SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha) - Rat Genome Database

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Gene: SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha) Pan paniscus
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Symbol: SUCLG1
Name: succinate-CoA ligase GDP/ADP-forming subunit alpha
RGD ID: 11940654
Description: ENCODES a protein that exhibits GDP binding (ortholog); protein-containing complex binding (ortholog); succinate-CoA ligase (ADP-forming) activity (ortholog); INVOLVED IN succinate metabolic process (ortholog); succinyl-CoA metabolic process (ortholog); tricarboxylic acid cycle (ortholog); PARTICIPATES IN citric acid cycle pathway; fumaric aciduria pathway; mitochondrial complex II deficiency pathway; ASSOCIATED WITH Disease Progression (ortholog); genetic disease (ortholog); mitochondrial DNA depletion syndrome (ortholog); FOUND IN protein-containing complex (ortholog); succinate-CoA ligase complex (GDP-forming) (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinate-CoA ligase alpha subunit; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21241,918,257 - 41,954,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A41,921,021 - 41,957,203 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A84,476,814 - 84,512,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,035,506 - 86,071,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,035,723 - 86,066,622 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SUCLG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21241,918,257 - 41,954,439 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A41,921,021 - 41,957,203 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A84,476,814 - 84,512,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A86,035,506 - 86,071,537 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A86,035,723 - 86,066,622 (-)Ensemblpanpan1.1panPan2
SUCLG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38284,423,528 - 84,459,280 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl284,423,528 - 84,460,045 (-)EnsemblGRCh38hg38GRCh38
GRCh37284,650,652 - 84,686,404 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36284,504,163 - 84,540,097 (-)NCBINCBI36Build 36hg18NCBI36
Build 34284,562,333 - 84,598,043NCBI
Celera284,479,456 - 84,515,401 (-)NCBICelera
Cytogenetic Map2p11.2NCBI
HuRef284,546,643 - 84,582,492 (-)NCBIHuRef
CHM1_1284,580,608 - 84,616,546 (-)NCBICHM1_1
T2T-CHM13v2.0284,425,228 - 84,460,977 (-)NCBIT2T-CHM13v2.0
Suclg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39673,225,488 - 73,253,890 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl673,225,365 - 73,253,894 (+)EnsemblGRCm39 Ensembl
GRCm38673,248,505 - 73,276,907 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl673,248,382 - 73,276,911 (+)EnsemblGRCm38mm10GRCm38
MGSCv37673,198,499 - 73,226,901 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36673,178,182 - 73,206,391 (+)NCBIMGSCv36mm8
Celera675,301,953 - 75,330,652 (+)NCBICelera
Cytogenetic Map6C1NCBI
cM Map632.4NCBI
Suclg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84106,866,329 - 106,895,686 (+)NCBIGRCr8
mRatBN7.24105,308,236 - 105,337,595 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4105,308,039 - 105,337,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4110,679,963 - 110,709,281 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04106,455,073 - 106,484,379 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04105,075,992 - 105,105,347 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04101,181,315 - 101,210,692 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4101,180,404 - 101,210,746 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04165,937,922 - 165,967,277 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44106,572,140 - 106,601,495 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1836,133,697 - 36,137,263 (-)NCBI
Celera494,449,454 - 94,478,818 (+)NCBICelera
Cytogenetic Map4q32NCBI
Suclg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554242,810,557 - 2,842,036 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554242,810,557 - 2,838,827 (+)NCBIChiLan1.0ChiLan1.0
SUCLG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11740,392,969 - 40,424,875 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1740,393,178 - 40,424,711 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1740,072,920 - 40,104,818 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01741,200,797 - 41,232,708 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1741,200,984 - 41,232,708 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11740,277,386 - 40,309,286 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01740,340,635 - 40,372,518 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01740,741,593 - 40,773,497 (+)NCBIUU_Cfam_GSD_1.0
Suclg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024406292869,277 - 904,045 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366503,275,019 - 3,313,599 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366503,278,769 - 3,313,537 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SUCLG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl360,142,435 - 60,177,378 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1360,142,340 - 60,177,497 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2363,138,718 - 63,174,813 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SUCLG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11422,712,622 - 22,748,648 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1422,712,661 - 22,748,845 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604589,647,622 - 89,683,679 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Suclg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474918,551,188 - 18,583,183 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474918,552,154 - 18,580,676 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000037462   ⟹   ENSPPAP00000014774
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A86,035,723 - 86,066,622 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000037466   ⟹   ENSPPAP00000014778
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A86,035,723 - 86,063,933 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000037468   ⟹   ENSPPAP00000014780
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A86,035,723 - 86,062,294 (-)Ensembl
RefSeq Acc Id: XM_003816596   ⟹   XP_003816644
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21241,918,257 - 41,954,439 (+)NCBI
NHGRI_mPanPan12A41,921,021 - 41,957,203 (+)NCBI
Mhudiblu_PPA_v02A84,476,814 - 84,512,920 (-)NCBI
PanPan1.12A86,035,506 - 86,071,537 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063594584   ⟹   XP_063450654
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21241,918,338 - 41,954,439 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003816644 (Get FASTA)   NCBI Sequence Viewer  
  XP_063450654 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000014774.1
  ENSPPAP00000014778.1
  ENSPPAP00000014780
  ENSPPAP00000014780.1
RefSeq Acc Id: XP_003816644   ⟸   XM_003816596
- Peptide Label: isoform X2
- UniProtKB: A0A2R9ABX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000014780   ⟸   ENSPPAT00000037468
Ensembl Acc Id: ENSPPAP00000014778   ⟸   ENSPPAT00000037466
Ensembl Acc Id: ENSPPAP00000014774   ⟸   ENSPPAT00000037462
RefSeq Acc Id: XP_063450654   ⟸   XM_063594584
- Peptide Label: isoform X1
Protein Domains
CoA-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030548 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037462.1 UniProtKB/TrEMBL
  ENSPPAT00000037466.1 UniProtKB/TrEMBL
  ENSPPAT00000037468.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.261 UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/TrEMBL
InterPro Cit_synth/succinyl-CoA_lig_AS UniProtKB/TrEMBL
  Citrt_syn/SCS-alpha_CS UniProtKB/TrEMBL
  CoA-bd UniProtKB/TrEMBL
  CoA_lig_alpha UniProtKB/TrEMBL
  CoA_ligase UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
  Succinyl-CoA_synth-like UniProtKB/TrEMBL
NCBI Gene SUCLG1 ENTREZGENE
PANTHER SUCCINATE--COA LIGASE [ADP/GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL UniProtKB/TrEMBL
  SUCCINYL-COA LIGASE SUBUNIT ALPHA UniProtKB/TrEMBL
Pfam CoA_binding UniProtKB/TrEMBL
  Ligase_CoA UniProtKB/TrEMBL
PIRSF SucCS_alpha UniProtKB/TrEMBL
PRINTS SCOASYNTHASE UniProtKB/TrEMBL
PROSITE SUCCINYL_COA_LIG_1 UniProtKB/TrEMBL
  SUCCINYL_COA_LIG_2 UniProtKB/TrEMBL
SMART CoA_binding UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
  SSF52210 UniProtKB/TrEMBL
UniProt A0A2R9ABX6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ABZ7_PANPA UniProtKB/TrEMBL
  A0A2R9AGW1_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 SUCLG1  succinate-CoA ligase GDP/ADP-forming subunit alpha  SUCLG1  succinate-CoA ligase alpha subunit  Symbol and/or name change 5135510 APPROVED