Lrrc32 (leucine rich repeat containing 32) - Rat Genome Database

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Gene: Lrrc32 (leucine rich repeat containing 32) Mus musculus
Analyze
Symbol: Lrrc32
Name: leucine rich repeat containing 32
RGD ID: 1623564
MGI Page MGI
Description: Exhibits transforming growth factor beta binding activity. Involved in negative regulation of activated T cell proliferation; regulation of gene expression; and secondary palate development. Predicted to localize to several cellular components, including cell surface; extracellular space; and nucleoplasm. Is expressed in several structures, including genitourinary system; lung; sensory organ; skeletal muscle; and skin. Orthologous to human LRRC32 (leucine rich repeat containing 32); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI426318; D11S833E; D11S833Eh; D7H11S833; D7H11S833E; EG434215; expressed sequence AI426318; G; Garp; garpin; glycoprotein A repetitions predominant; leucine-rich repeat-containing protein 32; transforming growth factor beta activator LRRC32
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,138,515 - 98,151,038 (+)NCBIGRCm39mm39
GRCm39 Ensembl798,138,490 - 98,151,388 (+)Ensembl
GRCm38798,489,305 - 98,501,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,489,283 - 98,502,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,642,732 - 105,650,341 (+)NCBIGRCm37mm9NCBIm37
MGSCv36788,242,266 - 88,245,111 (+)NCBImm8
MGSCv36798,369,414 - 98,375,198 (+)NCBImm8
Celera798,817,398 - 98,825,017 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.86NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:1543912   PMID:8840187   PMID:18628982   PMID:21267068   PMID:21543717   PMID:21873635   PMID:23576681   PMID:23645881   PMID:24115398   PMID:25127859   PMID:25182959   PMID:26246140  
PMID:27062243   PMID:28278197   PMID:28912269   PMID:29618665   PMID:29909984   PMID:30550785   PMID:30674536   PMID:31915300   PMID:32040930   PMID:32499651  


Genomics

Comparative Map Data
Lrrc32
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,138,515 - 98,151,038 (+)NCBIGRCm39mm39
GRCm39 Ensembl798,138,490 - 98,151,388 (+)Ensembl
GRCm38798,489,305 - 98,501,831 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl798,489,283 - 98,502,181 (+)EnsemblGRCm38mm10GRCm38
MGSCv377105,642,732 - 105,650,341 (+)NCBIGRCm37mm9NCBIm37
MGSCv36788,242,266 - 88,245,111 (+)NCBImm8
MGSCv36798,369,414 - 98,375,198 (+)NCBImm8
Celera798,817,398 - 98,825,017 (+)NCBICelera
Cytogenetic Map7E1NCBI
cM Map753.86NCBI
LRRC32
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1176,657,524 - 76,670,747 (-)EnsemblGRCh38hg38GRCh38
GRCh381176,657,524 - 76,670,747 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371176,368,568 - 76,381,791 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361176,046,222 - 76,058,543 (-)NCBINCBI36hg18NCBI36
Build 341176,046,222 - 76,058,543NCBI
Celera1173,676,360 - 73,689,583 (-)NCBI
Cytogenetic Map11q13.5NCBI
HuRef1172,666,014 - 72,679,237 (-)NCBIHuRef
CHM1_11176,252,093 - 76,265,313 (-)NCBICHM1_1
Lrrc32
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21152,785,709 - 152,802,997 (+)NCBI
Rnor_6.0 Ensembl1163,445,527 - 163,457,424 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01163,443,972 - 163,457,426 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01169,648,351 - 169,661,088 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41155,760,527 - 155,771,294 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11155,838,894 - 155,849,700 (+)NCBI
Celera1150,875,833 - 150,887,643 (+)NCBICelera
Cytogenetic Map1q32NCBI
Lrrc32
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541415,296,563 - 15,309,088 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541415,296,704 - 15,309,088 (+)NCBIChiLan1.0ChiLan1.0
LRRC32
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11175,354,997 - 75,368,187 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1175,354,997 - 75,367,440 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01171,708,222 - 71,721,426 (-)NCBIMhudiblu_PPA_v0panPan3
LRRC32
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12122,051,140 - 22,059,714 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2122,051,920 - 22,057,632 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2121,875,962 - 21,895,388 (+)NCBI
ROS_Cfam_1.02122,249,186 - 22,268,633 (+)NCBI
UMICH_Zoey_3.12122,024,459 - 22,043,872 (+)NCBI
UNSW_CanFamBas_1.02122,243,899 - 22,263,312 (+)NCBI
UU_Cfam_GSD_1.02122,163,062 - 22,182,511 (+)NCBI
Lrrc32
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,706,129 - 63,716,750 (-)NCBI
SpeTri2.0NW_0049364985,305,680 - 5,315,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC32
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl910,801,946 - 10,817,930 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1910,802,228 - 10,815,892 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2911,913,105 - 11,926,575 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC32
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,866,072 - 67,879,177 (-)NCBI
ChlSab1.1 Ensembl167,864,609 - 67,879,160 (-)Ensembl
Lrrc32
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624817497,415 - 510,061 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
26884404Huml1_mhumerus length 1, 5 week (mouse)730500000109400000Mouse
1301082Bbaa16_mB.burgdorferi-associated arthritis 16 (mouse)Not determined736580590116817642Mouse
1300791Abbp3_mA/J and C57BL/6 blood pressure 3 (mouse)Not determined740024463103860803Mouse
10043926Bw1n_mbody weight 1 in NSY (mouse)Not determined745512542119094307Mouse
13208555Lgth10_mbody length 10 (mouse)752000000126000000Mouse
27226751Femd5_mfemur midshaft diameter 5, 10 week (mouse)753600000143600000Mouse
25823170Hrsq7_mhost response to SARS QTL 7, log titer (mouse)755169841117223580Mouse
27226778Femd11_mfemur midshaft diameter 11, 16 week (mouse)757300000134400000Mouse
26884408Bzwq13_mbi-zygomatic width QTL 13, 16 week (mouse)762100000121800000Mouse
27095916Scvln15_msacral vertebrae length 2, 16 week (mouse)762100000124100000Mouse
25314305Vmm6_mvariable multisystem mineralization 6, eye (mouse)762200000103100000Mouse
26884440Sklq4_mskull length QTL 4, 5 week (mouse)765600000126900000Mouse
11553865Stmm1c_mskin tumor modifier of MSM 1c (mouse)766139778100139778Mouse
11553866Stmm1d_mskin tumor modifier of MSM 1d (mouse)766139778100139778Mouse
27095937Ulnl7_mulna length 7, 10 week (mouse)76680000098700000Mouse
1301784Ses2_msalmonella enteritidis susceptibility 2 (mouse)Not determined767640886101641032Mouse
1301826Pgia3_mproteoglycan induced arthritis 3 (mouse)Not determined767640886101641032Mouse
1300620Pgia21_mproteoglycan induced arthritis 21 (mouse)Not determined767640886101641032Mouse
26884418Bzwq7_mbi-zygomatic width QTL 7, 10 week (mouse)768200000105800000Mouse
27226715Metcl3_mmetatarsal-calcaneal length 3, 5 week (mouse)768200000119900000Mouse
26884444Sklq8_mskull length QTL 8, 10 week (mouse)768200000124600000Mouse
26884451Sklq14_mskull length QTL 14, 16 week (mouse)768200000125400000Mouse
1300654Bomd1_mbone mineral density 1 (mouse)Not determined768716387102716494Mouse
27095907Scvln4_msacral vertebrae length 2, 5 week (mouse)770300000120900000Mouse
1301155Bpq7_mblood pressure QTL 7 (mouse)Not determined770493929104494171Mouse
10043973Obq29_mobesity QTL 29 (mouse)Not determined772614164106614164Mouse
27095910Pglq13_mpelvic girdle length QTL 13, 16 week (mouse)773400000126100000Mouse
27095933Ulnl3_mulna length 3, 5 week (mouse)773500000143600000Mouse
11553869Stmm2b_mskin tumor modifier of MSM 2a (mouse)774076757108076757Mouse
27226745Metcl9_mmetatarsal-calcaneal length 9, 10 week (mouse)775200000122600000Mouse
27226781Tibl3_mtibia length 3, 5 week (mouse)775200000122600000Mouse
1301566Adip3_madiposity 3 (mouse)Not determined775745007109745138Mouse
14746989Manh62_mmandible shape 62 (mouse)776093321110093321Mouse
26884398Humsd6_mhumerus midshaft diameter 6, 16 week (mouse)779000000137300000Mouse
4142500Morq1_mmodifier of Rs1 QTL 1 (mouse)Not determined80902474114902584Mouse
10412110Cctq1_mcentral corneal thickness QTL 1 (mouse)Not determined780902474114902584Mouse
27095930Ulnl10_mulna length 10, 16 week (mouse)781200000127100000Mouse
27095923Pglq3_mpelvic girdle length QTL 3, 5 week (mouse)781600000124600000Mouse
27095903Scvln10_msacral vertebrae length 2, 10 week (mouse)781800000126900000Mouse
27226765Tibl18_mtibia length 18, 16 week (mouse)782200000126900000Mouse
27226763Feml20_mfemur length 20, 16 week (mouse)785400000124600000Mouse
1301997Cia7_mcollagen induced arthritis QTL 7 (mouse)Not determined785716387112934612Mouse
27226792Feml7_mfemur length 7, 5 week (mouse)78650000099300000Mouse
1301647Elpt_melevated leptin (mouse)Not determined786850979120851122Mouse
1302062Stheal6_msoft tissue heal 6 (mouse)Not determined787394725121394859Mouse
1301188Heal6_mwound healing/regeneration 6 (mouse)Not determined787394725121394859Mouse
13463473Hbbcq4_mhemoglobin concentration QTL 4 (mouse)787394725121394859Mouse
1301781Capsq3_mcapsaicin sensitivity related QTL 3 (mouse)Not determined787493929119886157Mouse
27226769Tibl12_mtibia length 12, 10 week (mouse)787600000126900000Mouse
27226790Feml15_mfemur length 15, 10 week (mouse)787600000126900000Mouse
27095929Pglq8_mpelvic girdle length QTL 8, 10 week (mouse)788200000108500000Mouse
1301937Skull10_mskull morphology 10 (mouse)Not determined791883789125883949Mouse
1357664Nba3_mNew Zealand Black autoimmunity 3 (mouse)Not determined791883789125883949Mouse
1300528Ssial3_msusceptibility to sialadenitis 3 (mouse)Not determined793792641127792834Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:951
Count of miRNA genes:516
Interacting mature miRNAs:629
Transcripts:ENSMUST00000165205
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000165205   ⟹   ENSMUSP00000133205
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl798,494,222 - 98,501,831 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205937   ⟹   ENSMUSP00000146299
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl798,489,283 - 98,498,254 (+)Ensembl
RefSeq Acc Id: ENSMUST00000205956   ⟹   ENSMUSP00000145859
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl798,489,697 - 98,502,181 (+)Ensembl
RefSeq Acc Id: NM_001113379   ⟹   NP_001106850
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,139,198 - 98,151,038 (+)NCBI
GRCm38798,489,991 - 98,501,831 (+)NCBI
Celera796,271,240 - 96,272,261 (+)NCBI
Celera798,817,398 - 98,825,017 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006507978   ⟹   XP_006508041
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,141,246 - 98,151,038 (+)NCBI
GRCm38798,492,040 - 98,501,831 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006507979   ⟹   XP_006508042
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39798,138,515 - 98,151,038 (+)NCBI
GRCm38798,489,305 - 98,501,831 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001106850 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508041 (Get FASTA)   NCBI Sequence Viewer  
  XP_006508042 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL16346 (Get FASTA)   NCBI Sequence Viewer  
  G3XA59 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001106850   ⟸   NM_001113379
- Peptide Label: precursor
- UniProtKB: G3XA59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508042   ⟸   XM_006507979
- Peptide Label: isoform X1
- UniProtKB: G3XA59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006508041   ⟸   XM_006507978
- Peptide Label: isoform X1
- UniProtKB: G3XA59 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000146299   ⟸   ENSMUST00000205937
RefSeq Acc Id: ENSMUSP00000145859   ⟸   ENSMUST00000205956
RefSeq Acc Id: ENSMUSP00000133205   ⟸   ENSMUST00000165205
Protein Domains
LRRCT   LRRNT


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:93882 AgrOrtholog
Ensembl Genes ENSMUSG00000090958 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000133205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000145859 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146299 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000165205 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000205937 UniProtKB/TrEMBL
  ENSMUST00000205956 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:434215 UniProtKB/Swiss-Prot
MGD MGI:93882 ENTREZGENE
NCBI Gene 434215 ENTREZGENE
Pfam LRR_8 UniProtKB/Swiss-Prot
PhenoGen Lrrc32 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot
SMART LRR_TYP UniProtKB/Swiss-Prot
UniProt A0A5H1ZRN3_MOUSE UniProtKB/TrEMBL
  G3XA59 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A0A0U1RQ93 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Lrrc32  leucine rich repeat containing 32  AI426318  expressed sequence AI426318  Data Merged 737654 PROVISIONAL
2014-09-17 Lrrc32  leucine rich repeat containing 32  EG434215  predicted gene, EG434215  Symbol and/or name change 5135510 APPROVED