SHF (Src homology 2 domain containing F) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: SHF (Src homology 2 domain containing F) Pan paniscus
Analyze
Symbol: SHF
Name: Src homology 2 domain containing F
RGD ID: 11737960
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2 domain-containing adapter protein F
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,393,075 - 34,439,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,571,242 - 38,617,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,100,832 - 24,146,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,468,468 - 42,489,184 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,469,202 - 42,500,239 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SHF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,393,075 - 34,439,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,571,242 - 38,617,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,100,832 - 24,146,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,468,468 - 42,489,184 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,469,202 - 42,500,239 (-)Ensemblpanpan1.1panPan2
SHF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,167,214 - 45,201,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,167,214 - 45,201,175 (-)EnsemblGRCh38hg38GRCh38
GRCh371545,459,412 - 45,493,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,246,704 - 43,280,665 (-)NCBINCBI36Build 36hg18NCBI36
Celera1522,350,695 - 22,384,650 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,283,482 - 22,317,406 (-)NCBIHuRef
CHM1_11545,578,088 - 45,611,982 (-)NCBICHM1_1
T2T-CHM13v2.01542,975,223 - 43,009,099 (-)NCBIT2T-CHM13v2.0
Shf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,179,373 - 122,199,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,179,373 - 122,199,643 (-)EnsemblGRCm39 Ensembl
GRCm382122,348,892 - 122,369,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,348,892 - 122,369,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv372122,174,628 - 122,194,654 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362122,040,333 - 122,058,265 (-)NCBIMGSCv36mm8
Celera2123,498,710 - 123,518,780 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.63NCBI
Shf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,749,903 - 129,769,912 (-)NCBIGRCr8
mRatBN7.23109,296,517 - 109,316,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,296,784 - 109,316,328 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03114,288,021 - 114,307,334 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,287,718 - 114,307,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,827,311 - 120,837,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,129,634 - 109,169,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3108,194,195 - 108,213,507 (-)NCBICelera
Cytogenetic Map3q35NCBI
Shf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,201,663 - 8,227,921 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,219,295 - 8,227,877 (+)NCBIChiLan1.0ChiLan1.0
SHF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,589,648 - 11,609,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,590,211 - 11,609,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,645,934 - 11,665,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,726,634 - 11,745,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,717,866 - 11,745,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,633,079 - 11,652,390 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,755,585 - 11,774,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,875,432 - 11,894,798 (-)NCBIUU_Cfam_GSD_1.0
Shf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,033,406 - 90,053,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,879,141 - 7,901,589 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,881,484 - 7,901,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,549,747 - 126,570,859 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,549,736 - 126,570,657 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,148,729 - 141,169,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,005,743 - 38,036,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048103,022,623 - 103,043,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,064,741 - 14,079,957 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,064,741 - 14,079,849 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000021897   ⟹   ENSPPAP00000004790
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,469,202 - 42,500,239 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000021909   ⟹   ENSPPAP00000004792
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,473,158 - 42,489,184 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000021910   ⟹   ENSPPAP00000004793
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1542,473,158 - 42,489,184 (-)Ensembl
RefSeq Acc Id: XM_008961935   ⟹   XP_008960183
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,407,405 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,585,576 - 38,606,320 (-)NCBI
Mhudiblu_PPA_v01524,114,841 - 24,135,571 (-)NCBI
PanPan1.11542,468,468 - 42,489,184 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034938685   ⟹   XP_034794576
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,407,405 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,585,576 - 38,606,320 (-)NCBI
Mhudiblu_PPA_v01524,114,841 - 24,135,571 (-)NCBI
RefSeq Acc Id: XM_034938690   ⟹   XP_034794581
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,407,405 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,585,576 - 38,606,320 (-)NCBI
Mhudiblu_PPA_v01524,114,205 - 24,135,571 (-)NCBI
RefSeq Acc Id: XM_034938691   ⟹   XP_034794582
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,407,405 - 34,439,252 (-)NCBI
NHGRI_mPanPan11538,585,576 - 38,617,444 (-)NCBI
Mhudiblu_PPA_v01524,114,841 - 24,146,702 (-)NCBI
RefSeq Acc Id: XM_055098384   ⟹   XP_054954359
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,393,075 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,571,242 - 38,606,320 (-)NCBI
RefSeq Acc Id: XM_055098386   ⟹   XP_054954361
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,410,547 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,588,718 - 38,606,320 (-)NCBI
RefSeq Acc Id: XM_055098388   ⟹   XP_054954363
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,410,547 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,588,718 - 38,606,320 (-)NCBI
RefSeq Acc Id: XM_055098389   ⟹   XP_054954364
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,407,405 - 34,439,369 (-)NCBI
NHGRI_mPanPan11538,585,576 - 38,617,573 (-)NCBI
RefSeq Acc Id: XR_008621069
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21634,393,075 - 34,428,135 (-)NCBI
NHGRI_mPanPan11538,571,242 - 38,606,320 (-)NCBI
RefSeq Acc Id: XP_008960183   ⟸   XM_008961935
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_034794581   ⟸   XM_034938690
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034794582   ⟸   XM_034938691
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034794576   ⟸   XM_034938685
- Peptide Label: isoform X1
Ensembl Acc Id: ENSPPAP00000004790   ⟸   ENSPPAT00000021897
Ensembl Acc Id: ENSPPAP00000004792   ⟸   ENSPPAT00000021909
Ensembl Acc Id: ENSPPAP00000004793   ⟸   ENSPPAT00000021910
RefSeq Acc Id: XP_054954359   ⟸   XM_055098384
- Peptide Label: isoform X2
- UniProtKB: A0A2R8ZIJ3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954364   ⟸   XM_055098389
- Peptide Label: isoform X8
RefSeq Acc Id: XP_054954363   ⟸   XM_055098388
- Peptide Label: isoform X5
- UniProtKB: A0A2R8ZIJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054954361   ⟸   XM_055098386
- Peptide Label: isoform X4
- UniProtKB: A0A2R8ZIJ3 (UniProtKB/TrEMBL)
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000019951 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000021897.1 UniProtKB/TrEMBL
  ENSPPAT00000021909.1 UniProtKB/TrEMBL
  ENSPPAT00000021910.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2_domain_adapters UniProtKB/TrEMBL
  SHF_SH2 UniProtKB/TrEMBL
NCBI Gene SHF ENTREZGENE
PANTHER HEAVYWEIGHT, ISOFORM A UniProtKB/TrEMBL
  PTHR15127:SF28 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R8ZIJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZIJ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZLI0_PANPA UniProtKB/TrEMBL