Nt5c (5', 3'-nucleotidase, cytosolic)

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Gene: Nt5c (5', 3'-nucleotidase, cytosolic) Ictidomys tridecemlineatus

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Symbol:

Nt5c

Name:

5', 3'-nucleotidase, cytosolic

RGD ID:

12512946

Description:

ENCODES a protein that exhibits 5'-nucleotidase activity (inferred); identical protein binding (inferred); IMP 5'-nucleotidase activity (inferred); INVOLVED IN deoxyribonucleotide catabolic process (ortholog); dephosphorylation (ortholog); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; ASSOCIATED WITH Colorectal Neoplasms (ortholog); FOUND IN cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

5'(3')-deoxyribonucleotidase, cytosolic type

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

SpeTri2.0 - Squirrel SpeTri2.0 Assembly

Position:

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	5,979,933 - 5,981,689 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	430,506 - 432,095 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Colorectal Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

allantoin metabolic process (IEA)

amide catabolic process (IEA)

dCMP catabolic process (IEA)

deoxyribonucleotide catabolic process (IEA,ISO)

dephosphorylation (ISO)

dGMP catabolic process (IEA)

dTMP catabolic process (IEA)

dUMP catabolic process (IEA)

IMP catabolic process (IEA)

pyrimidine deoxyribonucleotide catabolic process (IEA)

UMP catabolic process (IEA)

Cellular Component

cytoplasm (IEA)

cytosol (IEA,ISO)

mitochondrion (IEA)

nucleus (IEA)

Molecular Function

5'-nucleotidase activity (IEA)

identical protein binding (IEA)

IMP 5'-nucleotidase activity (IEA)

nucleotidase activity (IEA)

phosphatase activity (IEA)

pyrimidine nucleotide binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

gemcitabine pharmacodynamics pathway (ISO)

gemcitabine pharmacokinetics pathway (ISO)

lamivudine pharmacokinetics pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Nt5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	5,979,933 - 5,981,689 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	430,506 - 432,095 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NT5C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	75,130,228 - 75,131,742 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	75,130,225 - 75,131,757 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	73,126,323 - 73,127,837 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	70,637,918 - 70,639,472 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	70,637,918 - 70,639,472	NCBI
Celera	17	69,718,700 - 69,720,253 (-)	NCBI		Celera
Cytogenetic Map	17	q25.1	NCBI
HuRef	17	68,536,008 - 68,537,577 (-)	NCBI		HuRef
CHM1_1	17	73,190,820 - 73,192,389 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	76,021,691 - 76,023,204 (-)	NCBI		T2T-CHM13v2.0

Nt5c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	115,381,251 - 115,382,659 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	115,381,246 - 115,382,688 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	115,490,420 - 115,492,070 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	115,490,420 - 115,491,862 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	115,351,739 - 115,353,128 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	115,306,515 - 115,307,904 (-)	NCBI		MGSCv36	mm8
Celera	11	127,257,296 - 127,258,685 (-)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	80.84	NCBI

Nt5c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	101,238,552 - 101,240,666 (-)	NCBI		GRCr8
mRatBN7.2	10	100,739,591 - 100,742,276 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	100,739,588 - 100,741,954 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	105,799,983 - 105,801,929 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	105,263,054 - 105,264,998 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	100,660,564 - 100,662,519 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	104,052,807 - 104,054,805 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	104,052,831 - 104,054,805 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	104,225,988 - 104,227,164 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	105,574,754 - 105,576,848 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	99,314,518 - 99,316,243 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

Nt5c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955553	2,011,738 - 2,013,443 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955553	2,011,549 - 2,014,209 (-)	NCBI	ChiLan1.0	ChiLan1.0

NT5C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	91,169,491 - 91,171,558 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	95,992,532 - 95,994,620 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	69,077,021 - 69,078,998 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	74,632,846 - 74,634,136 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

NT5C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	5,342,793 - 5,344,432 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	5,343,378 - 5,344,380 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	6,021,430 - 6,023,200 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	6,013,116 - 6,014,887 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	6,013,114 - 6,014,835 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	6,051,001 - 6,052,770 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	6,161,347 - 6,163,135 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	6,221,467 - 6,223,256 (+)	NCBI		UU_Cfam_GSD_1.0

NT5C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	6,162,243 - 6,164,140 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	6,162,420 - 6,164,143 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	6,124,412 - 6,126,605 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NT5C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	46,531,820 - 46,533,763 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	46,532,216 - 46,535,736 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	17,309,387 - 17,311,299 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nt5c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	4,952,736 - 4,954,639 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	4,952,736 - 4,954,660 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005332546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JAESOR010000662	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSSTOT00000015166 ⟹ ENSSTOP00000013588

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
SpeTri2.0 Ensembl	NW_004936594	430,506 - 432,095 (-)	Ensembl

RefSeq Acc Id:

XM_005332546 ⟹ XP_005332603

Type:

CODING

Position:

Squirrel Assembly	Chr	Position (strand)	Source
HiC_Itri_2	NW_024405602	5,979,933 - 5,981,689 (+)	NCBI
SpeTri2.0	NW_004936594	430,274 - 432,027 (-)	NCBI

Sequence:

show sequence

TCGCGGCCCGGAAGCGGCGGCACTCGGCGCCCAGCGCTCCGCGCTTCCGGCCGGCTCAGCCCCT
GGGGTCCGAGACCCTCGCGACCCCGAGACCCCCGCAGCCTGGAGGCGATGGCGGCGCAGCGCGC
GCGGCCCGTGCGTGTGCTGGTGGACATGGACGGCGTGCTGGCCGACTTCGAGGCCGGCCTCCTG
CGGGGCTTCCACCGTCGCTTCCCCGGGGAGCCGCACGTGCCGCTCGAGCAGCGCCGCGGCTTCC
TGGCCAGCGAGCAGTACCGAGCCCTGCGGCCCGACCTGGCGGATAAAGTGGCCAGCGTGTATGA
AGCCCCAGGCTTTTTCTTAGACTTGGAGCCCATCCCGGGGGCTTTGGAAGCCTTGCGGGAGATG
AACGCCATGCCAGACACCGAGGTCTTCATCTGCTCCAGCCCTCTGCTGAAGTTTGACCACTGTG
TGGGTGAGAAGTACCGCTGGGTAGAGCGACACCTGGGACCCCAGTTTGTGGAGCGCATTATCCT
GACAAGAGACAAGACTGTAGTCTTGGGAGATCTGCTCATTGATGATAAGGACACCATTCAAGGC
CTAGAGGAAACCCCCAGCTGGGAGCACATCTTGTTCACCTGCTGCCACAATCAGCACCTGGCCC
TGCCCCCTTCAAGGAGACGTCTGCTCTCCTGGAGTGACAATTGGAGGGAAATTATAGAGAGCAA
GCGGGCAGCTGTGTAGTGGGAATGAGCTGGACCTGCAGGCGACAGTGCTGAAGTGAAGGCAGGC
AGGCTGGCAGGGAATCCCTGAAGAGCCAGGGACTCCTGCCATGCAGAATGGAGACCAGTAACCT
CTGCTTGCACAGGCCCAGCCACCTGGCACCTCCAGAGACGGCTGTCCCTGAGCACGACTGGCAT
AGAAATACAATGGAATATCAGCTAGTCAGGACCCTTTTAATAAAAAAAAAACTTGG

hide sequence

Protein Sequences


Protein RefSeqs	XP_005332603	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSSTOP00000013588.3
GenBank Protein	KAG3268528	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_005332603 ⟸ XM_005332546

- UniProtKB:

I3MP97 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAQRARPVRVLVDMDGVLADFEAGLLRGFHRRFPGEPHVPLEQRRGFLASEQYRALRPDLADK
VASVYEAPGFFLDLEPIPGALEALREMNAMPDTEVFICSSPLLKFDHCVGEKYRWVERHLGPQF
VERIILTRDKTVVLGDLLIDDKDTIQGLEETPSWEHILFTCCHNQHLALPPSRRRLLSWSDNWR
EIIESKRAAV

hide sequence

Ensembl Acc Id:

ENSSTOP00000013588 ⟸ ENSSTOT00000015166

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSSTOG00000015167	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSSTOT00000015166.3	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1000	UniProtKB/TrEMBL
InterPro	5'(3')-deoxyribonucleotidase	UniProtKB/TrEMBL
	HAD-like_sf	UniProtKB/TrEMBL
	HAD_sf	UniProtKB/TrEMBL
NCBI Gene	Nt5c	ENTREZGENE
PANTHER	5'(3')-DEOXYRIBONUCLEOTIDASE	UniProtKB/TrEMBL
	5'(3')-DEOXYRIBONUCLEOTIDASE, CYTOSOLIC TYPE	UniProtKB/TrEMBL
Pfam	NT5C	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56784	UniProtKB/TrEMBL
UniProt	I3MP97	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB

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Imported Disease Annotations - CTD

Imported Annotations - SMPDB