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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10876
Species: Mus musculus
RGD Object: Gene
Symbol: Lpl
Name: lipoprotein lipase
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lplmultiple interactionsEXP 6480464CTD[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of LPL mRNAPMID:25446853 PMID:29127188
Lplmultiple interactionsISOLpl (Rattus norvegicus)6480464CTD[Streptozocin co-treated with Cadmium] results in decreased activity of LPL protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein; [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]PMID:20696151 PMID:25240712
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