RGD Reference Report - MicroRNAs in ascending thoracic aortic aneurysms. - Rat Genome Database

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MicroRNAs in ascending thoracic aortic aneurysms.

Authors: Moushi, Areti  Pillar, Nir  Keravnou, Anna  Soteriou, Marinos  Shomron, Noam  Cariolou, Marios A  Bashiardes, Evy 
Citation: Moushi A, etal., Biosci Rep. 2020 Jul 31;40(7):BSR20200218. doi: 10.1042/BSR20200218.
RGD ID: 329347832
Pubmed: PMID:32678444   (View Abstract at PubMed)
PMCID: PMC7385583   (View Article at PubMed Central)
DOI: DOI:10.1042/BSR20200218   (Journal Full-text)

Thoracic Aortic Aneurysm (TAA) is characterized by the dilation of the aorta and is fatal if not diagnosed and treated appropriately. The underlying genetic mechanisms have not been completely delineated, so better knowledge of the physiopathology of TAAs is needed to improve detection and therapy. MicroRNAs (miRNAs) regulate gene expression post-transcriptionally and are known to be involved in cardiovascular diseases (CVDs). The current study aimed to identify miRNAs that can be used as possible biomarkers for the early diagnosis of patients with ascending TAAs (ATAAs). MiRNA expression was profiled by NanoString nCounter technology using 12 samples including tissue and pre- and post-surgical plasma from ATAA patients. Four miRNAs were selected and further validated by real time polymerase chain reaction (RT-PCR) in 22 plasma samples from which three miRNAs (hsa-miR140-5p, hsa-miR-191-5p and hsa-miR-214-3p) showed significant expression level differences between the two types of plasma samples. Further analyses of the corresponding predicted target genes by these miRNAs, revealed two genes (Myotubularin-related protein 4 (MTMR4) and Phosphatase 1 catalytic subunit β (PPP1CB)) whose expression was inversely correlated with the expression of their respective miRNAs. Overall, in this pilot study, we identified three miRNAs that might serve as potential biomarkers and therapeutic targets in ATAA.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MIR140Humanthoracic aortic aneurysm amelioratesIDA  RGD 
Mir140Mousethoracic aortic aneurysm amelioratesISOMIR140 (Homo sapiens) RGD 
Mir140Ratthoracic aortic aneurysm amelioratesISOMIR140 (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Mir140  (microRNA 140)

Genes (Mus musculus)
Mir140  (microRNA 140)

Genes (Homo sapiens)
MIR140  (microRNA 140)


Additional Information