidase, cytosolic) Canis lupus familiaris
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Symbol: NT5C
Name: 5', 3'-nucleotidase, cytosolic
RGD ID: 12271106
Description: ENCODES a protein that exhibits identical protein binding (ortholog); IMP 5'-nucleotidase activity (ortholog); nucleotidase activity (ortholog); INVOLVED IN dCMP catabolic process (ortholog); deoxyribonucleotide catabolic process (ortholog); dGMP catabolic process (ortholog); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: 5'(3')-deoxyribonucleotidase, cytosolic type
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,342,793 - 5,344,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBI
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBI
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBI
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBI
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleus  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
NT5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.195,342,793 - 5,344,432 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBI
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBI
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBI
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBI
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBI
NT5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1775,130,225 - 75,131,757 (-)EnsemblGRCh38hg38GRCh38
GRCh381775,130,228 - 75,131,965 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,126,323 - 73,127,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361770,637,918 - 70,639,472 (-)NCBINCBI36hg18NCBI36
Build 341770,637,918 - 70,639,472NCBI
Celera1769,718,700 - 69,720,253 (-)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1768,536,008 - 68,537,577 (-)NCBIHuRef
CHM1_11773,190,820 - 73,192,389 (-)NCBICHM1_1
Nt5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911115,381,246 - 115,382,896 (-)NCBIGRCm39mm39
GRCm39 Ensembl11115,381,246 - 115,382,688 (-)Ensembl
GRCm3811115,490,420 - 115,492,070 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11115,490,420 - 115,491,862 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711115,351,739 - 115,353,128 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611115,306,515 - 115,307,904 (-)NCBImm8
Celera11127,257,296 - 127,258,685 (-)NCBICelera
Cytogenetic Map11E2NCBI
Nt5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210100,739,591 - 100,742,276 (-)NCBI
Rnor_6.0 Ensembl10104,052,831 - 104,054,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.010104,052,807 - 104,054,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.010104,225,988 - 104,227,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,574,754 - 105,576,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1099,314,518 - 99,316,243 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Nt5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555532,011,738 - 2,013,443 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555532,011,549 - 2,014,209 (-)NCBIChiLan1.0ChiLan1.0
NT5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11774,632,846 - 74,634,136 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01769,077,021 - 69,078,998 (-)NCBIMhudiblu_PPA_v0panPan3
Nt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056025,979,933 - 5,981,689 (+)NCBI
SpeTri2.0NW_004936594430,274 - 432,027 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NT5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl126,139,439 - 6,164,142 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1126,162,420 - 6,164,143 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2126,124,412 - 6,126,605 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NT5C
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11646,531,820 - 46,533,763 (+)NCBI
ChlSab1.1 Ensembl1646,532,216 - 46,535,736 (+)Ensembl
Nt5c
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248014,952,736 - 4,954,660 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 10 6
Low 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000039741   ⟹   ENSCAFP00000035634
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl95,343,378 - 5,344,380 (+)Ensembl
RefSeq Acc Id: XM_038484945   ⟹   XP_038340873
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.196,051,001 - 6,052,770 (+)NCBI
RefSeq Acc Id: XM_038546635   ⟹   XP_038402563
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.096,221,467 - 6,223,256 (+)NCBI
RefSeq Acc Id: XM_038610626   ⟹   XP_038466554
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.096,161,347 - 6,163,135 (+)NCBI
RefSeq Acc Id: XM_038675755   ⟹   XP_038531683
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.096,013,116 - 6,014,887 (+)NCBI
RefSeq Acc Id: XM_540428   ⟹   XP_540428
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.195,342,793 - 5,344,432 (+)NCBI
Dog10K_Boxer_Tasha96,021,430 - 6,023,200 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_038340873 (Get FASTA)   NCBI Sequence Viewer  
  XP_038402563 (Get FASTA)   NCBI Sequence Viewer  
  XP_038466554 (Get FASTA)   NCBI Sequence Viewer  
  XP_038531683 (Get FASTA)   NCBI Sequence Viewer  
  XP_540428 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_540428   ⟸   XM_540428
- Sequence:
RefSeq Acc Id: ENSCAFP00000035634   ⟸   ENSCAFT00000039741
RefSeq Acc Id: XP_038340873   ⟸   XM_038484945
RefSeq Acc Id: XP_038466554   ⟸   XM_038610626
RefSeq Acc Id: XP_038531683   ⟸   XM_038675755
RefSeq Acc Id: XP_038402563   ⟸   XM_038546635


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000025532 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000035634 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000039741 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1000 UniProtKB/TrEMBL
InterPro 5'(3')-deoxyribonucleotidase UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
NCBI Gene NT5C ENTREZGENE
Pfam NT5C UniProtKB/TrEMBL
Superfamily-SCOP SSF56784 UniProtKB/TrEMBL
UniProt F1Q4B4_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:43994 ENTREZGENE