Shf (Src homology 2 domain containing F) - Rat Genome Database

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Gene: Shf (Src homology 2 domain containing F) Ictidomys tridecemlineatus
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Symbol: Shf
Name: Src homology 2 domain containing F
RGD ID: 12470257
Description: ENCODES a protein that exhibits phosphotyrosine residue binding (inferred); PARTICIPATES IN platelet-derived growth factor signaling pathway; ASSOCIATED WITH AGAT deficiency (ortholog); Bloom syndrome (ortholog); colorectal cancer (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: SH2 domain-containing adapter protein F; Src homology 2 domain containing F, transcript variant X2; Src homology 2 domain containing F, transcript variant X3; Src homology 2 domain containing F, transcript variant X4; Src homology 2 domain containing F, transcript variant X5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,033,406 - 90,053,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,879,141 - 7,901,589 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,881,484 - 7,901,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Shf
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864090,033,406 - 90,053,526 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364717,879,141 - 7,901,589 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364717,881,484 - 7,901,583 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SHF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381545,167,214 - 45,201,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1545,167,214 - 45,201,175 (-)EnsemblGRCh38hg38GRCh38
GRCh371545,459,412 - 45,493,314 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361543,246,704 - 43,280,665 (-)NCBINCBI36Build 36hg18NCBI36
Celera1522,350,695 - 22,384,650 (-)NCBICelera
Cytogenetic Map15q21.1NCBI
HuRef1522,283,482 - 22,317,406 (-)NCBIHuRef
CHM1_11545,578,088 - 45,611,982 (-)NCBICHM1_1
T2T-CHM13v2.01542,975,223 - 43,009,099 (-)NCBIT2T-CHM13v2.0
Shf
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392122,179,373 - 122,199,650 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2122,179,373 - 122,199,643 (-)EnsemblGRCm39 Ensembl
GRCm382122,348,892 - 122,369,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2122,348,892 - 122,369,162 (-)EnsemblGRCm38mm10GRCm38
MGSCv372122,174,628 - 122,194,654 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362122,040,333 - 122,058,265 (-)NCBIMGSCv36mm8
Celera2123,498,710 - 123,518,780 (-)NCBICelera
Cytogenetic Map2E5NCBI
cM Map260.63NCBI
Shf
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83129,749,903 - 129,769,912 (-)NCBIGRCr8
mRatBN7.23109,296,517 - 109,316,315 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3109,296,784 - 109,316,328 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.03114,288,021 - 114,307,334 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3114,287,718 - 114,307,250 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03120,827,311 - 120,837,513 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43109,129,634 - 109,169,928 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera3108,194,195 - 108,213,507 (-)NCBICelera
Cytogenetic Map3q35NCBI
Shf
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554098,201,663 - 8,227,921 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554098,219,295 - 8,227,877 (+)NCBIChiLan1.0ChiLan1.0
SHF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21634,393,075 - 34,439,369 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11538,571,242 - 38,617,573 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01524,100,832 - 24,146,702 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11542,468,468 - 42,489,184 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1542,469,202 - 42,500,239 (-)Ensemblpanpan1.1panPan2
SHF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13011,589,648 - 11,609,425 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3011,590,211 - 11,609,837 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3011,645,934 - 11,665,283 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03011,726,634 - 11,745,945 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3011,717,866 - 11,745,945 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13011,633,079 - 11,652,390 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03011,755,585 - 11,774,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03011,875,432 - 11,894,798 (-)NCBIUU_Cfam_GSD_1.0
SHF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1126,549,747 - 126,570,859 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11126,549,736 - 126,570,657 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21141,148,729 - 141,169,643 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SHF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12638,005,743 - 38,036,378 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666048103,022,623 - 103,043,343 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Shf
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473114,064,741 - 14,079,957 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473114,064,741 - 14,079,849 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000022665   ⟹   ENSSTOP00000023108
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364717,882,191 - 7,901,588 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000042960   ⟹   ENSSTOP00000026825
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049364717,879,141 - 7,901,589 (-)Ensembl
RefSeq Acc Id: XM_005316523   ⟹   XP_005316580
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864090,033,406 - 90,053,526 (-)NCBI
SpeTri2.0NW_0049364717,881,484 - 7,901,583 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005316524   ⟹   XP_005316581
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440864090,033,406 - 90,053,520 (-)NCBI
SpeTri2.0NW_0049364717,881,484 - 7,901,583 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005316580   ⟸   XM_005316523
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005316581   ⟸   XM_005316524
- Peptide Label: isoform X1
- UniProtKB: A0A287CZR0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSSTOP00000026825   ⟸   ENSSTOT00000042960
Ensembl Acc Id: ENSSTOP00000023108   ⟸   ENSSTOT00000022665
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000026488 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000022665.2 UniProtKB/TrEMBL
  ENSSTOT00000042960.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
InterPro SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH2_domain_adapters UniProtKB/TrEMBL
  SHF_SH2 UniProtKB/TrEMBL
NCBI Gene Shf ENTREZGENE
PANTHER HEAVYWEIGHT, ISOFORM A UniProtKB/TrEMBL
  PTHR15127:SF28 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A287CZR0 ENTREZGENE, UniProtKB/TrEMBL
  I3NFG1_ICTTR UniProtKB/TrEMBL