F2RL3 (F2R like thrombin or trypsin receptor 3)

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Gene: F2RL3 (F2R like thrombin or trypsin receptor 3) Pan paniscus

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Symbol:

F2RL3

Name:

F2R like thrombin or trypsin receptor 3

RGD ID:

11808944

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (inferred); protease binding (inferred); thrombin-activated receptor activity (inferred); INVOLVED IN platelet aggregation (ortholog); PARTICIPATES IN protease mediated signaling via protease-activated receptor 4; ASSOCIATED WITH Chemical and Drug Induced Liver Injury (ortholog); cholestasis (ortholog); peliosis hepatis (ortholog); FOUND IN membrane (inferred); plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

F2R like thrombin/trypsin receptor 3; proteinase-activated receptor 4

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	21,757,541 - 21,762,253 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	20,764,020 - 20,768,733 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,375,572 - 16,379,587 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,355,542 - 17,357,628 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,355,542 - 17,357,628 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Chemical and Drug Induced Liver Injury (ISO)

cholestasis (ISO)

peliosis hepatis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IEA)

G protein-coupled receptor signaling pathway (IEA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA)

platelet activation (IEA)

platelet aggregation (ISO)

positive regulation of release of sequestered calcium ion into cytosol (IEA)

positive regulation of Rho protein signal transduction (IEA)

regulation of biological quality (IEA)

thrombin-activated receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

plasma membrane (IEA)

Molecular Function

G protein-coupled receptor activity (IEA)

protease binding (IEA)

thrombin-activated receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

protease mediated signaling via protease-activated receptor 4 (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

F2RL3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	21,757,541 - 21,762,253 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	20,764,020 - 20,768,733 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	16,375,572 - 16,379,587 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	17,355,542 - 17,357,628 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	17,355,542 - 17,357,628 (+)	Ensembl	panpan1.1		panPan2

F2RL3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	16,888,999 - 16,892,606 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	16,888,999 - 16,892,606 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	16,999,810 - 17,003,417 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	16,860,826 - 16,863,830 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	16,860,825 - 16,870,516	NCBI
Celera	19	16,901,357 - 16,904,361 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	16,568,368 - 16,571,379 (+)	NCBI		HuRef
CHM1_1	19	16,999,569 - 17,002,573 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	17,023,836 - 17,027,443 (+)	NCBI		T2T-CHM13v2.0

F2rl3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	73,488,287 - 73,490,526 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	73,488,508 - 73,490,502 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	72,761,659 - 72,763,898 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	72,761,880 - 72,763,874 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	75,285,779 - 75,287,784 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	75,657,952 - 75,659,957 (+)	NCBI		MGSCv36	mm8
Celera	8	77,077,985 - 77,079,990 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	35.08	NCBI

F2rl3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	17,151,516 - 17,153,509 (-)	NCBI		GRCr8
mRatBN7.2	16	17,117,441 - 17,119,434 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	17,117,441 - 17,119,472 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	17,185,458 - 17,187,486 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	18,317,104 - 18,319,112 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	17,238,362 - 17,240,390 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	18,817,797 - 18,819,790 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	18,814,622 - 18,819,833 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	18,687,984 - 18,689,977 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	16	17,341,816 - 17,343,823 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

F2rl3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	1,044,792 - 1,047,819 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	1,045,493 - 1,047,924 (-)	NCBI	ChiLan1.0	ChiLan1.0

F2RL3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	45,738,587 - 45,740,564 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	45,738,587 - 45,740,473 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	45,652,073 - 45,655,003 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	46,224,593 - 46,227,523 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	46,225,014 - 46,226,479 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	45,460,781 - 45,463,709 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	45,871,392 - 45,874,323 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	46,146,994 - 46,149,271 (-)	NCBI		UU_Cfam_GSD_1.0

F2RL3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	60,742,996 - 60,744,864 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	60,742,978 - 60,747,014 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	60,307,031 - 60,309,288 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

F2RL3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	15,397,552 - 15,400,708 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666074	4,036,812 - 4,040,135 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

F2rl3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	762,356 - 766,563 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	761,067 - 764,562 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003813547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000038035 ⟹ ENSPPAP00000015345

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	17,355,542 - 17,357,628 (+)	Ensembl

RefSeq Acc Id:

XM_003813547 ⟹ XP_003813595

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	21,757,541 - 21,762,253 (+)	NCBI
NHGRI_mPanPan1	19	20,764,020 - 20,768,733 (+)	NCBI
Mhudiblu_PPA_v0	19	16,375,572 - 16,379,587 (+)	NCBI
PanPan1.1	19	17,355,542 - 17,357,628 (+)	NCBI

Sequence:

show sequence

GGGACCCCCCCTGCATCTTGCTGGCCTGGCACCTGGGTCCCTGGGAGGCGCCACACTGGATATA
GCCACGTGGGGCAGCCGGGTCTCCATAACCCACACTCCAGTCCTCCCACAGGCTGGCTGGCAAG
CGGCCCTGGTGGGTCTGCGGGGGCAGGGGCAGCCTTCCTGGTTTATCTCCACTGGCGCGATCTG
CTCATCCGCCCAGGCTCCAGAAGCTGGGGCTCAGGGTCTGGCGAGGTAGGAAGCCTGAGGCCAC
AGCCCAGAGCAGCCTGAGTGCAGTCATGTGGGGGCGACTGCTCCTGTGGCCCCTGGTGCTGGGG
TTCAGCCTGTCTGGCGGCACCCAGACCCCCAGCGTCTACGACGAGAGCGGGAGCACCGGAGGTG
GTGATGACAGCACGCCCTCAATCCTGCCTGCCCCCCGCGGCTACCCAGGCCAAGTCTGTGCCAA
TGACAGTGACACCCTGGAGCTCCCGGACAGCTCACGGGCACTGCTTCTGGGCTGGGTGCCCACC
AGGCTGGTGCCCGCCCTCTATGGGCTGGTCCTGGTGGTGGGGCTGCCGGCCAATGGGCTGGCGC
TGTGGGTGCTGGCCACGCAGGCACCTCGGCTGCCCTCCACCGTGCTGCTGATGAACCTGGCGGC
TGCTGACCTCCTGCTGGCCCTGGCGCTGCCCCTGCGGATCGCCTACCACCTGCGTGGCCAGCGC
TGGCCCTTCGGGGAGGCCGCCTGCCGCCTGGCCACGGCCGCACTCTATGGTCACATGTATGGCT
CAGTGCTGCTGCTGGCCGCCGTCAGCCTGGACCGCTACCTGGCCCTGGTGCACCCGCTGCGGGC
CCGCGCCCTGCGTGGCCGGCGCCTGGCCCTTGGACTCTGCATGGCTGCTTGGCTCATGGCGGCC
GCCCTGGCACTGCCCCTGACACTGCAGCGGCAGACCTTCCGGCTGGCGCGCTCCGATCGCGTGC
TCTGCCATGACGCGCTGCCCCTGGACGTACAGGCCTCCCACTGGCAACCGGCCTTCACCTGCCT
GGCGCTGTTGGGCTGTTTCCTGCCCCTGCTGGCCATGCTGCTGTGCTACGGGGCCACCCTGCAC
ACGCTGGCGGCCAGCGGCCGGCGCTACGGCCACGCGCTGAGGCTGACCGCAGTGGTGCTGGCCT
CCGCCGTGGCCTTCTTCGTGCCCAGCAACCTGCTGCTGCTGCTGCATTACTCGGACCCGAGCCC
CAGCGCCTGGGGCAACCTCTATGGTGCCTACGTGCCTAGCCTGGCGCTGAGCACCCTCAACAGC
TGCGTGGATCCCTTCATCTACTACTACGTGTCGGCCGAGTTCAGGGACAAGGTGCGGGCAGGGC
TCTTCCGACGGTCGCCGGGGGACACCGTGGCCTCCAAGGCCTCTGCAGAAGGGGGCAGCCGGGG
CATGGGCACCCACTCCTCTTTGGTCCAGTGACACAAAGTGGGGAAGGCTGTACTGGGTCGAACA
GGGTCCCTTCCCCCACTTCACGTCCTTCCTGGGACCTCAGAATGTGACCTTATTTGGAAATAGG
GTTGTTACAACTGTCACTAGCGGAGGTCACTTTGGAGAAGGGTGGGCCTTACATCCAGTGTGGG
TGGTGTCCTCATAAGATAAGGAGAGGCCAGGCCTGGTGGCTCATGCCTGTAATCCCAGCACTTT
AAGAGGCCAAGGCGGATGGATCACTTGAGCCCAGGAGTTCAACACCAGCCTGAGCAACATGGTA
AAACCCCATCTCTACCAAAAATACAAAAATTAGTTGGGCTTGGTGGCTGGCGCCTGTAATCCCA
GCTACTCAGGAGACTGAGGCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003813595	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000015345.1

RefSeq Acc Id:

XP_003813595 ⟸ XM_003813547

- UniProtKB:

A0A2R9ADF6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDTLELP
DSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTVLLMNLAAADLLLALA
LPLRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVHPLRARALRGRRL
ALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDVQASHWQPAFTCLALLGCFLP
LLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSNLLLLLHYSDPSPSAWGNLYG
AYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFRRSPGDTVASKASAEGGSRGMGTHSSLV
Q

hide sequence

Ensembl Acc Id:

ENSPPAP00000015345 ⟸ ENSPPAT00000038035

Protein Domains

G-protein coupled receptors family 1 profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030821	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000038035.1	UniProtKB/TrEMBL
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/TrEMBL
	Prot_act_rcpt_4	UniProtKB/TrEMBL
	Protea_act_rcpt	UniProtKB/TrEMBL
KEGG Report	pps:100988111	UniProtKB/TrEMBL
NCBI Gene	F2RL3	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/TrEMBL
	PROTEINASE-ACTIVATED RECEPTOR 4	UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/TrEMBL
PRINTS	GPCRRHODOPSN	UniProtKB/TrEMBL
	PROTEASEAR	UniProtKB/TrEMBL
	PROTEASEAR4	UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/TrEMBL
UniProt	A0A2R9ADF6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-06-06	F2RL3	F2R like thrombin or trypsin receptor 3		F2R like thrombin/trypsin receptor 3	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

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Imported Disease Annotations - CTD

RGD Manual Annotations