PSMC4 (proteasome 26S subunit, ATPase 4) - Rat Genome Database

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Gene: PSMC4 (proteasome 26S subunit, ATPase 4) Chlorocebus sabaeus
Analyze
Symbol: PSMC4
Name: proteasome 26S subunit, ATPase 4
RGD ID: 18703530
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); nucleotide binding (inferred); INVOLVED IN blastocyst development (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Carpenter Syndrome 2 (ortholog); congenital hypoplastic anemia (ortholog); FOUND IN cytosolic proteasome complex (ortholog); inclusion body (ortholog); synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: 26S protease regulatory subunit 6B; 26S proteasome regulatory subunit 6B
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,486,303 - 34,495,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,486,338 - 34,495,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,578,624 - 12,587,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PSMC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1634,486,303 - 34,495,392 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl634,486,338 - 34,495,251 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607312,578,624 - 12,587,383 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
PSMC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381939,971,165 - 39,981,764 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1939,971,165 - 39,981,764 (+)EnsemblGRCh38hg38GRCh38
GRCh371940,477,072 - 40,487,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361945,168,913 - 45,179,193 (+)NCBINCBI36Build 36hg18NCBI36
Build 341945,168,912 - 45,179,191NCBI
Celera1937,275,447 - 37,285,724 (+)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1936,913,453 - 36,924,135 (+)NCBIHuRef
CHM1_11940,476,958 - 40,487,716 (+)NCBICHM1_1
T2T-CHM13v2.01942,791,375 - 42,801,971 (+)NCBIT2T-CHM13v2.0
Psmc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39727,741,127 - 27,749,517 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl727,741,132 - 27,749,526 (-)EnsemblGRCm39 Ensembl
GRCm38728,041,702 - 28,050,092 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,041,707 - 28,050,101 (-)EnsemblGRCm38mm10GRCm38
MGSCv37728,826,721 - 28,835,111 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36727,750,477 - 27,758,803 (-)NCBIMGSCv36mm8
Celera722,608,215 - 22,616,605 (-)NCBICelera
Cytogenetic Map7A3NCBI
cM Map716.11NCBI
Psmc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8192,476,690 - 92,485,268 (-)NCBIGRCr8
mRatBN7.2183,349,127 - 83,357,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl183,348,592 - 83,357,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx188,759,384 - 88,767,734 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0197,217,473 - 97,225,843 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0190,515,238 - 90,523,588 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0184,978,220 - 84,986,536 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl184,978,206 - 84,986,581 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0186,194,919 - 86,203,235 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,151,149 - 83,159,464 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1183,229,258 - 83,237,575 (-)NCBI
Celera177,748,725 - 77,757,041 (-)NCBICelera
Cytogenetic Map1q21NCBI
Psmc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555781,113,445 - 1,120,370 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555781,113,445 - 1,120,050 (-)NCBIChiLan1.0ChiLan1.0
PSMC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22046,232,549 - 46,243,056 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11948,103,185 - 48,113,698 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01937,018,112 - 37,028,490 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11945,533,141 - 45,543,245 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1945,533,141 - 45,543,245 (+)Ensemblpanpan1.1panPan2
PSMC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11113,548,351 - 113,557,725 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1113,548,373 - 113,557,630 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1112,952,245 - 112,961,621 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01114,148,644 - 114,157,982 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1114,148,650 - 114,157,892 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11113,707,548 - 113,716,884 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01113,340,335 - 113,349,711 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01114,334,441 - 114,343,783 (-)NCBIUU_Cfam_GSD_1.0
Psmc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934914,094,546 - 14,100,215 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366612,522,615 - 2,528,284 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366612,522,665 - 2,528,279 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl648,406,376 - 48,416,215 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1648,406,237 - 48,414,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Psmc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624925119,777 - 130,723 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624925119,837 - 127,678 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

endocrine system hemolymphoid system nervous system
High
Medium 36 20 60
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_007996804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JACDXN010000041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCSAT00000001803   ⟹   ENSCSAP00000000140
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl634,486,338 - 34,495,251 (+)Ensembl
RefSeq Acc Id: XM_007996804   ⟹   XP_007994995
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1634,486,303 - 34,495,392 (+)NCBI
Vero_WHO_p1.0NW_02366607312,578,624 - 12,587,383 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_007994995 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000000140
  ENSCSAP00000000140.1
Reference Protein Sequences
RefSeq Acc Id: XP_007994995   ⟸   XM_007996804
- UniProtKB: A0A0D9QUV1 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSCSAP00000000140   ⟸   ENSCSAT00000001803


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000003774 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000001803.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
KEGG Report csab:103234690 UniProtKB/TrEMBL
NCBI Gene PSMC4 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/TrEMBL
  26S PROTEASOME REGULATORY SUBUNIT 6B UniProtKB/TrEMBL
Pfam AAA UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/TrEMBL
  Prot_ATP_ID_OB UniProtKB/TrEMBL
PROSITE AAA UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0D9QUV1 ENTREZGENE, UniProtKB/TrEMBL