MIR140 (microRNA mir-140) - Rat Genome Database

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Gene: MIR140 (microRNA mir-140) Canis lupus familiaris
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Symbol: MIR140
Name: microRNA mir-140 (Ensembl:microRNA 140)
RGD ID: 12263814
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: cfa-mir-140; microRNA 140
RGD Orthologs
Human
Mouse
Rat
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,814,256 - 79,814,316 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,814,246 - 79,814,326 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,803,222 - 79,803,282 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,244,523 - 80,244,583 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,244,513 - 80,244,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,072,654 - 80,072,714 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,761,757 - 79,761,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,394,432 - 80,394,492 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cartilage development  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to hypoxia  (ISO)
cellular response to lipopolysaccharide  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IEA)
myelination  (ISO)
negative regulation of chemokine production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-1 beta production  (ISO)
negative regulation of interleukin-6 production  (ISO)
negative regulation of NF-kappaB transcription factor activity  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
negative regulation of SMAD protein signal transduction  (ISO)
negative regulation of toll-like receptor 4 signaling pathway  (ISO)
negative regulation of toll-like receptor signaling pathway  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
ossification  (ISO)
positive regulation of BMP signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
regulation of gene expression  (ISO)
response to bacterium  (ISO)
response to oxygen levels  (ISO)
sensory perception of sound  (ISO)
skeletal system development  (ISO)
tissue homeostasis  (ISO)

Cellular Component
RISC complex  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:16381832   PMID:18392026  


Genomics

Comparative Map Data
MIR140
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1579,814,256 - 79,814,316 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl579,814,246 - 79,814,326 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha579,803,222 - 79,803,282 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,244,523 - 80,244,583 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,244,513 - 80,244,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,072,654 - 80,072,714 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0579,761,757 - 79,761,817 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,394,432 - 80,394,492 (-)NCBIUU_Cfam_GSD_1.0
MIR140
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,933,081 - 69,933,180 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,933,081 - 69,933,180 (+)EnsemblGRCh38hg38GRCh38
GRCh371669,966,984 - 69,967,083 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,524,484 - 68,524,583 (+)NCBINCBI36Build 36hg18NCBI36
Celera1654,482,297 - 54,482,396 (+)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,845,129 - 55,845,228 (+)NCBIHuRef
CHM1_11671,374,858 - 71,374,957 (+)NCBICHM1_1
T2T-CHM13v2.01675,735,661 - 75,735,760 (+)NCBIT2T-CHM13v2.0
Mir140
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398108,277,876 - 108,277,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8108,277,876 - 108,277,945 (+)EnsemblGRCm39 Ensembl
GRCm388107,551,244 - 107,551,313 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,551,244 - 107,551,313 (+)EnsemblGRCm38mm10GRCm38
MGSCv378110,075,144 - 110,075,213 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera8111,782,593 - 111,782,662 (+)NCBICelera
Cytogenetic Map8D3NCBI
cM Map854.33NCBI
Mir140
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81952,375,293 - 52,375,391 (+)NCBIGRCr8
mRatBN7.21935,465,577 - 35,465,675 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1935,465,577 - 35,465,675 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1942,281,002 - 42,281,100 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,934,362 - 42,934,460 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01945,239,004 - 45,239,102 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,608,951 - 39,609,049 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,608,951 - 39,609,049 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01950,471,253 - 50,471,351 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1934,887,662 - 34,887,760 (+)NCBICelera
Cytogenetic Map19q12NCBI
MIR140
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,077,507 - 17,077,620 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,077,530 - 17,077,599 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 6 5 2 3 2 2 3 4 5

Sequence


Ensembl Acc Id: ENSCAFT00000032562
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl579,814,246 - 79,814,326 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845015979
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl580,244,513 - 80,244,593 (-)Ensembl
RefSeq Acc Id: NR_049327
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1579,814,256 - 79,814,316 (-)NCBI
Dog10K_Boxer_Tasha579,803,222 - 79,803,282 (-)NCBI
ROS_Cfam_1.0580,244,523 - 80,244,583 (-)NCBI
UMICH_Zoey_3.1580,072,654 - 80,072,714 (-)NCBI
UNSW_CanFamBas_1.0579,761,757 - 79,761,817 (-)NCBI
UU_Cfam_GSD_1.0580,394,432 - 80,394,492 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000020455 Ensembl
  ENSCAFG00845009071 Ensembl, ENTREZGENE
Ensembl Transcript ENSCAFT00845015979 ENTREZGENE
miRBase MI0008100 ENTREZGENE
NCBI Gene MIR140 ENTREZGENE
RNAcentral URS000075ECC0 RNACentral
  URS00007E375D RNACentral
  URS0000D5096A RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 MIR140  microRNA mir-140    microRNA 140  Symbol and/or name change 5135510 APPROVED