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Gene: CASP2 (caspase 2) Pan paniscus

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Symbol:

CASP2

Name:

caspase 2

RGD ID:

11917748

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activity (inferred); cysteine-type peptidase activity (inferred); death domain binding (inferred); INVOLVED IN apoptotic signaling pathway (ortholog); ectopic germ cell programmed cell death (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Autosomal Recessive Intellectual Developmental Disorder 80 (ortholog); Breast Cancer, Familial (ortholog); FOUND IN caspase complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

caspase-2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP2 (caspase 2)	NCBI	Ortholog
Mus musculus (house mouse):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	180,141,294 - 180,166,578 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	32,151,551 - 32,176,835 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	135,283,072 - 135,307,855 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	147,773,749 - 147,792,958 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	147,773,749 - 147,792,958 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Autosomal Recessive Intellectual Developmental Disorder 80 (ISO)

Breast Cancer, Familial (ISO)

cervical cancer (ISO)

cholangiocarcinoma (ISO)

colorectal cancer (ISO)

head and neck squamous cell carcinoma (ISO)

intellectual disability (ISO)

lung cancer (ISO)

nonpapillary renal cell carcinoma (ISO)

ovarian serous cystadenocarcinoma (ISO)

pancreatic adenocarcinoma (ISO)

renal cell carcinoma (ISO)

sarcoma (ISO)

status epilepticus (ISO)

stroke (ISO)

temporal lobe epilepsy (ISO)

Thyroid Carcinoma, Nonmedullary 1 (ISO)

uterine corpus endometrial carcinoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

apoptotic signaling pathway (ISO)

cellular response to mechanical stimulus (IEA)

DNA damage response, signal transduction by p53 class mediator (IEA)

ectopic germ cell programmed cell death (ISO)

extrinsic apoptotic signaling pathway in absence of ligand (ISO)

luteolysis (ISO)

negative regulation of necroptotic process (ISO)

neural retina development (ISO)

positive regulation of apoptotic process (IEA)

positive regulation of apoptotic signaling pathway (ISO)

positive regulation of neuron apoptotic process (ISO)

protein maturation (IEA)

protein processing (IEA)

proteolysis (IEA)

regulation of apoptotic process (IEA)

release of cytochrome c from mitochondria (ISO)

Cellular Component

caspase complex (ISO)

cytoplasm (IEA)

endopeptidase complex (IEA)

mitochondrion (IEA)

nucleus (IEA)

Molecular Function

cysteine-type endopeptidase activity (IEA)

cysteine-type peptidase activity (IEA)

death domain binding (IEA)

identical protein binding (IEA)

protease binding (IEA)

protein domain specific binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	180,141,294 - 180,166,578 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	32,151,551 - 32,176,835 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	135,283,072 - 135,307,855 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	147,773,749 - 147,792,958 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	147,773,749 - 147,792,958 (+)	Ensembl		PanPan1.1 Ensembl	panPan2	panpan1.1

CASP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	143,288,351 - 143,307,696 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	143,288,215 - 143,307,696 (+)	Ensembl		GRCh38.p14 Ensembl	hg38	GRCh38
GRCh37	7	142,985,444 - 143,004,789 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	142,695,524 - 142,714,907 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	7	137,822,267 - 137,841,650 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	137,322,670 - 137,342,153 (+)	NCBI		HuRef
CHM1_1	7	142,922,195 - 142,941,676 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	144,643,759 - 144,663,112 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	142,387,424 - 142,406,906 (+)	NCBI

Casp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	42,241,942 - 42,259,442 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	42,241,918 - 42,259,443 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	6	42,264,902 - 42,282,508 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	42,264,985 - 42,282,508 (+)	Ensembl		GRCm38.p6 Ensembl	mm10	GRCm38
MGSCv37	6	42,215,038 - 42,232,495 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	6	42,194,646 - 42,212,103 (+)	NCBI		MGSCv36	mm8
Celera	6	42,209,337 - 42,226,794 (+)	NCBI		Celera
Cytogenetic Map	6	B2.1	NCBI
cM Map	6	20.54	NCBI

Casp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	72,116,265 - 72,134,023 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	4	72,116,246 - 72,134,022 (+)	Ensembl				GRCr8
mRatBN7.2	4	71,149,632 - 71,167,388 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	71,149,669 - 71,167,379 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	4	76,069,535 - 76,087,171 (+)	NCBI	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	71,982,792 - 72,000,428 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	70,402,261 - 70,419,895 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd	4	73,843,793 - 73,861,427 (+)	NCBI
Lyon_Normotensive	4	71,233,496 - 71,251,130 (+)	NCBI
Lyon_Hypertensive	4	71,847,044 - 71,864,678 (+)	NCBI
F344_StmMcwi	4	71,545,036 - 71,562,670 (+)	NCBI
Rnor_6.0	4	71,652,358 - 71,670,228 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	71,652,354 - 71,670,239 (+)	Ensembl		Rnor_6.0 Ensembl	rn6	Rnor6.0
Rnor_5.0	4	136,454,723 - 136,474,625 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	4	70,029,728 - 70,047,164 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	4	66,080,364 - 66,098,003 (+)	NCBI		Celera
RGSC_v3.1	4	70,305,857 - 70,323,294 (+)	NCBI
Cytogenetic Map	4	q24	NCBI

Casp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	353,310 - 368,873 (-)	Ensembl		ChiLan1.0 Ensembl
ChiLan1.0	NW_004955494	353,572 - 369,207 (-)	NCBI	ChiLan1.0	ChiLan1.0

CASP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	6,378,447 - 6,396,251 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	6,379,913 - 6,396,646 (-)	Ensembl		CanFam3.1 Ensembl	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	7,368,808 - 7,385,123 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	6,232,171 - 6,251,272 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	6,232,210 - 6,250,056 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	6,181,045 - 6,197,357 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,032,942 - 6,049,262 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	6,108,280 - 6,124,667 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mIctTri1.hap1	2	220,128,692 - 220,143,636 (+)	NCBI		mIctTri1.hap1
HiC_Itri_2	NW_024405118	12,149,166 - 12,164,126 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	739,281 - 754,331 (+)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	739,325 - 754,259 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,941,937 - 6,966,061 (-)	Ensembl		Sscrofa11.1 Ensembl	susScr11	Sscrofa11.1
Sscrofa11.1	18	6,946,432 - 6,966,088 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	7,183,208 - 7,206,964 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mChlSab1.0.hap1	21	116,559,258 - 116,577,982 (+)	NCBI		mChlSab1.0.hap1
Vero_WHO_p1.0	NW_023666072	8,895,441 - 8,914,545 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0
ChlSab1.1	21	112,172,614 - 112,189,574 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	112,172,733 - 112,188,744 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM

Casp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624800	11,451,784 - 11,468,791 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2
HetGla_female_1.0 Ensembl	NW_004624800	11,451,038 - 11,468,205 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl

Casp2
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	6	97,937,054 - 97,954,856 (-)	NCBI	Rrattus_CSIRO_v1	Rrattus_CSIRO_v1

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034965144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_004672681	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010112812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000033487 ⟹ ENSPPAP00000010833

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	147,773,749 - 147,792,958 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000033495 ⟹ ENSPPAP00000010841

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	147,773,990 - 147,779,590 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000033498 ⟹ ENSPPAP00000010844

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	147,773,990 - 147,779,541 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000033503 ⟹ ENSPPAP00000010849

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	147,773,990 - 147,778,690 (+)	Ensembl

RefSeq Acc Id:

XM_003820542 ⟹ XP_003820590

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	180,141,294 - 180,160,566 (+)	NCBI
NHGRI_mPanPan1	7	32,151,551 - 32,170,823 (+)	NCBI
Mhudiblu_PPA_v0	7	135,283,083 - 135,302,429 (+)	NCBI
PanPan1.1	7	147,773,749 - 147,792,958 (+)	NCBI

Sequence:

show sequence

CTTTTGTCTGTCCGCCGAGCACCCCACTTCACCCCATTGGACCGCGCGGCCACCGCTAGAGCTC
TGCGCCTGCGCACGCACCGGGCCGGGGACTGGGTGGCCTGGTGTGTGGGCGCGGCAGGGCGCAG
GCGCAGGCGCAGTGTGCGTCCGCGTCTGAGGGGAGGGATGTGGGGGAAGCGACGGCCCACGGTT
TGTTTGGGCTGTGGGCGGTGCGCAGCGCAGAGCCCGGGAAAAGCGGGAAATGGCGGCGCCGAGC
GCGGGGTCTTGGTCCACCTTCCAGCACAAGGAGCTGATGGCCGCTGACAGGGGACGCAGGATAT
TGGGAGTGTGTGGCATGCATCCTCATCATCAGGAAACTCTAAAAAAGAACCGAGTGGTGCTAGC
CAAACAGCTGTTGTTGAGTGAATTGTTAGAACATCTTCTGGAGAAGGACATCATCACCTTGGAA
ATGAGGGAGCTCATCCAGGCCAAAGTGGGCAGTTTCAGCCAGAATGTGGAACTCCTCAACTTGC
TGCCTAAGAGGGGTCCCCAAGCTTTTGATGCCTTCTGTGAAGCACTGAGGGAGACCAAGCAAGG
CCACCTGGAGGATATGTTGCTCACCACCCTTTCTGGGCTTCAGCATGTACTCCCACCGTTGAGC
TGTGACTACGACTTGAGTCTCCCTTTTCCAGTGTGTGAGTCCTGTCCCCTTTACAAGAAGCTCC
GCCTGTCGACAGATACTGTGGAACACTCCCTAGACAATAAAGATGGTCCTGTCTGCCTTCAGGT
GAAGCCTTGCACTCCTGAATTTTATCAAACACACTTCCAGCTGGCATATAGGTTGCAGTCTCGG
CCTCGTGGCCTAGCACTGGTGTTGAGCAATGTGCACTTCACTGGAGAGAAAGAACTGGAATTTC
GCTCTGGAGGGGATGTGGACCACAGTACTCTAGTCACCCTCTTCAAGCTTTTGGGCTATGACGT
CCATGTTCTATGTGACCAGACTGCACAGGAAATGCAAGAGAAACTGCAGAATTTTGCACAGTTA
CCTGCACACCGAGTCACGGACTCCTGCATCGTGGCACTCCTCTCGCATGGTGTGGAGGGCGCCA
TCTATGGTGTGGATGGGAAACTGCTCCAGCTACAAGAGGTTTTTCAGCTCTTTGACAACGCCAA
CTGCCCAAGCCTACAGAACAAACCAAAAATGTTCTTCATCCAGGCCTGCCGTGGAGATGAGACT
GATCGTGGGGTTGACCAACAAGATGGAAAGAACCACGCAGGATCCCCTGGGTGCGAGGAGAGTG
ATGCCGGTAAAGAAAAGTTGCCGAAGATGAGACTGCCCACGCGCTCAGACATGATATGCGGCTA
TGCCTGCCTCAAAGGGACTGCCGCCATGCGGAACACCAAACGAGGTTCCTGGTACATCGAGGCT
CTTGCTCAAGTGTTTTCTGAGCGGGCTTGTGATATGCACGTGGCCGACATGCTGGTTAAGGTGA
ACGCACTTATCAAGGATCGGGAAGGTTATGCTCCTGGCACAGAGTTCCACCGGTGCAAGGAGAT
GTCTGAATACTGCAGCACTCTGTGCCGCCACCTCTACCTGTTCCCAGGACACCCTCCCACATGA
TGTCACCTCCCCATCATCCACGCCAAGTGGAAGCCACTGGACCACAGGAGGTGTGATATAGAGC
CTTTGATCTTCAGGATGCACGGTTTCTGTTCTGCCCCCTCAGGGATGTGGGAATCTCCCAGACT
TGTTTCCTGTGCCCATGATCTCTGCCTTTGAGTGTGGGACTCCAGGCCAGCTCCTTTTCTGTGA
AGCCCTTTGCCTGTAGAGCCAGCTTTGGTTGGACCTATTGCCAGGAATGTTTCAGCTACAGTTG
AAGAGCCTCACAAGTGAAGTTGTAAACACAGTGTGGTTATGGGGAGAGGGCATGTAAGTTCCCC
ATATTTGTGTTCAGTTCCAGCTTTTGTAGATGGCACTTTAGTGATTGCTTTTATTACATTAGTT
AAGATGTCTGAGAGACCATCTCCTGTCTTTTATTTCATTCATATCCTCTGCCCTTCTTGTCCTA
GAGTGAGAGTTTGGAAGGTGTCCAAATTTAACATAGACATTATCTTTTGGCTCTGAAGAGGCAA
ACATGACTAGAGACGCACCTTGCTGCAGTGTCCAGAAGCGGCCTGTGCGTTCCCTTCAGTACTG
CAGGGCACCCAGTGGAAGGACACTCTTGGCTCGTTTGGGCTCAAGGCACCGCAGCCTGTCAGCC
AACGTTGCCTTGCATTTGTACCTTATTGATCTTTGCCCATGGAAGTCTCAAAGATCTTTCGTTG
GTTGTTTCTCTGAGCTTTGTTACTGAAATGAGCCTCGTGGGGAGCATCAGAGAAGGCCAGGAAG
AATGGTGTGTTTCCCTAGACTCTGTAACCACCTCTCTGTCTTTTTCCTTCCTGAGAAACGTCCA
TCTCTCTCCCTTACTATTCCCACTTTCATTCAATCAACCTGCACTTCATATCTAGATTTCTAGA
AAAGCTTCCTAGCTTATCTCCCTGCTTCATATCTCTCTCCTCTTTACCTTCATTTCATCCTGTT
GGCTGCTGCCACCAAATCTGTCTAGAATCCTGCTTTACTGGATCATGTAAATGCTCAAAGCTGT
AATGTAGTTCTTTGTTCCTGCTTTCTCCTTCAGTATTAAACTCTCCTTTGATATTATGTGGCTT
TTATTTCAGTGCCATACGTGTTATTTTTTTCAACCTAGAAACCTTTATCCCTGCTTATCTGAAA
CTTCCCAACTTCCCTGTTCTTTAAGACGTTTTTTTTTTTTTTTTTTTTTTTTGTAGACGGAGTC
TCGCCCTGTTGCCCAGGCTGGAGTGCAGTGGCGCTATCGCGGCTCACTGCAACCTCTGCCTCCC
AGGTTCATGCCATTCTCCTGCCTCAGCCTTCCAAGTAGCTGGGACTACAGGCGCCCGCCACTGT
GCCCAGCTAATTTTTTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTAGCCGGGATGGTCTT
GATCTCCTGACCTCATGATCCACCCACCTCAGCCTCCCAAAGTGTTGGGATTACAGGCGTGAGC
CACTGCGCCCGGGCAAGACCTTTTTTTAAAGAAAAAAAAGCAAACTTCCATTCTTTCTTCCTCC
AGTCTGTTCTCCACATAACAGAGTAGTTTTGGTTTTTAATTTTTTTTTTGGTTGTTAGGTGTTT
TTTGTTTTTTAAGGTGAGTTCTCACTATGTTTCTCAGACTGGTCTCGAACTCCTGGCCTCAAGC
CATCTTCCCGCCTCAGCCTCTCAAATAGCTGGGCCTGCAGGCATGAGCCACCACACCTGGCCAG
GTTTTGGTTGTTTAAATATAAATCTGATCACCCGCCTGCTTAGAACCCTTCTGCTTTCTATTAC
CCCTCATTTAAAATGTAAACTCTTCACCTTGGTTTATGAGAACTGGTTCTTGCCTTCCCCTTGA
ACCTTATTAAATGGTGATTTCTTGCTAAGCTCCAGCCCGAGTGGTCTCCTCTCAGCTTCTAATT
TTGTGCTCTTTCCTGCCCTTTTCCTGGGCCTTCTCAGCTCTCCACCCCCACCACTCTTGACTCA
GGTGGTGTCCTTATTCCTCAAGTCTTGACAATTCCCGGGCCCTTCAGTCCCTGAGCAGTCTACT
TCTGTGTCTGTCACCACATCTTGTCTTTTCCCCTCATTGCATTTATTGCAGTTTATATGTATGC
TACTTTTACTTGTTCATTTCTGTCTCCCCTACCAGGCTGTAAATGAGGGCAGAAACCTTGTTTG
TTTTATTCACCATCATGTACCAAGTGCTTGGCACATAGTGGGCCTTCAGTAAATGTTTGTTGAA
TAAAAGAGGGAAGAAGGCAAGCCAACCTTAGCTACAATCCTACCTTTTGATAAAATGTTCCTTT
TGACAATATACACGGATTATTATTTGTACTTTGTTTTTCCATGTGTTTTGCTTTTATCCACTGG
CATTTTTAGCTCCTTGAAGACATATCATGTGTGAGATAACTTCCTTCACATCTCCCATGGTCCC
TAGCAAAATGCTAGGCCTGTAGTAGTCAAGGTGCTCAATAAATATTTGTTCTATGAGCTGGGTG
GTTTGAAGCCTTGCTGCCAAGTCCTGCCTTTGGGTCGACATAGTATGGAAGTATTTGAGAGAGA
GAACCTTTCCACTCCCACTGCCAGGATTTTGTATTGCCATCGGGTGCCAAATAAATGCTCATAT
TTATTACTGA

hide sequence

RefSeq Acc Id:

XM_034965144 ⟹ XP_034821035

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	180,141,294 - 180,156,793 (+)	NCBI
NHGRI_mPanPan1	7	32,151,551 - 32,163,566 (+)	NCBI
Mhudiblu_PPA_v0	7	135,283,072 - 135,298,647 (+)	NCBI

RefSeq Acc Id:

XR_004672681

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	180,141,294 - 180,166,578 (+)	NCBI
NHGRI_mPanPan1	7	32,151,551 - 32,176,835 (+)	NCBI
Mhudiblu_PPA_v0	7	135,283,082 - 135,307,855 (+)	NCBI

RefSeq Acc Id:

XR_010112812

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	180,141,294 - 180,147,199 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003820590	(Get FASTA)	NCBI Sequence Viewer
	XP_034821035	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000010833.1
	ENSPPAP00000010841.1
	ENSPPAP00000010844.1
	ENSPPAP00000010849.1
	ENSPPAP00050045858

RefSeq Acc Id:	XP_003820590 ⟸ XM_003820542
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9A1X3 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKD IITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHV LPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAY RLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQ NFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQAC RGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGS WYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPG HPPT hide sequence

RefSeq Acc Id:	XP_034821035 ⟸ XM_034965144
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSPPAP00000010841 ⟸ ENSPPAT00000033495

Ensembl Acc Id:

ENSPPAP00000010844 ⟸ ENSPPAT00000033498

Ensembl Acc Id:

ENSPPAP00000010833 ⟸ ENSPPAT00000033487

Ensembl Acc Id:

ENSPPAP00000010849 ⟸ ENSPPAT00000033503

Protein Domains

CARD Caspase family p10 Caspase family p20

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000028627	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050032150	ENTREZGENE
Ensembl Transcript	ENSPPAT00000033487.1	UniProtKB/TrEMBL
	ENSPPAT00000033495.1	UniProtKB/TrEMBL
	ENSPPAT00000033498.1	UniProtKB/TrEMBL
	ENSPPAT00000033503.1	UniProtKB/TrEMBL
	ENSPPAT00050069127	ENTREZGENE
	ENSPPAT00050069168	ENTREZGENE
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.1460	UniProtKB/TrEMBL
	Caspase-like	UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/TrEMBL
	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_2	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	CRADD	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	Pept_C14	UniProtKB/TrEMBL
	Pept_C14_caspase	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
KEGG Report	pps:100984572	UniProtKB/TrEMBL
NCBI Gene	CASP2	ENTREZGENE
PANTHER	CASPASE 2	UniProtKB/TrEMBL
	CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18	UniProtKB/TrEMBL
	DEATH DOMAIN-CONTAINING PROTEIN CRADD	UniProtKB/TrEMBL
	DEATH DOMAIN-CONTAINING PROTEIN CRADD	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/TrEMBL
	Peptidase_C14	UniProtKB/TrEMBL
PIRSF	Caspase_ICE	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CARD	UniProtKB/TrEMBL
	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
SMART	CARD	UniProtKB/TrEMBL
	CASc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/TrEMBL
	SSF52129	UniProtKB/TrEMBL
UniProt	A0A2R9A0R1_PANPA	UniProtKB/TrEMBL
	A0A2R9A1X3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9A523_PANPA	UniProtKB/TrEMBL
	A0A2R9A528_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

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