TFR2 (transferrin receptor 2) - Rat Genome Database

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Gene: TFR2 (transferrin receptor 2) Canis lupus familiaris
Analyze
Symbol: TFR2
Name: transferrin receptor 2
RGD ID: 12142751
Description: ENCODES a protein that exhibits co-receptor binding (inferred); transferrin receptor activity (inferred); INVOLVED IN acute-phase response (ortholog); multicellular organismal-level iron ion homeostasis (ortholog); ASSOCIATED WITH acute myeloid leukemia (ortholog); beta thalassemia (ortholog); genetic disease (ortholog); FOUND IN cytoplasmic vesicle (inferred); external side of plasma membrane (inferred); HFE-transferrin receptor complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transferrin receptor protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,059,501 - 9,076,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,060,629 - 9,076,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,763,917 - 10,781,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,993,681 - 9,010,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,993,652 - 9,010,354 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,846,198 - 8,863,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,823,694 - 8,841,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,006,114 - 9,023,274 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TFR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.169,059,501 - 9,076,646 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl69,060,629 - 9,076,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha610,763,917 - 10,781,061 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.068,993,681 - 9,010,842 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl68,993,652 - 9,010,354 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.168,846,198 - 8,863,361 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.068,823,694 - 8,841,037 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.069,006,114 - 9,023,274 (+)NCBIUU_Cfam_GSD_1.0
TFR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387100,620,420 - 100,641,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7100,620,416 - 100,642,779 (-)EnsemblGRCh38hg38GRCh38
GRCh377100,218,043 - 100,239,175 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,055,975 - 100,077,109 (-)NCBINCBI36Build 36hg18NCBI36
Build 34799,862,690 - 99,883,810NCBI
Celera794,947,821 - 94,968,950 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef794,849,520 - 94,870,648 (-)NCBIHuRef
CHM1_17100,148,586 - 100,169,685 (-)NCBICHM1_1
T2T-CHM13v2.07101,860,501 - 101,881,634 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2799,577,671 - 99,598,799 (-)NCBI
Tfr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,568,127 - 137,586,344 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5137,568,102 - 137,585,743 (+)EnsemblGRCm39 Ensembl
GRCm385137,569,822 - 137,588,081 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,569,840 - 137,587,481 (+)EnsemblGRCm38mm10GRCm38
MGSCv375138,011,079 - 138,028,709 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365137,800,593 - 137,817,260 (+)NCBIMGSCv36mm8
Celera5134,553,519 - 134,571,033 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.57NCBI
Tfr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81224,744,450 - 24,761,413 (-)NCBIGRCr8
mRatBN7.21219,107,673 - 19,124,622 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1219,107,673 - 19,124,591 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1220,263,117 - 20,280,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,875,998 - 20,893,008 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01219,940,332 - 19,957,342 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01222,177,382 - 22,194,330 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,177,382 - 22,194,299 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,194,288 - 24,211,237 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,638,502 - 19,655,420 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11219,628,960 - 19,644,982 (+)NCBI
Celera1220,912,852 - 20,929,749 (-)NCBICelera
Cytogenetic Map12q12NCBI
Tfr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573272,289 - 291,668 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955573272,315 - 289,227 (+)NCBIChiLan1.0ChiLan1.0
TFR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26118,531,714 - 118,554,217 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17166,796,330 - 166,818,842 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0792,647,431 - 92,669,889 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17106,048,497 - 106,060,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,048,935 - 106,069,238 (-)Ensemblpanpan1.1panPan2
Tfr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344133,353,500 - 133,368,393 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936543668,157 - 682,174 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936543667,570 - 681,872 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TFR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,539,320 - 8,578,763 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,539,316 - 8,553,993 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.237,934,261 - 7,948,960 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TFR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12812,570,604 - 12,592,269 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2812,571,841 - 12,592,266 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660703,712,690 - 3,733,677 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tfr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474016,452,504 - 16,466,781 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474016,451,520 - 16,469,393 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TFR2
252 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005621038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022419636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038477988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038539249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038603329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038668034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_546952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCAFT00000022742   ⟹   ENSCAFP00000021123
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl69,060,629 - 9,076,158 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845002317   ⟹   ENSCAFP00845001837
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl68,993,652 - 9,010,354 (+)Ensembl
RefSeq Acc Id: XM_022419636   ⟹   XP_022275344
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.169,060,406 - 9,076,646 (+)NCBI
Dog10K_Boxer_Tasha610,764,831 - 10,781,061 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038477987   ⟹   XP_038333915
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,847,112 - 8,863,361 (+)NCBI
RefSeq Acc Id: XM_038477988   ⟹   XP_038333916
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.168,846,198 - 8,862,873 (+)NCBI
RefSeq Acc Id: XM_038539248   ⟹   XP_038395176
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,007,028 - 9,023,274 (+)NCBI
RefSeq Acc Id: XM_038539249   ⟹   XP_038395177
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.069,006,114 - 9,022,786 (+)NCBI
RefSeq Acc Id: XM_038603328   ⟹   XP_038459256
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,824,608 - 8,841,037 (+)NCBI
RefSeq Acc Id: XM_038603329   ⟹   XP_038459257
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.068,823,694 - 8,840,549 (+)NCBI
RefSeq Acc Id: XM_038668033   ⟹   XP_038523961
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,994,595 - 9,010,842 (+)NCBI
RefSeq Acc Id: XM_038668034   ⟹   XP_038523962
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.068,993,681 - 9,010,354 (+)NCBI
RefSeq Acc Id: XM_546952   ⟹   XP_546952
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.169,059,501 - 9,076,158 (+)NCBI
Dog10K_Boxer_Tasha610,763,917 - 10,780,573 (+)NCBI
Sequence:
RefSeq Acc Id: XP_546952   ⟸   XM_546952
- UniProtKB: A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL),   A0A8C0P7I2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022275344   ⟸   XM_022419636
- UniProtKB: A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL),   A0A8C0P7I2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000021123   ⟸   ENSCAFT00000022742
RefSeq Acc Id: XP_038333916   ⟸   XM_038477988
RefSeq Acc Id: XP_038333915   ⟸   XM_038477987
RefSeq Acc Id: XP_038459257   ⟸   XM_038603329
RefSeq Acc Id: XP_038459256   ⟸   XM_038603328
RefSeq Acc Id: XP_038523962   ⟸   XM_038668034
- UniProtKB: A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL),   A0A8C0P7I2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038523961   ⟸   XM_038668033
- UniProtKB: A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL),   A0A8C0P7I2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395177   ⟸   XM_038539249
- UniProtKB: A0A8C0P7I2 (UniProtKB/TrEMBL),   A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038395176   ⟸   XM_038539248
- UniProtKB: A0A8C0P7I2 (UniProtKB/TrEMBL),   A0A8C0SHF8 (UniProtKB/TrEMBL),   A0A8I3MDN1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845001837   ⟸   ENSCAFT00845002317
Protein Domains
PA   Peptidase M28

Promoters
RGD ID:13683529
Promoter ID:EPDNEW_C1597
Type:initiation region
Name:TFR2_1
Description:transferrin receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.169,059,487 - 9,059,547EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000014311 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021316 UniProtKB/TrEMBL
  ENSCAFG00040013459 UniProtKB/TrEMBL
  ENSCAFG00845001347 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000022742.5 UniProtKB/TrEMBL
  ENSCAFT00030039325.1 UniProtKB/TrEMBL
  ENSCAFT00040024871.1 UniProtKB/TrEMBL
  ENSCAFT00845002317 ENTREZGENE
  ENSCAFT00845002317.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.930.40 UniProtKB/TrEMBL
  3.50.30.30 UniProtKB/TrEMBL
  Zn peptidases UniProtKB/TrEMBL
InterPro PA_dom_sf UniProtKB/TrEMBL
  PA_domain UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/TrEMBL
  Peptidase_M28B UniProtKB/TrEMBL
  TFR-like_dimer_dom_sf UniProtKB/TrEMBL
  TfR1/2_PA UniProtKB/TrEMBL
NCBI Gene TFR2 ENTREZGENE
PANTHER PTHR10404 UniProtKB/TrEMBL
  TRANSFERRIN RECEPTOR PROTEIN 2 UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/TrEMBL
  PF02225 UniProtKB/TrEMBL
Superfamily-SCOP PA domain UniProtKB/TrEMBL
  SSF47672 UniProtKB/TrEMBL
  Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A0A8C0P7I2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SHF8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MDN1 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:47304 ENTREZGENE