RGD Reference Report - Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats.

Authors: Goodla, Lavanya  Manubolu, Manjunath  Pathakoti, Kavitha  Jayakumar, Thanasekaran  Sheu, Jeon-Rong  Fraker, Mike  Tchounwou, Paul B  Poondamalli, Parthasarathy R 
Citation: Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
RGD ID: 401827907
Pubmed: PMID:31018559   (View Abstract at PubMed)
PMCID: PMC6517918   (View Article at PubMed Central)
DOI: DOI:10.3390/ijerph16081440   (Journal Full-text)

Ammannia baccifera Linn. is commonly used as a traditional medicine in India and China. The antioxidant potential of an ethanolic extract of A. baccifera (EEAB; 250 mg/kg and 500 mg/kg) was evaluated against CCL4-induced toxicity in rats. Antioxidant activity was assessed by measuring the enzymatic and non-enzymatic antioxidants. Phytochemical constituents of EEAB were also analyzed by using UHPLC-QTOF-MS. EEAB treatment markedly reduced CCl4 effects on lipid peroxidation, cholesterol, triacylglycerides, and protein carbonyls. It increased the levels of phospholipids, total sulfhydryl, and antioxidant enzymes, which were reduced by CCl4 intoxication. Treatment with EEAB significantly alleviated the CCl4 effect on non-enzymatic antioxidants. Isoenzyme pattern analyses revealed that significant alterations in superoxide dismutase (SOD1), glutathione peroxidase (GPx2, GPx3), and catalase (CAT) occurred in rats that were exposed to CCl4 and restored post EEAB treatment. Moreover, CCl4-induced down regulation of SOD, CAT, and GPx gene expression was conversely counteracted by EEAB. Its bioactivity may be due to its incorporation of major compounds, such as chlorogenic acid, quercetin, protocatechuic acid, lamioside, crocetin, and khayasin C. These results suggest that EEAB may be used as a potent antioxidant and hepatoprotective agent since it is a rich source of flavonoids and phenolic compounds.



RGD Manual Disease Annotations    Click to see Annotation Detail View
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
GPX2HumanCarbon Tetrachloride Poisoning treatmentISOGpx2 (Rattus norvegicus) RGD 
GPX3HumanCarbon Tetrachloride Poisoning treatmentISOGpx3 (Rattus norvegicus) RGD 
Gpx2RatCarbon Tetrachloride Poisoning treatmentIEP  RGD 
Gpx2MouseCarbon Tetrachloride Poisoning treatmentISOGpx2 (Rattus norvegicus) RGD 
Gpx3RatCarbon Tetrachloride Poisoning treatmentIEP  RGD 
Gpx3MouseCarbon Tetrachloride Poisoning treatmentISOGpx3 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gpx2  (glutathione peroxidase 2)
Gpx3  (glutathione peroxidase 3)

Genes (Mus musculus)
Gpx2  (glutathione peroxidase 2)
Gpx3  (glutathione peroxidase 3)

Genes (Homo sapiens)
GPX2  (glutathione peroxidase 2)
GPX3  (glutathione peroxidase 3)


Additional Information