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Gene: Oca2 (oculocutaneous albinism II) Mus musculus
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Symbol: Oca2
Name: oculocutaneous albinism II
Description: Involved in several processes, including melanin biosynthetic process; melanocyte differentiation; and spermatid development. Predicted to localize to bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in 4th ventricle; brain; choroid plexus; and lateral ventricle choroid plexus. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein); INTERACTS WITH 5,6-dihydroxyindole-2-carboxylic acid; Cysteinyldopa; N-ethyl-N-nitrosourea.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D7H15S12; D7Icr28RN; D7Nic1; melanocyte-specific transporter protein; Oca2; p; p; pink-eyed dilution protein
Orthologs:
Homo sapiens (human) : OCA2 (OCA2 melanosomal transmembrane protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Oca2 (OCA2 melanosomal transmembrane protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oca2 (OCA2 melanosomal transmembrane protein)
Pan paniscus (bonobo/pygmy chimpanzee) : OCA2 (OCA2 melanosomal transmembrane protein)
Canis lupus familiaris (dog) : OCA2 (OCA2 melanosomal transmembrane protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oca2 (OCA2 melanosomal transmembrane protein)
Sus scrofa (pig) : OCA2 (OCA2 melanosomal transmembrane protein)
Chlorocebus sabaeus (African green monkey) : OCA2 (OCA2 melanosomal transmembrane protein)
Heterocephalus glaber (naked mole-rat) : Oca2 (OCA2 melanosomal transmembrane protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl756,239,760 - 56,536,518 (+)EnsemblGRCm38mm10GRCm38
GRCm38756,239,593 - 56,536,518 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37763,495,141 - 63,791,887 (+)NCBIGRCm37mm9NCBIm37
MGSCv36756,107,790 - 56,404,536 (+)NCBImm8
Celera753,578,935 - 53,870,549 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Oca2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11027
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.