PSMC4 (proteasome 26S subunit, ATPase 4) - Rat Genome Database

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Gene: PSMC4 (proteasome 26S subunit, ATPase 4) Canis lupus familiaris
Analyze
Symbol: PSMC4
Name: proteasome 26S subunit, ATPase 4
RGD ID: 12089827
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); nucleotide binding (inferred); INVOLVED IN blastocyst development (inferred); positive regulation of proteasomal protein catabolic process (inferred); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Carpenter syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cytosolic proteasome complex (ortholog); inclusion body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 26S protease regulatory subunit 6B; 26S proteasome regulatory subunit 6B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,548,351 - 113,557,725 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,548,373 - 113,557,630 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,952,245 - 112,961,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,148,644 - 114,157,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,148,650 - 114,157,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,707,548 - 113,716,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,340,335 - 113,349,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,334,441 - 114,343,783 (-)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PSMC4DogCarpenter syndrome 2  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Carpenter syndrome 2ClinVarPMID:28492532
PSMC4Dogcongenital hypoplastic anemia  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital hypoplastic anemiaClinVarPMID:28492532
PSMC4Dogcraniosynostosis 1  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: TWIST1-related craniosynostosisClinVarPMID:28492532
PSMC4DogDiamond-Blackfan anemia  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Aase syndromeClinVarPMID:28492532
PSMC4Dogmaple syrup urine disease  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Maple syrup urine diseaseClinVarPMID:28492532
PSMC4Dogmaturity-onset diabetes of the young type 1  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
PSMC4Dogtype 2 diabetes mellitus  ISOPSMC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Type 2 diabetes mellitusClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PSMC4Dogamyotrophic lateral sclerosis  ISOPsmc4 (Mus musculus)9068941 MouseDO 


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PSMC4Dogblastocyst development acts_upstream_of_or_withinIEAUniProtKB:P54775 and ensembl:ENSMUSP00000032824150520179 EnsemblGO_REF:0000107
PSMC4Dogpositive regulation of proteasomal protein catabolic process involved_inIEAGO:0036402150520179 GOCGO_REF:0000108
PSMC4Dogproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0015282 more ...150520179 GO_CentralGO_REF:0000033

Cellular Component
1 to 9 of 9 rows

  
1 to 9 of 9 rows

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
PSMC4DogATP binding enablesIEAUniProtKB-KW:KW-0067150520179 UniProtGO_REF:0000043
PSMC4DogATP binding enablesIEAInterPro:IPR003959 and InterPro:IPR003960150520179 InterProGO_REF:0000002
PSMC4DogATP hydrolysis activity enablesIEAInterPro:IPR003593 more ...150520179 InterProGO_REF:0000002
PSMC4Dognucleotide binding enablesIEAUniProtKB-KW:KW-0547150520179 UniProtGO_REF:0000043
PSMC4Dogproteasome-activating activity enablesIBAPANTHER:PTN000553037 more ...150520179 GO_CentralGO_REF:0000033
PSMC4Dogprotein binding enablesISOUniProtKB:O75832 more ...9068941 PMID:33961781 and PMID:35271311IntActPMID:33961781 and PMID:35271311
PSMC4Dogprotein binding enablesISOUniProtKB:P550369068941 PMID:16990800IntActPMID:16990800
PSMC4Dogprotein binding enablesISOUniProtKB:Q9Z2X29068941 PMID:17292836IntActPMID:17292836
PSMC4Dogprotein binding enablesISOUniProtKB:Q0PF169068941 PMID:22078707UniProtPMID:22078707
PSMC4Dogprotein binding enablesISOUniProtKB:Q8TCF19068941 PMID:29804830UniProtPMID:29804830
PSMC4Dogprotein binding enablesISOUniProtKB:O75832 more ...9068941 PMID:19490896IntActPMID:19490896
PSMC4Dogprotein binding enablesISOUniProtKB:O758329068941 PMID:12525503 more ...IntActPMID:12525503 more ...
PSMC4Dogprotein binding enablesISOUniProtKB:P00441 more ...9068941 PMID:32814053IntActPMID:32814053
PSMC4Dogprotein binding enablesISOUniProtKB:P621919068941 PMID:26496610IntActPMID:26496610
PSMC4Dogprotein binding enablesISOUniProtKB:P623339068941 PMID:27342858 and PMID:29636472IntActPMID:27342858 and PMID:29636472
PSMC4Dogprotein binding enablesISOUniProtKB:O75832 and UniProtKB:P621959068941 PMID:16189514 and PMID:32296183IntActPMID:16189514 and PMID:32296183
PSMC4Dogprotein binding enablesISOUniProtKB:P621959068941 PMID:29892012IntActPMID:29892012
PSMC4Dogprotein binding enablesISOUniProtKB:P369579068941 PMID:29128334IntActPMID:29128334
1 to 18 of 18 rows

PMID:22301074   PMID:30032202  



PSMC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,548,351 - 113,557,725 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,548,373 - 113,557,630 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,952,245 - 112,961,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,148,644 - 114,157,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,148,650 - 114,157,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,707,548 - 113,716,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,340,335 - 113,349,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,334,441 - 114,343,783 (-)NCBIUU_Cfam_GSD_1.0
PSMC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,971,165 - 39,981,764 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,971,165 - 39,981,764 (+)EnsemblGRCh38hg38GRCh38
GRCh371940,477,072 - 40,487,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,168,913 - 45,179,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 341945,168,912 - 45,179,191NCBI
Celera1937,275,447 - 37,285,724 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,913,453 - 36,924,135 (+)NCBIHuRef
CHM1_11940,476,958 - 40,487,716 (+)NCBICHM1_1
T2T-CHM13v2.01942,791,375 - 42,801,971 (+)NCBIT2T-CHM13v2.0
Psmc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,741,127 - 27,749,517 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,741,132 - 27,749,526 (-)EnsemblGRCm39 Ensembl
GRCm38728,041,702 - 28,050,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,041,707 - 28,050,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv37728,826,721 - 28,835,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,750,477 - 27,758,803 (-)NCBIMGSCv36mm8
Celera722,608,215 - 22,616,605 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.11NCBI
Psmc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,476,690 - 92,485,268 (-)NCBIGRCr8
mRatBN7.2183,349,127 - 83,357,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,348,592 - 83,357,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,759,384 - 88,767,734 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,217,473 - 97,225,843 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,515,238 - 90,523,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,978,220 - 84,986,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,978,206 - 84,986,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,194,919 - 86,203,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,151,149 - 83,159,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,229,258 - 83,237,575 (-)NCBI
Celera177,748,725 - 77,757,041 (-)NCBICelera
Cytogenetic Map1q21NCBI
Psmc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,113,445 - 1,120,370 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555781,113,445 - 1,120,050 (-)NCBIChiLan1.0ChiLan1.0
PSMC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,232,549 - 46,243,056 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,103,185 - 48,113,698 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,018,112 - 37,028,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,533,141 - 45,543,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,533,141 - 45,543,245 (+)Ensemblpanpan1.1panPan2
Psmc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,094,546 - 14,100,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,522,615 - 2,528,284 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,522,665 - 2,528,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,406,376 - 48,416,215 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,406,237 - 48,414,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PSMC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,486,303 - 34,495,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,486,338 - 34,495,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,578,624 - 12,587,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925119,777 - 130,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925119,837 - 127,678 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in PSMC4
102 total Variants



adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10



Ensembl Acc Id: ENSCAFT00000008685   ⟹   ENSCAFP00000008051
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1113,548,373 - 113,557,630 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845007350   ⟹   ENSCAFP00845005828
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl1114,148,650 - 114,157,892 (-)Ensembl
RefSeq Acc Id: XM_005616577   ⟹   XP_005616634
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11113,548,351 - 113,557,725 (-)NCBI
Dog10K_Boxer_Tasha1112,952,245 - 112,961,621 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038468147   ⟹   XP_038324075
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.11113,707,548 - 113,716,884 (-)NCBI
RefSeq Acc Id: XM_038528897   ⟹   XP_038384825
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.01114,334,441 - 114,343,783 (-)NCBI
RefSeq Acc Id: XM_038593166   ⟹   XP_038449094
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.01113,340,335 - 113,349,711 (-)NCBI
RefSeq Acc Id: XM_038656994   ⟹   XP_038512922
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.01114,148,644 - 114,157,982 (-)NCBI
RefSeq Acc Id: XP_005616634   ⟸   XM_005616577
- UniProtKB: A0A8C0SF08 (UniProtKB/TrEMBL),   A0A8C0KT89 (UniProtKB/TrEMBL),   A0A8I3MR89 (UniProtKB/TrEMBL),   A0A8C0LWE0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000008051   ⟸   ENSCAFT00000008685
RefSeq Acc Id: XP_038324075   ⟸   XM_038468147
RefSeq Acc Id: XP_038449094   ⟸   XM_038593166
RefSeq Acc Id: XP_038512922   ⟸   XM_038656994
- UniProtKB: A0A8C0SF08 (UniProtKB/TrEMBL),   A0A8C0KT89 (UniProtKB/TrEMBL),   A0A8I3MR89 (UniProtKB/TrEMBL),   A0A8C0LWE0 (UniProtKB/TrEMBL)
AAA+ ATPase

RGD ID:13682302
Promoter ID:EPDNEW_C371
Type:initiation region
Name:PSMC4_1
Description:proteasome 26S subunit, ATPase 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11113,557,645 - 113,557,705EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
Ensembl Genes ENSCAFG00000005398 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030000909 UniProtKB/TrEMBL
  ENSCAFG00040012331 UniProtKB/TrEMBL
  ENSCAFG00845004088 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000008685.5 UniProtKB/TrEMBL
  ENSCAFT00030001548.1 UniProtKB/TrEMBL
  ENSCAFT00030001567.1 UniProtKB/TrEMBL
  ENSCAFT00040022738.1 UniProtKB/TrEMBL
  ENSCAFT00845007350 ENTREZGENE
  ENSCAFT00845007350.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro 26S_Proteasome_ATPase UniProtKB/TrEMBL
  AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
KEGG Report cfa:100855613 UniProtKB/TrEMBL
NCBI Gene PSMC4 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A8C0KT89 ENTREZGENE
  A0A8C0LWE0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0SF08 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3MR89 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:45104 ENTREZGENE
1 to 35 of 35 rows