Nt5c (5', 3'-nucleotidase, cytosolic)

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Gene: Nt5c (5', 3'-nucleotidase, cytosolic) Ictidomys tridecemlineatus

Analyze

Symbol:

Nt5c

Name:

5', 3'-nucleotidase, cytosolic

RGD ID:

12512946

Description:

ENCODES a protein that exhibits 5'-nucleotidase activity (ortholog); identical protein binding (ortholog); IMP 5'-nucleotidase activity (ortholog); INVOLVED IN dCMP catabolic process (ortholog); deoxyribonucleotide catabolic process (ortholog); dephosphorylation (ortholog); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

5'(3')-deoxyribonucleotidase, cytosolic type

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Dog

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dCMP catabolic process (ISO)

deoxyribonucleotide catabolic process (ISO)

dephosphorylation (ISO)

dGMP catabolic process (ISO)

dTMP catabolic process (ISO)

dUMP catabolic process (ISO)

IMP catabolic process (ISO)

pyrimidine deoxyribonucleotide catabolic process (ISO)

UMP catabolic process (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleus (ISO)

Molecular Function

5'-nucleotidase activity (ISO)

identical protein binding (ISO)

IMP 5'-nucleotidase activity (ISO)

nucleotidase activity (ISO)

phosphatase activity (ISO)

pyrimidine nucleotide binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

References

Genomics

Comparative Map Data

Nt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NT5C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	75,130,225 - 75,131,757 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	75,130,228 - 75,131,965 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	73,126,323 - 73,127,837 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	17	73,126,320 - 73,127,890 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	70,637,918 - 70,639,472 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	17	70,637,918 - 70,639,472	NCBI
Celera	17	69,718,700 - 69,720,253 (-)	NCBI
Cytogenetic Map	17	q25.1	NCBI
HuRef	17	68,536,008 - 68,537,577 (-)	NCBI		HuRef
CHM1_1	17	73,190,820 - 73,192,389 (-)	NCBI		CHM1_1

Nt5c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	115,381,246 - 115,382,896 (-)	NCBI	GRCm39		mm39
GRCm38	11	115,490,420 - 115,492,070 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	115,490,420 - 115,491,862 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	115,351,739 - 115,353,128 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	115,306,515 - 115,307,904 (-)	NCBI			mm8
Celera	11	127,257,296 - 127,258,685 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI

Nt5c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	100,739,591 - 100,742,276 (-)	NCBI
Rnor_6.0 Ensembl	10	104,052,831 - 104,054,805 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	104,052,807 - 104,054,805 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	104,225,988 - 104,227,164 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	105,574,754 - 105,576,848 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
Celera	10	99,314,518 - 99,316,243 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Nt5c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955553	2,011,738 - 2,013,443 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955553	2,011,549 - 2,014,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

NT5C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	74,632,846 - 74,634,136 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	17	69,077,021 - 69,078,998 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

NT5C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	9	5,343,378 - 5,344,380 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	9	5,342,793 - 5,344,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

NT5C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	6,139,439 - 6,164,142 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	6,162,420 - 6,164,143 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	6,124,412 - 6,126,605 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NT5C
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	46,531,820 - 46,533,763 (+)	NCBI
ChlSab1.1 Ensembl	16	46,532,216 - 46,535,736 (+)	Ensembl

Nt5c
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624801	4,952,736 - 4,954,660 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGTP01070489	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_005332546 ⟹ XP_005332603

RefSeq Status:

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI

Sequence:

show sequence

TCGCGGCCCGGAAGCGGCGGCACTCGGCGCCCAGCGCTCCGCGCTTCCGGCCGGCTCAGCCCCT
GGGGTCCGAGACCCTCGCGACCCCGAGACCCCCGCAGCCTGGAGGCGATGGCGGCGCAGCGCGC
GCGGCCCGTGCGTGTGCTGGTGGACATGGACGGCGTGCTGGCCGACTTCGAGGCCGGCCTCCTG
CGGGGCTTCCACCGTCGCTTCCCCGGGGAGCCGCACGTGCCGCTCGAGCAGCGCCGCGGCTTCC
TGGCCAGCGAGCAGTACCGAGCCCTGCGGCCCGACCTGGCGGATAAAGTGGCCAGCGTGTATGA
AGCCCCAGGCTTTTTCTTAGACTTGGAGCCCATCCCGGGGGCTTTGGAAGCCTTGCGGGAGATG
AACGCCATGCCAGACACCGAGGTCTTCATCTGCTCCAGCCCTCTGCTGAAGTTTGACCACTGTG
TGGGTGAGAAGTACCGCTGGGTAGAGCGACACCTGGGACCCCAGTTTGTGGAGCGCATTATCCT
GACAAGAGACAAGACTGTAGTCTTGGGAGATCTGCTCATTGATGATAAGGACACCATTCAAGGC
CTAGAGGAAACCCCCAGCTGGGAGCACATCTTGTTCACCTGCTGCCACAATCAGCACCTGGCCC
TGCCCCCTTCAAGGAGACGTCTGCTCTCCTGGAGTGACAATTGGAGGGAAATTATAGAGAGCAA
GCGGGCAGCTGTGTAGTGGGAATGAGCTGGACCTGCAGGCGACAGTGCTGAAGTGAAGGCAGGC
AGGCTGGCAGGGAATCCCTGAAGAGCCAGGGACTCCTGCCATGCAGAATGGAGACCAGTAACCT
CTGCTTGCACAGGCCCAGCCACCTGGCACCTCCAGAGACGGCTGTCCCTGAGCACGACTGGCAT
AGAAATACAATGGAATATCAGCTAGTCAGGACCCTTTTAATAAAAAAAAAACTTGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332603	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005332603 ⟸ XM_005332546

- UniProtKB:

I3MP97 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAQRARPVRVLVDMDGVLADFEAGLLRGFHRRFPGEPHVPLEQRRGFLASEQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALEALREMNAMPDTEVFICSSPLLKFDHCVGEKYRWVERHLGPQF
VERIILTRDKTVVLGDLLIDDKDTIQGLEETPSWEHILFTCCHNQHLALPPSRRRLLSWSDNWR
EIIESKRAAV

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Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015167	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSSTOP00000013588	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015166	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1000	UniProtKB/TrEMBL
InterPro	5'(3')-deoxyribonucleotidase	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
NCBI Gene	Nt5c	ENTREZGENE
Pfam	NT5C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
UniProt	I3MP97	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB