H2AZ1 (H2A.Z variant histone 1) - Rat Genome Database

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Gene: H2AZ1 (H2A.Z variant histone 1) Canis lupus familiaris
Analyze
Symbol: H2AZ1
Name: H2A.Z variant histone 1
RGD ID: 12226838
Description: ENCODES a protein that exhibits chromatin DNA binding (ortholog); nucleosomal DNA binding (ortholog); RNA polymerase II cis-regulatory region sequence-specific DNA binding (ortholog); INVOLVED IN cellular response to estradiol stimulus (ortholog); cellular response to insulin stimulus (ortholog); positive regulation of transcription by RNA polymerase II (ortholog); PARTICIPATES IN histone modification pathway; FOUND IN Barr body (ortholog); euchromatin (ortholog); heterochromatin (ortholog)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: H2A histone family, member Z; H2AFZ; histone H2AF
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,889,890 - 21,892,165 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,889,877 - 21,892,102 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,004,606 - 20,006,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03222,110,961 - 22,113,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3222,110,948 - 22,113,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13222,087,386 - 22,089,720 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,874,328 - 21,876,660 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03217,991,798 - 17,994,133 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
Barr body  (ISO)
chromosome  (IEA)
euchromatin  (ISO)
heterochromatin  (ISO)
nucleosome  (IEA,ISO)
nucleus  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:8015430   PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
H2AZ1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13221,889,890 - 21,892,165 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3221,889,877 - 21,892,102 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3220,004,606 - 20,006,940 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03222,110,961 - 22,113,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3222,110,948 - 22,113,297 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13222,087,386 - 22,089,720 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03221,874,328 - 21,876,660 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03217,991,798 - 17,994,133 (+)NCBIUU_Cfam_GSD_1.0
H2AZ1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38499,948,088 - 99,950,275 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl499,948,086 - 99,950,355 (-)EnsemblGRCh38hg38GRCh38
GRCh374100,869,245 - 100,871,432 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364101,088,267 - 101,090,535 (-)NCBINCBI36Build 36hg18NCBI36
Build 344101,226,421 - 101,228,690NCBI
Celera498,166,664 - 98,168,932 (-)NCBICelera
Cytogenetic Map4q23NCBI
HuRef496,607,568 - 96,609,836 (-)NCBIHuRef
CHM1_14100,845,766 - 100,848,034 (-)NCBICHM1_1
T2T-CHM13v2.04103,263,572 - 103,265,759 (-)NCBIT2T-CHM13v2.0
H2az1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393137,570,248 - 137,572,683 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3137,570,248 - 137,572,683 (+)EnsemblGRCm39 Ensembl
GRCm383137,864,487 - 137,866,922 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3137,864,487 - 137,866,922 (+)EnsemblGRCm38mm10GRCm38
MGSCv373137,527,563 - 137,529,886 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363138,361,991 - 138,368,602 (+)NCBIMGSCv36mm8
MGSCv363137,801,986 - 137,804,309 (+)NCBIMGSCv36mm8
Celera6118,011,137 - 118,011,992 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map363.94NCBI
H2az1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82229,026,464 - 229,031,411 (+)NCBIGRCr8
mRatBN7.22226,355,668 - 226,357,984 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2226,355,708 - 226,358,485 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2234,110,339 - 234,112,450 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02232,010,121 - 232,012,232 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02226,874,738 - 226,876,849 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02243,105,224 - 243,107,333 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2243,105,674 - 243,106,956 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02261,653,464 - 261,655,573 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42235,353,027 - 235,355,136 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12235,339,772 - 235,341,875 (+)NCBI
Celera2218,522,206 - 218,524,315 (+)NCBICelera
Cytogenetic Map2q43NCBI
LOC102021365
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554967,733,918 - 7,735,525 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554967,733,910 - 7,735,525 (+)NCBIChiLan1.0ChiLan1.0
LOC100974973
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2398,029,591 - 98,032,659 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1498,313,384 - 98,316,452 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0492,371,150 - 92,373,454 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14103,031,339 - 103,033,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4103,030,469 - 103,033,397 (-)Ensemblpanpan1.1panPan2
LOC101974663
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530119,716,171 - 19,718,489 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365203,059,623 - 3,061,941 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
H2AZ1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8120,563,752 - 120,566,177 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18120,563,752 - 120,566,023 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28129,744,062 - 129,745,412 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103236032
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1748,079,894 - 48,082,147 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603726,551,875 - 26,554,212 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101701243
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248307,238,929 - 7,240,563 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248307,238,897 - 7,240,566 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in H2AZ1
20 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 5 22 6 6 6 6 6 12 8 10 6
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000016883   ⟹   ENSCAFP00000015623
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3221,889,890 - 21,891,760 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069095   ⟹   ENSCAFP00000045187
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3221,889,890 - 21,892,102 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000077597   ⟹   ENSCAFP00000049190
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3221,889,877 - 21,891,760 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042422   ⟹   ENSCAFP00845033260
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,110,948 - 22,113,234 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042497   ⟹   ENSCAFP00845033311
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,110,961 - 22,113,297 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845042533   ⟹   ENSCAFP00845033341
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,110,961 - 22,113,047 (-)Ensembl
RefSeq Acc Id: NM_001287092   ⟹   NP_001274021
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13221,889,890 - 21,892,165 (-)NCBI
Dog10K_Boxer_Tasha3220,004,606 - 20,006,940 (+)NCBI
ROS_Cfam_1.03222,110,961 - 22,113,297 (-)NCBI
UMICH_Zoey_3.13222,087,386 - 22,089,720 (-)NCBI
UNSW_CanFamBas_1.03221,874,328 - 21,876,660 (-)NCBI
UU_Cfam_GSD_1.03217,991,798 - 17,994,133 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038443793   ⟹   XP_038299721
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03222,110,961 - 22,113,289 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001274021   ⟸   NM_001287092
- UniProtKB: A0A8C0Z4D4 (UniProtKB/TrEMBL),   A0A8I3PL79 (UniProtKB/TrEMBL),   A0A8I3NKM9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000045187   ⟸   ENSCAFT00000069095
RefSeq Acc Id: ENSCAFP00000049190   ⟸   ENSCAFT00000077597
RefSeq Acc Id: ENSCAFP00000015623   ⟸   ENSCAFT00000016883
RefSeq Acc Id: XP_038299721   ⟸   XM_038443793
- Peptide Label: isoform X1
- UniProtKB: A0A8C0L0N3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCAFP00845033311   ⟸   ENSCAFT00845042497
RefSeq Acc Id: ENSCAFP00845033260   ⟸   ENSCAFT00845042422
RefSeq Acc Id: ENSCAFP00845033341   ⟸   ENSCAFT00845042533
Protein Domains
Histone H2A C-terminal   Histone H2A/H2B/H3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010615 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021896 UniProtKB/TrEMBL
  ENSCAFG00040022273 UniProtKB/TrEMBL
  ENSCAFG00845011363 UniProtKB/TrEMBL
  ENSCAFG00845024032 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000016883.5 UniProtKB/TrEMBL
  ENSCAFT00000069095.2 UniProtKB/TrEMBL
  ENSCAFT00000077597.2 UniProtKB/TrEMBL
  ENSCAFT00030040196.1 UniProtKB/TrEMBL
  ENSCAFT00040041344.1 UniProtKB/TrEMBL
  ENSCAFT00040041364.1 UniProtKB/TrEMBL
  ENSCAFT00845020188.1 UniProtKB/TrEMBL
  ENSCAFT00845042422.1 UniProtKB/TrEMBL
  ENSCAFT00845042497 ENTREZGENE
  ENSCAFT00845042497.1 UniProtKB/TrEMBL
  ENSCAFT00845042533.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.10 UniProtKB/TrEMBL
InterPro Histone-fold UniProtKB/TrEMBL
  Histone_H2A UniProtKB/TrEMBL
  Histone_H2A/H2B/H3 UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
  Histone_H2A_CS UniProtKB/TrEMBL
KEGG Report cfa:478493 UniProtKB/TrEMBL
NCBI Gene H2AFZ ENTREZGENE
PANTHER HISTONE H2A UniProtKB/TrEMBL
  HISTONE H2A.V UniProtKB/TrEMBL
  HISTONE H2A.Z UniProtKB/TrEMBL
  PTHR23430 UniProtKB/TrEMBL
Pfam Histone UniProtKB/TrEMBL
  Histone_H2A_C UniProtKB/TrEMBL
PRINTS HISTONEH2A UniProtKB/TrEMBL
PROSITE HISTONE_H2A UniProtKB/TrEMBL
SMART H2A UniProtKB/TrEMBL
Superfamily-SCOP SSF47113 UniProtKB/TrEMBL
UniProt A0A8C0L0N3 ENTREZGENE
  A0A8C0TKN0_CANLF UniProtKB/TrEMBL
  A0A8C0Z4D4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3NKM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PL79 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PLP0_CANLF UniProtKB/TrEMBL
  A0A8I3PV82_CANLF UniProtKB/TrEMBL
  A0A8P0T1Z4_CANLF UniProtKB/TrEMBL
UniProt Secondary A0A8P0SFF4 UniProtKB/TrEMBL
VGNC ID VGNC:83696 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-11-05 H2AZ1  H2A.Z variant histone 1  H2AFZ  H2A histone family, member Z  Symbol and/or name change 5135510 APPROVED