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Gene: TFR2 (transferrin receptor 2) Homo sapiens
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Symbol: TFR2
Name: transferrin receptor 2
Description: Exhibits co-receptor binding activity and transferrin receptor activity. Involved in several processes, including iron ion transport; positive regulation of gene expression; and positive regulation of transport. Localizes to several cellular components, including the HFE-transferrin receptor complex; external side of plasma membrane; and integral component of plasma membrane. Implicated in hemochromatosis and hemochromatosis type 3. Biomarker of acute myeloid leukemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HFE3; MGC126368; TFRC2; transferrin receptor protein 2
Orthologs:
Mus musculus (house mouse) : Tfr2 (transferrin receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfr2 (transferrin receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfr2 (transferrin receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TFR2 (transferrin receptor 2)
Canis lupus familiaris (dog) : TFR2 (transferrin receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfr2 (transferrin receptor 2)
Sus scrofa (pig) : TFR2 (transferrin receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7100,620,416 - 100,642,779 (-)Ensembl
GRCh387100,620,416 - 100,641,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,218,039 - 100,240,332 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,055,975 - 100,077,109 (-)NCBINCBI36hg18NCBI36
Build 34799,862,690 - 99,883,810NCBI
Celera794,947,821 - 94,968,950 (-)NCBI
Cytogenetic Map7q22.1NCBI
HuRef794,849,520 - 94,870,648 (-)NCBIHuRef
CHM1_17100,148,586 - 100,169,685 (-)NCBICHM1_1
CRA_TCAGchr7v2799,577,671 - 99,598,799 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TFR2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1320887
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-12-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.