MRPL12 (mitochondrial ribosomal protein L12)

Gene: MRPL12 (mitochondrial ribosomal protein L12) Pan paniscus

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Symbol:

MRPL12

Name:

mitochondrial ribosomal protein L12

RGD ID:

12048627

Description:

ENCODES a protein that exhibits mRNA binding (inferred); structural constituent of ribosome (inferred); INVOLVED IN mitochondrial transcription (inferred); positive regulation of DNA-templated transcription (inferred); translation (inferred); ASSOCIATED WITH Animal Disease Models (ortholog); combined oxidative phosphorylation deficiency 45 (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (inferred); cytosolic large ribosomal subunit (inferred); mitochondrial large ribosomal subunit (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

39S ribosomal protein L12, mitochondrial; large ribosomal subunit protein bL12m

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,293,308 - 98,297,555 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,193,727 - 103,197,951 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,162,710 - 76,166,862 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	81,863,522 - 81,867,734 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	81,863,518 - 81,867,734 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Disease Models (ISO)

combined oxidative phosphorylation deficiency 45 (ISO)

COVID-19 (ISO)

genetic disease (ISO)

lung adenocarcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

mitochondrial transcription (IEA)

positive regulation of DNA-templated transcription (IEA)

translation (IEA)

Cellular Component

cytoplasm (IEA)

cytosolic large ribosomal subunit (IEA)

mitochondrial large ribosomal subunit (IEA)

mitochondrial matrix (IEA)

mitochondrion (IEA)

ribonucleoprotein complex (IEA)

ribosome (IEA)

Molecular Function

mRNA binding (IEA)

protein binding (ISO)

structural constituent of ribosome (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

MRPL12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	98,293,308 - 98,297,555 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	103,193,727 - 103,197,951 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	76,162,710 - 76,166,862 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	81,863,522 - 81,867,734 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	81,863,518 - 81,867,734 (+)	Ensembl	panpan1.1		panPan2

MRPL12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	81,703,367 - 81,707,517 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	81,703,367 - 81,707,517 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	79,670,397 - 79,674,547 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	77,280,812 - 77,284,953 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	77,280,811 - 77,284,953	NCBI
Celera	17	76,315,553 - 76,319,694 (+)	NCBI		Celera
Cytogenetic Map	17	q25.3	NCBI
HuRef	17	75,116,299 - 75,120,450 (+)	NCBI		HuRef
CHM1_1	17	79,756,619 - 79,760,775 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	82,620,267 - 82,624,415 (+)	NCBI		T2T-CHM13v2.0

Mrpl12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	120,375,463 - 120,379,580 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	120,375,439 - 120,379,891 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	120,484,637 - 120,488,754 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	120,484,613 - 120,489,065 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	120,345,983 - 120,350,068 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	120,300,759 - 120,304,844 (+)	NCBI		MGSCv36	mm8
Celera	11	132,220,001 - 132,224,086 (+)	NCBI		Celera
Cytogenetic Map	11	E2	NCBI
cM Map	11	84.18	NCBI

Mrpl12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	106,256,746 - 106,261,249 (+)	NCBI		GRCr8
mRatBN7.2	10	105,758,410 - 105,762,913 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	105,758,410 - 105,762,913 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	110,862,572 - 110,867,073 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	110,325,603 - 110,330,104 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	105,678,867 - 105,683,370 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	109,658,032 - 109,662,535 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	109,658,032 - 109,662,535 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	109,251,300 - 109,255,803 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	109,870,160 - 109,874,664 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	10	104,302,342 - 104,306,842 (+)	NCBI		Celera
Cytogenetic Map	10	q32.3	NCBI

Mrpl12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955506	1,398,445 - 1,404,409 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955506	1,400,439 - 1,404,409 (-)	NCBI	ChiLan1.0	ChiLan1.0

MRPL12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	493,536 - 498,154 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	1,095,712 - 1,100,406 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	1,087,000 - 1,091,703 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	1,085,859 - 1,091,645 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	1,111,962 - 1,116,653 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	1,238,549 - 1,243,249 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	1,317,578 - 1,322,281 (-)	NCBI		UU_Cfam_GSD_1.0

Mrpl12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	1,105,214 - 1,110,096 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936594	5,301,866 - 5,305,362 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936594	5,301,846 - 5,305,362 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MRPL12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	1,200,461 - 1,203,822 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	1,200,458 - 1,203,817 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

MRPL12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	73,633,786 - 73,639,142 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	73,633,918 - 73,638,902 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	45,042,518 - 45,047,078 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Mrpl12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624801	10,635,802 - 10,639,697 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624801	10,635,597 - 10,639,995 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008956500	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000061500 ⟹ ENSPPAP00000038596

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	17	81,863,518 - 81,867,734 (+)	Ensembl

RefSeq Acc Id:

XM_008956500 ⟹ XP_008954748

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	19	98,293,308 - 98,297,555 (+)	NCBI
NHGRI_mPanPan1	17	103,193,727 - 103,197,951 (+)	NCBI
Mhudiblu_PPA_v0	17	76,162,710 - 76,166,862 (+)	NCBI
PanPan1.1	17	81,863,522 - 81,867,734 (+)	NCBI

Sequence:

show sequence

CCGCCTTGTGGGTAATCTCAGGGTGAGACGAGGCTAGCGCGAGGTGCGGCTAGAGCGTCATTTC
CGGCTCGAATGCCCGGCGGCCGAGGCGGCTAGAGCGTTCCTCCCCAGCTCGAATGCCCGGCGGC
CGAGGCGGCTAGAGCGTCGCCTCCACCCGGGGAACCGCGTGTGACCTTCCAGCCCGCGGACCGA
TGCTGCCGGCGGCCGCTCGCCCCCTGTGGGGGCCTTGCCTTGGGCTTCGGGCCGCTGCGTTCCG
CCTTGCCAGGCGACAGGTGCCATGTGTCTGTGCCGTGCGACATATGAGGAGCAGCGGCCATCAG
AGGTGTGAGGCCCTCGCTGGTGCACCCCTGGATAACGCCCCCAAGGAGTACCCCCCCAAGATAC
AGCAGCTCGTCCAGGACATCGCCAGCCTCACTCTCTTGGAAATCTCAGACCTCAACGAGCTCCT
GAAGAAAACGTTGAAGATCCAGGATGTCGGGCTTGTGCCGATGGGTGGTGTGATGCCTGGGGCT
GTCCCTGCTGCAGCAGCCCAGGAGGCAGTGGAAGAAGATATCCCCATAGCGAAAGAACGGACAC
ATTTCACCGTCCGCCTGACCGAGGCGAAGCCCGTGGACAAAGTGAAGCTGATCAAGGAAATCAA
GAACTACATCCAAGGCATCAACCTCGTCCAGGCAAAGAAGCTGGTGGAGTCCCTGCCCCAGGAA
ATCAAAGCCAATGTCGCCAAAGCTGAGGCGGAGAAGATCAAGGCGGCCCTGGAGGCGGTGGGCG
GCACCGTGGTTCTGGAGTAGCCTCCAGCTCGGAGGACTTGTGTTCAGGGGTCCCTGGGCCCCGG
GCGAGGTCCCGCCCTCCCGTGGTCACTGGCTCCGCCCCCAGCACCAGGCGCCCAGTGGAGCCGT
TTGGGAGAATTGCCTGCGCCACGCAGCGGGGCCGGACAGGCCGCACAGACCTACTGTGGCGGGA
GGGAGGGGCGGCTGCTGCCTGGTGACGGCACCCGGAGGCCCAGCAGGACGCGCCACCGGTGAAT
GTGCCTCTGGTGGCTGCTGAGAAAAATACACTGTGCAGCTCAG

hide sequence

Protein Sequences


Protein RefSeqs	XP_008954748	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000038596
	ENSPPAP00000038596.1

RefSeq Acc Id:

XP_008954748 ⟸ XM_008956500

- UniProtKB:

A0A2R9C9I4 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQRCEALAGAPLDNAPKEYPPKI
QQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGGVMPGAVPAAAAQEAVEEDIPIAKERT
HFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVG
GTVVLE

hide sequence

RefSeq Acc Id:

ENSPPAP00000038596 ⟸ ENSPPAT00000061500

Protein Domains

Large ribosomal subunit protein bL12 Large ribosomal subunit protein bL12 C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042009	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000061500.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.710	UniProtKB/TrEMBL
	3.30.1390.10	UniProtKB/TrEMBL
InterPro	Ribosomal_L7/12	UniProtKB/TrEMBL
	Ribosomal_L7/12_C/ClpS-like	UniProtKB/TrEMBL
	Ribosomal_L7/L12_C	UniProtKB/TrEMBL
	Ribosomal_L7/L12_oligo	UniProtKB/TrEMBL
	Ribosomal_L7/L12_oligo_N_sf	UniProtKB/TrEMBL
KEGG Report	pps:103783751	UniProtKB/TrEMBL
NCBI Gene	MRPL12	ENTREZGENE
PANTHER	39S RIBOSOMAL PROTEIN L12, MITOCHONDRIAL	UniProtKB/TrEMBL
	PTHR45987	UniProtKB/TrEMBL
Pfam	Ribosomal_L12	UniProtKB/TrEMBL
	Ribosomal_L12_N	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48300	UniProtKB/TrEMBL
	SSF54736	UniProtKB/TrEMBL
UniProt	A0A2R9C9I4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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