RAPGEF5 (Rap guanine nucleotide exchange factor 5) - Rat Genome Database

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Gene: RAPGEF5 (Rap guanine nucleotide exchange factor 5) Pan paniscus
Analyze
Symbol: RAPGEF5
Name: Rap guanine nucleotide exchange factor 5
RGD ID: 11768650
Description: ENCODES a protein that exhibits GTP-dependent protein binding (ortholog); INVOLVED IN Ras protein signal transduction (inferred); small GTPase-mediated signal transduction (inferred); ASSOCIATED WITH amphetamine abuse (ortholog); dilated cardiomyopathy 1A (ortholog); genetic disease (ortholog); FOUND IN nuclear body (ortholog); nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2626,984,630 - 27,225,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,309,356 - 75,550,210 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0722,806,855 - 23,047,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1722,118,332 - 22,317,650 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl722,122,434 - 22,317,650 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RAPGEF5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2626,984,630 - 27,225,479 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1775,309,356 - 75,550,210 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0722,806,855 - 23,047,663 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1722,118,332 - 22,317,650 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl722,122,434 - 22,317,650 (-)Ensemblpanpan1.1panPan2
RAPGEF5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38722,118,236 - 22,357,154 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl722,118,236 - 22,357,154 (-)EnsemblGRCh38hg38GRCh38
GRCh37722,157,854 - 22,396,773 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36722,124,433 - 22,363,058 (-)NCBINCBI36Build 36hg18NCBI36
Celera722,143,557 - 22,382,091 (-)NCBICelera
Cytogenetic Map7p15.3NCBI
HuRef722,043,471 - 22,243,092 (-)NCBIHuRef
CHM1_1722,158,708 - 22,397,156 (-)NCBICHM1_1
T2T-CHM13v2.0722,254,475 - 22,493,270 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2722,209,210 - 22,447,742 (-)NCBI
Rapgef5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912117,480,146 - 117,723,472 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12117,480,099 - 117,723,472 (+)EnsemblGRCm39 Ensembl
GRCm3812117,516,526 - 117,759,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12117,516,479 - 117,759,737 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712118,754,952 - 118,995,451 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612117,958,488 - 118,198,654 (+)NCBIMGSCv36mm8
MGSCv3612111,717,001 - 111,958,157 (+)NCBIMGSCv36mm8
Cytogenetic Map12F2NCBI
cM Map1263.06NCBI
Rapgef5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86144,588,162 - 144,822,908 (+)NCBIGRCr8
mRatBN7.26138,445,184 - 138,679,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6138,437,991 - 138,679,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6141,880,425 - 142,115,425 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06138,497,846 - 138,732,849 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06139,052,896 - 139,287,512 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06145,387,890 - 145,625,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6145,546,595 - 145,625,236 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06154,308,057 - 154,541,118 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46144,949,908 - 145,030,090 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6136,254,550 - 136,332,824 (+)NCBICelera
Cytogenetic Map6q33NCBI
Rapgef5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541024,525,748 - 24,716,372 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541024,525,748 - 24,716,151 (-)NCBIChiLan1.0ChiLan1.0
RAPGEF5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11435,979,393 - 36,208,849 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1435,982,444 - 36,209,214 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1435,520,950 - 35,750,469 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01435,904,738 - 36,135,155 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1435,904,768 - 36,135,551 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11436,024,971 - 36,254,867 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01435,721,839 - 35,951,074 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01436,057,456 - 36,287,333 (-)NCBIUU_Cfam_GSD_1.0
Rapgef5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511880,185,677 - 80,381,255 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365467,864,608 - 8,051,356 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365467,860,795 - 8,051,351 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAPGEF5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl990,958,078 - 91,578,992 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1990,958,078 - 91,232,256 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29100,401,677 - 100,899,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAPGEF5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12135,894,481 - 36,132,041 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2135,940,360 - 36,133,715 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604268,454,107 - 68,689,515 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rapgef5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247398,427,796 - 8,610,694 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247398,388,172 - 8,614,469 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059849   ⟹   ENSPPAP00000036954
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl722,122,434 - 22,309,651 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059877   ⟹   ENSPPAP00000036981
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl722,130,945 - 22,317,650 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059885   ⟹   ENSPPAP00000036989
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl722,130,945 - 22,194,437 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000059889   ⟹   ENSPPAP00000036993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl722,194,466 - 22,309,651 (-)Ensembl
RefSeq Acc Id: XM_034963787   ⟹   XP_034819678
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2626,984,630 - 27,225,479 (-)NCBI
NHGRI_mPanPan1775,309,356 - 75,550,210 (-)NCBI
Mhudiblu_PPA_v0722,806,855 - 23,047,663 (-)NCBI
RefSeq Acc Id: XM_055115754   ⟹   XP_054971729
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2626,984,630 - 27,086,435 (-)NCBI
NHGRI_mPanPan1775,309,356 - 75,411,158 (-)NCBI
RefSeq Acc Id: XM_055115755   ⟹   XP_054971730
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2627,001,169 - 27,061,246 (-)NCBI
NHGRI_mPanPan1775,325,899 - 75,385,970 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034819678 (Get FASTA)   NCBI Sequence Viewer  
  XP_054971729 (Get FASTA)   NCBI Sequence Viewer  
  XP_054971730 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000036954.1
  ENSPPAP00000036981.1
  ENSPPAP00000036989.1
  ENSPPAP00000036993.1
Reference Protein Sequences
RefSeq Acc Id: XP_034819678   ⟸   XM_034963787
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C552 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000036981   ⟸   ENSPPAT00000059877
RefSeq Acc Id: ENSPPAP00000036993   ⟸   ENSPPAT00000059889
RefSeq Acc Id: ENSPPAP00000036989   ⟸   ENSPPAT00000059885
RefSeq Acc Id: ENSPPAP00000036954   ⟸   ENSPPAT00000059849
RefSeq Acc Id: XP_054971729   ⟸   XM_055115754
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054971730   ⟸   XM_055115755
- Peptide Label: isoform X3
Protein Domains
N-terminal Ras-GEF   Ras-GEF


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041225 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059849.1 UniProtKB/TrEMBL
  ENSPPAT00000059877.1 UniProtKB/TrEMBL
  ENSPPAT00000059885.1 UniProtKB/TrEMBL
  ENSPPAT00000059889.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.10.840.10 UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/TrEMBL
InterPro Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
NCBI Gene RAPGEF5 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 5 UniProtKB/TrEMBL
Pfam RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PROSITE RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
  SSF48366 UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A2R9C4W6_PANPA UniProtKB/TrEMBL
  A0A2R9C552 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C588_PANPA UniProtKB/TrEMBL
  A0A2R9C7U8_PANPA UniProtKB/TrEMBL