LRRC32 (leucine rich repeat containing 32) - Rat Genome Database

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Gene: LRRC32 (leucine rich repeat containing 32) Pan paniscus
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Symbol: LRRC32
Name: leucine rich repeat containing 32
RGD ID: 11687074
Description: ENCODES a protein that exhibits receptor ligand inhibitor activity (inferred); transforming growth factor beta binding (inferred); INVOLVED IN negative regulation of activated T cell proliferation (ortholog); negative regulation of cytokine production (ortholog); positive regulation of gene expression (ortholog); ASSOCIATED WITH Cleft Palate, Proliferative Retinopathy, and Developmental Delay (ortholog); Developmental Disabilities (ortholog); intellectual disability (ortholog); FOUND IN cell surface (inferred); membrane (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat-containing protein 32; transforming growth factor beta activator LRRC32
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,579,273 - 77,592,573 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,624,450 - 78,637,749 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01171,708,222 - 71,721,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,354,997 - 75,368,187 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,354,997 - 75,367,440 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA)
membrane  (IEA)
nucleoplasm  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
LRRC32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2977,579,273 - 77,592,573 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11178,624,450 - 78,637,749 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01171,708,222 - 71,721,426 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11175,354,997 - 75,368,187 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,354,997 - 75,367,440 (-)Ensemblpanpan1.1panPan2
LRRC32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381176,657,524 - 76,670,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1176,657,524 - 76,670,747 (-)EnsemblGRCh38hg38GRCh38
GRCh371176,368,568 - 76,381,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,046,222 - 76,058,543 (-)NCBINCBI36Build 36hg18NCBI36
Build 341176,046,222 - 76,058,543NCBI
Celera1173,676,360 - 73,689,583 (-)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1172,666,014 - 72,679,237 (-)NCBIHuRef
CHM1_11176,252,093 - 76,265,313 (-)NCBICHM1_1
T2T-CHM13v2.01176,588,003 - 76,601,225 (-)NCBIT2T-CHM13v2.0
Lrrc32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,138,515 - 98,151,038 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,138,490 - 98,151,388 (+)EnsemblGRCm39 Ensembl
GRCm38798,489,305 - 98,501,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,489,283 - 98,502,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,642,732 - 105,650,341 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36798,369,414 - 98,375,198 (+)NCBIMGSCv36mm8
MGSCv36788,242,266 - 88,245,111 (+)NCBIMGSCv36mm8
Celera798,817,398 - 98,825,017 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.86NCBI
Lrrc32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81162,196,995 - 162,209,563 (+)NCBIGRCr8
mRatBN7.21152,785,709 - 152,802,997 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1152,786,511 - 152,798,373 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1160,775,758 - 160,787,610 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01167,955,926 - 167,967,778 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01160,829,451 - 160,841,303 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01163,443,972 - 163,457,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1163,445,527 - 163,457,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01169,648,351 - 169,661,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,760,527 - 155,771,294 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11155,838,894 - 155,849,700 (+)NCBI
Celera1150,875,833 - 150,887,643 (+)NCBICelera
Cytogenetic Map1q32NCBI
Lrrc32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,296,563 - 15,309,088 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,296,704 - 15,309,088 (+)NCBIChiLan1.0ChiLan1.0
LRRC32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,051,140 - 22,059,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,051,920 - 22,057,632 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,875,962 - 21,895,388 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02122,249,186 - 22,268,633 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2122,249,292 - 22,261,763 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12122,024,459 - 22,043,872 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02122,243,899 - 22,263,312 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02122,163,062 - 22,182,511 (+)NCBIUU_Cfam_GSD_1.0
Lrrc32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,706,129 - 63,716,750 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364985,305,545 - 5,315,539 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364985,305,680 - 5,315,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,802,236 - 10,815,563 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,802,228 - 10,815,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,913,105 - 11,926,575 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC32
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,866,072 - 67,879,177 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,864,609 - 67,879,160 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604357,909,760 - 57,923,072 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc32
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624817497,372 - 510,580 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624817497,415 - 510,061 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000032838   ⟹   ENSPPAP00000010190
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1175,354,997 - 75,367,440 (-)Ensembl
RefSeq Acc Id: XM_003808154   ⟹   XP_003808202
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2977,579,273 - 77,592,573 (-)NCBI
NHGRI_mPanPan11178,625,958 - 78,637,726 (-)NCBI
Mhudiblu_PPA_v01171,708,222 - 71,721,423 (-)NCBI
PanPan1.11175,354,997 - 75,368,187 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346939   ⟹   XP_014202425
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2977,579,273 - 77,592,137 (-)NCBI
NHGRI_mPanPan11178,625,958 - 78,637,015 (-)NCBI
Mhudiblu_PPA_v01171,708,222 - 71,720,892 (-)NCBI
PanPan1.11175,354,997 - 75,367,561 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034933416   ⟹   XP_034789307
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2977,579,273 - 77,592,502 (-)NCBI
NHGRI_mPanPan11178,624,450 - 78,637,749 (-)NCBI
Mhudiblu_PPA_v01171,708,222 - 71,721,426 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003808202 (Get FASTA)   NCBI Sequence Viewer  
  XP_014202425 (Get FASTA)   NCBI Sequence Viewer  
  XP_034789307 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000010190.1
RefSeq Acc Id: XP_003808202   ⟸   XM_003808154
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A4I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014202425   ⟸   XM_014346939
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A4I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034789307   ⟸   XM_034933416
- Peptide Label: isoform X2
Ensembl Acc Id: ENSPPAP00000010190   ⟸   ENSPPAT00000032838
Protein Domains
LRRNT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028327 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000032838.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Dev_Immune_Receptor UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
KEGG Report pps:100977955 UniProtKB/TrEMBL
NCBI Gene LRRC32 ENTREZGENE
PANTHER SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/TrEMBL
  TIR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_BAC UniProtKB/TrEMBL
  LRR_RI UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  Outer arm dynein light chain 1 UniProtKB/TrEMBL
UniProt A0A2R9A4I4 ENTREZGENE, UniProtKB/TrEMBL