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Gene: FPR2 (formyl peptide receptor 2) Pan paniscus

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Symbol:

FPR2

Name:

formyl peptide receptor 2

RGD ID:

11777343

Description:

ENCODES a protein that exhibits amyloid-beta binding (ortholog); cargo receptor activity (ortholog); N-formyl peptide receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); astrocyte activation (ortholog); calcium-mediated signaling (ortholog); ASSOCIATED WITH Crohn's disease (ortholog); dentin caries (ortholog); lung adenocarcinoma (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

LOC129394723; N-formyl peptide receptor 2; uncharacterized LOC129394723

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,795,766 - 57,814,162 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	59,727,403 - 59,738,468 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	48,663,622 - 48,715,535 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	57,586,681 - 57,593,320 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	dentin caries		ISO	Fpr2 (Rattus norvegicus)	9068941		RGD	PMID:29396644 and REF_RGD_ID:408427365

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	lung adenocarcinoma		ISO	FPR2 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Lung adenocarcinoma	ClinVar	PMID:27993330

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	Crohn's disease		ISO	FPR2 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:21659618

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	involved_in	ISO	UniProtKB:P05067-PRO_0000000092 and UniProtKB:Q9UEW3	9068941	PMID:20141570	ARUK-UCL	PMID:20141570
FPR2	Bonobo	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	astrocyte activation	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	calcium-mediated signaling	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:11160457	ARUK-UCL	PMID:11160457
FPR2	Bonobo	cell surface receptor signaling pathway	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	cellular response to amyloid-beta	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:11316806	ARUK-UCL	PMID:11316806
FPR2	Bonobo	cellular response to amyloid-beta	involved_in	ISO	Fpr2 (Mus musculus)	9068941	PMID:11316806	ARUK-UCL	PMID:11316806
FPR2	Bonobo	cellular response to amyloid-beta	involved_in	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	defense response to bacterium	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	dentinogenesis		ISO	Fpr2 (Rattus norvegicus)	9068941		RGD	PMID:29396644 and REF_RGD_ID:408427365
FPR2	Bonobo	G protein-coupled receptor signaling pathway	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:11160457	ARUK-UCL	PMID:11160457
FPR2	Bonobo	immune response-regulating cell surface receptor signaling pathway	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	microglial cell activation	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	negative regulation of inflammatory response	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	negative regulation of neuron apoptotic process	acts_upstream_of_or_within	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:30511586	ARUK-UCL	PMID:30511586 and REF_RGD_ID:14695080
FPR2	Bonobo	phospholipase C-activating G protein-coupled receptor signaling pathway	acts_upstream_of_or_within	ISO	Fpr2 (Mus musculus)	9068941	PMID:22859307	MGI	PMID:22859307
FPR2	Bonobo	positive chemotaxis	involved_in	ISO	UniProtKB:O88536	9068941	PMID:11316806	ARUK-UCL	PMID:11316806
FPR2	Bonobo	positive regulation of ERK1 and ERK2 cascade	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:20141570	ARUK-UCL	PMID:20141570
FPR2	Bonobo	positive regulation of ERK1 and ERK2 cascade	involved_in	ISO	UniProtKB:P05067-PRO_0000000092 and UniProtKB:Q9UEW3	9068941	PMID:20141570	ARUK-UCL	PMID:20141570
FPR2	Bonobo	positive regulation of ERK1 and ERK2 cascade	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	positive regulation of innate immune response	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	positive regulation of monocyte chemotaxis	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:11160457	ARUK-UCL	PMID:11160457
FPR2	Bonobo	positive regulation of phagocytosis	involved_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	involved_in	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:30511586	ARUK-UCL	PMID:30511586 and REF_RGD_ID:14695080
FPR2	Bonobo	positive regulation of superoxide anion generation	involved_in	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:11316806	ARUK-UCL	PMID:11316806
FPR2	Bonobo	receptor-mediated endocytosis	involved_in	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	cytoplasm	located_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:11689470	ARUK-UCL	PMID:11689470
FPR2	Bonobo	cytoplasm	located_in	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	plasma membrane	located_in	ISO	FPR2 (Homo sapiens)	9068941	PMID:11689470 and PMID:15465011	UniProt	PMID:11689470 and PMID:15465011

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
FPR2	Bonobo	amyloid-beta binding	enables	ISO	UniProtKB:P05067-PRO_0000000092	9068941	PMID:11316806	ARUK-UCL	PMID:11316806
FPR2	Bonobo	cargo receptor activity	enables	ISO	Fpr2 (Rattus norvegicus)	9068941	PMID:18723082	ARUK-UCL	PMID:18723082 and REF_RGD_ID:12910993
FPR2	Bonobo	N-formyl peptide receptor activity	enables	ISO	Fpr2 (Mus musculus)	9068941	PMID:22859307	MGI	PMID:22859307
FPR2	Bonobo	protein binding	enables	ISO	UniProtKB:Q8IVG9	9068941	PMID:15465011	UniProt	PMID:15465011
FPR2	Bonobo	protein binding	enables	ISO	UniProtKB:Q9UEW3	9068941	PMID:20141570	ARUK-UCL	PMID:20141570
FPR2	Bonobo	protein binding	enables	ISO	UniProtKB:P05090 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
FPR2	Bonobo	protein binding	enables	ISO	UniProtKB:P05067	9068941	PMID:32814053	IntAct	PMID:32814053
FPR2	Bonobo	RAGE receptor binding		ISO	Ager (Rattus norvegicus)	9068941		RGD	PMID:23164356 and REF_RGD_ID:7244287
FPR2	Bonobo	scavenger receptor binding	enables	ISO	UniProtKB:Q9UEW3	9068941	PMID:20141570	ARUK-UCL	PMID:20141570
FPR2	Bonobo	signaling receptor activity	enables	ISO	FPR2 (Homo sapiens)	9068941	PMID:25505240	ARUK-UCL	PMID:25505240
FPR2	Bonobo	signaling receptor activity	enables	ISO	Fpr2 (Mus musculus)	9068941	PMID:12218158	MGI	PMID:12218158

PMID:30032202

FPR2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	57,795,766 - 57,814,162 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	59,727,403 - 59,738,468 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	48,663,622 - 48,715,535 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	57,586,681 - 57,593,320 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

FPR2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	51,761,180 - 51,770,531 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	51,752,026 - 51,770,531 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	52,264,433 - 52,273,784 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	56,956,265 - 56,965,591 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	56,958,453 - 56,965,589	NCBI
Celera	19	49,314,014 - 49,323,339 (+)	NCBI		Celera
Cytogenetic Map	19	q13.41	NCBI
HuRef	19	48,595,209 - 48,604,534 (+)	NCBI		HuRef
CHM1_1	19	52,266,274 - 52,275,599 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	54,839,202 - 54,857,725 (+)	NCBI		T2T-CHM13v2.0

Fpr2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	18,108,086 - 18,114,214 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	18,108,086 - 18,114,214 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	17,887,824 - 17,893,952 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	17,887,824 - 17,893,952 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	18,024,788 - 18,030,916 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	17,592,442 - 17,598,570 (+)	NCBI		MGSCv36	mm8
Celera	17	18,828,566 - 18,834,697 (+)	NCBI		Celera
Cytogenetic Map	17	A3.2	NCBI
cM Map	17	10.66	NCBI

Fpr2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	67,449,637 - 67,458,272 (+)	NCBI		GRCr8
mRatBN7.2	1	58,776,592 - 58,785,227 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	58,776,752 - 58,786,019 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	1	59,800,558 - 59,809,507 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	59,800,984 - 59,802,401 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	60,719,375 - 60,727,932 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	56,622,816 - 56,624,057 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	1	54,955,259 - 54,964,212 (+)	NCBI		Celera
Cytogenetic Map	1	q12	NCBI

FPR
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	105,343,096 - 105,353,563 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	105,344,463 - 105,372,070 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	104,916,610 - 104,927,170 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	105,853,006 - 105,863,566 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	105,855,489 - 105,856,544 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	105,525,388 - 105,535,950 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	105,164,383 - 105,175,163 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	105,961,120 - 105,971,680 (-)	NCBI		UU_Cfam_GSD_1.0

FPR2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	44,580,342 - 44,591,187 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	44,589,334 - 44,590,389 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	24,634,825 - 24,645,669 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fpr2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624832	3,275,365 - 3,282,308 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_034944764	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055103569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_055103569 ⟹ XP_054959544

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	57,795,766 - 57,814,162 (+)	NCBI
NHGRI_mPanPan1	19	59,727,403 - 59,738,468 (+)	NCBI


Protein RefSeqs	XP_054959544	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

XP_054959544 ⟸ XM_055103569

Database	Acc Id	Source(s)
NCBI Gene	FPR2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2024-03-14	FPR2	formyl peptide receptor 2	LOC129394723	uncharacterized LOC129394723	Data Merged	737654	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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