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Gene: Oca2 (oculocutaneous albinism II) Mus musculus
Symbol: Oca2
Name: oculocutaneous albinism II
Description: Involved in several processes, including melanin biosynthetic process; melanocyte differentiation; and spermatid development. Predicted to localize to bounding membrane of organelle and endoplasmic reticulum membrane. Is expressed in 4th ventricle; brain; choroid plexus; and lateral ventricle choroid plexus. Used to study oculocutaneous albinism. Human ortholog(s) of this gene implicated in actinic keratosis; oculocutaneous albinism type II; pigmentation disease; skin cancer (multiple); and squamous cell carcinoma. Orthologous to human OCA2 (OCA2 melanosomal transmembrane protein); INTERACTS WITH 5,6-dihydroxyindole-2-carboxylic acid; Cysteinyldopa; N-ethyl-N-nitrosourea.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: D7H15S12; D7Icr28RN; D7Nic1; melanocyte-specific transporter protein; Oca2; p; p; pink-eyed dilution protein
Homo sapiens (human) : OCA2 (OCA2 melanosomal transmembrane protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Oca2 (OCA2 melanosomal transmembrane protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Oca2 (OCA2 melanosomal transmembrane protein)
Pan paniscus (bonobo/pygmy chimpanzee) : OCA2 (OCA2 melanosomal transmembrane protein)
Canis lupus familiaris (dog) : OCA2 (OCA2 melanosomal transmembrane protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Oca2 (OCA2 melanosomal transmembrane protein)
Sus scrofa (pig) : OCA2 (OCA2 melanosomal transmembrane protein)
Chlorocebus sabaeus (African green monkey) : OCA2 (OCA2 melanosomal transmembrane protein)
Heterocephalus glaber (naked mole-rat) : Oca2 (OCA2 melanosomal transmembrane protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl756,239,760 - 56,536,518 (+)EnsemblGRCm38mm10GRCm38
GRCm38756,239,593 - 56,536,518 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37763,495,141 - 63,791,887 (+)NCBIGRCm37mm9NCBIm37
MGSCv36756,107,790 - 56,404,536 (+)NCBImm8
Celera753,578,935 - 53,870,549 (+)NCBICelera
Cytogenetic Map7B5NCBI
cM Map733.44NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Oca2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11027
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.