CASP2 (caspase 2) - Rat Genome Database

Name: CASP2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: CASP2 (caspase 2) Canis lupus familiaris

Analyze

Symbol:

CASP2

Name:

caspase 2

RGD ID:

12089106

Description:

ENCODES a protein that exhibits cysteine-type endopeptidase activity (inferred); cysteine-type endopeptidase activity involved in apoptotic process (inferred); cysteine-type peptidase activity (inferred); INVOLVED IN apoptotic signaling pathway (ortholog); ectopic germ cell programmed cell death (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); ASSOCIATED WITH Alzheimer's disease (ortholog); Autosomal Recessive Intellectual Developmental Disorder 80 (ortholog); genetic disease (ortholog); FOUND IN endopeptidase complex (ortholog)

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

caspase 2, apoptosis-related cysteine peptidase; caspase 2, apoptosis-related cysteine peptidase (neural precursor cell expressed, developmentally down-regulated 2); caspase-2

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CASP2 (caspase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Treefam
Mus musculus (house mouse):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CASP2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Casp2 (caspase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	6,378,447 - 6,396,251 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	6,379,913 - 6,396,646 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	7,368,808 - 7,385,123 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	6,232,171 - 6,251,272 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	6,232,210 - 6,250,056 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	6,181,045 - 6,197,357 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,032,942 - 6,049,262 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	6,108,280 - 6,124,667 (-)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

Autosomal Recessive Intellectual Developmental Disorder 80 (ISO)

genetic disease (ISO)

intellectual disability (ISO)

renal cell carcinoma (ISO)

status epilepticus (ISO)

Stroke (ISO)

temporal lobe epilepsy (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic signaling pathway (IEA,ISO)

cellular response to mechanical stimulus (IEA)

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (IEA)

ectopic germ cell programmed cell death (IEA,ISO)

extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

luteolysis (ISO)

neural retina development (ISO)

positive regulation of apoptotic process (IEA)

positive regulation of apoptotic signaling pathway (IEA,ISO)

positive regulation of neuron apoptotic process (ISO)

protein processing (IEA)

proteolysis (IEA)

regulation of apoptotic process (IEA)

Cellular Component

cytoplasm (IEA)

endopeptidase complex (IEA,ISO)

nucleus (IEA)

Molecular Function

cysteine-type endopeptidase activity (IEA)

cysteine-type endopeptidase activity involved in apoptotic process (IEA)

cysteine-type peptidase activity (IEA)

death domain binding (IEA)

identical protein binding (IEA)

protease binding (IEA)

protein binding (ISO)

protein domain specific binding (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

CASP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	16	6,378,447 - 6,396,251 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	16	6,379,913 - 6,396,646 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	16	7,368,808 - 7,385,123 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	16	6,232,171 - 6,251,272 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	16	6,232,210 - 6,250,056 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	16	6,181,045 - 6,197,357 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	16	6,032,942 - 6,049,262 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	16	6,108,280 - 6,124,667 (-)	NCBI		UU_Cfam_GSD_1.0

CASP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	143,288,351 - 143,307,696 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	143,288,215 - 143,307,696 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	142,985,444 - 143,004,789 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	142,695,524 - 142,714,907 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	137,822,267 - 137,841,650 (+)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI
HuRef	7	137,322,670 - 137,342,153 (+)	NCBI		HuRef
CHM1_1	7	142,922,195 - 142,941,676 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	144,643,759 - 144,663,112 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	142,387,424 - 142,406,906 (+)	NCBI

Casp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	6	42,241,942 - 42,259,442 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	6	42,241,919 - 42,259,442 (+)	Ensembl		GRCm39 Ensembl
GRCm38	6	42,264,902 - 42,282,508 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	6	42,264,985 - 42,282,508 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	6	42,215,038 - 42,232,495 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	6	42,194,646 - 42,212,103 (+)	NCBI		MGSCv36	mm8
Celera	6	42,209,337 - 42,226,794 (+)	NCBI		Celera
Cytogenetic Map	6	B2.1	NCBI
cM Map	6	20.54	NCBI

Casp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	72,116,265 - 72,134,023 (+)	NCBI		GRCr8
mRatBN7.2	4	71,149,632 - 71,167,388 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	71,149,669 - 71,167,379 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	76,069,535 - 76,087,171 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	71,982,792 - 72,000,428 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	70,402,261 - 70,419,895 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	71,652,358 - 71,670,228 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	71,652,354 - 71,670,239 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	136,454,723 - 136,474,625 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	70,029,728 - 70,047,164 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	70,305,857 - 70,323,294 (+)	NCBI
Celera	4	66,080,364 - 66,098,003 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI

Casp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955494	353,310 - 368,873 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955494	353,572 - 369,207 (-)	NCBI	ChiLan1.0	ChiLan1.0

CASP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	180,141,294 - 180,166,578 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	32,151,551 - 32,176,835 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	135,283,072 - 135,307,855 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	147,773,749 - 147,792,958 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	147,773,749 - 147,792,958 (+)	Ensembl	panpan1.1		panPan2

Casp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	12,149,166 - 12,164,126 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936527	739,281 - 754,331 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936527	739,325 - 754,259 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CASP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	18	6,941,937 - 6,966,061 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	18	6,946,432 - 6,966,088 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	18	7,183,208 - 7,206,964 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CASP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	112,172,614 - 112,189,574 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	112,172,733 - 112,188,744 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666072	8,895,441 - 8,914,545 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Casp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624800	11,451,038 - 11,468,205 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624800	11,451,784 - 11,468,791 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in CASP2
150 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium	1		11		4		6		6		10
Low	4	5	11	6	2	6		6	6	8		6
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001195151	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005629484	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022403604	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022403606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688872	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688873	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038688874	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF462046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000104	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000005840 ⟹ ENSCAFP00000005409

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,379,913 - 6,396,646 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000005851 ⟹ ENSCAFP00000005420

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,379,913 - 6,396,230 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000074318 ⟹ ENSCAFP00000052834

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,381,063 - 6,396,230 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000083196 ⟹ ENSCAFP00000048274

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,391,170 - 6,396,230 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000083555 ⟹ ENSCAFP00000056920

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,383,867 - 6,396,230 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00000092823 ⟹ ENSCAFP00000047249

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	16	6,379,913 - 6,396,646 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845030452 ⟹ ENSCAFP00845023884

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	16	6,232,210 - 6,250,056 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845030563 ⟹ ENSCAFP00845023976

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	16	6,232,210 - 6,249,983 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845030647 ⟹ ENSCAFP00845024047

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	16	6,234,611 - 6,249,988 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845030789 ⟹ ENSCAFP00845024139

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	16	6,237,590 - 6,250,031 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845030909 ⟹ ENSCAFP00845024226

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	16	6,244,894 - 6,250,031 (-)	Ensembl

RefSeq Acc Id:

NM_001195151 ⟹ NP_001182080

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	16	6,379,913 - 6,396,230 (-)	NCBI
Dog10K_Boxer_Tasha	16	7,368,808 - 7,385,123 (-)	NCBI
ROS_Cfam_1.0	16	6,233,633 - 6,249,962 (-)	NCBI
UMICH_Zoey_3.1	16	6,181,045 - 6,197,357 (-)	NCBI
UNSW_CanFamBas_1.0	16	6,032,942 - 6,049,262 (-)	NCBI
UU_Cfam_GSD_1.0	16	6,108,280 - 6,124,667 (-)	NCBI

Sequence:

show sequence

GCGGAGGGCGCGAGGGCGCTGGGTCTGCCTGGACTGTGGGCGGGGCGCGCACAGCCCGGGAAAA
GCGGTAAATGGCGGCGGCGAGCGCGGGCCGCCCGGCCGCCCTGCAGCGGAAGGCGCCGACGGCC
GCTGGCAGAGGGCGCAGGATATTGGGAGTGTGTGGCATGCATCCTGACCATCAGGAAGCACTAA
AAAAGAACCGAGTGGTGCTAGCCAAACAGCTGTTGCTGAGTGAACTGTTAGAACACCTCCTGGA
GAAGGACATCATCACCTTGGAAATGAGGGAGCACATTCAGGCCAAAGTGGGCGGCTTCAGCCAA
AATGTGGAACTTCTCAACTTGCTGCCCAAGAGGGGTCCCCAGGCTTTTGATGCCTTCTGTGTGG
CCCTGAGAGAGACCAAGCAGGGTCACCTGGAGGATCTGTTGCTCACAACCCTCTCTGGTCTTCA
GCATGGACTCCCACCGTTGAGCTGTGACTACGACCTGAGTCTCACCTTCCCGATGTGTGAGTCC
TGTCCCCCTCAGAAACAACTTCGCCTGTCTCCAGATACTGTGGAACACTCCCTAGACAACGGAG
ATGGTCCTCCTTGCCTTCAGGTGAAGCCTTGCACTCCCGAGTTTTATCAAACACACTACCAGCT
GGCTTATAGGTTACAGTCTCGGCCTCGTGGCCTGGCACTGGTGCTGAGCAATGTGCACTTCACT
GGAGAGAAAGACCTGGAATTTCGCTCTGGAGGGGATGTGGACCACAGCACTCTGGTCACCCTCT
TCAAGCTCTTGGGCTACAAAGTCCATGTTCTACTTGACCAGACTGCACAGGAAATGAAAGAGAA
ACTCCAGAATTTTGCCCAGTTGCCTGCCCACCGTGTCACTGACTCCTGCATTGTGGCACTTCTC
TCTCATGGCGTGGAGGGAGGCATCTATGGTGTGGACGGCAAACTGCTTCAGCTTCAGGAAGTTT
TTCGGCTCTTTGACAATGCCAGCTGCCCAAACCTACAGAACAAGCCGAAAATGTTCTTCATCCA
GGCCTGCCGTGGAGATGAAACCGACCGTGGGGTCGACCAGCAAGATGGAAAGAACCACACGGGA
TCCTCTGAGTGCGAGGAGAGTGACGCCAGCAAAGAGGAGTTGCTGAAAACCCGACTGCCCACAC
GCTCAGACATGATCTGTGGCTATGCCTGCCTCAGAGGGACTGCTGCCATGCGGAACACCAAACG
GGGTTCCTGGTACATTGAGGCCCTCACTCAAGTGTTCTCCGAGAGGGCTTGTGACACGCACGTG
GCCGACATGCTTGTGAAGGTGAACGCACTCATCAAGGAGCGTGAAGGCTATGCCCCCGGCACCG
AGTTCCACCGCTGCAAGGAGATGTCTGAGTACTGCAGCACTCTGTGCCGGCACCTCTACCTGTT
CCCAGGACACCCTCCCACGTGATGCCGTCCCCACCGCCCTGCCACATGGAGACTGCTGGACCAT
TGGAGGCCTGATGGAGCCTCTTTTCTTCCAATGCACGGTTTCTGTTCTCCCTCAGGGATTGGGA
GTCTCTCAGGCTTGTGGAGTATGCCTGTCATCTCTGCCTTGTCGTGCAGGACCACAGGCCAGCT
CCTCCTGTGAAAGCTCCCTTCCTGTAGAGCCAGGTCTGGCTGGACCGCTTGTCAGGAGTGTTTG
GCTGCTGTAGAGGAGCCTGGCCAACAATATAATGAACACAGTGTCTTTATGGGGAGAGGGCCTG
TGGGTTTCCCTCACTGTTTGCATTCGGTTCCTGCCCCCAAGGCTTTTGTAGACCGGCACTTTGG
TAATTGTTTTTATTACATTAGCTAAGATGTTTCAGAGACCATCTCCTGTCTTTTGTTTCTTCCC
TATTCAAACCCCATTTATACCAGACTGAGTGTTTGGAAGGTGTCCTGATTCAGCGTAGGCATTT
TTTGTTTAGTCTCAGAACAAATGGGACTGGCGGCAAGGTGCCACCAAGGGCGTGGTGGTGACCT
GTGTGCCCCCTTGCGGTACCACAAGGCCACCCAGTGGAAGGCAGTGTTGTCCGCTCCACTCTCA
GTTCCTTTGGGCTCTAGGAATCCAGCCTCTCAGCAGAGTTTACAGCATGGACACCTTGTACCTG
GAACTCACTGATCTTTGCCTGGGGAAGTTCCAAAGATCTTCTAATCAGTTATTCTCTCTCTGAG
CTTTGTTACTGAAGTGAACCTCAGCAGAGAGTACTAGTGGAGGCAGATAAAAGTGATACTCTTC
CTCATACCTTGTAACCTGTCACCTTATCTTTTGCTTCCTCTGAAGTGTCTTTTTC

hide sequence

RefSeq Acc Id:

XM_038688871 ⟹ XP_038544799

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	6,232,171 - 6,249,210 (-)	NCBI

RefSeq Acc Id:

XM_038688872 ⟹ XP_038544800

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	6,232,171 - 6,249,210 (-)	NCBI

RefSeq Acc Id:

XM_038688873 ⟹ XP_038544801

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	6,232,171 - 6,251,272 (-)	NCBI

RefSeq Acc Id:

XM_038688874 ⟹ XP_038544802

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	16	6,235,078 - 6,249,974 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001182080	(Get FASTA)	NCBI Sequence Viewer
	XP_038544799	(Get FASTA)	NCBI Sequence Viewer
	XP_038544800	(Get FASTA)	NCBI Sequence Viewer
	XP_038544801	(Get FASTA)	NCBI Sequence Viewer
	XP_038544802	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000005420.4
	ENSCAFP00000048274.1
	ENSCAFP00000052834.2
	ENSCAFP00030017731.1
	ENSCAFP00030017835.1
	ENSCAFP00030017888.1
	ENSCAFP00030017967.1
	ENSCAFP00040008431.1
	ENSCAFP00040008466.1
	ENSCAFP00040008490.1
	ENSCAFP00040008536.1
	ENSCAFP00040008579.1
	ENSCAFP00845023884
	ENSCAFP00845023884.1
	ENSCAFP00845023976
	ENSCAFP00845023976.1
	ENSCAFP00845024047
	ENSCAFP00845024047.1
	ENSCAFP00845024139.1
	ENSCAFP00845024226.1

RefSeq Acc Id:

NP_001182080 ⟸ NM_001195151

- UniProtKB:

A0A8C0MZD7 (UniProtKB/TrEMBL), A0A8C0L5B1 (UniProtKB/TrEMBL), A0A8I3P463 (UniProtKB/TrEMBL), A0A8C0Q9S5 (UniProtKB/TrEMBL), A0A8I3P3E6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAASAGRPAALQRKAPTAAGRGRRILGVCGMHPDHQEALKKNRVVLAKQLLLSELLEHLLEKD
IITLEMREHIQAKVGGFSQNVELLNLLPKRGPQAFDAFCVALRETKQGHLEDLLLTTLSGLQHG
LPPLSCDYDLSLTFPMCESCPPQKQLRLSPDTVEHSLDNGDGPPCLQVKPCTPEFYQTHYQLAY
RLQSRPRGLALVLSNVHFTGEKDLEFRSGGDVDHSTLVTLFKLLGYKVHVLLDQTAQEMKEKLQ
NFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNASCPNLQNKPKMFFIQAC
RGDETDRGVDQQDGKNHTGSSECEESDASKEELLKTRLPTRSDMICGYACLRGTAAMRNTKRGS
WYIEALTQVFSERACDTHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPG
HPPT

hide sequence

RefSeq Acc Id:

ENSCAFP00000005420 ⟸ ENSCAFT00000005851

RefSeq Acc Id:

ENSCAFP00000005409 ⟸ ENSCAFT00000005840

RefSeq Acc Id:

ENSCAFP00000052834 ⟸ ENSCAFT00000074318

RefSeq Acc Id:

ENSCAFP00000047249 ⟸ ENSCAFT00000092823

RefSeq Acc Id:

ENSCAFP00000056920 ⟸ ENSCAFT00000083555

RefSeq Acc Id:

ENSCAFP00000048274 ⟸ ENSCAFT00000083196

RefSeq Acc Id:	XP_038544801 ⟸ XM_038688873
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0Q9S5 (UniProtKB/TrEMBL), A0A8I3P3E6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038544800 ⟸ XM_038688872
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0Q9S5 (UniProtKB/TrEMBL), A0A8I3P3E6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038544799 ⟸ XM_038688871
- Peptide Label:	isoform X1
- UniProtKB:	A0A8C0Q9S5 (UniProtKB/TrEMBL), A0A8I3P3E6 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038544802 ⟸ XM_038688874
- Peptide Label:	isoform X2
- UniProtKB:	A0A5F4CTZ8 (UniProtKB/TrEMBL), A0A8C0QGJ1 (UniProtKB/TrEMBL), A0A8C0L8X4 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845024226 ⟸ ENSCAFT00845030909

RefSeq Acc Id:

ENSCAFP00845023884 ⟸ ENSCAFT00845030452

RefSeq Acc Id:

ENSCAFP00845024047 ⟸ ENSCAFT00845030647

RefSeq Acc Id:

ENSCAFP00845024139 ⟸ ENSCAFT00845030789

RefSeq Acc Id:

ENSCAFP00845023976 ⟸ ENSCAFT00845030563

Protein Domains

CARD Caspase family p10 Caspase family p20

Promoters

RGD ID:

13686028

Promoter ID:

EPDNEW_C4096

Type:

multiple initiation site

Name:

CASP2_1

Description:

caspase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	16	6,396,256 - 6,396,316	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000003623	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00030010994	UniProtKB/TrEMBL
	ENSCAFG00040005213	UniProtKB/TrEMBL
	ENSCAFG00845017207	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000005851.4	UniProtKB/TrEMBL
	ENSCAFT00000074318.2	UniProtKB/TrEMBL
	ENSCAFT00000083196.2	UniProtKB/TrEMBL
	ENSCAFT00030020327.1	UniProtKB/TrEMBL
	ENSCAFT00030020443.1	UniProtKB/TrEMBL
	ENSCAFT00030020506.1	UniProtKB/TrEMBL
	ENSCAFT00030020601.1	UniProtKB/TrEMBL
	ENSCAFT00040009729.1	UniProtKB/TrEMBL
	ENSCAFT00040009771.1	UniProtKB/TrEMBL
	ENSCAFT00040009801.1	UniProtKB/TrEMBL
	ENSCAFT00040009849.1	UniProtKB/TrEMBL
	ENSCAFT00040009894.1	UniProtKB/TrEMBL
	ENSCAFT00845030452	ENTREZGENE
	ENSCAFT00845030452.1	UniProtKB/TrEMBL
	ENSCAFT00845030563	ENTREZGENE
	ENSCAFT00845030563.1	UniProtKB/TrEMBL
	ENSCAFT00845030647	ENTREZGENE
	ENSCAFT00845030647.1	UniProtKB/TrEMBL
	ENSCAFT00845030789.1	UniProtKB/TrEMBL
	ENSCAFT00845030909.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/TrEMBL
	3.40.50.1460	UniProtKB/TrEMBL
	Caspase-like	UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/TrEMBL
	Caspase-like_dom_sf	UniProtKB/TrEMBL
	Caspase_cys_AS	UniProtKB/TrEMBL
	Caspase_his_AS	UniProtKB/TrEMBL
	CRADD	UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/TrEMBL
	Pept_C14_caspase	UniProtKB/TrEMBL
	Pept_C14_p10	UniProtKB/TrEMBL
	Pept_C14_p20	UniProtKB/TrEMBL
	Pept_C14A	UniProtKB/TrEMBL
KEGG Report	cfa:482737	UniProtKB/TrEMBL
NCBI Gene	CASP2	ENTREZGENE
PANTHER	CASPASE 2	UniProtKB/TrEMBL
	CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18	UniProtKB/TrEMBL
	DEATH DOMAIN-CONTAINING PROTEIN CRADD	UniProtKB/TrEMBL
	DEATH DOMAIN-CONTAINING PROTEIN CRADD	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/TrEMBL
	Peptidase_C14	UniProtKB/TrEMBL
PIRSF	Caspase_ICE	UniProtKB/TrEMBL
PRINTS	IL1BCENZYME	UniProtKB/TrEMBL
PROSITE	CARD	UniProtKB/TrEMBL
	CASPASE_CYS	UniProtKB/TrEMBL
	CASPASE_HIS	UniProtKB/TrEMBL
	CASPASE_P10	UniProtKB/TrEMBL
	CASPASE_P20	UniProtKB/TrEMBL
SMART	CARD	UniProtKB/TrEMBL
	CASc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/TrEMBL
	SSF52129	UniProtKB/TrEMBL
UniProt	A0A5F4CTZ8	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0L5B1	ENTREZGENE
	A0A8C0L8X4	ENTREZGENE
	A0A8C0MZD7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0Q403_CANLF	UniProtKB/TrEMBL
	A0A8C0Q9S5	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C0QGJ1	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P3E6	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3P463	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I3RZW3_CANLF	UniProtKB/TrEMBL
	A0A8P0P2H8_CANLF	UniProtKB/TrEMBL
VGNC ID	VGNC:38733	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-09-12	CASP2	caspase 2		caspase 2, apoptosis-related cysteine peptidase	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM