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Gene: RAPGEF5 (Rap guanine nucleotide exchange factor 5) Pan paniscus

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Symbol:

RAPGEF5

Name:

Rap guanine nucleotide exchange factor 5

RGD ID:

11768650

Description:

ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); INVOLVED IN Ras protein signal transduction (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); dilated cardiomyopathy 1A (ortholog); hypomyelinating leukodystrophy 5 (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	26,984,630 - 27,225,479 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	75,309,356 - 75,550,210 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	22,806,855 - 23,047,663 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	22,118,332 - 22,317,650 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	22,122,434 - 22,317,650 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
RAPGEF5	Bonobo	dilated cardiomyopathy 1A		ISO	RAPGEF5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Dilated cardiomyopathy 1A	ClinVar
RAPGEF5	Bonobo	hypomyelinating leukodystrophy 5		ISO	RAPGEF5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Hypomyelination and Congenital Cataract	ClinVar	PMID:18022865 more ...
RAPGEF5	Bonobo	pleomorphic xanthoastrocytoma		ISO	RAPGEF5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Pleomorphic xanthoastrocytoma	ClinVar	PMID:28299358
RAPGEF5	Bonobo	primary ciliary dyskinesia		ISO	RAPGEF5 (Homo sapiens)	8554872	ClinVar Annotator: match by term: Primary ciliary dyskinesia	ClinVar	PMID:18022865 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
RAPGEF5	Bonobo	amphetamine abuse		ISO	RAPGEF5 (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:18316681

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
RAPGEF5	Bonobo	Ras protein signal transduction	involved_in	IEA	PANTHER:PTN000561183 and PANTHER:PTN002750085	150520179		TreeGrafter	GO_REF:0000118
RAPGEF5	Bonobo	small GTPase-mediated signal transduction	involved_in	IEA	InterPro:IPR001895 more ...	150520179		InterPro	GO_REF:0000002

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
RAPGEF5	Bonobo	nuclear body	located_in	ISO	RAPGEF5 (Homo sapiens)	9068941		HPA	GO_REF:0000052
RAPGEF5	Bonobo	nucleoplasm	located_in	ISO	RAPGEF5 (Homo sapiens)	9068941		HPA	GO_REF:0000052
RAPGEF5	Bonobo	nucleus	located_in	ISO	RAPGEF5 (Homo sapiens)	9068941	PMID:10486569	UniProt	PMID:10486569
RAPGEF5	Bonobo	plasma membrane	located_in	IEA	PANTHER:PTN000561183 and PANTHER:PTN002750085	150520179		TreeGrafter	GO_REF:0000118

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
RAPGEF5	Bonobo	GTP-dependent protein binding	enables	ISO	UniProtKB:O14807	9068941	PMID:10934204	UniProt	PMID:10934204
RAPGEF5	Bonobo	guanyl-nucleotide exchange factor activity	enables	IEA	UniProtKB-KW:KW-0344	150520179		UniProt	GO_REF:0000043
RAPGEF5	Bonobo	guanyl-nucleotide exchange factor activity	enables	IEA	PANTHER:PTN000561183 and PANTHER:PTN002750085	150520179		TreeGrafter	GO_REF:0000118
RAPGEF5	Bonobo	guanyl-nucleotide exchange factor activity	enables	IEA	InterPro:IPR001895 more ...	150520179		InterPro	GO_REF:0000002
RAPGEF5	Bonobo	protein binding	enables	ISO	UniProtKB:Q12955	9068941	PMID:33961781	IntAct	PMID:33961781

PMID:22301074	PMID:30032202

RAPGEF5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	26,984,630 - 27,225,479 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	75,309,356 - 75,550,210 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	22,806,855 - 23,047,663 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	22,118,332 - 22,317,650 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	22,122,434 - 22,317,650 (-)	Ensembl	panpan1.1		panPan2

RAPGEF5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	22,118,236 - 22,357,154 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	22,118,236 - 22,357,154 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	22,157,854 - 22,396,773 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	22,124,433 - 22,363,058 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	22,143,557 - 22,382,091 (-)	NCBI		Celera
Cytogenetic Map	7	p15.3	NCBI
HuRef	7	22,043,471 - 22,243,092 (-)	NCBI		HuRef
CHM1_1	7	22,158,708 - 22,397,156 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	22,254,475 - 22,493,270 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	22,209,210 - 22,447,742 (-)	NCBI

Rapgef5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	117,480,146 - 117,723,472 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	117,480,099 - 117,723,472 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	117,516,526 - 117,759,737 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	117,516,479 - 117,759,737 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	118,754,952 - 118,995,451 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	117,958,488 - 118,198,654 (+)	NCBI		MGSCv36	mm8
MGSCv36	12	111,717,001 - 111,958,157 (+)	NCBI		MGSCv36	mm8
Cytogenetic Map	12	F2	NCBI
cM Map	12	63.06	NCBI

Rapgef5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	144,588,162 - 144,822,908 (+)	NCBI		GRCr8
mRatBN7.2	6	138,445,184 - 138,679,943 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	138,437,991 - 138,679,936 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	141,880,425 - 142,115,425 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	138,497,846 - 138,732,849 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	139,052,896 - 139,287,512 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	145,387,890 - 145,625,243 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	145,546,595 - 145,625,236 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	154,308,057 - 154,541,118 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	144,949,908 - 145,030,090 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	136,254,550 - 136,332,824 (+)	NCBI		Celera
Cytogenetic Map	6	q33	NCBI

Rapgef5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	24,525,748 - 24,716,372 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	24,525,748 - 24,716,151 (-)	NCBI	ChiLan1.0	ChiLan1.0

RAPGEF5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	14	35,979,393 - 36,208,849 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	14	35,982,444 - 36,209,214 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	14	35,520,950 - 35,750,469 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	14	35,904,738 - 36,135,155 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	14	35,904,768 - 36,135,551 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	14	36,024,971 - 36,254,867 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	14	35,721,839 - 35,951,074 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	14	36,057,456 - 36,287,333 (-)	NCBI		UU_Cfam_GSD_1.0

Rapgef5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	80,185,677 - 80,381,255 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936546	7,864,608 - 8,051,356 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936546	7,860,795 - 8,051,351 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAPGEF5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	90,958,078 - 91,578,992 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	90,958,078 - 91,232,256 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	100,401,677 - 100,899,598 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAPGEF5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	35,894,481 - 36,132,041 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	35,940,360 - 36,133,715 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	68,454,107 - 68,689,515 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rapgef5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	8,427,796 - 8,610,694 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	8,388,172 - 8,614,469 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_034963787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034963788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055115754	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055115755	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000059849 ⟹ ENSPPAP00000036954

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	22,122,434 - 22,309,651 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059877 ⟹ ENSPPAP00000036981

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	22,130,945 - 22,317,650 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059885 ⟹ ENSPPAP00000036989

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	22,130,945 - 22,194,437 (-)	Ensembl

Ensembl Acc Id:

ENSPPAT00000059889 ⟹ ENSPPAP00000036993

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	22,194,466 - 22,309,651 (-)	Ensembl

RefSeq Acc Id:

XM_034963787 ⟹ XP_034819678

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	26,984,630 - 27,225,479 (-)	NCBI
NHGRI_mPanPan1	7	75,309,356 - 75,550,210 (-)	NCBI
Mhudiblu_PPA_v0	7	22,806,855 - 23,047,663 (-)	NCBI

RefSeq Acc Id:

XM_055115754 ⟹ XP_054971729

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	26,984,630 - 27,086,435 (-)	NCBI
NHGRI_mPanPan1	7	75,309,356 - 75,411,158 (-)	NCBI

RefSeq Acc Id:

XM_055115755 ⟹ XP_054971730

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	27,001,169 - 27,061,246 (-)	NCBI
NHGRI_mPanPan1	7	75,325,899 - 75,385,970 (-)	NCBI


Protein RefSeqs	XP_034819678	(Get FASTA)	NCBI Sequence Viewer
	XP_054971729	(Get FASTA)	NCBI Sequence Viewer
	XP_054971730	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000036954.1
	ENSPPAP00000036981.1
	ENSPPAP00000036989.1
	ENSPPAP00000036993.1

RefSeq Acc Id:	XP_034819678 ⟸ XM_034963787
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R9C552 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSPPAP00000036981 ⟸ ENSPPAT00000059877

Ensembl Acc Id:

ENSPPAP00000036993 ⟸ ENSPPAT00000059889

Ensembl Acc Id:

ENSPPAP00000036989 ⟸ ENSPPAT00000059885

Ensembl Acc Id:

ENSPPAP00000036954 ⟸ ENSPPAT00000059849

Protein Domains

N-terminal Ras-GEF Ras-GEF

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000041225	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000059849.1	UniProtKB/TrEMBL
	ENSPPAT00000059877.1	UniProtKB/TrEMBL
	ENSPPAT00000059885.1	UniProtKB/TrEMBL
	ENSPPAT00000059889.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.10.10	UniProtKB/TrEMBL
	1.10.840.10	UniProtKB/TrEMBL
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/TrEMBL
	Son of sevenless (SoS) protein Chain: S domain 1	UniProtKB/TrEMBL
InterPro	Ras-like_GEF	UniProtKB/TrEMBL
	Ras-like_Gua-exchang_fac_N	UniProtKB/TrEMBL
	Ras_G-nucl-exch_fac_CS	UniProtKB/TrEMBL
	Ras_GEF_dom_sf	UniProtKB/TrEMBL
	RASGEF_cat_dom	UniProtKB/TrEMBL
	RASGEF_cat_dom_sf	UniProtKB/TrEMBL
	Ubiquitin-like_domsf	UniProtKB/TrEMBL
	WH-like_DNA-bd_sf	UniProtKB/TrEMBL
	WH_DNA-bd_sf	UniProtKB/TrEMBL
NCBI Gene	RAPGEF5	ENTREZGENE
PANTHER	PTHR23113	UniProtKB/TrEMBL
	RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5	UniProtKB/TrEMBL
Pfam	RasGEF	UniProtKB/TrEMBL
	RasGEF_N	UniProtKB/TrEMBL
PROSITE	RASGEF	UniProtKB/TrEMBL
	RASGEF_CAT	UniProtKB/TrEMBL
	RASGEF_NTER	UniProtKB/TrEMBL
SMART	RasGEF	UniProtKB/TrEMBL
	RasGEFN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF46785	UniProtKB/TrEMBL
	SSF48366	UniProtKB/TrEMBL
	SSF54236	UniProtKB/TrEMBL
UniProt	A0A2R9C4W6_PANPA	UniProtKB/TrEMBL
	A0A2R9C552	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9C588_PANPA	UniProtKB/TrEMBL
	A0A2R9C7U8_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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