GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tnf | decreases expression | EXP | | 6480464 | CTD | Thalidomide results in decreased expression of TNF mRNA | PMID:14617101 | Tnf | multiple interactions | EXP | | 6480464 | CTD | Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide] | PMID:10720640 PMID:15060740 PMID:16510725 PMID:16680017 PMID:23510834 PMID:25478868 PMID:26051520 | Tnf | decreases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein | PMID:11367517 PMID:11592764 PMID:11788559 PMID:12422154 PMID:15863203 PMID:15982930 PMID:16454849 | Tnf | decreases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Thalidomide results in decreased expression of TNF protein | PMID:16078585 PMID:16597438 PMID:18291259 | Tnf | increases degradation | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Thalidomide results in increased degradation of TNF mRNA | PMID:16078585 | Tnf | increases expression | ISO | TNF (Homo sapiens) | 6480464 | CTD | Thalidomide results in increased expression of TNF protein | PMID:9623511 | Tnf | increases expression | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Thalidomide results in increased expression of TNF mRNA | PMID:16549389 | Tnf | multiple interactions | ISO | TNF (Homo sapiens) | 6480464 | CTD | Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein] | PMID:10496904 PMID:12411981 PMID:14687169 PMID:15687330 PMID:9068814 | Tnf | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein] | PMID:15464241 PMID:16597438 PMID:16604421 PMID:16815871 PMID:16943688 PMID:19050852 PMID:26221080 | | ||||||||||||||||||||||
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