GPX2 (glutathione peroxidase 2) - Rat Genome Database

Name: GPX2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: GPX2 (glutathione peroxidase 2) Pan paniscus

Analyze

Symbol:

GPX2

Name:

glutathione peroxidase 2

RGD ID:

12016786

Description:

ENCODES a protein that exhibits glutathione peroxidase activity (ortholog); phospholipid-hydroperoxide glutathione peroxidase activity (ortholog); INVOLVED IN biological process involved in interaction with symbiont (ortholog); negative regulation of inflammatory response to antigenic stimulus (ortholog); response to salicylic acid (ortholog); ASSOCIATED WITH autism spectrum disorder (ortholog); Breast Neoplasms (ortholog); Carbon Tetrachloride Poisoning (ortholog); FOUND IN cytosol (ortholog); intercellular bridge (ortholog); mitotic spindle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

glutathione peroxidase 2 (gastrointestinal)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPX2 (glutathione peroxidase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Gpx2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Gpx2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpx2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPX2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpx2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPX2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPX2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpx2 (glutathione peroxidase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	66,048,329 - 66,056,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	65,264,842 - 65,273,236 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	45,522,558 - 45,526,678 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	64,401,921 - 64,405,720 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

Breast Neoplasms (ISO)

Carbon Tetrachloride Poisoning (ISO)

colon cancer (ISO)

colorectal adenoma (ISO)

colorectal cancer (ISO)

colorectal carcinoma (ISO)

genetic disease (ISO)

Liver Neoplasms (ISO)

Neoplasm Metastasis (ISO)

ulcerative colitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological process involved in interaction with symbiont (ISO)

negative regulation of inflammatory response to antigenic stimulus (ISO)

response to salicylic acid (ISO)

response to selenium ion (ISO)

response to symbiotic bacterium (ISO)

temperature homeostasis (ISO)

Cellular Component

cytosol (ISO)

intercellular bridge (ISO)

mitotic spindle (ISO)

Molecular Function

glutathione peroxidase activity (ISO)

phospholipid-hydroperoxide glutathione peroxidase activity (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GPX2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	66,048,329 - 66,056,792 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	65,264,842 - 65,273,236 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	45,522,558 - 45,526,678 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	64,401,921 - 64,405,720 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

GPX2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	64,939,158 - 64,942,745 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	64,939,152 - 64,942,746 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	65,405,876 - 65,409,463 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	64,475,625 - 64,479,284 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	64,475,624 - 64,479,284	NCBI
Celera	14	45,460,457 - 45,464,116 (-)	NCBI		Celera
Cytogenetic Map	14	q23.3	NCBI
HuRef	14	45,575,494 - 45,579,247 (-)	NCBI		HuRef
CHM1_1	14	65,344,036 - 65,347,793 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	59,144,027 - 59,147,614 (-)	NCBI		T2T-CHM13v2.0

Gpx2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	76,839,109 - 76,842,328 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	76,839,107 - 76,842,273 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	76,792,335 - 76,795,554 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	76,792,333 - 76,795,554 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	77,893,322 - 77,896,541 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	77,711,177 - 77,714,346 (-)	NCBI		MGSCv36	mm8
Celera	12	77,874,684 - 77,877,908 (-)	NCBI		Celera
Cytogenetic Map	12	C3	NCBI
cM Map	12	33.73	NCBI

Gpx2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	101,226,745 - 101,230,033 (-)	NCBI		GRCr8
mRatBN7.2	6	95,493,589 - 95,496,877 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	95,493,589 - 95,496,877 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	95,882,234 - 95,885,509 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	96,180,771 - 96,184,046 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	95,609,574 - 95,612,849 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	99,839,960 - 99,843,245 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	99,839,960 - 99,843,245 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	109,236,420 - 109,239,718 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	99,372,418 - 99,376,230 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	99,375,879 - 99,379,686 (-)	NCBI
Celera	6	93,912,759 - 93,916,226 (-)	NCBI		Celera
Cytogenetic Map	6	q24	NCBI

Gpx2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955466	4,984,631 - 4,987,457 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955466	4,983,532 - 4,987,780 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPX2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	39,322,040 - 39,325,833 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	39,322,034 - 39,325,817 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	39,014,111 - 39,017,902 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	39,544,781 - 39,548,609 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	39,544,775 - 39,548,593 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	39,166,063 - 39,169,883 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	39,238,883 - 39,242,643 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	39,597,955 - 39,601,701 (-)	NCBI		UU_Cfam_GSD_1.0

Gpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	65,598,245 - 65,601,474 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936495	8,590,556 - 8,593,367 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936495	8,590,225 - 8,593,511 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPX2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	89,007,375 - 89,011,620 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	89,007,636 - 89,011,620 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	95,388,550 - 95,392,539 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPX2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	42,151,205 - 42,155,335 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666053	30,321,541 - 30,325,285 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpx2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	36,086,902 - 36,089,855 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	36,086,831 - 36,090,180 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003824048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003824048 ⟹ XP_003824096

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	66,048,329 - 66,056,792 (-)	NCBI
NHGRI_mPanPan1	14	65,264,842 - 65,273,236 (-)	NCBI
Mhudiblu_PPA_v0	14	45,522,558 - 45,526,678 (-)	NCBI
PanPan1.1	14	64,401,921 - 64,405,720 (-)	NCBI

Sequence:

show sequence

GCGGCCTTGTTCAGTCTGTTAATAGGAGGAGCAACCTCCTTGTTCAAACAGCACTTACAGGTGG
GGGCCTCTTTTTGCTAAGTCATCCTGGGGATGCTCAAAGCTCCATTGTTAGATCCTTTCTGTCC
TCCTTCCTGGCTCCTCCTTCCTCCCCACCCCTCTAATAGGCTCATAAGTGGGCTCAGGCCTCTC
TGCGGGGCTCACTCTGCGCTTCACCATGGCTTTCATTGCCAAGTCCTTCTACGACCTCAGTGCC
ATCAGCCTGGATGGGGAGAAGGTAGATTTCAATACGTTCCGGGGCAGGGCCGTGCTGATTGAGA
ATGTGGCTTCGCTCTGAGGCACAACCACCCGGGACTTCACCCAGCTCAACGAGCTGCAATGCCG
CTTTCCCAGGCGCCTGGTGGTCCTTGGCTTCCCTTGCAACCAATTTGGACATCAGGAGAACTGT
CAGAATGAGGAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCT
TCACCCTTGTCCAAAAATGTGACGTGAATGGGCAGAACGAGCATCCTGTCTTCGCCTACCTGAA
GGACAAGCTCCCCTACCCTTATGATGACCCATTTTCCCTCATGACCGATCCCAAGCTCATCATT
TGGAGCCCTGTGCGCCGCTCAGATGTGGCCTGGAACTTTGAGAAGTTCCTCATAGGGCCGGAGG
GAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCTGACATCAAGCG
CCTCCTTAAAGTTGCCATATAGATGTGAACTGCTCAGCACACAGATCTCCTACTCCATCCAGTC
CTGAGGAGCCTTAGGATGCAGCATGCCCTCAGGAGACACTGCTGGACCTCAGCATTCCCTTGAT
ATCAGTCCCTTTCACTGCAGAGCCTTGCCTTTCCCCTCTGCCTGTTTCCTTTTCCTCTCCCAAC
CCTCTGGTTGGTGATTTAACTTGGGCTCCAAGACTTGGGTAAGCTCTGGGCCTTCACAGAATGA
TGGCACCTTCCTAAACCCTCATGGGTGGTGTCTGAGAGGCGTGAAGGGCCTGGAGCCACTCTGC
TAGAAGAGACCAATAAAGGGCAGGTGTGGAAACGGCCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003824096	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_003824096 ⟸ XM_003824048
- Sequence:	show sequence MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVL GFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCDVNGQNEHPVFAYLKDKLPYPYD DPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	GPX2	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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