POLR3C (RNA polymerase III subunit C)

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Gene: POLR3C (RNA polymerase III subunit C) Pan paniscus

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Symbol:

POLR3C

Name:

RNA polymerase III subunit C

RGD ID:

11910165

Description:

ENCODES a protein that exhibits single-stranded DNA binding (inferred); INVOLVED IN DNA-templated transcription (inferred); positive regulation of innate immune response (inferred); positive regulation of interferon-beta production (inferred); PARTICIPATES IN RNA polymerase III transcription pathway; ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); neutropenia (ortholog); parathyroid carcinoma (ortholog); FOUND IN DNA-directed RNA polymerase complex (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA-directed RNA polymerase III subunit RPC3; polymerase (RNA) III (DNA directed) polypeptide C (62kD)

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	103,215,715 - 103,234,689 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	102,804,442 - 102,822,966 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	121,917,371 - 121,935,976 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	113,733,846 - 113,752,486 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	113,733,846 - 113,752,486 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

gastrointestinal stromal tumor (ISO)

neutropenia (ISO)

parathyroid carcinoma (ISO)

schizophrenia (ISO)

thrombocytopenia-absent radius syndrome (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA-templated transcription (IEA)

positive regulation of innate immune response (IEA)

positive regulation of interferon-beta production (IEA)

Cellular Component

DNA-directed RNA polymerase complex (IEA)

nucleoplasm (IEA)

nucleus (IEA)

RNA polymerase III complex (IEA)

Molecular Function

protein binding (ISO)

single-stranded DNA binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase III transcription pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

POLR3C
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	103,215,715 - 103,234,689 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	102,804,442 - 102,822,966 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	121,917,371 - 121,935,976 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	113,733,846 - 113,752,486 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	113,733,846 - 113,752,486 (+)	Ensembl	panpan1.1		panPan2

POLR3C
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	145,824,200 - 145,844,402 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	145,824,053 - 145,844,402 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	145,590,666 - 145,610,913 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	144,303,962 - 144,322,241 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	143,081,648 - 143,099,928	NCBI
Celera	1	119,795,949 - 119,814,224 (-)	NCBI		Celera
Cytogenetic Map	1	q21.1	NCBI
HuRef	1	119,556,179 - 119,574,446 (-)	NCBI		HuRef
CHM1_1	1	147,192,355 - 147,210,631 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	144,941,003 - 144,961,205 (+)	NCBI		T2T-CHM13v2.0

Polr3c
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	96,618,836 - 96,634,803 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	96,618,806 - 96,634,944 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	96,711,520 - 96,727,498 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	96,711,490 - 96,727,628 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	96,515,818 - 96,531,362 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	96,796,895 - 96,813,033 (-)	NCBI		MGSCv36	mm8
Celera	3	98,120,927 - 98,136,493 (-)	NCBI		Celera
Cytogenetic Map	3	F2.1	NCBI
cM Map	3	41.96	NCBI

Polr3c
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	186,935,038 - 186,950,962 (-)	NCBI		GRCr8
mRatBN7.2	2	184,246,201 - 184,262,150 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	184,246,204 - 184,262,208 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	191,917,143 - 191,932,613 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	189,710,614 - 189,726,210 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	184,549,704 - 184,565,173 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	198,836,282 - 198,852,368 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	198,836,285 - 198,852,161 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	218,323,216 - 218,339,302 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	191,511,970 - 191,527,849 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	191,474,726 - 191,490,603 (-)	NCBI
Celera	2	176,770,713 - 176,786,592 (-)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

Polr3c
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955568	243,073 - 261,418 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955568	242,834 - 263,053 (-)	NCBI	ChiLan1.0	ChiLan1.0

POLR3C
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	58,634,299 - 58,646,056 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	58,636,244 - 58,645,838 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	58,102,454 - 58,114,110 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	59,631,014 - 59,642,722 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	59,633,068 - 59,642,718 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	58,503,834 - 58,515,493 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	58,564,812 - 58,576,460 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	59,291,372 - 59,303,029 (+)	NCBI		UU_Cfam_GSD_1.0

Polr3c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	20,710,347 - 20,723,121 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936867	586,439 - 600,694 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936867	586,798 - 599,069 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

POLR3C
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	99,479,372 - 99,494,142 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	99,480,213 - 99,494,137 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	109,123,503 - 109,134,738 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

POLR3C
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	12,901,879 - 12,919,748 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	12,901,898 - 12,919,783 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	15,581,292 - 15,599,651 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Polr3c
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624772	17,196,388 - 17,212,727 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624772	17,196,418 - 17,212,265 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003806199	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000027908 ⟹ ENSPPAP00000006523

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	113,733,846 - 113,752,486 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000027922 ⟹ ENSPPAP00000006529

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	113,735,454 - 113,752,150 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000027925 ⟹ ENSPPAP00000006532

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	113,735,454 - 113,752,083 (+)	Ensembl

RefSeq Acc Id:

XM_003806199 ⟹ XP_003806247

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	103,215,715 - 103,234,689 (+)	NCBI
NHGRI_mPanPan1	1	102,804,442 - 102,822,966 (+)	NCBI
Mhudiblu_PPA_v0	1	121,917,371 - 121,935,976 (-)	NCBI
PanPan1.1	1	113,733,846 - 113,752,486 (+)	NCBI

Sequence:

show sequence

CGGAAGCCGCCGAAACTCTGGGGTAGAGTGGCACGCGCTTTTTGCTTTTCCGCATCTTCTTCGG
TGGCGATCCTCGTCCTAGAAAGGGCGGTGGGCTCCACCTCGGCCTAGAAGGCCAGCGGGAGCCG
TAGGAAGCCGTCGCGGGAAGCTCAGCAGAATTGGAGTTGGAGCCCCCGGATTGCGCTGACCCTG
AGCTCTCAGACTCCCCAGTACAATGACTCAAGCAGAAATTAAGCTCTGTTCTTTGTTGCTGCAA
GAGCATTTTGGAGAGATTGTAGAAAAAATTGGAGTCCATCTGATAAGAACCGGCAGCCAGCCAC
TAAGAGTAATTGCCCATGACACAGGAACATCACTGGATCAGGTGAAGAAAGCCTTGTGTGTCCT
CGTCCAACATAACCTGGTGAGTTATCAAGTGCACAAACGTGGTGTGGTGGAGTATGAAGCCCAG
TGCAGCCGGGTATTGCGAATGCTTAGATATCCCCGGTACATCTATACTACCAAAACTCTGTACA
GTGACACTGGAGAGCTGATTGTTGAGGAGCTTCTGTTGAACGGCAAACTGACAATGTCAGCTGT
TGTGAAGAAAGTGGCAGACCGGCTCACAGAGACCATGGAGGATGGCAAGACCATGGACTATGCT
GAAGTATCAAACACATTTGTGCGACTGGCAGACACACACTTTGTACAACGCTGCCCTTCGGTAC
CTACCACTGAGAATTCAGACCCTGGGCCACCACCACCTGCCCCCACACTTGTCATTAATGAAAA
GGACATGTACCTGGTTCCTAAACTCACCTTGATAGGGAAAGGTAAAAGGAGGAGATCATCTGAT
GAAGATGCTGCTGGGGAGCCCAAGGCCAAGAGACCAAAATATACTACAGATAACAAGGAGCCCA
TTCCAGATGATGGGATTTATTGGCAGGCCAACCTTGACAGATTCCACCAACACTTCCGTGACCA
AGCCATTGTGAGCGCAGTTGCTAACAGGATGGACCAGACAAGCAGCGAGATTGTGCGAACCATG
CTCCGAATGAGTGAGATTACCACTTCCTCTAGTGCTCCCTTCACCCAGCCATTGTCTTCCAATG
AGATCTTCAGATCCCTACCTGTTGGCTATAACATCTCTAAGCAAGTTCTTGATCAGTATCTCAC
TCTGCTGGCAGATGATCCACTAGAGTTTGTTGGAAAGTCTGGCGACAGTGGTGGAGGAATGTAT
GTCATCAACCTCCATAAGGCATTAGCATCCCTAGCCACAGCCACTCTGGAGTCCGTCGTACAGG
AGAGATTTGGGTCTCGCTGTGCTAGAATATTCCGTCTAGTTTTGCAGAAGAAACACATAGAGCA
GAAGCAAGTGGAAGACTTTGCAATGATTCCTGCAAAGGAGGCAAAGGATATGCTATATAAGATG
CTCTCAGAAAATTTCATGTCACTCCAGGAAATTCCCAAAACACCAGACCATGCCCCATCCAGGA
CCTTCTATTTATATACTGTGAACATCCTGTCAGCTGCCCGAATGTTGTTGCACAGGTGCTACAA
GAGCATAGCCAACTTGATAGAAAGGAGGCAATTTGAAACCAAAGAGAATAAGCGTCTACTAGAA
AAATCTCAGAGGGTAGAAGCCATCATTGCATCTATGCAGGCTACTGGTGCAGAGGAAGCACAGT
TACAAGAAATAGAGGAGATGATCACAGCTCCTGAACGTCAGCAGCTAGAGACCCTGAAACGTAA
TGTCAACAAGTTGGATGCCAGTGAGATCCAGGTGGACGAAACCATCTTCCTGCTGGAGTCTTAC
ATTGAGTGCACCATGAAGAGACAGTGATCCAGAAGAAGCATCTTCCTCAGAAGATCTGGGGGGA
TGGAAAGCAAAATAAAGGAGGTGCCTGGATGCATTATTTGCAGTGGGATAAGTCGCAGAGTCTT
CAACTAAACCCCCCTCTCTATCCCCTGCAGCCCAGGATACACCTGAAAGAATTTGGCATATTTA
GATCCATTGCTGTAGTCTCCCCTCATCAAATCTTGGCAGTGGGAAGAACCTTAAATCAACAAGG
TTAATCATCTATCAGAAGCATCTGTTCCCATAAAGAAGTTACCCACACCTATGGTTACCTATAT
CCCTGGCAATAGGAAACTTCCTAAGAAGTTAATTTTATTTTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003806247	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000006523
	ENSPPAP00000006523.1
	ENSPPAP00000006529.1
	ENSPPAP00000006532.1

RefSeq Acc Id:

XP_003806247 ⟸ XM_003806199

- UniProtKB:

A0A2R8ZRI2 (UniProtKB/TrEMBL), A0A2R8ZUH5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTQAEIKLCSLLLQEHFGEIVEKIGVHLIRTGSQPLRVIAHDTGTSLDQVKKALCVLVQHNLVS
YQVHKRGVVEYEAQCSRVLRMLRYPRYIYTTKTLYSDTGELIVEELLLNGKLTMSAVVKKVADR
LTETMEDGKTMDYAEVSNTFVRLADTHFVQRCPSVPTTENSDPGPPPPAPTLVINEKDMYLVPK
LTLIGKGKRRRSSDEDAAGEPKAKRPKYTTDNKEPIPDDGIYWQANLDRFHQHFRDQAIVSAVA
NRMDQTSSEIVRTMLRMSEITTSSSAPFTQPLSSNEIFRSLPVGYNISKQVLDQYLTLLADDPL
EFVGKSGDSGGGMYVINLHKALASLATATLESVVQERFGSRCARIFRLVLQKKHIEQKQVEDFA
MIPAKEAKDMLYKMLSENFMSLQEIPKTPDHAPSRTFYLYTVNILSAARMLLHRCYKSIANLIE
RRQFETKENKRLLEKSQRVEAIIASMQATGAEEAQLQEIEEMITAPERQQLETLKRNVNKLDAS
EIQVDETIFLLESYIECTMKRQ

hide sequence

Ensembl Acc Id:

ENSPPAP00000006523 ⟸ ENSPPAT00000027908

Ensembl Acc Id:

ENSPPAP00000006532 ⟸ ENSPPAT00000027925

Ensembl Acc Id:

ENSPPAP00000006529 ⟸ ENSPPAT00000027922

Protein Domains

RNA polymerase III Rpc82 C -terminal RNA polymerase III subunit RPC82-related helix-turn-

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000025184	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000027908.1	UniProtKB/TrEMBL
	ENSPPAT00000027922.1	UniProtKB/TrEMBL
	ENSPPAT00000027925.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	6.10.140.1450	UniProtKB/TrEMBL
InterPro	RNA_pol_III_RPC82-rel_HTH	UniProtKB/TrEMBL
	RNA_pol_III_Rpc82_C	UniProtKB/TrEMBL
	RPC3	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
KEGG Report	pps:100968512	UniProtKB/TrEMBL
NCBI Gene	POLR3C	ENTREZGENE
PANTHER	DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3	UniProtKB/TrEMBL
	PTHR12949	UniProtKB/TrEMBL
Pfam	HTH_9	UniProtKB/TrEMBL
	POLR3C_WHD	UniProtKB/TrEMBL
	RNA_pol_Rpc82	UniProtKB/TrEMBL
	RPC3_helical	UniProtKB/TrEMBL
UniProt	A0A2R8ZPU8_PANPA	UniProtKB/TrEMBL
	A0A2R8ZRI2	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZUH5	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

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Imported Disease Annotations - ClinVar

RGD Manual Annotations