Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:streptozocin
go back to main search page
Accession:CHEBI:9288 term browser browse the term
Definition:An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Synonyms:exact_synonym: 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
 related_synonym: 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose;   2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose;   Formula=C8H15N3O7;   InChI=1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1;   InChIKey=ZSJLQEPLLKMAKR-GKHCUFPYSA-N;   N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff;   N-D-Glucosyl-(2)-N'-nitrosomethylurea;   SMILES=CN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O;   Streptozocinium;   Streptozotocin;   Zanosar;   estreptozocina;   streptozocine;   streptozocinum
 xref: Beilstein:2060675;   CAS:18883-66-4;   DrugBank:DB00428;   HMDB:HMDB0014572;   KEGG:C07313;   KEGG:D05932
 xref_mesh: MESH:D013311
 xref: PMID:12613763;   PMID:23151907;   PMID:23333576;   PMID:23600389;   PMID:23612842;   PMID:23662406;   PMID:2954873;   Patent:FR1434920;   Patent:US2005271747;   Patent:US2005272738;   Patent:US2008085882;   Patent:US4156777;   Reaxys:2060675;   Wikipedia:Streptozocin


show annotations for term's descendants           Sort by:
 
streptozocin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G 1810013A23Rik RIKEN cDNA 1810013A23 gene multiple interactions
decreases expression
ISO Olive Oil inhibits the reaction [Streptozocin results in decreased expression of PPARD mRNA] CTD PMID:25246140 NCBI chr17:28,271,708...28,273,163
Ensembl chr17:28,232,700...28,301,474
JBrowse link
G Abcb11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 increases activity
increases expression
ISO
EXP
Streptozocin results in increased activity of ABCB11 protein
Streptozocin results in increased expression of ABCB11 protein
CTD PMID:12055592, PMID:23319174 NCBI chr 2:69,238,282...69,342,616
Ensembl chr 2:69,238,282...69,342,616
JBrowse link
G Abcb1b ATP-binding cassette, sub-family B (MDR/TAP), member 1B decreases expression
increases expression
EXP Streptozocin results in decreased expression of ABCB1B mRNA; Streptozocin results in decreased expression of ABCB1B protein
Streptozocin results in increased expression of ABCB1B protein
CTD PMID:22531820, PMID:23319174 NCBI chr 5:8,798,147...8,866,314
Ensembl chr 5:8,798,147...8,866,315
JBrowse link
G Abcb4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 increases expression ISO Streptozocin results in increased expression of ABCB4 mRNA; Streptozocin results in increased expression of ABCB4 protein CTD PMID:12055592 NCBI chr 5:8,893,614...8,959,226
Ensembl chr 5:8,893,717...8,959,231
JBrowse link
G Abcc1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 increases expression EXP Streptozocin results in increased expression of ABCC1 mRNA; Streptozocin results in increased expression of ABCC1 protein CTD PMID:22531820, PMID:23319174 NCBI chr16:14,361,453...14,474,878
Ensembl chr16:14,361,558...14,475,737
JBrowse link
G Abcc2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 increases expression ISO
EXP
Streptozocin results in increased expression of ABCC2 mRNA
Streptozocin results in increased expression of ABCC2 mRNA; Streptozocin results in increased expression of ABCC2 protein
CTD PMID:11752103, PMID:22531820, PMID:23319174 NCBI chr19:43,782,308...43,838,332
Ensembl chr19:43,782,192...43,840,740
JBrowse link
G Abcc3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 decreases expression
multiple interactions
increases expression
EXP
ISO
Streptozocin results in decreased expression of ABCC3 mRNA
[resveratrol co-treated with Streptozocin] results in increased expression of ABCC3 mRNA
Streptozocin results in increased expression of ABCC3 mRNA; Streptozocin results in increased expression of ABCC3 protein
CTD PMID:22531820, PMID:23319174, PMID:25905778 NCBI chr11:94,343,295...94,393,017
Ensembl chr11:94,343,295...94,392,997
JBrowse link
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 increases expression
multiple interactions
EXP Streptozocin results in increased expression of ABCC4 mRNA; Streptozocin results in increased expression of ABCC4 protein
[Dietary Fats co-treated with Streptozocin] results in increased expression of ABCC4 mRNA
CTD PMID:22531820, PMID:23319174, PMID:29382564 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Abcc5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 increases expression EXP Streptozocin results in increased expression of ABCC5 mRNA; Streptozocin results in increased expression of ABCC5 protein CTD PMID:22531820, PMID:23319174 NCBI chr16:20,331,303...20,426,428
Ensembl chr16:20,331,303...20,426,394
JBrowse link
G Abcc6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 decreases expression EXP Streptozocin results in decreased expression of ABCC6 protein CTD PMID:22531820 NCBI chr 7:45,974,110...46,030,491
Ensembl chr 7:45,967,555...46,030,302
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 (Junior blood group) increases expression EXP Streptozocin results in increased expression of ABCG2 mRNA; Streptozocin results in increased expression of ABCG2 protein CTD PMID:23319174 NCBI chr 6:58,584,491...58,692,451
Ensembl chr 6:58,584,523...58,695,676
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 increases expression EXP Streptozocin results in increased expression of ABCG5 mRNA CTD PMID:23319174 NCBI chr17:84,658,174...84,683,011
Ensembl chr17:84,658,234...84,683,011
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Streptozocin results in increased expression of ABCG8 mRNA CTD PMID:23319174 NCBI chr17:84,676,302...84,700,333
Ensembl chr17:84,676,302...84,700,333
JBrowse link
G Abhd2 abhydrolase domain containing 2 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ABHD2 mRNA CTD PMID:29127188 NCBI chr 7:79,273,266...79,361,601
Ensembl chr 7:79,273,199...79,365,508
JBrowse link
G Acaca acetyl-Coenzyme A carboxylase alpha multiple interactions
increases expression
decreases expression
decreases activity
ISO Fructose inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Fructose inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]; Triiodothyronine inhibits the reaction [Streptozocin results in decreased activity of ACACA protein]; Triiodothyronine inhibits the reaction [Streptozocin results in decreased expression of ACACA mRNA]
Streptozocin results in increased expression of ACACA mRNA
CTD PMID:1973097, PMID:28822685 NCBI chr11:84,129,635...84,401,651
Ensembl chr11:84,129,672...84,401,651
JBrowse link
G Acadm acyl-Coenzyme A dehydrogenase, medium chain decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ACADM protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ACADM protein]
CTD PMID:19634143 NCBI chr 3:153,922,353...153,944,643
Ensembl chr 3:153,922,357...153,944,632
JBrowse link
G Acat1 acetyl-Coenzyme A acetyltransferase 1 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ACAT1 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ACAT1 protein]
CTD PMID:19634143 NCBI chr 9:53,580,522...53,610,350
Ensembl chr 9:53,580,522...53,610,382
JBrowse link
G Acbd6 acyl-Coenzyme A binding domain containing 6 increases expression ISO Streptozocin results in increased expression of ACBD6 mRNA CTD PMID:25905778 NCBI chr 1:155,558,099...155,687,474
Ensembl chr 1:155,558,120...155,691,330
JBrowse link
G Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 multiple interactions
increases expression
ISO Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of ACE protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ACE protein]
Streptozocin results in increased expression of ACE mRNA; Streptozocin results in increased expression of ACE protein
CTD PMID:15793251, PMID:16979161, PMID:22191573, PMID:23733546 NCBI chr11:105,967,948...105,989,964
Ensembl chr11:105,967,945...105,989,964
JBrowse link
G Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2 decreases expression
multiple interactions
EXP
ISO
Streptozocin results in decreased expression of ACE2 protein
ACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]; ACE2 inhibits the reaction [Streptozocin results in increased expression of TGFB1 protein]; ACE2 inhibits the reaction [Streptozocin results in increased expression of VEGFA protein]
telmisartan inhibits the reaction [Streptozocin results in decreased expression of ACE2 protein]
CTD PMID:20844835, PMID:21381899 NCBI chr  X:164,139,342...164,188,418
Ensembl chr  X:164,139,332...164,188,420
JBrowse link
G Acer2 alkaline ceramidase 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of ACER2 mRNA CTD PMID:25905778 NCBI chr 4:86,874,348...86,932,524
Ensembl chr 4:86,874,396...86,934,822
JBrowse link
G Ache acetylcholinesterase multiple interactions
increases activity
EXP
ISO
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Alendronate inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Curcumin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Genistein inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Indinavir inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Lisinopril inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Physostigmine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Telmisartan inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein; alpha-Tocopherol inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Canagliflozin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of ACHE protein]; Donepezil inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; geraniol inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Melatonin inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; pyrazolanthrone inhibits the reaction [Streptozocin results in increased activity of ACHE protein]; Tocotrienols inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
CTD PMID:18208924, PMID:18343489, PMID:19464315, PMID:19705549, PMID:20369229, PMID:20600246, PMID:23060470, PMID:24752916, PMID:27087133, PMID:27566243, PMID:28259689, PMID:28499986, PMID:30120923, PMID:30481507 NCBI chr 5:137,288,247...137,294,466
Ensembl chr 5:137,287,519...137,294,466
JBrowse link
G Acmsd amino carboxymuconate semialdehyde decarboxylase increases activity
increases expression
ISO Streptozocin results in increased activity of ACMSD protein
Streptozocin results in increased expression of ACMSD mRNA
CTD PMID:12042425 NCBI chr 1:127,729,413...127,767,564
Ensembl chr 1:127,729,413...127,767,978
JBrowse link
G Aco2 aconitase 2, mitochondrial decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ACO2 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ACO2 protein]
CTD PMID:19634143 NCBI chr15:81,872,463...81,915,137
Ensembl chr15:81,872,309...81,915,133
JBrowse link
G Acot1 acyl-CoA thioesterase 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ACOT1 mRNA CTD PMID:29127188 NCBI chr12:84,009,502...84,017,670
Ensembl chr12:84,009,490...84,018,371
JBrowse link
G Acot2 acyl-CoA thioesterase 2 multiple interactions ISO
EXP
[resveratrol co-treated with Streptozocin] results in decreased expression of ACOT2 mRNA
[Streptozocin co-treated with Dietary Fats] results in increased expression of ACOT2 mRNA
CTD PMID:25905778, PMID:29127188 NCBI chr12:83,987,861...83,993,877
Ensembl chr12:83,987,861...83,993,873
JBrowse link
G Acot9 acyl-CoA thioesterase 9 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ACOT9 mRNA CTD PMID:29127188 NCBI chr  X:155,262,443...155,297,654
Ensembl chr  X:155,262,443...155,297,654
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 increases expression ISO Streptozocin results in increased expression of ACSM2 mRNA CTD PMID:25905778 NCBI chr 7:119,554,340...119,600,694
Ensembl chr 7:119,554,340...119,600,690
JBrowse link
G Acss1 acyl-CoA synthetase short-chain family member 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ACSS1 mRNA CTD PMID:29127188 NCBI chr 2:150,618,111...150,668,240
Ensembl chr 2:150,618,105...150,668,500
JBrowse link
G Acta2 actin, alpha 2, smooth muscle, aorta multiple interactions ISO
EXP
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]; [Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]]
[Dietary Fats co-treated with Streptozocin] results in increased expression of ACTA2 mRNA; [Streptozocin co-treated with fatostatin] results in increased expression of ACTA2 protein; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of ACTA2 mRNA]
CTD PMID:29420703, PMID:29988851, PMID:30551545 NCBI chr19:34,240,336...34,255,585
Ensembl chr19:34,241,090...34,255,590
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 decreases expression ISO Streptozocin results in decreased expression of ACTC1 protein CTD PMID:21136691 NCBI chr 2:114,047,282...114,052,875
Ensembl chr 2:114,047,282...114,053,548
JBrowse link
G Actn4 actinin alpha 4 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ACTN4 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein]
CTD PMID:19634143 NCBI chr 7:28,893,248...28,962,351
Ensembl chr 7:28,893,248...28,962,340
JBrowse link
G Acy1 aminoacylase 1 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ACY1 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ACY1 protein]
CTD PMID:19634143 NCBI chr 9:106,432,981...106,438,236
Ensembl chr 9:106,432,981...106,438,319
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
increases expression
ISO
EXP
stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of ADGRE1 protein]]
Streptozocin results in increased expression of ADGRE1 mRNA
[fatostatin co-treated with Streptozocin] results in increased expression of ADGRE1 mRNA
CTD PMID:23611540, PMID:29420703 NCBI chr17:57,358,581...57,483,529
Ensembl chr17:57,358,691...57,483,527
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) increases expression ISO Streptozocin results in increased expression of ADH1 mRNA CTD PMID:25905778 NCBI chr 3:138,277,585...138,290,698
Ensembl chr 3:138,260,991...138,290,698
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions
decreases expression
ISO
EXP
[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of ADIPOQ protein; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; geraniol promotes the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ADIPOQ protein]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of ADIPOQ protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]
[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of ADIPOQ protein; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of ADIPOQ protein]
Streptozocin results in decreased expression of ADIPOQ mRNA; Streptozocin results in decreased expression of ADIPOQ protein
CTD PMID:17270171, PMID:21439372, PMID:21912612, PMID:22675305, PMID:24854284, PMID:27488359, PMID:28178614, PMID:29988851 NCBI chr16:23,146,536...23,157,968
Ensembl chr16:23,146,536...23,158,028
JBrowse link
G Adipor1 adiponectin receptor 1 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ADIPOR1 protein
resveratrol inhibits the reaction [Streptozocin results in decreased expression of ADIPOR1 protein]
CTD PMID:17270171, PMID:24413998 NCBI chr 1:134,415,378...134,433,351
Ensembl chr 1:134,415,378...134,433,351
JBrowse link
G Adipor2 adiponectin receptor 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr 6:119,353,150...119,417,699
Ensembl chr 6:119,353,150...119,417,704
JBrowse link
G Adora2a adenosine A2a receptor increases expression EXP Streptozocin results in increased expression of ADORA2A protein CTD PMID:26654777 NCBI chr10:75,316,877...75,334,792
Ensembl chr10:75,316,877...75,334,784
JBrowse link
G Adra1a adrenergic receptor, alpha 1a increases expression ISO Streptozocin results in increased expression of ADRA1A mRNA; Streptozocin results in increased expression of ADRA1A protein CTD PMID:19133277 NCBI chr14:66,635,251...66,771,240
Ensembl chr14:66,635,251...66,771,168
JBrowse link
G Adra1b adrenergic receptor, alpha 1b increases expression ISO Streptozocin results in increased expression of ADRA1B mRNA CTD PMID:19298542 NCBI chr11:43,774,605...43,901,250
Ensembl chr11:43,774,606...43,901,210
JBrowse link
G Adra1d adrenergic receptor, alpha 1d decreases expression ISO Streptozocin results in decreased expression of ADRA1D mRNA CTD PMID:19298542 NCBI chr 2:131,545,357...131,562,497
Ensembl chr 2:131,545,850...131,562,283
JBrowse link
G Adrb1 adrenergic receptor, beta 1 multiple interactions
decreases expression
ISO Metoprolol inhibits the reaction [Streptozocin results in decreased expression of ADRB1 protein] CTD PMID:18703049 NCBI chr19:56,722,117...56,725,150
Ensembl chr19:56,722,199...56,733,113
JBrowse link
G Adrb2 adrenergic receptor, beta 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ADRB2 protein
Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB2 protein]
CTD PMID:18703049 NCBI chr18:62,177,713...62,179,981
Ensembl chr18:62,177,816...62,179,959
JBrowse link
G Adrb3 adrenergic receptor, beta 3 multiple interactions
increases expression
ISO Metoprolol promotes the reaction [Streptozocin results in increased expression of ADRB3 protein] CTD PMID:18703049 NCBI chr 8:27,225,776...27,230,845
Ensembl chr 8:27,225,776...27,250,616
JBrowse link
G Afmid arylformamidase increases expression ISO Streptozocin results in increased expression of AFMID mRNA CTD PMID:25905778 NCBI chr11:117,825,503...117,839,908
Ensembl chr11:117,825,924...117,839,908
JBrowse link
G Afp alpha fetoprotein multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of AFP mRNA CTD PMID:29127188 NCBI chr 5:90,490,714...90,508,907
Ensembl chr 5:90,490,737...90,508,907
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression
increases response to substance
multiple interactions
ISO
EXP
Streptozocin results in increased expression of AGER mRNA; Streptozocin results in increased expression of AGER protein
AGER protein results in increased susceptibility to Streptozocin
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]
Kangen-karyu inhibits the reaction [Streptozocin results in increased expression of AGER protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of AGER protein]; Sodium Selenite inhibits the reaction [Streptozocin results in increased expression of AGER protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of AGER mRNA]
CTD PMID:19397970, PMID:19833897, PMID:22476978, PMID:25199697, PMID:27109771, PMID:31009641 NCBI chr17:34,597,460...34,600,937
Ensembl chr17:34,597,862...34,600,936
JBrowse link
G Agrp agouti related neuropeptide multiple interactions
increases expression
ISO INS protein inhibits the reaction [Streptozocin results in increased expression of AGRP mRNA] CTD PMID:20219977 NCBI chr 8:105,566,695...105,579,845
Ensembl chr 8:105,566,698...105,637,393
JBrowse link
G Agt angiotensinogen (serpin peptidase inhibitor, clade A, member 8) multiple interactions
increases expression
EXP
ISO
IGF1 protein inhibits the reaction [Streptozocin results in increased expression of AGT protein]
Streptozocin results in increased expression of AGT mRNA; Streptozocin results in increased expression of AGT protein
Streptozocin results in increased expression of AGT mRNA; Streptozocin results in increased expression of AGT protein; Streptozocin results in increased expression of AGT protein modified form
ACE2 inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]; AGT protein modified form inhibits the reaction [Streptozocin results in decreased abundance of Cyclic GMP]; AGT protein modified form inhibits the reaction [Streptozocin results in increased expression of PDE5 mRNA]; benazepril inhibits the reaction [Streptozocin results in increased expression of AGT protein modified form]; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGT protein]
CTD PMID:11375343, PMID:15643138, PMID:17724226, PMID:18487452, PMID:20547220, PMID:20844835, PMID:28299329 NCBI chr 8:124,556,587...124,569,706
Ensembl chr 8:124,556,534...124,569,706
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions
increases expression
EXP
ISO
telmisartan inhibits the reaction [Streptozocin results in increased expression of AGTR1A protein]
[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA; esculetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR1A mRNA]
Streptozocin results in increased expression of AGTR1A mRNA; Streptozocin results in increased expression of AGTR1A protein
CTD PMID:17724226, PMID:18487452, PMID:21381899, PMID:28946194 NCBI chr13:30,336,356...30,382,867
Ensembl chr13:30,336,441...30,382,867
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of AGTR2 mRNA; Streptozocin results in increased expression of AGTR2 protein
[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGTR2 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in increased expression of AGTR2 protein]; esculetin promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGTR2 mRNA]
CTD PMID:15587404, PMID:17724226, PMID:28946194 NCBI chr  X:21,484,624...21,488,833
Ensembl chr  X:21,484,544...21,489,164
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 multiple interactions
decreases expression
ISO Trientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein] CTD PMID:19634143 NCBI chr15:10,358,516...10,410,158
Ensembl chr15:10,358,532...10,410,153
JBrowse link
G Ahcy S-adenosylhomocysteine hydrolase multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of AHCY mRNA; [Streptozocin co-treated with Dietary Fats] results in increased methylation of AHCY gene CTD PMID:29127188 NCBI chr 2:155,059,310...155,074,497
Ensembl chr 2:155,059,310...155,074,497
JBrowse link
G Ahr aryl-hydrocarbon receptor decreases expression EXP Streptozocin results in decreased expression of AHR mRNA CTD PMID:22531820 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 increases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of AIFM1 protein
[Streptozocin co-treated with NQO1 protein mutant form] results in increased expression of AIFM1 protein; FGF21 protein affects the reaction [Streptozocin results in increased expression of AIFM1]
Trientine inhibits the reaction [Streptozocin results in increased expression of AIFM1 protein]
CTD PMID:19634143, PMID:23458895, PMID:23499715 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Ak4 adenylate kinase 4 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of AK4 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein]
CTD PMID:19634143 NCBI chr 4:101,416,478...101,467,771
Ensembl chr 4:101,419,277...101,466,995
JBrowse link
G Akr1a1 aldo-keto reductase family 1, member A1 (aldehyde reductase) increases expression
multiple interactions
ISO Streptozocin results in increased expression of AKR1A1 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein]
CTD PMID:19634143 NCBI chr 4:116,636,510...116,651,674
Ensembl chr 4:116,636,510...116,651,680
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) multiple interactions ISO Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]; Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]; Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK8 protein]; Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK9 protein] CTD PMID:25541468 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 multiple interactions ISO
EXP
[resveratrol co-treated with Streptozocin] results in decreased expression of AKR1C3 mRNA
[Streptozocin co-treated with Dietary Fats] results in increased expression of AKR1C18 mRNA
CTD PMID:25905778, PMID:29127188 NCBI chr13:4,132,615...4,150,646
Ensembl chr13:4,132,615...4,150,654
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
decreases expression
ISO
EXP
[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein; [Resveratrol co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; [Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of AKT1 protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Propofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]; tin mesoporphyrin inhibits the reaction [[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased phosphorylation of AKT1 protein]
[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; perilla seed oil inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]
Streptozocin results in decreased expression of AKT1 mRNA; Streptozocin results in decreased expression of AKT1 protein
CTD PMID:16595661, PMID:19002579, PMID:22675305, PMID:24810525, PMID:25541178, PMID:26071184, PMID:27417257, PMID:31743741, PMID:31877369 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Akt2 thymoma viral proto-oncogene 2 multiple interactions ISO [Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein; Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein] CTD PMID:27270450 NCBI chr 7:27,591,552...27,640,826
Ensembl chr 7:27,591,552...27,640,826
JBrowse link
G Alad aminolevulinate, delta-, dehydratase multiple interactions EXP [Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein; alpha-Tocopherol inhibits the reaction [[Streptozocin results in increased abundance of Blood Glucose] which results in decreased expression of ALAD protein] CTD PMID:7728901 NCBI chr 4:62,505,984...62,520,063
Ensembl chr 4:62,509,169...62,519,918
JBrowse link
G Alas1 aminolevulinic acid synthase 1 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ALAS1 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of ALAS1 mRNA]
CTD PMID:16684804 NCBI chr 9:106,233,455...106,247,954
Ensembl chr 9:106,233,455...106,248,654
JBrowse link
G Alb albumin multiple interactions
increases expression
decreases expression
increases secretion
EXP
ISO
[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein; naringenin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Carboxymethylcellulose Sodium] results in increased expression of ALB protein]; TXN protein inhibits the reaction [Streptozocin results in increased secretion of ALB protein]
Streptozocin results in increased expression of ALB protein
Streptozocin results in decreased expression of ALB protein
[Streptozocin co-treated with Cadmium] results in increased expression of ALB protein; [Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein; Curcumin inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Gallic Acid inhibits the reaction [Streptozocin results in decreased expression of ALB protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased secretion of ALB protein]; LR-90 inhibits the reaction [Streptozocin results in increased expression of ALB protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of ALB protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of ALB protein]
CTD PMID:12845431, PMID:14871415, PMID:17360766, PMID:18204486, PMID:21450970, PMID:24923654, PMID:25199697, PMID:25240712, PMID:29331653, PMID:31063766 NCBI chr 5:90,460,870...90,476,602
Ensembl chr 5:90,460,897...90,476,602
JBrowse link
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases expression ISO Streptozocin results in increased expression of ALDH1A1 mRNA CTD PMID:25905778 NCBI chr19:20,492,583...20,643,463
Ensembl chr19:20,492,715...20,643,465
JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases expression
multiple interactions
decreases expression
ISO Streptozocin results in increased expression of ALDH2 protein
Ethanol inhibits the reaction [Streptozocin results in decreased expression of ALDH2]
Streptozocin results in decreased expression of ALDH2 mRNA; Streptozocin results in decreased expression of ALDH2 protein
CTD PMID:21136691, PMID:23500772 NCBI chr 5:121,566,027...121,593,824
Ensembl chr 5:121,566,027...121,593,824
JBrowse link
G Aldob aldolase B, fructose-bisphosphate increases expression
multiple interactions
ISO Streptozocin results in increased expression of ALDOB protein
Trientine inhibits the reaction [Streptozocin results in increased expression of ALDOB protein]
CTD PMID:19634143 NCBI chr 4:49,535,993...49,549,546
Ensembl chr 4:49,535,995...49,549,546
JBrowse link
G Alkbh3 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase multiple interactions ISO [Streptozocin co-treated with Dietary Fats] results in decreased expression of ALKBH3 mRNA CTD PMID:20665664 NCBI chr 2:93,980,624...94,010,824
Ensembl chr 2:93,980,550...94,010,807
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ALOX5AP mRNA CTD PMID:29127188 NCBI chr 5:149,265,004...149,288,153
Ensembl chr 5:149,264,767...149,288,153
JBrowse link
G Alpk1 alpha-kinase 1 increases response to substance
multiple interactions
ISO ALPK1 protein results in increased susceptibility to Streptozocin
[ALPK1 protein results in increased susceptibility to Streptozocin] which results in decreased expression of PRKG2 mRNA; [ALPK1 protein results in increased susceptibility to Streptozocin] which results in increased expression of TGFB1 mRNA; [ALPK1 protein results in increased susceptibility to Streptozocin] which results in increased expression of TGFB1 protein; ALPK1 protein promotes the reaction [Streptozocin results in decreased secretion of INS1 protein]; ALPK1 protein promotes the reaction [Streptozocin results in increased abundance of Blood Glucose]
CTD PMID:27542954 NCBI chr 3:127,666,718...127,780,547
Ensembl chr 3:127,670,310...127,780,527
JBrowse link
G Angpt1 angiopoietin 1 increases expression
decreases expression
ISO Streptozocin results in increased expression of ANGPT1 mRNA; Streptozocin results in increased expression of ANGPT1 protein
Streptozocin results in decreased expression of ANGPT1 mRNA
CTD PMID:15643138, PMID:19958114 NCBI chr15:42,424,667...42,676,977
Ensembl chr15:42,424,723...42,676,977
JBrowse link
G Angpt2 angiopoietin 2 multiple interactions
increases expression
ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of ANGPT2 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of ANGPT2 protein]
Streptozocin results in increased expression of ANGPT2 mRNA; Streptozocin results in increased expression of ANGPT2 protein
CTD PMID:15643138, PMID:19958114, PMID:20821229 NCBI chr 8:18,690,263...18,741,562
Ensembl chr 8:18,690,263...18,741,562
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of ANGPTL4 mRNA CTD PMID:25905778 NCBI chr17:33,774,900...33,781,575
Ensembl chr17:33,773,750...33,781,830
JBrowse link
G Ankrd1 ankyrin repeat domain 1 (cardiac muscle) increases expression
multiple interactions
ISO Streptozocin results in increased expression of ANKRD1 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of ANKRD1 mRNA]
CTD PMID:16684804 NCBI chr19:36,111,965...36,119,844
Ensembl chr19:36,111,961...36,120,099
JBrowse link
G Anpep alanyl (membrane) aminopeptidase decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ANPEP protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein]
CTD PMID:19634143 NCBI chr 7:79,821,803...79,848,210
Ensembl chr 7:79,821,803...79,861,059
JBrowse link
G Anxa3 annexin A3 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ANXA3 protein
[resveratrol co-treated with Streptozocin] results in increased expression of ANXA3 mRNA; Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein]
CTD PMID:21136691, PMID:25905778 NCBI chr 5:96,793,385...96,845,968
Ensembl chr 5:96,793,339...96,845,966
JBrowse link
G Anxa5 annexin A5 decreases expression
multiple interactions
increases expression
ISO Streptozocin results in decreased expression of ANXA5 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ANXA5 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA5 protein]
CTD PMID:19634143, PMID:21136691 NCBI chr 3:36,448,923...36,475,887
Ensembl chr 3:36,448,923...36,475,894
JBrowse link
G Apex1 apurinic/apyrimidinic endonuclease 1 increases response to substance ISO APEX1 protein mutant form results in increased susceptibility to Streptozocin CTD PMID:19470598 NCBI chr14:50,924,949...50,927,188
Ensembl chr14:50,924,968...50,927,139
JBrowse link
G Apoa1 apolipoprotein A-I multiple interactions
increases expression
ISO Trientine inhibits the reaction [Streptozocin results in increased expression of APOA1 protein] CTD PMID:19634143 NCBI chr 9:46,228,630...46,230,469
Ensembl chr 9:46,228,580...46,230,466
JBrowse link
G Apoa4 apolipoprotein A-IV multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of APOA4 mRNA CTD PMID:25905778 NCBI chr 9:46,240,844...46,243,458
Ensembl chr 9:46,240,696...46,243,459
JBrowse link
G Apoe apolipoprotein E increases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of APOE mRNA
[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine; INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine]
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of APOE mRNA]
CTD PMID:16380481, PMID:16684804 NCBI chr 7:19,696,244...19,701,310
Ensembl chr 7:19,696,109...19,699,188
JBrowse link
G App amyloid beta (A4) precursor protein multiple interactions
increases expression
ISO
EXP
Memantine inhibits the reaction [Streptozocin results in increased expression of APP protein modified form]
Alendronate inhibits the reaction [Streptozocin results in increased expression of APP protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of APP protein]
Streptozocin results in increased expression of APP mRNA; Streptozocin results in increased expression of APP protein
CTD PMID:21069392, PMID:21290839, PMID:30481507 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Aqp1 aquaporin 1 multiple interactions
decreases expression
ISO Trientine inhibits the reaction [Streptozocin results in decreased expression of AQP1 protein] CTD PMID:19634143 NCBI chr 6:55,336,299...55,348,555
Ensembl chr 6:55,336,432...55,348,555
JBrowse link
G Aqp7 aquaporin 7 increases expression
multiple interactions
ISO Streptozocin results in increased expression of AQP7 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of AQP7 mRNA]
CTD PMID:16684804 NCBI chr 4:41,033,074...41,048,237
Ensembl chr 4:41,033,074...41,048,139
JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Streptozocin results in increased expression of AQP9 protein CTD PMID:22114114 NCBI chr 9:71,110,659...71,167,849
Ensembl chr 9:71,110,659...71,168,682
JBrowse link
G Arg1 arginase, liver multiple interactions
increases expression
EXP [NTN1 protein co-treated with Streptozocin] results in increased expression of ARG1 protein; ARG1 gene mutant form inhibits the reaction [Streptozocin results in increased expression of GLB1 protein]
Streptozocin results in increased expression of ARG1 protein
CTD PMID:29059224, PMID:29673160 NCBI chr10:24,915,207...24,927,470
Ensembl chr10:24,915,221...24,927,484
JBrowse link
G Arhgap9 Rho GTPase activating protein 9 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of ARHGAP9 mRNA CTD PMID:25905778 NCBI chr10:127,321,913...127,329,947
Ensembl chr10:127,321,964...127,329,943
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ARNTL mRNA CTD PMID:29127188 NCBI chr 7:113,178,471...113,314,126
Ensembl chr 7:113,207,465...113,314,126
JBrowse link
G Asns asparagine synthetase multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of ASNS mRNA CTD PMID:25905778 NCBI chr 6:7,675,165...7,693,209
Ensembl chr 6:7,675,169...7,693,254
JBrowse link
G Atf2 activating transcription factor 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ATF2 protein
resveratrol inhibits the reaction [Streptozocin results in increased expression of ATF2 protein]
CTD PMID:26499206 NCBI chr 2:73,816,509...73,892,677
Ensembl chr 2:73,816,509...73,892,639
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions
increases phosphorylation
increases expression
EXP
ISO
sulforafan inhibits the reaction [Streptozocin results in increased expression of ATF4 protein]
4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased phosphorylation of ATF4 protein]
CTD PMID:24967692, PMID:30980806 NCBI chr15:80,255,184...80,257,545
Ensembl chr15:80,255,184...80,257,541
JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO Streptozocin results in decreased expression of ATF5 mRNA CTD PMID:25905778 NCBI chr 7:44,812,256...44,816,658
Ensembl chr 7:44,812,256...44,816,658
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions
increases cleavage
ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of ATF6 protein] CTD PMID:30980806 NCBI chr 1:170,704,457...170,868,585
Ensembl chr 1:170,704,674...170,867,771
JBrowse link
G Atg12 autophagy related 12 increases expression EXP Streptozocin results in increased expression of ATG12 mRNA CTD PMID:24889822 NCBI chr18:46,732,417...46,741,724
Ensembl chr18:46,730,144...46,741,580
JBrowse link
G Atg5 autophagy related 5 increases expression EXP Streptozocin results in increased expression of ATG5 mRNA CTD PMID:24889822 NCBI chr10:44,268,322...44,364,299
Ensembl chr10:44,268,358...44,364,291
JBrowse link
G Atox1 antioxidant 1 copper chaperone decreases expression ISO Streptozocin results in decreased expression of ATOX1 protein CTD PMID:24927960 NCBI chr11:55,446,637...55,461,208
Ensembl chr11:55,446,641...55,461,239
JBrowse link
G Atp2a2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 decreases activity
decreases expression
multiple interactions
ISO
EXP
Streptozocin results in decreased activity of ATP2A2 protein
Streptozocin results in decreased expression of ATP2A2 mRNA
[bisphenol A co-treated with Streptozocin] results in decreased expression of ATP2A2 mRNA; [Ethinyl Estradiol co-treated with Streptozocin] results in decreased expression of ATP2A2 mRNA; [octylphenol co-treated with Streptozocin] results in decreased expression of ATP2A2 mRNA
CTD PMID:16685413, PMID:29935216 NCBI chr 5:122,453,513...122,502,225
Ensembl chr 5:122,453,513...122,502,225
JBrowse link
G Atp2a3 ATPase, Ca++ transporting, ubiquitous multiple interactions EXP [Streptozocin co-treated with bisphenol A] results in decreased expression of ATP2A3 mRNA; [Streptozocin co-treated with octylphenol] results in decreased expression of ATP2A3 mRNA CTD PMID:29935216 NCBI chr11:72,961,169...72,993,043
Ensembl chr11:72,961,169...72,993,044
JBrowse link
G Atp2b1 ATPase, Ca++ transporting, plasma membrane 1 multiple interactions
increases expression
EXP [Streptozocin co-treated with bisphenol A] results in increased expression of ATP2B1 mRNA; [Streptozocin co-treated with octylphenol] results in increased expression of ATP2B1 mRNA
Streptozocin results in increased expression of ATP2B1 mRNA
CTD PMID:29935216 NCBI chr10:98,914,630...99,026,143
Ensembl chr10:98,914,406...99,026,143
JBrowse link
G Atp5a1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ATP5F1A protein
Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1A protein]
CTD PMID:21136691 NCBI chr18:77,773,768...77,782,869
Ensembl chr18:77,773,729...77,782,869
JBrowse link
G Atp5b ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit increases expression
multiple interactions
ISO Streptozocin results in increased expression of ATP5F1B protein
Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1B protein]
CTD PMID:21136691 NCBI chr10:128,083,307...128,090,388
Ensembl chr10:128,083,273...128,090,391
JBrowse link
G Atp5j2 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2 affects expression
multiple interactions
increases expression
EXP
ISO
Streptozocin affects the expression of ATP5J2 mRNA
Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5MF protein]
CTD PMID:18583417, PMID:19634143 NCBI chr 5:145,183,704...145,191,541
Ensembl chr 5:145,183,698...145,192,062
JBrowse link
G Atp5o ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit increases expression
multiple interactions
ISO Streptozocin results in increased expression of ATP5PO protein
Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5PO protein]
CTD PMID:19634143 NCBI chr16:91,925,223...91,931,630
Ensembl chr16:91,925,214...91,931,687
Ensembl chr16:91,925,214...91,931,687
JBrowse link
G Atp6ap2 ATPase, H+ transporting, lysosomal accessory protein 2 multiple interactions
increases expression
ISO (3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; (3,4-dihydroxyphenylamino)-2-imidazoline inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ATP6AP2 protein]
Streptozocin results in increased expression of ATP6AP2 mRNA; Streptozocin results in increased expression of ATP6AP2 protein
CTD PMID:18192338 NCBI chr  X:12,587,759...12,617,051
Ensembl chr  X:12,587,801...12,617,049
JBrowse link
G Atp7a ATPase, Cu++ transporting, alpha polypeptide multiple interactions
decreases expression
EXP ATP7A gene mutant form promotes the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; ATP7A protein inhibits the reaction [Streptozocin results in increased chemical synthesis of Superoxides]; INS protein inhibits the reaction [Streptozocin results in decreased expression of ATP7A protein] CTD PMID:23884884 NCBI chr  X:106,027,224...106,128,161
Ensembl chr  X:106,027,276...106,124,926
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide decreases expression ISO Streptozocin results in decreased expression of ATP7B protein CTD PMID:24927960 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Avp arginine vasopressin multiple interactions EXP [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of AVP mRNA; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of AVP mRNA] CTD PMID:32303808 NCBI chr 2:130,580,620...130,582,588
Ensembl chr 2:130,580,620...130,582,554
JBrowse link
G Axl AXL receptor tyrosine kinase increases expression ISO Streptozocin results in increased expression of AXL protein CTD PMID:12644472 NCBI chr 7:25,756,500...25,788,924
Ensembl chr 7:25,757,273...25,788,705
JBrowse link
G B3galnt1 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of B3GALNT1 mRNA CTD PMID:25905778 NCBI chr 3:69,573,919...69,598,960
Ensembl chr 3:69,574,158...69,598,960
JBrowse link
G Baat bile acid-Coenzyme A: amino acid N-acyltransferase multiple interactions EXP [Dietary Fats co-treated with Streptozocin] results in decreased expression of BAAT mRNA CTD PMID:29382564 NCBI chr 4:49,489,416...49,507,915
Ensembl chr 4:49,489,422...49,506,557
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 multiple interactions
increases expression
EXP Alendronate inhibits the reaction [Streptozocin results in increased expression of BACE1 protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of BACE1 protein] CTD PMID:30481507 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
increases expression
decreases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BAD protein modified form]; Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAD protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BAD protein]; Streptozocin results in increased phosphorylation of and results in decreased activity of BAD protein
Streptozocin results in decreased expression of BAD protein; Streptozocin results in decreased expression of BAD protein modified form
CTD PMID:15976052, PMID:19682444, PMID:28856781 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in increased expression of BAK1 protein] CTD PMID:28856781 NCBI chr17:27,019,812...27,028,627
Ensembl chr17:27,019,810...27,029,009
JBrowse link
G Bax BCL2-associated X protein multiple interactions
affects expression
increases expression
EXP
ISO
IGF1 protein inhibits the reaction [Streptozocin results in increased expression of BAX protein]; montelukast inhibits the reaction [Streptozocin results in increased expression of BAX protein]; sulforafan inhibits the reaction [Streptozocin results in increased expression of BAX protein]
Streptozocin affects the expression of BAX protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in increased expression of BAX protein]]; 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Streptozocin results in increased expression of BAX protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]; [Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in increased expression of BAX protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]; Calcitriol inhibits the reaction [Streptozocin results in increased expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BAX protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Diazoxide inhibits the reaction [Streptozocin results in increased expression of BAX protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of BAX protein]; ferulic acid inhibits the reaction [Streptozocin results in increased expression of BAX protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BAX protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Organoselenium Compounds inhibits the reaction [Streptozocin results in increased expression of BAX protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of BAX]; Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of BAX protein]; Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]]]; Zinc inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Zinc inhibits the reaction [Streptozocin results in increased expression of BAX protein]
Streptozocin results in increased expression of BAX; Streptozocin results in increased expression of BAX mRNA; Streptozocin results in increased expression of BAX protein
CTD PMID:11375343, PMID:18758938, PMID:19931367, PMID:20574430, PMID:20650802, PMID:22429817, PMID:23267840, PMID:24954035, PMID:24967692, PMID:25191525, PMID:25301743, PMID:25541178, PMID:27702591, PMID:29953732, PMID:30611788, PMID:30980806, PMID:31009641, PMID:31029786, PMID:31323227 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Baz1b bromodomain adjacent to zinc finger domain, 1B affects expression EXP Streptozocin affects the expression of BAZ1B mRNA CTD PMID:26073000 NCBI chr 5:135,187,323...135,246,131
Ensembl chr 5:135,187,264...135,246,129
JBrowse link
G Bbox1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase) multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of BBOX1 mRNA CTD PMID:25905778 NCBI chr 2:110,264,056...110,314,813
Ensembl chr 2:110,262,697...110,314,560
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of BCHE protein] CTD PMID:27087133, PMID:30481507 NCBI chr 3:73,635,805...73,708,436
Ensembl chr 3:73,635,808...73,708,415
JBrowse link
G Bckdha branched chain ketoacid dehydrogenase E1, alpha polypeptide affects expression EXP Streptozocin affects the expression of BCKDHA mRNA CTD PMID:18583417 NCBI chr 7:25,629,852...25,658,782
Ensembl chr 7:25,629,946...25,658,981
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 increases expression
affects expression
multiple interactions
decreases expression
ISO
EXP
Streptozocin results in increased expression of BCL2 protein
Streptozocin affects the expression of BCL2 protein
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Calcitriol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]]; 2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; 3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; [Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein; Angiotensin-Converting Enzyme Inhibitors inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Calcitriol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Streptozocin affects the expression of BCL2 protein]; Diazoxide inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Drugs, Chinese Herbal inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; fasudil inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Hesperidin inhibits the reaction [2-chloro-5-nitrobenzanilide promotes the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]]; Hesperidin inhibits the reaction [[Streptozocin co-treated with Isoproterenol] affects the expression of BCL2 protein]; Organoselenium Compounds inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Propofol inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of BCL2 protein]; Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Testosterone promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Sildenafil Citrate promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Testosterone promotes the reaction [Tadalafil inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]; Testosterone promotes the reaction [Tadalafil promotes the reaction [Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]]]; Zinc inhibits the reaction [Streptozocin results in decreased expression of BCL2 mRNA]; Zinc inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]
[Streptozocin co-treated with bisphenol A] results in increased expression of BCL2 mRNA; [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of BCL2 mRNA; [Streptozocin co-treated with octylphenol] results in increased expression of BCL2 mRNA; bisphenol A promotes the reaction [Streptozocin results in decreased expression of BCL2 protein]; Ethinyl Estradiol promotes the reaction [Streptozocin results in decreased expression of BCL2 protein]; montelukast inhibits the reaction [Streptozocin results in decreased expression of BCL2 protein]; octylphenol promotes the reaction [Streptozocin results in decreased expression of BCL2 protein]; Streptozocin inhibits the reaction [Cisplatin results in increased expression of BCL2 protein]
Streptozocin results in decreased expression of BCL2 mRNA; Streptozocin results in decreased expression of BCL2 protein
CTD PMID:15056984, PMID:15587404, PMID:15976052, PMID:16909474, PMID:18758938, PMID:19682444, PMID:20574430, PMID:20650802, PMID:22429817, PMID:24781736, PMID:24810525, PMID:24954035, PMID:25301743, PMID:25541178, PMID:25665769, PMID:27702591, PMID:28856781, PMID:29953732, PMID:30611788, PMID:31009641, PMID:31323227 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Bcl2a1b B cell leukemia/lymphoma 2 related protein A1b multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of BCL2A1 mRNA CTD PMID:25905778 NCBI chr 9:89,199,273...89,207,838
Ensembl chr 9:89,199,209...89,207,827
JBrowse link
G Bcl2l1 BCL2-like 1 increases expression
decreases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of BCL2L1 protein
Streptozocin results in decreased expression of BCL2L1 mRNA
Streptozocin results in decreased expression of BCL2L1 protein
Anthocyanins inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased expression of BCL2L1 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]; tin mesoporphyrin inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of BCL2L1 protein]]
CTD PMID:15976052, PMID:16595661, PMID:18758938, PMID:19682444, PMID:24781736, PMID:28856781 NCBI chr 2:152,758,732...152,833,803
Ensembl chr 2:152,780,668...152,831,728
JBrowse link
G Bcl3 B cell leukemia/lymphoma 3 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of BCL3 mRNA CTD PMID:25905778 NCBI chr 7:19,808,462...19,822,824
Ensembl chr 7:19,808,462...19,822,770
JBrowse link
G Bdh1 3-hydroxybutyrate dehydrogenase, type 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of BDH1 mRNA CTD PMID:25905778 NCBI chr16:31,422,297...31,458,901
Ensembl chr16:31,422,280...31,458,901
JBrowse link
G Bdkrb1 bradykinin receptor, beta 1 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of BDKRB1 mRNA
[HOE 140, desArg(10)- binds to and results in decreased activity of BDKRB1 protein] which results in decreased susceptibility to Streptozocin
CTD PMID:17989505, PMID:19516248 NCBI chr12:105,604,091...105,605,511
Ensembl chr12:105,603,085...105,605,428
JBrowse link
G Bdkrb2 bradykinin receptor, beta 2 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of BDKRB2 mRNA
[icatibant binds to and results in decreased activity of BDKRB2 protein] which results in decreased susceptibility to Streptozocin
CTD PMID:17989505, PMID:19516248 NCBI chr12:105,563,172...105,595,244
Ensembl chr12:105,563,226...105,595,237
JBrowse link
G Becn1 beclin 1, autophagy related increases expression EXP Streptozocin results in increased expression of BECN1 mRNA; Streptozocin results in increased expression of BECN1 protein CTD PMID:24889822 NCBI chr11:101,288,258...101,302,286
Ensembl chr11:101,285,952...101,302,286
JBrowse link
G Bglap bone gamma carboxyglutamate protein decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of BGLAP mRNA; Streptozocin results in decreased expression of BGLAP protein
[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of BGLAP protein modified form]
CTD PMID:25617479, PMID:27488359 NCBI chr 3:88,383,495...88,384,466
Ensembl chr 3:88,383,501...88,384,464
JBrowse link
G Bhmt betaine-homocysteine methyltransferase increases activity
multiple interactions
increases expression
ISO
EXP
Streptozocin results in increased activity of BHMT protein
[Streptozocin co-treated with Dietary Fats] affects the expression of BHMT mRNA
Streptozocin results in increased expression of BHMT mRNA
CTD PMID:16835399, PMID:29127188 NCBI chr13:93,616,891...93,637,758
Ensembl chr13:93,616,675...93,637,961
JBrowse link
G Bmp6 bone morphogenetic protein 6 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of BMP6 mRNA
esculetin inhibits the reaction [Streptozocin results in decreased expression of BMP6 mRNA]
CTD PMID:21450970 NCBI chr13:38,345,716...38,500,314
Ensembl chr13:38,345,107...38,500,302
JBrowse link
G Bmp7 bone morphogenetic protein 7 increases expression
affects expression
ISO Streptozocin results in increased expression of BMP7 protein
Streptozocin affects the expression of BMP7 mRNA
CTD PMID:17437042 NCBI chr 2:172,868,012...172,940,321
Ensembl chr 2:172,868,012...172,940,321
JBrowse link
G C1qa complement component 1, q subcomponent, alpha polypeptide multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of C1QA mRNA CTD PMID:25905778 NCBI chr 4:136,895,916...136,898,844
Ensembl chr 4:136,895,917...136,898,803
JBrowse link
G C1qb complement component 1, q subcomponent, beta polypeptide increases expression
multiple interactions
ISO Streptozocin results in increased expression of C1QB mRNA
[resveratrol co-treated with Streptozocin] results in increased expression of C1QB mRNA; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C1QB mRNA]
CTD PMID:16684804, PMID:25905778 NCBI chr 4:136,880,126...136,886,200
Ensembl chr 4:136,880,129...136,886,187
JBrowse link
G C1qc complement component 1, q subcomponent, C chain multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of C1QC mRNA CTD PMID:25905778 NCBI chr 4:136,889,801...136,892,936
Ensembl chr 4:136,889,804...136,893,065
JBrowse link
G C4b complement component 4B (Chido blood group) increases expression
multiple interactions
ISO Streptozocin results in increased expression of C4B mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of C4B mRNA]
CTD PMID:16684804 NCBI chr17:34,728,139...34,743,902
Ensembl chr17:34,728,380...34,743,882
JBrowse link
G Cacna1c calcium channel, voltage-dependent, L type, alpha 1C subunit multiple interactions
increases expression
EXP [bisphenol A co-treated with Streptozocin] results in decreased expression of CACNA1C mRNA; [octylphenol co-treated with Streptozocin] results in decreased expression of CACNA1C mRNA
Streptozocin results in increased expression of CACNA1C mRNA
CTD PMID:29935216 NCBI chr 6:118,587,240...119,197,384
Ensembl chr 6:118,587,240...119,196,890
Ensembl chr 6:118,587,240...119,196,890
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
decreases expression
ISO Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in decreased expression of CALCA protein]; capsazepine inhibits the reaction [Streptozocin results in decreased expression of CALCA protein]; RN 1734 inhibits the reaction [Streptozocin results in decreased expression of CALCA protein]; U 0126 inhibits the reaction [Streptozocin results in decreased expression of CALCA protein] CTD PMID:30583000 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Calm1 calmodulin 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of CALM1 protein; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of CALM1 protein] CTD PMID:32303808 NCBI chr12:100,199,435...100,209,824
Ensembl chr12:100,199,435...100,209,814
JBrowse link
G Calm3 calmodulin 3 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CALM3 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of CALM3 protein]
CTD PMID:19634143 NCBI chr 7:16,915,379...16,924,032
Ensembl chr 7:16,915,379...16,924,114
JBrowse link
G Calr calreticulin decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CALR protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of CALR protein]
CTD PMID:19634143 NCBI chr 8:84,842,088...84,846,931
Ensembl chr 8:84,841,850...84,846,934
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
decreases expression
EXP
ISO
myristoylated autocamtide-2-related inhibitory peptide inhibits the reaction [Streptozocin results in increased phosphorylation of CAMK2A protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein]; Streptozocin results in increased expression of and results in increased phosphorylation of and results in increased activity of CAMK2A protein
Streptozocin results in decreased expression of CAMK2A mRNA; Streptozocin results in decreased expression of CAMK2A protein
Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of CAMK2A protein]
CTD PMID:20424226, PMID:24333387 NCBI chr18:60,925,307...60,988,152
Ensembl chr18:60,925,618...60,988,152
JBrowse link
G Capg capping protein (actin filament), gelsolin-like multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CAPG mRNA CTD PMID:25905778 NCBI chr 6:72,538,282...72,562,983
Ensembl chr 6:72,544,391...72,562,983
JBrowse link
G Car3 carbonic anhydrase 3 multiple interactions
decreases expression
ISO [resveratrol co-treated with Streptozocin] results in decreased expression of CAR3 mRNA
Streptozocin results in decreased expression of CAR3 mRNA
CTD PMID:25905778 NCBI chr 3:14,863,538...14,872,381
Ensembl chr 3:14,863,512...14,872,523
JBrowse link
G Cartpt CART prepropeptide decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CARTPT mRNA
GHRL protein promotes the reaction [Streptozocin results in decreased expression of CARTPT mRNA]
CTD PMID:20219977 NCBI chr13:99,898,483...99,910,179
Ensembl chr13:99,898,489...99,901,091
JBrowse link
G Casp1 caspase 1 multiple interactions
increases expression
ISO
EXP
Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]; palbinone inhibits the reaction [Streptozocin results in increased expression of and results in increased cleavage of CASP1 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of CASP1 protein]; Streptozocin results in increased expression of and results in increased cleavage of CASP1 protein
[Streptozocin co-treated with Dietary Fats] results in increased activity of CASP1 protein; NLRP3 protein promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of CASP1 protein]
Streptozocin results in increased expression of CASP1 mRNA; Streptozocin results in increased expression of CASP1 protein
CTD PMID:23647015, PMID:27783111, PMID:32202043 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp12 caspase 12 increases expression
multiple interactions
increases cleavage
EXP
ISO
Streptozocin results in increased expression of CASP12 protein modified form
Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
FGF21 protein affects the reaction [Streptozocin results in increased expression of CASP12 protein modified form]; sulforafan inhibits the reaction [Streptozocin results in increased cleavage of CASP12 protein]
CTD PMID:23499715, PMID:24967692, PMID:25541178 NCBI chr 9:5,345,442...5,373,034
Ensembl chr 9:5,345,430...5,373,032
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
increases cleavage
decreases cleavage
ISO
EXP
3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Anthocyanins inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; diallyl trisulfide inhibits the reaction [Streptozocin results in decreased cleavage of CASP3 protein]; ferulic acid analog inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA]; Propofol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Streptozocin results in increased expression of and results in increased cleavage of CASP3 protein; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP3 protein]
Streptozocin results in increased expression of CASP3 mRNA; Streptozocin results in increased expression of CASP3 protein modified form
[Streptozocin co-treated with bisphenol A] results in increased expression of CASP3 mRNA; [Streptozocin co-treated with NQO1 protein mutant form] results in increased expression of CASP3 protein modified form; [Streptozocin co-treated with octylphenol] results in increased expression of CASP3 mRNA; fatostatin promotes the reaction [Streptozocin results in increased cleavage of CASP3 protein]; montelukast inhibits the reaction [Streptozocin results in increased expression of CASP3 protein modified form]; NTN1 protein inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Quercetin inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased activity of CASP3 protein]; Streptozocin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]; Streptozocin inhibits the reaction [Ethinyl Estradiol results in decreased expression of CASP3 mRNA]; sulforafan inhibits the reaction [Streptozocin results in increased cleavage of CASP3 protein]
Streptozocin analog results in increased activity of CASP3 protein; Streptozocin results in increased activity of CASP3 protein
CTD PMID:12502508, PMID:15976052, PMID:18721751, PMID:18758938, PMID:19133311, PMID:19682444, PMID:19840221, PMID:19931367, PMID:19951573, PMID:20053369, PMID:20224876, PMID:20424226, PMID:20654064, PMID:21599458, PMID:23267840, PMID:23453443, PMID:23458895, PMID:24333387, PMID:24810525, PMID:24967692, PMID:25541178, PMID:25665769, PMID:26499206, PMID:26887929, PMID:27702591, PMID:28856781, PMID:29059224, PMID:29420703, PMID:29935216, PMID:30980806, PMID:31029786, PMID:31323227 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Casp7 caspase 7 increases expression
multiple interactions
ISO Streptozocin results in increased expression of CASP7 protein
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]
CTD PMID:15976052, PMID:30551545 NCBI chr19:56,396,833...56,442,348
Ensembl chr19:56,397,129...56,442,344
JBrowse link
G Casp8 caspase 8 multiple interactions
increases cleavage
increases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased cleavage of CASP8 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CASP8 mRNA]
Streptozocin results in increased expression of CASP8 mRNA; Streptozocin results in increased expression of CASP8 protein
CTD PMID:23267840, PMID:25541178, PMID:28856781 NCBI chr 1:58,795,233...58,847,503
Ensembl chr 1:58,795,374...58,847,503
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
increases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]; Streptozocin results in increased expression of and results in increased cleavage of CASP9 protein; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]
Streptozocin results in increased activity of CASP9 protein
CTD PMID:15976052, PMID:19951573, PMID:22940631, PMID:28856781 NCBI chr 4:141,793,612...141,815,978
Ensembl chr 4:141,793,612...141,815,976
JBrowse link
G Cat catalase increases expression
decreases activity
increases activity
multiple interactions
decreases expression
increases phosphorylation
decreases response to substance
EXP
ISO
Streptozocin results in increased expression of CAT mRNA
Streptozocin results in decreased activity of CAT protein
Streptozocin results in increased activity of CAT protein
2-hydroxy-4-methoxy benzoic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; 5,3'-dihydroxy-3,6,7,4',5'-pentamethoxyflavone inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; [Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein; [Dietary Fats co-treated with Streptozocin] results in decreased expression of CAT protein; [Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein; [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; [pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Quercetin co-treated with coenzyme Q10] inhibits the reaction [Streptozocin results in increased activity of CAT protein]; [Quercetin co-treated with Streptozocin] results in increased activity of CAT protein; [Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein; [Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein; [Streptozocin co-treated with Isoproterenol] affects the activity of CAT protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; caryophyllene inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of GNA11 protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of GNAQ protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of PLCB1 protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of PLCB2 protein]; Chromium inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; corilagin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; coumarin inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; crocin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Diltiazem inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; fenugreek seed meal inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; Gallic Acid inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; geraniol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; isoquercitrin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Losartan inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; mangiferin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; naringenin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; palbinone inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; pinitol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Pioglitazone inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; Pioglitazone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Quercetin inhibits the reaction [Streptozocin results in increased activity of CAT protein]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of CAT protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]; Resveratrol promotes the reaction [Streptozocin results in decreased expression of CAT mRNA]; Rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the activity of CAT protein]; S-allylcysteine inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Saponins inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Streptozocin inhibits the reaction [Lipopolysaccharides results in increased expression of CAT protein]; Streptozocin inhibits the reaction [Streptozocin results in increased expression of CAT protein]; Streptozocin results in decreased expression of and results in decreased activity of CAT protein; Streptozocin results in increased expression of and results in increased activity of CAT protein; thymoquinone inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Tocotrienols inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; U 78517F inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of CAT protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of CAT protein]
Streptozocin results in decreased expression of CAT mRNA; Streptozocin results in decreased expression of CAT protein
[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; Alendronate inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Donepezil inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of CAT protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased expression of CAT]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of CAT protein]; rhodioloside inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; sulforafan inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]; sulforafan inhibits the reaction [Streptozocin results in decreased expression of CAT protein]
Streptozocin results in decreased expression of CAT; Streptozocin results in decreased expression of CAT mRNA
Streptozocin results in increased phosphorylation of CAT protein
CAT protein results in decreased susceptibility to Streptozocin
CAT protein promotes the reaction [SOD2 protein results in decreased susceptibility to Streptozocin]; SOD2 protein promotes the reaction [CAT protein results in decreased susceptibility to Streptozocin]
CTD PMID:9522273, PMID:11424224, PMID:12123627, PMID:12242689, PMID:15298345, PMID:15821039, PMID:15855331, PMID:15957552, PMID:16177186, PMID:16581090, PMID:16780994, PMID:17042909, PMID:17145126, PMID:18779489, PMID:19133311, PMID:19464315, PMID:19682444, PMID:19840221, PMID:19931367, PMID:20053369, PMID:20307516, PMID:20643114, PMID:20691780, PMID:20828602, PMID:20951120, PMID:21382363, PMID:21439372, PMID:21457706, PMID:21630391, PMID:22056647, PMID:22476978, PMID:22733486, PMID:23122718, PMID:23677724, PMID:23716880, PMID:24740756, PMID:24752916, PMID:24760747, PMID:24854284, PMID:24877639, PMID:24954035, PMID:24967692, PMID:25057273, PMID:25362599, PMID:25503068, PMID:25617480, PMID:25986969, PMID:26286521, PMID:26341651, PMID:26499206, PMID:26690102, PMID:26700463, PMID:26748309, PMID:27350165, PMID:28178614, PMID:28757134, PMID:29223569, PMID:29247773, PMID:29331653, PMID:29409856, PMID:29988851, PMID:30144451, PMID:30481507, PMID:30582900, PMID:30817903, PMID:30958922, PMID:31009641, PMID:31100278, PMID:31682803, PMID:32202043 NCBI chr 2:103,453,904...103,485,153
Ensembl chr 2:103,453,849...103,485,160
JBrowse link
G Cav1 caveolin 1, caveolae protein multiple interactions
increases expression
ISO resveratrol inhibits the reaction [Streptozocin promotes the reaction [CAV1 protein binds to NOS3 protein]]; resveratrol inhibits the reaction [Streptozocin results in increased expression of CAV1 protein]; Streptozocin promotes the reaction [CAV1 protein binds to NOS3 protein] CTD PMID:18266981 NCBI chr 6:17,306,335...17,341,328
Ensembl chr 6:17,306,335...17,341,452
JBrowse link
G Cav3 caveolin 3 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein]]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of CAV3 protein]; Streptozocin inhibits the reaction [CAV3 protein binds to SLC2A4 protein] CTD PMID:18266981 NCBI chr 6:112,459,505...112,472,872
Ensembl chr 6:112,459,505...112,472,872
JBrowse link
G Cbr1 carbonyl reductase 1 decreases activity ISO Streptozocin results in decreased activity of CBR1 protein CTD PMID:11057757 NCBI chr16:93,607,837...93,610,349
Ensembl chr16:93,605,853...93,610,505
JBrowse link
G Cbs cystathionine beta-synthase multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of CBS mRNA CTD PMID:29127188 NCBI chr17:31,612,623...31,637,233
Ensembl chr17:31,608,894...31,637,238
JBrowse link
G Ccl2 chemokine (C-C motif) ligand 2 increases expression
increases secretion
multiple interactions
affects response to substance
EXP
ISO
Streptozocin results in increased expression of CCL2; Streptozocin results in increased expression of CCL2 mRNA; Streptozocin results in increased expression of CCL2 protein
Streptozocin results in increased secretion of CCL2 protein
4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein; [fatostatin co-treated with Streptozocin] results in increased expression of CCL2 protein; EPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of CCL2 mRNA]; stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]]
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; [Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein; Flavonoids inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; PD 123319 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; procyanidin B2 inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; prolinedithiocarbamate inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of CCL2 protein]; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]
CCL2 affects the susceptibility to Streptozocin
CTD PMID:15284299, PMID:16374426, PMID:16684804, PMID:17624267, PMID:18413206, PMID:18999900, PMID:19921414, PMID:21832210, PMID:23611540, PMID:24513509, PMID:25199697, PMID:27769711, PMID:29420703, PMID:29988851, PMID:30551545, PMID:31696645 NCBI chr11:82,035,577...82,037,452
Ensembl chr11:82,035,571...82,037,453
JBrowse link
G Ccl5 chemokine (C-C motif) ligand 5 increases expression EXP Streptozocin results in increased expression of CCL5 mRNA CTD PMID:29420703 NCBI chr11:83,525,778...83,530,518
Ensembl chr11:83,525,778...83,530,518
JBrowse link
G Ccl6 chemokine (C-C motif) ligand 6 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CCL6 mRNA CTD PMID:25905778 NCBI chr11:83,587,886...83,593,087
Ensembl chr11:83,587,882...83,593,087
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of CCN2; Streptozocin results in increased expression of CCN2 protein
Streptozocin results in increased expression of CCN2 mRNA; Streptozocin results in increased expression of CCN2 protein
[Streptozocin co-treated with Dietary Fats] results in increased expression of CCN2 protein; sulforafan inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CCN2 protein]; sulforafan inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in decreased expression of CCN2 protein; Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]; Aspirin inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]; fenugreek seed meal inhibits the reaction [Streptozocin results in increased expression of CCN2 mRNA]; fenugreek seed meal inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]; idebenone inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]; XLF-III-43 inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of CCN2 protein]
CTD PMID:10026205, PMID:14586741, PMID:17270171, PMID:19369054, PMID:19657322, PMID:19895808, PMID:21416479, PMID:24707343, PMID:24967692, PMID:25057273, PMID:28648635, PMID:31062909 NCBI chr10:24,595,442...24,598,683
Ensembl chr10:24,595,442...24,598,683
JBrowse link
G Ccnt1 cyclin T1 multiple interactions ISO [Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA; [Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein]; rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 mRNA]; rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CCNT1 protein] CTD PMID:20828602 NCBI chr15:98,538,690...98,567,736
Ensembl chr15:98,538,689...98,570,923
JBrowse link
G Ccs copper chaperone for superoxide dismutase decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CCS mRNA; Streptozocin results in decreased expression of CCS protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein]
CTD PMID:24927960 NCBI chr19:4,825,366...4,839,356
Ensembl chr19:4,825,366...4,839,332
JBrowse link
G Cd14 CD14 antigen multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CD14 mRNA CTD PMID:29127188 NCBI chr18:36,725,064...36,726,815
Ensembl chr18:36,725,067...36,726,798
JBrowse link
G Cd163 CD163 antigen multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CD163 mRNA CTD PMID:25905778 NCBI chr 6:124,304,636...124,330,529
Ensembl chr 6:124,304,656...124,330,527
JBrowse link
G Cd200r4 CD200 receptor 4 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CD200R1L mRNA CTD PMID:25905778 NCBI chr16:44,811,650...44,839,150
Ensembl chr16:44,811,733...44,839,150
JBrowse link
G Cd24a CD24a antigen multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CD24A mRNA CTD PMID:29127188 NCBI chr10:43,579,169...43,584,265
Ensembl chr10:43,578,284...43,584,265
JBrowse link
G Cd36 CD36 molecule multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CD36 mRNA CTD PMID:29127188 NCBI chr 5:17,781,690...17,888,959
Ensembl chr 5:17,781,690...17,888,801
JBrowse link
G Cd53 CD53 antigen multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CD53 mRNA CTD PMID:25905778 NCBI chr 3:106,758,861...106,790,149
Ensembl chr 3:106,759,921...106,790,149
JBrowse link
G Cd5l CD5 antigen-like multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CD5L mRNA CTD PMID:25905778 NCBI chr 3:87,357,881...87,371,074
Ensembl chr 3:87,357,881...87,371,073
JBrowse link
G Cd68 CD68 antigen multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of CD68 mRNA; nifuroxazide inhibits the reaction [Streptozocin results in increased expression of CD68 protein] CTD PMID:25905778, PMID:29291386 NCBI chr11:69,664,213...69,666,170
Ensembl chr11:69,664,213...69,666,153
JBrowse link
G Cd80 CD80 antigen multiple interactions
increases expression
EXP Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD80 protein] CTD PMID:15892581 NCBI chr16:38,457,430...38,495,958
Ensembl chr16:38,455,561...38,496,335
JBrowse link
G Cd86 CD86 antigen multiple interactions
increases expression
EXP
ISO
Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of CD86 protein]
[resveratrol co-treated with Streptozocin] results in increased expression of CD86 mRNA
CTD PMID:15892581, PMID:25905778 NCBI chr16:36,568,956...36,666,158
Ensembl chr16:36,603,869...36,666,081
JBrowse link
G Cdh1 cadherin 1 decreases expression ISO Streptozocin results in decreased expression of CDH1 CTD PMID:32469605 NCBI chr 8:106,603,350...106,670,247
Ensembl chr 8:106,603,351...106,670,246
JBrowse link
G Cdh2 cadherin 2 multiple interactions
decreases expression
EXP rhodioloside inhibits the reaction [Streptozocin results in decreased expression of CDH2 protein] CTD PMID:31682803 NCBI chr18:16,588,877...16,809,246
Ensembl chr18:16,588,877...16,809,246
JBrowse link
G Cdk9 cyclin-dependent kinase 9 (CDC2-related kinase) multiple interactions ISO [Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA; [Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Berberine affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; Fenofibrate affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein]; rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 mRNA]; rosiglitazone affects the reaction [[Streptozocin co-treated with Dietary Carbohydrates co-treated with Dietary Fats] affects the expression of CDK9 protein] CTD PMID:20828602 NCBI chr 2:32,705,782...32,712,784
Ensembl chr 2:32,705,784...32,713,076
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A (P21) multiple interactions
increases expression
EXP
ISO
2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of CDKN1A mRNA]; [Streptozocin co-treated with Dietary Fats] results in increased expression of CDKN1A mRNA; Quercetin inhibits the reaction [Streptozocin results in increased expression of CDKN1A mRNA]; SIRT1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN1A]
Organoselenium Compounds inhibits the reaction [Streptozocin results in increased expression of CDKN1A protein]; Streptozocin promotes the reaction [SETD7 protein binds to CDKN1A promoter]
Streptozocin results in increased expression of CDKN1A mRNA; Streptozocin results in increased expression of CDKN1A protein
Streptozocin results in increased expression of CDKN1A; Streptozocin results in increased expression of CDKN1A mRNA
CTD PMID:19496084, PMID:22744176, PMID:25301743, PMID:27652271, PMID:29127188, PMID:29673160 NCBI chr17:29,090,979...29,100,722
Ensembl chr17:29,090,976...29,100,727
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A increases expression
multiple interactions
EXP Streptozocin results in increased expression of CDKN2A mRNA; Streptozocin results in increased expression of CDKN2A protein
2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA]; 2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of CDKN2A protein]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A mRNA]; NTN1 protein inhibits the reaction [Streptozocin results in increased expression of CDKN2A protein]
CTD PMID:29059224, PMID:29673160 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cebpd CCAAT/enhancer binding protein (C/EBP), delta multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CEBPD mRNA CTD PMID:25905778 NCBI chr16:15,887,286...15,889,545
Ensembl chr16:15,887,286...15,891,031
JBrowse link
G Ces2c carboxylesterase 2C multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CES2C mRNA CTD PMID:25905778 NCBI chr 8:104,847,068...104,854,483
Ensembl chr 8:104,847,068...104,854,483
JBrowse link
G Cfd complement factor D (adipsin) increases expression ISO Streptozocin results in increased expression of CFD mRNA CTD PMID:3299706 NCBI chr10:79,890,853...79,892,655
Ensembl chr10:79,890,853...79,892,655
JBrowse link
G Cfl1 cofilin 1, non-muscle multiple interactions
increases phosphorylation
ISO fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of CFL1 protein] CTD PMID:22062134 NCBI chr19:5,490,455...5,494,031
Ensembl chr19:5,490,455...5,495,201
JBrowse link
G Cfp complement factor properdin multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CFP mRNA CTD PMID:25905778 NCBI chr  X:20,925,454...20,931,555
Ensembl chr  X:20,925,454...20,931,555
JBrowse link
G Chat choline acetyltransferase multiple interactions
affects localization
ISO Inositol inhibits the reaction [Streptozocin affects the localization of CHAT protein] CTD PMID:2431858 NCBI chr14:32,408,203...32,465,909
Ensembl chr14:32,408,203...32,465,989
JBrowse link
G Chka choline kinase alpha multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CHKA mRNA CTD PMID:29127188 NCBI chr19:3,851,585...3,894,369
Ensembl chr19:3,851,773...3,894,369
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2, cardiac multiple interactions
increases expression
affects expression
ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 mRNA]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of CHRM2 protein]
Streptozocin results in increased expression of CHRM2 mRNA; Streptozocin results in increased expression of CHRM2 protein
CTD PMID:17989502, PMID:18715473 NCBI chr 6:36,387,991...36,528,638
Ensembl chr 6:36,388,084...36,528,414
JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3, cardiac multiple interactions
affects expression
ISO 1-hexacosanol inhibits the reaction [Streptozocin affects the expression of CHRM3 mRNA] CTD PMID:17989502 NCBI chr13:9,875,486...10,361,062
Ensembl chr13:9,875,486...10,360,847
JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase multiple interactions
increases expression
ISO Quercetin inhibits the reaction [Streptozocin results in increased expression of CHUK protein] CTD PMID:16177186 NCBI chr19:44,073,334...44,107,505
Ensembl chr19:44,073,335...44,107,480
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A multiple interactions ISO
EXP
[resveratrol co-treated with Streptozocin] results in increased expression of CIDEA mRNA
[Streptozocin co-treated with Dietary Fats] results in increased expression of CIDEA mRNA
CTD PMID:25905778, PMID:29127188 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of CISD1 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of CISD1 protein]
CTD PMID:19634143 NCBI chr10:71,330,494...71,344,849
Ensembl chr10:71,330,480...71,344,954
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 increases expression
decreases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of CITED2 mRNA
Streptozocin results in decreased expression of CITED2 mRNA
SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of CITED2 mRNA]
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CITED2 mRNA]
CTD PMID:16684804, PMID:27629361 NCBI chr10:17,723,228...17,725,674
Ensembl chr10:17,723,218...17,725,674
JBrowse link
G Ckmt2 creatine kinase, mitochondrial 2 multiple interactions
decreases expression
ISO vanadyl sulfate inhibits the reaction [Streptozocin results in decreased expression of CKMT2 mRNA] CTD PMID:16684804 NCBI chr13:91,853,386...91,876,923
Ensembl chr13:91,853,387...91,876,885
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Streptozocin results in decreased expression of CLDN1 mRNA CTD PMID:25905778 NCBI chr16:26,356,645...26,371,839
Ensembl chr16:26,356,642...26,371,841
JBrowse link
G Cldn11 claudin 11 multiple interactions
decreases expression
EXP rhodioloside inhibits the reaction [Streptozocin results in decreased expression of CLDN11 protein] CTD PMID:31682803 NCBI chr 3:31,149,920...31,164,326
Ensembl chr 3:31,149,920...31,164,324
JBrowse link
G Cldn2 claudin 2 decreases expression ISO Streptozocin results in decreased expression of CLDN2 mRNA CTD PMID:25905778 NCBI chr  X:139,800,808...139,811,386
Ensembl chr  X:139,800,828...139,811,386
JBrowse link
G Clec4f C-type lectin domain family 4, member f multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CLEC4F mRNA CTD PMID:25905778 NCBI chr 6:83,644,542...83,656,116
Ensembl chr 6:83,644,542...83,656,187
JBrowse link
G Clic4 chloride intracellular channel 4 (mitochondrial) affects expression EXP Streptozocin affects the expression of CLIC4 mRNA CTD PMID:18583417 NCBI chr 4:135,213,969...135,272,760
Ensembl chr 4:135,213,969...135,272,814
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects expression EXP Streptozocin affects the expression of CLPP mRNA CTD PMID:18583417 NCBI chr17:56,990,264...56,996,371
Ensembl chr17:56,990,305...56,996,188
JBrowse link
G Clu clusterin increases expression
multiple interactions
ISO Streptozocin results in increased expression of CLU protein
Trientine inhibits the reaction [Streptozocin results in increased expression of CLU protein]
CTD PMID:19634143 NCBI chr14:65,968,483...65,981,548
Ensembl chr14:65,968,483...65,981,547
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) multiple interactions ISO [Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of CNR1 mRNA] CTD PMID:31468622 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
increases expression
EXP [Dietary Fats co-treated with Streptozocin] results in increased expression of COL1A1 mRNA; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of COL1A1 mRNA]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of COL1A1 mRNA] CTD PMID:28700904, PMID:29988851 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col4a1 collagen, type IV, alpha 1 decreases expression
multiple interactions
increases expression
EXP
ISO
Streptozocin results in decreased expression of COL4A1 mRNA
[fatostatin co-treated with Streptozocin] results in increased expression of COL4A1 mRNA
Streptozocin results in increased expression of COL4A1 mRNA
benazepril inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]; MFN2 protein mutant form inhibits the reaction [Streptozocin promotes the reaction [TFAP2A protein binds to COL4A1 promoter]]; MFN2 protein mutant form inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA]; Streptozocin promotes the reaction [TFAP2A protein binds to COL4A1 promoter]
CTD PMID:11798618, PMID:15496156, PMID:17582205, PMID:27997345, PMID:29420703 NCBI chr 8:11,198,423...11,312,889
Ensembl chr 8:11,198,423...11,312,826
JBrowse link
G Col4a3 collagen, type IV, alpha 3 multiple interactions
increases expression
ISO Zinc inhibits the reaction [Streptozocin results in increased expression of COL4A3 mRNA] CTD PMID:31009641 NCBI chr 1:82,586,921...82,722,059
Ensembl chr 1:82,586,921...82,722,059
JBrowse link
G Col6a1 collagen, type VI, alpha 1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of COL6A1 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A1 protein]
CTD PMID:19634143 NCBI chr10:76,708,792...76,726,044
Ensembl chr10:76,708,792...76,726,168
JBrowse link
G Col6a2 collagen, type VI, alpha 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of COL6A2 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A2 protein]
CTD PMID:19634143 NCBI chr10:76,595,756...76,623,630
Ensembl chr10:76,595,762...76,623,630
JBrowse link
G Col6a3 collagen, type VI, alpha 3 increases expression
multiple interactions
ISO Streptozocin results in increased expression of COL6A3 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein]
CTD PMID:19634143 NCBI chr 1:90,766,860...90,844,001
Ensembl chr 1:90,765,923...90,843,971
JBrowse link
G Cotl1 coactosin-like 1 (Dictyostelium) multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of COTL1 mRNA CTD PMID:25905778 NCBI chr 8:119,809,214...119,840,579
Ensembl chr 8:119,809,222...119,840,544
JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone affects expression EXP Streptozocin affects the expression of COX17 mRNA CTD PMID:18583417 NCBI chr16:38,346,983...38,352,763
Ensembl chr16:38,346,991...38,352,763
Ensembl chr16:38,346,991...38,352,763
JBrowse link
G Cp ceruloplasmin multiple interactions
decreases expression
ISO caryophyllene inhibits the reaction [Streptozocin results in decreased expression of CP protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of CP protein] CTD PMID:26748309 NCBI chr 3:19,956,933...20,009,750
Ensembl chr 3:19,957,054...20,009,145
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1a, liver increases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of CPT1A mRNA
[Dietary Fats co-treated with Streptozocin] results in decreased expression of CPT1A mRNA; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CPT1A mRNA]
[resveratrol co-treated with Streptozocin] results in decreased expression of CPT1A mRNA; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CPT1A mRNA]
CTD PMID:16684804, PMID:25905778, PMID:29988851 NCBI chr19:3,322,326...3,385,735
Ensembl chr19:3,322,334...3,385,733
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of CPT2 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of CPT2 protein]
CTD PMID:21136691 NCBI chr 4:107,903,982...107,923,589
Ensembl chr 4:107,903,981...107,923,610
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases phosphorylation
ISO
EXP
[Streptozocin co-treated with Dietary Fats] results in decreased expression of CREB1 mRNA; Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]; xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of CREB1 protein]
[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein; CREB1 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]; MIR10A mRNA affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]
CTD PMID:20665664, PMID:23562514, PMID:27292126 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Crebbp CREB binding protein decreases expression ISO Streptozocin results in decreased expression of CREBBP mRNA CTD PMID:25905778 NCBI chr16:4,081,334...4,213,957
Ensembl chr16:4,081,328...4,213,997
JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CROT mRNA
[resveratrol co-treated with Streptozocin] results in decreased expression of CROT mRNA
CTD PMID:25905778 NCBI chr 5:8,966,033...8,997,146
Ensembl chr 5:8,966,033...8,997,324
JBrowse link
G Cry1 cryptochrome 1 (photolyase-like) increases expression ISO Streptozocin results in increased expression of CRY1 mRNA CTD PMID:25905778 NCBI chr10:85,131,700...85,185,054
Ensembl chr10:85,131,700...85,185,064
JBrowse link
G Cryz crystallin, zeta decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CRYZ protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of CRYZ protein]
CTD PMID:19634143 NCBI chr 3:154,596,711...154,623,182
Ensembl chr 3:154,596,711...154,623,182
JBrowse link
G Csf1r colony stimulating factor 1 receptor multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CSF1R mRNA CTD PMID:25905778 NCBI chr18:61,105,572...61,131,139
Ensembl chr18:61,100,598...61,132,149
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 increases expression
multiple interactions
ISO Streptozocin results in increased expression of CSRP3 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CSRP3 mRNA]
CTD PMID:16684804 NCBI chr 7:48,830,398...48,848,051
Ensembl chr 7:48,830,398...48,848,033
JBrowse link
G Cst3 cystatin C multiple interactions ISO [Streptozocin co-treated with Fructose] results in increased expression of CST3 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 2:148,871,722...148,875,512
Ensembl chr 2:148,871,722...148,875,692
JBrowse link
G Cth cystathionase (cystathionine gamma-lyase) multiple interactions EXP [Streptozocin co-treated with Dietary Fats] affects the expression of CTH mRNA CTD PMID:29127188 NCBI chr 3:157,894,248...157,925,081
Ensembl chr 3:157,894,248...157,925,077
JBrowse link
G Ctsk cathepsin K increases expression ISO Streptozocin results in increased expression of CTSK mRNA; Streptozocin results in increased expression of CTSK protein CTD PMID:25617479 NCBI chr 3:95,499,210...95,509,387
Ensembl chr 3:95,499,256...95,509,362
JBrowse link
G Ctss cathepsin S increases expression
multiple interactions
ISO Streptozocin results in increased expression of CTSS mRNA
[resveratrol co-treated with Streptozocin] results in increased expression of CTSS mRNA; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of CTSS mRNA]
CTD PMID:16684804, PMID:25905778 NCBI chr 3:95,526,786...95,556,405
Ensembl chr 3:95,526,786...95,556,403
JBrowse link
G Cxcl12 chemokine (C-X-C motif) ligand 12 multiple interactions
decreases expression
EXP [Streptozocin co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[Streptozocin co-treated with Oxygen deficiency] results in decreased expression of CXCL12 mRNA]
Streptozocin results in decreased expression of CXCL12 mRNA; Streptozocin results in decreased expression of CXCL12 protein
CTD PMID:18227068 NCBI chr 6:117,168,535...117,181,368
Ensembl chr 6:117,168,535...117,181,367
JBrowse link
G Cxcr4 chemokine (C-X-C motif) receptor 4 multiple interactions ISO [Streptozocin co-treated with Tobacco Smoke Pollution] results in increased expression of CXCR4 protein CTD PMID:30421503 NCBI chr 1:128,588,199...128,592,299
Ensembl chr 1:128,588,199...128,592,293
JBrowse link
G Cyba cytochrome b-245, alpha polypeptide multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of CYBA mRNA; Bezafibrate inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA]; candesartan inhibits the reaction [Streptozocin results in increased expression of CYBA mRNA] CTD PMID:12967931, PMID:16139267, PMID:25905778 NCBI chr 8:122,424,771...122,432,940
Ensembl chr 8:122,424,776...122,432,930
JBrowse link
G Cybb cytochrome b-245, beta polypeptide increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of CYBB protein; Streptozocin results in increased expression of NOX2 mRNA
[fatostatin co-treated with Streptozocin] results in increased expression of NOX2 mRNA; Telmisartan inhibits the reaction [Streptozocin results in increased expression of CYBB protein]
CTD PMID:19957251, PMID:21381899, PMID:29420703 NCBI chr  X:9,435,252...9,487,766
Ensembl chr  X:9,435,252...9,487,771
JBrowse link
G Cyc1 cytochrome c-1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of CYC1 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of CYC1 protein]
CTD PMID:19634143 NCBI chr15:76,343,513...76,346,260
Ensembl chr15:76,343,523...76,346,260
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO Streptozocin affects the localization of CYCS protein
arjunolic acid inhibits the reaction [Streptozocin affects the localization of CYCS protein]; Thioctic Acid inhibits the reaction [Streptozocin affects the localization of CYCS protein]
CTD PMID:19682444, PMID:19951573 NCBI chr 6:50,562,563...50,566,569
Ensembl chr 6:50,562,563...50,566,538
JBrowse link
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 increases expression ISO Streptozocin results in increased expression of CYP11B2 mRNA; Streptozocin results in increased expression of CYP11B2 protein CTD PMID:16043663 NCBI chr15:74,834,892...74,841,643
Ensembl chr15:74,834,125...74,841,643
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
EXP
ISO
Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA]; Streptozocin promotes the reaction [Dietary Fats results in decreased expression of CYP1A1 mRNA]
[resveratrol co-treated with Streptozocin] results in increased expression of CYP1A1 mRNA
CTD PMID:22342832, PMID:25905778, PMID:29382564 NCBI chr 9:57,687,928...57,703,824
Ensembl chr 9:57,687,928...57,703,824
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression
multiple interactions
increases expression
EXP
ISO
Streptozocin results in decreased expression of CYP1A2 protein
[Streptozocin co-treated with Dietary Fats] results in decreased expression of CYP1A2 mRNA
Streptozocin results in decreased expression of CYP1A2 mRNA
[resveratrol co-treated with Streptozocin] results in decreased expression of CYP1A2 mRNA; [Streptozocin results in increased expression of CYP1A2 protein] which results in increased metabolism of Diazinon
CTD PMID:12700423, PMID:17442507, PMID:25905778, PMID:29127188 NCBI chr 9:57,676,937...57,683,655
Ensembl chr 9:57,676,937...57,683,703
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CYP26A1 mRNA CTD PMID:25905778 NCBI chr19:37,697,738...37,701,536
Ensembl chr19:37,697,798...37,701,536
JBrowse link
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CYP26B1 mRNA CTD PMID:25905778 NCBI chr 6:84,571,414...84,593,908
Ensembl chr 6:84,571,414...84,593,908
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 multiple interactions EXP [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP27A1 mRNA CTD PMID:29382564 NCBI chr 1:74,713,148...74,737,897
Ensembl chr 1:74,713,574...74,737,892
JBrowse link
G Cyp2a22 cytochrome P450, family 2, subfamily a, polypeptide 22 decreases expression ISO Streptozocin results in decreased expression of CYP2A1 mRNA CTD PMID:25905778 NCBI chr 7:26,931,631...26,939,413
Ensembl chr 7:26,931,631...26,939,384
JBrowse link
G Cyp2b10 cytochrome P450, family 2, subfamily b, polypeptide 10 multiple interactions
increases expression
EXP
ISO
Berberine inhibits the reaction [Streptozocin results in increased expression of CYP2B10 mRNA]; Streptozocin promotes the reaction [Dietary Fats results in decreased expression of CYP2B10 mRNA]
[resveratrol co-treated with Streptozocin] results in increased expression of CYP2B1 mRNA
Streptozocin results in increased expression of CYP2B1 mRNA
CTD PMID:22342832, PMID:25905778, PMID:29382564 NCBI chr 7:25,897,658...25,926,624
Ensembl chr 7:25,897,620...25,926,624
JBrowse link
G Cyp2b13 cytochrome P450, family 2, subfamily b, polypeptide 13 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CYP2B13 mRNA CTD PMID:29127188 NCBI chr 7:26,061,388...26,096,197
Ensembl chr 7:26,061,497...26,096,197
JBrowse link
G Cyp2b9 cytochrome P450, family 2, subfamily b, polypeptide 9 multiple interactions
increases expression
EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CYP2B9 mRNA; Berberine promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA]; Metformin promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA] CTD PMID:22342832, PMID:29127188 NCBI chr 7:26,173,350...26,210,661
Ensembl chr 7:26,173,411...26,210,661
JBrowse link
G Cyp2c39 cytochrome P450, family 2, subfamily c, polypeptide 39 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of CYP2C39 mRNA CTD PMID:29127188 NCBI chr19:39,347,346...39,569,568
Ensembl chr19:39,510,862...39,568,529
JBrowse link
G Cyp2c52-ps cytochrome P450, family 2, subfamily c, polypeptide 52, pseudogene multiple interactions ISO [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP2C11 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP2C11 protein CTD PMID:24815820 NCBI chr19:38,976,662...39,003,627
Ensembl chr19:38,976,647...39,003,289
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
increases expression
EXP
ISO
Streptozocin results in decreased expression of CYP2E1 protein
[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased activity of CYP2E1 protein
Streptozocin results in increased expression of CYP2E1 mRNA; Streptozocin results in increased expression of CYP2E1 protein
CTD PMID:11752103, PMID:12700423, PMID:14693714, PMID:24815820, PMID:25905778 NCBI chr 7:140,763,819...140,774,990
Ensembl chr 7:140,763,739...140,774,987
JBrowse link
G Cyp2j9 cytochrome P450, family 2, subfamily j, polypeptide 9 increases expression ISO Streptozocin results in increased expression of CYP2J4 mRNA CTD PMID:25905778 NCBI chr 4:96,568,424...96,592,523
Ensembl chr 4:96,568,429...96,591,578
JBrowse link
G Cyp3a11 cytochrome P450, family 3, subfamily a, polypeptide 11 multiple interactions
increases expression
EXP [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP3A11 mRNA; Berberine inhibits the reaction [Streptozocin results in increased expression of CYP3A11 mRNA] CTD PMID:22342832, PMID:29382564 NCBI chr 5:145,854,607...145,879,854
Ensembl chr 5:145,854,426...145,879,964
JBrowse link
G Cyp4a10 cytochrome P450, family 4, subfamily a, polypeptide 10 increases expression
multiple interactions
EXP Streptozocin results in increased expression of CYP4A10 mRNA
Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A10 mRNA]
CTD PMID:22342832 NCBI chr 4:115,518,287...115,533,649
Ensembl chr 4:115,518,264...115,533,649
JBrowse link
G Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of CYP4A1 mRNA
[Dietary Fats co-treated with Streptozocin] results in increased expression of CYP4A1 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of CYP4A1 protein; [resveratrol co-treated with Streptozocin] results in decreased expression of CYP4A1 mRNA
CTD PMID:24815820, PMID:25905778 NCBI chr 4:115,411,624...115,439,034
Ensembl chr 4:115,411,624...115,439,034
JBrowse link
G Cyp4a14 cytochrome P450, family 4, subfamily a, polypeptide 14 multiple interactions
increases expression
EXP Berberine inhibits the reaction [Streptozocin results in increased expression of CYP4A14 mRNA] CTD PMID:22342832, PMID:23319174 NCBI chr 4:115,486,200...115,496,158
Ensembl chr 4:115,486,200...115,496,142
JBrowse link
G Cyp4f14 cytochrome P450, family 4, subfamily f, polypeptide 14 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of CYP4F14 mRNA CTD PMID:29127188 NCBI chr17:32,903,357...32,917,376
Ensembl chr17:32,905,070...32,917,342
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of CYP7A1 mRNA
[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein; Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]
CTD PMID:10393316, PMID:29382564, PMID:31100278 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Cyp7b1 cytochrome P450, family 7, subfamily b, polypeptide 1 multiple interactions EXP [Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7B1 mRNA; [Streptozocin co-treated with Dietary Fats] results in decreased expression of CYP7B1 mRNA CTD PMID:29127188, PMID:29382564 NCBI chr 3:18,071,944...18,243,890
Ensembl chr 3:18,071,950...18,243,338
JBrowse link
G Cyp8b1 cytochrome P450, family 8, subfamily b, polypeptide 1 multiple interactions
increases expression
ISO
EXP
[resveratrol co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNA; INS1 protein inhibits the reaction [Streptozocin results in increased expression of CYP8B1 mRNA]; Streptozocin inhibits the reaction [resveratrol results in increased expression of CYP8B1 mRNA]
[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP8B1 mRNA
Streptozocin results in increased expression of CYP8B1 mRNA; Streptozocin results in increased expression of CYP8B1 protein
CTD PMID:10393316, PMID:25905778, PMID:29382564 NCBI chr 9:121,914,356...121,916,305
Ensembl chr 9:121,914,356...121,916,305
JBrowse link
G Cysltr1 cysteinyl leukotriene receptor 1 increases expression
multiple interactions
EXP Streptozocin results in increased expression of CYSLTR1 mRNA; Streptozocin results in increased expression of CYSLTR1 protein
montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 mRNA]; montelukast inhibits the reaction [Streptozocin results in increased expression of CYSLTR1 protein]
CTD PMID:27702591 NCBI chr  X:106,576,509...106,603,679
Ensembl chr  X:106,574,346...106,603,679
JBrowse link
G Cyyr1 cysteine and tyrosine-rich protein 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of CYYR1 mRNA CTD PMID:25905778 NCBI chr16:85,452,858...85,550,905
Ensembl chr16:85,421,533...85,553,397
JBrowse link
G Dao D-amino acid oxidase increases expression
multiple interactions
ISO Streptozocin results in increased expression of DAO protein
Trientine inhibits the reaction [Streptozocin results in increased expression of DAO protein]
CTD PMID:19634143 NCBI chr 5:113,999,635...114,025,675
Ensembl chr 5:114,003,703...114,025,682
JBrowse link
G Dapk1 death associated protein kinase 1 decreases expression ISO Streptozocin results in decreased expression of DAPK1 mRNA CTD PMID:25905778 NCBI chr13:60,601,723...60,763,191
Ensembl chr13:60,601,947...60,763,191
JBrowse link
G Dbn1 drebrin 1 decreases expression ISO Streptozocin results in decreased expression of DBN1 protein CTD PMID:23333261 NCBI chr13:55,473,428...55,488,126
Ensembl chr13:55,473,429...55,488,111
JBrowse link
G Dbt dihydrolipoamide branched chain transacylase E2 affects expression EXP Streptozocin affects the expression of DBT mRNA CTD PMID:18583417 NCBI chr 3:116,513,070...116,549,981
Ensembl chr 3:116,513,070...116,549,981
JBrowse link
G Dcc deleted in colorectal carcinoma multiple interactions
increases expression
EXP NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC mRNA]; NTN1 protein promotes the reaction [Streptozocin results in increased expression of DCC protein]
Streptozocin results in increased expression of DCC mRNA; Streptozocin results in increased expression of DCC protein
CTD PMID:29059224 NCBI chr18:71,253,613...72,351,228
Ensembl chr18:71,253,634...72,351,069
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of DDIT3; Streptozocin results in increased expression of DDIT3 mRNA; Streptozocin results in increased expression of DDIT3 protein
4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]
[Streptozocin co-treated with bisphenol A] results in increased expression of DDIT3 protein; [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of DDIT3 mRNA; [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of DDIT3 protein; [Streptozocin co-treated with octylphenol] results in increased expression of DDIT3 mRNA; [Streptozocin co-treated with octylphenol] results in increased expression of DDIT3 protein; FGF21 protein affects the reaction [Streptozocin results in increased expression of DDIT3]; Streptozocin promotes the reaction [bisphenol A results in increased expression of DDIT3 mRNA]; sulforafan inhibits the reaction [Streptozocin results in increased expression of DDIT3 protein]
CTD PMID:23499715, PMID:24967692, PMID:29935216, PMID:30980806 NCBI chr10:127,290,793...127,296,291
Ensembl chr10:127,290,774...127,296,288
Ensembl chr10:127,290,774...127,296,288
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of DDIT4 mRNA CTD PMID:25905778 NCBI chr10:59,949,675...59,951,770
Ensembl chr10:59,949,669...59,951,834
JBrowse link
G Decr1 2,4-dienoyl CoA reductase 1, mitochondrial increases expression
multiple interactions
ISO Streptozocin results in increased expression of DECR1 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of DECR1 mRNA]
CTD PMID:16684804 NCBI chr 4:15,917,240...15,945,377
Ensembl chr 4:15,917,240...15,945,507
JBrowse link
G Derl1 Der1-like domain family, member 1 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of DERL1 protein] CTD PMID:30980806 NCBI chr15:57,869,502...57,892,418
Ensembl chr15:57,869,502...57,892,448
JBrowse link
G Des desmin multiple interactions
increases expression
ISO Mycophenolic Acid inhibits the reaction [Streptozocin results in increased expression of DES protein]; Valsartan inhibits the reaction [Streptozocin results in increased expression of DES protein] CTD PMID:12197670, PMID:17624267 NCBI chr 1:75,360,292...75,368,579
Ensembl chr 1:75,360,329...75,368,579
JBrowse link
G Dgkh diacylglycerol kinase, eta multiple interactions ISO [Streptozocin co-treated with Dietary Fats] results in decreased expression of DGKH mRNA CTD PMID:20665664 NCBI chr14:78,559,349...78,732,729
Ensembl chr14:78,558,750...78,732,776
JBrowse link
G Dhrs7 dehydrogenase/reductase (SDR family) member 7 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of DHRS7 mRNA CTD PMID:25905778 NCBI chr12:72,650,353...72,664,828
Ensembl chr12:72,650,353...72,664,909
JBrowse link
G Dhrs9 dehydrogenase/reductase (SDR family) member 9 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of DHRS9 mRNA CTD PMID:29127188 NCBI chr 2:69,380,462...69,403,086
Ensembl chr 2:69,380,445...69,404,533
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions EXP [Streptozocin co-treated with NQO1 protein mutant form] results in increased secretion of DIABLO protein CTD PMID:23458895 NCBI chr 5:123,511,330...123,524,164
Ensembl chr 5:123,509,765...123,524,176
JBrowse link
G Dio1 deiodinase, iodothyronine, type I multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of DIO1 mRNA CTD PMID:25905778 NCBI chr 4:107,291,465...107,307,168
Ensembl chr 4:107,291,465...107,307,169
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) multiple interactions
increases expression
ISO Trientine inhibits the reaction [Streptozocin results in increased expression of DLAT protein] CTD PMID:21136691 NCBI chr 9:50,634,633...50,659,780
Ensembl chr 9:50,634,633...50,659,780
JBrowse link
G Dld dihydrolipoamide dehydrogenase increases expression
multiple interactions
ISO Streptozocin results in increased expression of DLD protein
Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein]
CTD PMID:21136691 NCBI chr12:31,331,562...31,351,471
Ensembl chr12:31,331,277...31,351,453
JBrowse link
G Dlg4 discs large MAGUK scaffold protein 4 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein]; Memantine inhibits the reaction [Streptozocin results in decreased expression of DLG4 protein] CTD PMID:24333387 NCBI chr11:70,017,203...70,045,535
Ensembl chr11:70,016,942...70,047,522
JBrowse link
G Dlgap2 DLG associated protein 2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA]; Memantine inhibits the reaction [Streptozocin results in decreased expression of DLGAP2 mRNA] CTD PMID:24333387 NCBI chr 8:14,095,776...14,853,426
Ensembl chr 8:14,095,865...14,847,680
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) multiple interactions
increases expression
ISO Trientine inhibits the reaction [Streptozocin results in increased expression of DLST protein] CTD PMID:19634143, PMID:21136691 NCBI chr12:85,110,822...85,134,091
Ensembl chr12:85,110,833...85,134,845
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of DMBT1 mRNA CTD PMID:25905778 NCBI chr 7:131,032,057...131,121,628
Ensembl chr 7:131,032,046...131,121,628
JBrowse link
G Dnm1l dynamin 1-like increases expression
multiple interactions
ISO Streptozocin results in increased expression of DNM1L protein
ferulic acid inhibits the reaction [Streptozocin results in increased expression of DNM1L protein]
CTD PMID:31029786 NCBI chr16:16,312,228...16,359,038
Ensembl chr16:16,312,230...16,358,959
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 multiple interactions
decreases expression
EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT1 mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT1 protein; Folic Acid deficiency promotes the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]; Folic Acid inhibits the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of DNMT1 mRNA] CTD PMID:28422052, PMID:29127188 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Dnmt3a DNA methyltransferase 3A multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT3A mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT3A protein CTD PMID:29127188 NCBI chr12:3,801,559...3,914,443
Ensembl chr12:3,806,007...3,914,443
JBrowse link
G Dnmt3b DNA methyltransferase 3B multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT3B mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of DNMT3B protein CTD PMID:29127188 NCBI chr 2:153,649,411...153,687,730
Ensembl chr 2:153,649,450...153,687,730
JBrowse link
G Dpp4 dipeptidylpeptidase 4 increases response to substance
increases expression
decreases expression
decreases activity
ISO DPP4 results in increased susceptibility to Streptozocin
Streptozocin results in increased expression of DPP4 mRNA
Streptozocin results in decreased expression of DPP4 protein
Streptozocin results in decreased activity of DPP4 protein
CTD PMID:16045816, PMID:18931022 NCBI chr 2:62,330,073...62,412,315
Ensembl chr 2:62,330,073...62,412,231
JBrowse link
G Echs1 enoyl Coenzyme A hydratase, short chain, 1, mitochondrial increases expression ISO Streptozocin results in increased expression of ECHS1 protein CTD PMID:21136691 NCBI chr 7:140,105,710...140,116,421
Ensembl chr 7:140,105,710...140,116,476
JBrowse link
G Edem1 ER degradation enhancer, mannosidase alpha-like 1 increases expression ISO Streptozocin results in increased expression of EDEM1 mRNA CTD PMID:25905778 NCBI chr 6:108,824,045...108,859,356
Ensembl chr 6:108,828,641...108,859,356
JBrowse link
G Edn1 endothelin 1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of EDN1 mRNA
diphenyleneiodonium inhibits the reaction [Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Streptozocin promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]
Bezafibrate inhibits the reaction [Streptozocin results in increased expression of EDN1 mRNA]
CTD PMID:12458661, PMID:12967931, PMID:20691780 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Efnb2 ephrin B2 affects expression EXP Streptozocin affects the expression of EFNB2 mRNA CTD PMID:26073000 NCBI chr 8:8,617,235...8,661,242
Ensembl chr 8:8,617,434...8,661,242
JBrowse link
G Ehhadh enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase increases expression ISO Streptozocin results in increased expression of EHHADH mRNA CTD PMID:25905778 NCBI chr16:21,761,285...21,787,834
Ensembl chr16:21,761,287...21,787,807
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases expression
ISO vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of EIF4EBP1 mRNA] CTD PMID:16684804 NCBI chr 8:27,260,327...27,275,656
Ensembl chr 8:27,260,329...27,276,674
JBrowse link
G Elk1 ELK1, member of ETS oncogene family increases phosphorylation ISO Streptozocin results in increased phosphorylation of ELK1 protein CTD PMID:12642375 NCBI chr  X:20,933,395...20,950,608
Ensembl chr  X:20,933,395...20,950,608
JBrowse link
G Elovl7 ELOVL family member 7, elongation of long chain fatty acids (yeast) multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of ELOVL7 mRNA CTD PMID:29127188 NCBI chr13:108,214,326...108,287,109
Ensembl chr13:108,214,404...108,285,683
JBrowse link
G Eno1 enolase 1, alpha non-neuron increases expression ISO Streptozocin results in increased expression of ENO1 protein CTD PMID:24924950 NCBI chr 4:150,236,708...150,248,879
Ensembl chr 4:150,236,721...150,248,879
JBrowse link
G Enpep glutamyl aminopeptidase multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of ENPEP mRNA CTD PMID:25905778 NCBI chr 3:129,269,177...129,332,749
Ensembl chr 3:129,269,175...129,332,720
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of ENPP2 mRNA CTD PMID:25905778 NCBI chr15:54,838,901...54,952,789
Ensembl chr15:54,838,901...54,952,892
JBrowse link
G Ep300 E1A binding protein p300 increases expression
multiple interactions
ISO Streptozocin results in increased expression of EP300 mRNA
3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of EP300 mRNA]
CTD PMID:22228707 NCBI chr15:81,586,209...81,652,077
Ensembl chr15:81,585,351...81,652,077
JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of EPCAM mRNA CTD PMID:25905778 NCBI chr17:87,635,979...87,651,127
Ensembl chr17:87,635,979...87,651,129
JBrowse link
G Ephx1 epoxide hydrolase 1, microsomal increases expression
multiple interactions
ISO Streptozocin results in increased expression of EPHX1 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein]
CTD PMID:19634143 NCBI chr 1:180,989,556...181,017,569
Ensembl chr 1:180,976,210...181,020,904
JBrowse link
G Ephx2 epoxide hydrolase 2, cytoplasmic increases expression
decreases response to substance
multiple interactions
ISO
EXP
Streptozocin results in increased expression of EPHX2 protein
EPHX2 gene mutant form results in decreased susceptibility to Streptozocin
EPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased activity of RELA protein]; EPHX2 gene mutant form inhibits the reaction [Streptozocin results in increased secretion of CCL2 protein]
CTD PMID:21832210, PMID:23611540 NCBI chr14:66,084,372...66,124,522
Ensembl chr14:66,084,374...66,124,500
JBrowse link
G Epo erythropoietin multiple interactions
increases expression
decreases expression
ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of EPO mRNA]; Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPO protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPO mRNA] CTD PMID:19958114, PMID:20821229 NCBI chr 5:137,483,020...137,485,816
Ensembl chr 5:137,483,020...137,533,242
JBrowse link
G Epor erythropoietin receptor multiple interactions
increases expression
decreases expression
ISO Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]; Enalapril inhibits the reaction [Streptozocin results in increased expression of EPOR protein]; Simvastatin inhibits the reaction [Streptozocin results in decreased expression of EPOR protein]; Simvastatin inhibits the reaction [Streptozocin results in increased expression of EPOR mRNA]
Streptozocin results in increased expression of EPOR mRNA; Streptozocin results in increased expression of EPOR protein
CTD PMID:19958114, PMID:20821229 NCBI chr 9:21,958,897...21,963,576
Ensembl chr 9:21,958,897...21,963,506
JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 increases expression
multiple interactions
ISO Streptozocin results in increased expression of ERCC1 mRNA; Streptozocin results in increased expression of ERCC1 protein
3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC1 mRNA]
CTD PMID:22228707 NCBI chr 7:19,344,067...19,356,524
Ensembl chr 7:19,344,778...19,356,524
JBrowse link
G Ercc4 excision repair cross-complementing rodent repair deficiency, complementation group 4 multiple interactions
increases expression
ISO 3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ERCC4 mRNA]
Streptozocin results in increased expression of ERCC4 mRNA; Streptozocin results in increased expression of ERCC4 protein
CTD PMID:22228707 NCBI chr16:13,109,366...13,152,009
Ensembl chr16:13,109,684...13,150,617
JBrowse link
G Ern1 endoplasmic reticulum (ER) to nucleus signalling 1 multiple interactions
increases expression
ISO 4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of ERN1 protein modified form] CTD PMID:20399799 NCBI chr11:106,397,620...106,487,796
Ensembl chr11:106,394,650...106,487,852
JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions
increases expression
decreases expression
EXP
ISO
bisphenol A inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]; octylphenol inhibits the reaction [Streptozocin results in decreased expression of ESR1 mRNA]
Streptozocin results in increased expression of ESR1
[Streptozocin co-treated with Tobacco Smoke Pollution] results in increased expression of ESR1 protein
CTD PMID:24781736, PMID:30421503, PMID:32469605 NCBI chr10:4,611,989...5,005,633
Ensembl chr10:4,611,593...5,005,614
JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions
decreases expression
EXP bisphenol A inhibits the reaction [Streptozocin results in decreased expression of ESR2 mRNA]; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased expression of ESR2 mRNA]; octylphenol inhibits the reaction [Streptozocin results in decreased expression of ESR2 mRNA] CTD PMID:24781736 NCBI chr12:76,120,419...76,177,259
Ensembl chr12:76,120,419...76,177,259
JBrowse link
G Etfa electron transferring flavoprotein, alpha polypeptide decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ETFA protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFA protein]
CTD PMID:19634143 NCBI chr 9:55,454,436...55,512,243
Ensembl chr 9:55,454,508...55,512,243
JBrowse link
G Etfb electron transferring flavoprotein, beta polypeptide decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of ETFB protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFB protein]
CTD PMID:19634143 NCBI chr 7:43,444,072...43,457,800
Ensembl chr 7:43,444,083...43,457,800
JBrowse link
G Etfdh electron transferring flavoprotein, dehydrogenase affects expression EXP Streptozocin affects the expression of ETFDH mRNA CTD PMID:18583417 NCBI chr 3:79,603,788...79,628,767
Ensembl chr 3:79,603,788...79,629,500
JBrowse link
G Ets1 E26 avian leukemia oncogene 1, 5' domain multiple interactions
decreases expression
ISO
EXP
SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of ETS1 mRNA] CTD PMID:27629361 NCBI chr 9:32,636,241...32,757,820
Ensembl chr 9:32,636,221...32,757,820
JBrowse link
G Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of EZH2 mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of EZH2 protein CTD PMID:29127188 NCBI chr 6:47,530,274...47,595,270
Ensembl chr 6:47,530,139...47,595,341
JBrowse link
G Fabp4 fatty acid binding protein 4, adipocyte multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of FABP4 mRNA CTD PMID:29127188 NCBI chr 3:10,204,342...10,208,616
Ensembl chr 3:10,204,088...10,208,576
JBrowse link
G Fabp7 fatty acid binding protein 7, brain multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of FABP7 mRNA CTD PMID:29127188 NCBI chr10:57,784,923...57,788,450
Ensembl chr10:57,784,881...57,788,450
JBrowse link
G Fadd Fas (TNFRSF6)-associated via death domain increases expression
multiple interactions
ISO Streptozocin results in increased expression of FADD protein
Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FADD protein]
CTD PMID:28856781 NCBI chr 7:144,578,323...144,582,441
Ensembl chr 7:144,577,318...144,582,463
JBrowse link
G Fads1 fatty acid desaturase 1 decreases expression ISO Streptozocin results in decreased expression of FADS1 mRNA CTD PMID:25246140 NCBI chr19:10,182,877...10,196,874
Ensembl chr19:10,182,888...10,196,877
JBrowse link
G Fars2 phenylalanine-tRNA synthetase 2 (mitochondrial) affects expression EXP Streptozocin affects the expression of FARS2 mRNA CTD PMID:18583417 NCBI chr13:36,117,428...36,537,595
Ensembl chr13:36,117,412...36,726,280
JBrowse link
G Fas Fas (TNF receptor superfamily member 6) multiple interactions
increases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FAS protein] CTD PMID:28856781 NCBI chr19:34,290,647...34,327,775
Ensembl chr19:34,290,666...34,327,772
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions
increases expression
ISO Anthocyanins inhibits the reaction [Streptozocin results in increased expression of FASLG protein]; rosiglitazone inhibits the reaction [Streptozocin results in increased expression of FASLG mRNA]
Streptozocin results in increased expression of FASLG mRNA; Streptozocin results in increased expression of FASLG protein
CTD PMID:21791967, PMID:28856781 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fasn fatty acid synthase decreases expression
multiple interactions
increases expression
ISO
EXP
Streptozocin results in decreased expression of FASN mRNA
[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of FASN mRNA; esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of FASN mRNA]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FASN mRNA]
Streptozocin results in increased expression of FASN mRNA; Streptozocin results in increased expression of FASN protein
Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of FASN protein]; GHRL protein promotes the reaction [Streptozocin results in decreased expression of FASN mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of FASN mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of FASN protein]
CTD PMID:20219977, PMID:23647015, PMID:27769711, PMID:29988851 NCBI chr11:120,805,958...120,825,166
Ensembl chr11:120,805,846...120,824,547
JBrowse link
G Fbp1 fructose bisphosphatase 1 increases activity
multiple interactions
ISO Streptozocin results in increased activity of FBP1 protein
citronellol inhibits the reaction [Streptozocin results in increased activity of FBP1 protein]
CTD PMID:26944432 NCBI chr13:62,864,753...62,888,298
Ensembl chr13:62,864,753...62,888,282
JBrowse link
G Fbp2 fructose bisphosphatase 2 multiple interactions EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of FBP2 protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of FBP2 protein CTD PMID:25446853 NCBI chr13:62,836,884...62,858,400
Ensembl chr13:62,836,877...62,858,422
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions
increases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of FBXO32 protein] CTD PMID:30635400, PMID:30980806 NCBI chr15:58,175,879...58,214,892
Ensembl chr15:58,175,879...58,214,932
JBrowse link
G Fcer1g Fc receptor, IgE, high affinity I, gamma polypeptide multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of FCER1G mRNA CTD PMID:25905778 NCBI chr 1:171,229,572...171,234,349
Ensembl chr 1:171,229,572...171,234,365
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III increases expression
multiple interactions
ISO Streptozocin results in increased expression of FCGR3 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of FCGR3 mRNA]
CTD PMID:16684804 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fcna ficolin A multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of FCNA mRNA CTD PMID:25905778 NCBI chr 2:25,624,665...25,635,440
Ensembl chr 2:25,624,666...25,628,030
JBrowse link
G Fgf15 fibroblast growth factor 15 multiple interactions EXP [Dietary Fats co-treated with Streptozocin] results in increased expression of FGF15 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of FGF15 protein CTD PMID:29382564 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Fgf17 fibroblast growth factor 17 multiple interactions EXP [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of FGF17 mRNA; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in increased expression of FGF17 mRNA] CTD PMID:32303808 NCBI chr14:70,636,203...70,642,268
Ensembl chr14:70,636,203...70,642,268
JBrowse link
G Fgf21 fibroblast growth factor 21 multiple interactions
affects response to substance
EXP [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of FGF21 mRNA; FGF21 protein affects the reaction [Streptozocin results in increased expression of AIFM1]; FGF21 protein affects the reaction [Streptozocin results in increased expression of CASP12 protein modified form]; FGF21 protein affects the reaction [Streptozocin results in increased expression of DDIT3]; Glucagon analog promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of FGF21 protein]
FGF21 protein affects the susceptibility to Streptozocin
CTD PMID:23499715, PMID:29127188, PMID:29988851 NCBI chr 7:45,613,890...45,615,490
Ensembl chr 7:45,613,886...45,615,490
JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 multiple interactions
decreases expression
ISO rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of FGFR1] CTD PMID:24136780 NCBI chr 8:25,518,759...25,575,718
Ensembl chr 8:25,513,654...25,575,718
JBrowse link
G Fh1 fumarate hydratase 1 affects expression EXP Streptozocin affects the expression of FH1 mRNA CTD PMID:18583417 NCBI chr 1:175,601,378...175,625,635
Ensembl chr 1:175,600,374...175,625,635
JBrowse link
G Fitm2 fat storage-inducing transmembrane protein 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of FITM2 mRNA CTD PMID:25905778 NCBI chr 2:163,468,703...163,472,629
Ensembl chr 2:163,466,379...163,472,629
JBrowse link
G Fkbp1b FK506 binding protein 1b multiple interactions EXP Streptozocin promotes the reaction [bisphenol A results in decreased expression of FKBP1B mRNA]; Streptozocin promotes the reaction [octylphenol results in decreased expression of FKBP1B mRNA] CTD PMID:29935216 NCBI chr12:4,833,176...4,841,573
Ensembl chr12:4,833,174...4,841,591
JBrowse link
G Flt1 FMS-like tyrosine kinase 1 multiple interactions
increases expression
ISO
EXP
Simvastatin inhibits the reaction [Streptozocin results in increased expression of FLT1 mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein]; Streptozocin results in increased phosphorylation of and results in increased expression of FLT1 protein CTD PMID:20821229, PMID:26073000 NCBI chr 5:147,561,604...147,726,438
Ensembl chr 5:147,561,604...147,726,011
JBrowse link
G Fmo2 flavin containing monooxygenase 2 increases expression ISO Streptozocin results in increased expression of FMO2 mRNA CTD PMID:25905778 NCBI chr 1:162,874,317...162,898,758
Ensembl chr 1:162,874,317...162,898,726
JBrowse link
G Fmo4 flavin containing monooxygenase 4 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of FMO4 mRNA CTD PMID:25905778 NCBI chr 1:162,793,188...162,816,072
Ensembl chr 1:162,793,188...162,813,972
JBrowse link
G Fn1 fibronectin 1 increases expression
multiple interactions
ISO
EXP
Streptozocin results in increased expression of FN1; Streptozocin results in increased expression of FN1 mRNA; Streptozocin results in increased expression of FN1 protein
[fatostatin co-treated with Streptozocin] results in increased expression of FN1 mRNA; [fatostatin co-treated with Streptozocin] results in increased expression of FN1 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein; CREB1 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]
3-aminobenzamide inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; [Streptozocin co-treated with Cadmium] results in increased expression of FN1 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein; Aspirin inhibits the reaction [Streptozocin results in increased expression of FN1]; benazepril inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Carvedilol inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; esculetin inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; fenugreek seed meal inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased expression of FN1 protein]; Organoselenium Compounds inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of FN1 protein]]; Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]; XLF-III-43 inhibits the reaction [Streptozocin results in increased expression of FN1 protein]; Zinc inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA]
CTD PMID:11798618, PMID:12140129, PMID:14586741, PMID:16973718, PMID:19895808, PMID:21300041, PMID:21450970, PMID:21998146, PMID:22228707, PMID:22733486, PMID:23376009, PMID:23611540, PMID:24413998, PMID:24877639, PMID:25057273, PMID:25240712, PMID:25301743, PMID:26341651, PMID:27292126, PMID:29420703, PMID:31009641 NCBI chr 1:71,585,473...71,653,280
Ensembl chr 1:71,585,520...71,653,200
JBrowse link
G Foxa2 forkhead box A2 multiple interactions ISO copper bis(3,5-diisopropylsalicylate) inhibits the reaction [Streptozocin results in decreased expression of FOXA2] CTD PMID:23795780 NCBI chr 2:148,042,877...148,046,969
Ensembl chr 2:148,042,877...148,046,969
JBrowse link
G Foxo1 forkhead box O1 multiple interactions
decreases expression
increases acetylation
EXP
ISO
[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein; resveratrol inhibits the reaction [Streptozocin results in increased acetylation of FOXO1 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of FOXO1 protein]
Streptozocin results in decreased expression of FOXO1 mRNA
[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein; Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of FOXO1 mRNA]; resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in decreased activity of FOXO1 protein]; Streptozocin results in increased phosphorylation of and results in decreased activity of FOXO1 protein
CTD PMID:22733486, PMID:24889822, PMID:26522834, PMID:27270450 NCBI chr 3:52,268,337...52,350,109
Ensembl chr 3:52,268,336...52,353,221
JBrowse link
G Foxo3 forkhead box O3 decreases expression
multiple interactions
increases expression
ISO
EXP
Streptozocin results in decreased expression of FOXO3 protein
[Streptozocin co-treated with Resveratrol co-treated with Ramipril] results in increased phosphorylation of FOXO3 protein; [Streptozocin co-treated with Resveratrol] results in increased phosphorylation of FOXO3 protein; Resveratrol inhibits the reaction [Streptozocin results in increased expression of FOXO3 protein]
Streptozocin results in increased expression of FOXO3 protein; Streptozocin results in increased expression of FOXO3 protein modified form
CTD PMID:17082237, PMID:18703049, PMID:23792339, PMID:31062909 NCBI chr10:42,181,845...42,276,695
Ensembl chr10:42,181,841...42,276,755
JBrowse link
G Fshb follicle stimulating hormone beta decreases expression
multiple interactions
ISO
EXP
Streptozocin results in decreased expression of FSHB protein
Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of FSHB protein]; vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein]
CTD PMID:19931367, PMID:30365938 NCBI chr 2:107,055,986...107,059,651
Ensembl chr 2:107,056,140...107,059,656
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of FXYD2 mRNA CTD PMID:25905778 NCBI chr 9:45,399,709...45,410,278
Ensembl chr 9:45,399,669...45,410,278
JBrowse link
G G6pc glucose-6-phosphatase, catalytic multiple interactions
decreases expression
increases expression
increases activity
decreases activity
ISO
EXP
4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]; bis(maltolato)oxovanadium(IV) inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]; citronellol inhibits the reaction [Streptozocin results in increased activity of G6PC protein]; Glyburide inhibits the reaction [Streptozocin results in increased activity of G6PC protein]; Phlorhizin inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]; Plant Extracts inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]; Plant Extracts inhibits the reaction [Streptozocin results in increased expression of G6PC mRNA]; plumbagin inhibits the reaction [Streptozocin results in increased activity of G6PC protein]; Polysaccharides inhibits the reaction [Streptozocin results in decreased activity of G6PC protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of G6PC protein]
Streptozocin results in decreased expression of G6PC mRNA
Streptozocin results in increased expression of G6PC mRNA; Streptozocin results in increased expression of G6PC protein
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein]; [Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of G6PC protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA; esculetin promotes the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of G6PC protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of G6PC mRNA]
CTD PMID:12446591, PMID:19634143, PMID:22960630, PMID:25446853, PMID:25641191, PMID:25905778, PMID:26522834, PMID:26616445, PMID:26944432, PMID:27038876, PMID:27769711 NCBI chr11:101,367,716...101,377,903
Ensembl chr11:101,367,561...101,377,903
JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions
decreases activity
ISO 4-hydroxyphenylethanol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; [Phytic Acid co-treated with Inositol] inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; [Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein; [Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; citronellol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; geraniol inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Gliclazide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of G6PD protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of G6PD protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of G6PD protein] CTD PMID:19059388, PMID:19133311, PMID:19682444, PMID:24923654, PMID:25641191, PMID:26944432, PMID:28330423, PMID:28757134 NCBI chr  X:74,409,483...74,428,880
Ensembl chr  X:74,409,483...74,429,194
JBrowse link
G Gabrr1 gamma-aminobutyric acid (GABA) C receptor, subunit rho 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of GABRR1 mRNA; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of GABRR1 mRNA] CTD PMID:32303808 NCBI chr 4:33,132,556...33,163,588
Ensembl chr 4:33,132,521...33,163,588
JBrowse link
G Gad1 glutamate decarboxylase 1 multiple interactions
decreases expression
ISO Curcumin inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of GAD1 mRNA] CTD PMID:23267840 NCBI chr 2:70,561,303...70,602,014
Ensembl chr 2:70,553,072...70,602,014
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible 45 beta multiple interactions ISO
EXP
[resveratrol co-treated with Streptozocin] results in increased expression of GADD45B mRNA
[Streptozocin co-treated with Dietary Fats] results in increased expression of GADD45B mRNA
CTD PMID:25905778, PMID:29127188 NCBI chr10:80,930,091...80,932,204
Ensembl chr10:80,930,073...80,932,204
JBrowse link
G Galt galactose-1-phosphate uridyl transferase decreases expression ISO Streptozocin results in decreased expression of GALT mRNA CTD PMID:25905778 NCBI chr 4:41,755,517...41,759,243
Ensembl chr 4:41,755,228...41,758,695
JBrowse link
G Gas6 growth arrest specific 6 increases expression ISO Streptozocin results in increased expression of GAS6 protein CTD PMID:12644472 NCBI chr 8:13,465,374...13,494,535
Ensembl chr 8:13,465,374...13,494,490
JBrowse link
G Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) multiple interactions
decreases expression
ISO Trientine inhibits the reaction [Streptozocin results in decreased expression of GATM protein] CTD PMID:19634143 NCBI chr 2:122,594,473...122,611,277
Ensembl chr 2:122,594,467...122,611,303
JBrowse link
G Gcg glucagon multiple interactions
decreases expression
ISO [Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA; Butyric Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of GCG mRNA]; Sitagliptin Phosphate inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCG mRNA] CTD PMID:18998217, PMID:23466488, PMID:27270450 NCBI chr 2:62,474,530...62,483,653
Ensembl chr 2:62,474,530...62,483,650
JBrowse link
G Gck glucokinase multiple interactions
decreases expression
EXP
ISO
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein]; [Dietary Fats co-treated with Streptozocin] results in decreased activity of GCK protein; [Dietary Fats co-treated with Streptozocin] results in decreased expression of GCK protein; [Streptozocin co-treated with Dietary Fats] results in decreased expression of GCK mRNA
Streptozocin results in decreased expression of GCK mRNA
Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of GCK mRNA]
CTD PMID:25446853, PMID:26522834, PMID:27038876, PMID:27769711, PMID:29127188 NCBI chr11:5,900,816...5,950,081
Ensembl chr11:5,900,820...5,950,081
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA; [Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein]; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC mRNA]; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GCLC protein] CTD PMID:21439372 NCBI chr 9:77,754,535...77,794,489
Ensembl chr 9:77,754,535...77,794,485
JBrowse link
G Gcnt2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme increases expression ISO Streptozocin results in increased expression of GCNT2 mRNA CTD PMID:25905778 NCBI chr13:40,859,768...40,960,892
Ensembl chr13:40,859,754...40,960,892
JBrowse link
G Gda guanine deaminase increases expression ISO Streptozocin results in increased expression of GDA mRNA CTD PMID:25905778 NCBI chr19:21,391,307...21,472,661
Ensembl chr19:21,391,307...21,473,445
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
decreases expression
increases expression
ISO
EXP
Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of GFAP protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of GFAP protein]
Streptozocin results in decreased expression of GFAP protein
Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]; Physostigmine inhibits the reaction [Streptozocin results in decreased expression of GFAP protein]
Streptozocin results in increased expression of GFAP mRNA; Streptozocin results in increased expression of GFAP protein
CTD PMID:24333387, PMID:28499986 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Gfm1 G elongation factor, mitochondrial 1 affects expression EXP Streptozocin affects the expression of GFM1 mRNA CTD PMID:18583417 NCBI chr 3:67,430,115...67,475,068
Ensembl chr 3:67,430,096...67,476,529
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of GGT1 protein
[resveratrol co-treated with Streptozocin] results in increased expression of GGT1 mRNA; Trientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein]
CTD PMID:19634143, PMID:25905778 NCBI chr10:75,561,076...75,586,193
Ensembl chr10:75,561,604...75,586,200
JBrowse link
G Ghr growth hormone receptor multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of GHR mRNA CTD PMID:25905778 NCBI chr15:3,317,755...3,583,352
Ensembl chr15:3,317,760...3,583,492
JBrowse link
G Ghrl ghrelin multiple interactions ISO GHRL protein promotes the reaction [Streptozocin results in decreased expression of CARTPT mRNA]; GHRL protein promotes the reaction [Streptozocin results in decreased expression of FASN mRNA]; GHRL protein promotes the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA] CTD PMID:20219977 NCBI chr 6:113,716,119...113,719,911
Ensembl chr 6:113,716,119...113,719,880
JBrowse link
G Gk glycerol kinase decreases expression ISO Streptozocin results in decreased expression of GK mRNA CTD PMID:25905778 NCBI chr  X:85,701,937...85,776,819
Ensembl chr  X:85,701,937...85,776,819
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions
increases expression
EXP 2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of GLB1 protein]; ARG1 gene mutant form inhibits the reaction [Streptozocin results in increased expression of GLB1 protein] CTD PMID:29673160 NCBI chr 9:114,401,078...114,474,379
Ensembl chr 9:114,401,076...114,474,898
JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO [Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein]; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GLO1 protein] CTD PMID:21439372 NCBI chr17:30,592,861...30,612,659
Ensembl chr17:30,584,936...30,626,871
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions ISO [Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA; Ghrelin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased expression of GLP1R mRNA] CTD PMID:31468622 NCBI chr17:30,901,867...30,936,510
Ensembl chr17:30,901,817...30,940,791
JBrowse link
G Glul glutamate-ammonia ligase (glutamine synthetase) multiple interactions
decreases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of GLUL mRNA; resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL mRNA]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of GLUL protein]
Streptozocin results in decreased expression of GLUL mRNA; Streptozocin results in decreased expression of GLUL protein
CTD PMID:25905778, PMID:26677078 NCBI chr 1:153,899,929...153,909,723
Ensembl chr 1:153,899,944...153,909,723
JBrowse link
G Gna11 guanine nucleotide binding protein, alpha 11 multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNA11 protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of GNA11 protein] CTD PMID:20691780 NCBI chr10:81,528,724...81,545,162
Ensembl chr10:81,528,724...81,545,190
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI2 protein] CTD PMID:18441196 NCBI chr 9:107,614,125...107,635,391
Ensembl chr 9:107,614,125...107,635,367
JBrowse link
G Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein]; diphenyleneiodonium inhibits the reaction [Streptozocin results in decreased expression of GNAI3 protein] CTD PMID:18441196 NCBI chr 3:108,107,275...108,146,152
Ensembl chr 3:108,107,280...108,146,146
JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide multiple interactions
increases expression
ISO acetovanillone inhibits the reaction [Streptozocin results in increased expression of GNAQ protein]; CAT protein inhibits the reaction [Streptozocin results in increased expression of GNAQ protein] CTD PMID:20691780 NCBI chr19:16,132,684...16,388,520
Ensembl chr19:16,132,831...16,387,463
JBrowse link
G Gnmt glycine N-methyltransferase multiple interactions
increases expression
increases activity
ISO Folic Acid inhibits the reaction [Streptozocin results in increased activity of GNMT protein]
Streptozocin results in increased expression of GNMT mRNA; Streptozocin results in increased expression of GNMT protein
CTD PMID:16835399 NCBI chr17:46,725,664...46,729,211
Ensembl chr17:46,725,664...46,729,168
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble multiple interactions
increases secretion
ISO [Resveratrol co-treated with Streptozocin] results in decreased expression of GOT1 mRNA; Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GOT1 protein] CTD PMID:25905778, PMID:30657622 NCBI chr19:43,499,752...43,524,605
Ensembl chr19:43,499,752...43,524,605
JBrowse link
G Got2 glutamatic-oxaloacetic transaminase 2, mitochondrial increases expression
multiple interactions
ISO Streptozocin results in increased expression of GOT2 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of GOT2 protein]
CTD PMID:19634143 NCBI chr 8:95,864,133...95,888,401
Ensembl chr 8:95,864,134...95,888,547
JBrowse link
G Gpc1 glypican 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of GPC1 mRNA CTD PMID:29127188 NCBI chr 1:92,831,645...92,860,211
Ensembl chr 1:92,831,645...92,860,779
JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of GPD1 mRNA CTD PMID:25905778 NCBI chr15:99,717,587...99,725,014
Ensembl chr15:99,717,515...99,725,005
JBrowse link
G Gprc6a G protein-coupled receptor, family C, group 6, member A multiple interactions ISO [Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of GPRC6A mRNA] CTD PMID:27488359 NCBI chr10:51,614,823...51,631,458
Ensembl chr10:51,614,823...51,631,461
JBrowse link
G Gpt glutamic pyruvic transaminase, soluble multiple interactions
increases secretion
increases activity
increases expression
ISO
EXP
[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein; [Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein; allyl isothiocyanate inhibits the reaction [Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]]; Atorvastatin inhibits the reaction [Streptozocin results in increased secretion of GPT protein]; Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Ficusin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]; Fungal Polysaccharides inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]; Glyburide inhibits the reaction [Streptozocin results in increased activity of GPT protein]; mangiferin inhibits the reaction [Streptozocin results in increased activity of GPT protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]; naringenin inhibits the reaction [Streptozocin results in increased activity of GPT protein]; Pioglitazone inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of GPT protein]; sodium tungstate(VI) inhibits the reaction [Streptozocin results in increased activity of GPT protein]; Streptozocin promotes the reaction [Dietary Fats results in increased expression of GPT protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased activity of GPT protein]
[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein; Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; perilla seed oil inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]
CTD PMID:11357483, PMID:24854284, PMID:24877639, PMID:26071184, PMID:27350165, PMID:29223569, PMID:29614383, PMID:30144451, PMID:30657622, PMID:30927557, PMID:31100278, PMID:31743741 NCBI chr15:76,696,726...76,699,675
Ensembl chr15:76,695,716...76,699,686
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
decreases expression
increases expression
decreases activity
EXP
ISO
Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GPX1 protein]; Sodium Selenite inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]
Curcumin inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Resveratrol inhibits the reaction [Streptozocin results in decreased expression of GPX1 mRNA]; Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein]
CTD PMID:18789669, PMID:19634143, PMID:23267840, PMID:24740756 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of GPX2 mRNA CTD PMID:25905778 NCBI chr12:76,792,335...76,795,554
Ensembl chr12:76,792,333...76,795,554
JBrowse link
G Gpx3 glutathione peroxidase 3 increases expression
multiple interactions
ISO Streptozocin results in increased expression of GPX3 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein]
CTD PMID:19634143 NCBI chr11:54,902,854...54,910,387
Ensembl chr11:54,902,453...54,910,377
JBrowse link
G Grem1 gremlin 1, DAN family BMP antagonist increases expression ISO Streptozocin results in increased expression of GREM1 mRNA CTD PMID:10744662 NCBI chr 2:113,748,675...113,758,648
Ensembl chr 2:113,746,164...113,758,646
JBrowse link
G Gria4 glutamate receptor, ionotropic, AMPA4 (alpha 4) multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIA4 protein] CTD PMID:23267840 NCBI chr 9:4,417,893...4,796,234
Ensembl chr 9:4,417,896...4,796,234
JBrowse link
G Grin1 glutamate receptor, ionotropic, NMDA1 (zeta 1) multiple interactions
increases expression
ISO Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of GRIN1 protein]
Streptozocin results in increased expression of GRIN1 mRNA; Streptozocin results in increased expression of GRIN1 protein
CTD PMID:23267840 NCBI chr 2:25,291,177...25,319,187
Ensembl chr 2:25,291,181...25,319,187
JBrowse link
G Grm5 glutamate receptor, metabotropic 5 increases expression ISO Streptozocin results in increased expression of GRM5 protein CTD PMID:19840219 NCBI chr 7:87,583,981...88,135,063
Ensembl chr 7:87,584,168...88,134,907
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation
increases expression
multiple interactions
ISO
EXP
Streptozocin results in decreased phosphorylation of GSK3B protein
Streptozocin results in increased expression of GSK3B mRNA
[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein; Curcumin inhibits the reaction [Streptozocin results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Plant Extracts inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Plant Extracts inhibits the reaction [Streptozocin results in increased expression of GSK3B mRNA]
CTD PMID:25541178, PMID:27038876, PMID:28422052, PMID:31877369 NCBI chr16:38,089,001...38,246,084
Ensembl chr16:38,089,001...38,246,084
JBrowse link
G Gsr glutathione reductase multiple interactions
affects activity
increases activity
decreases activity
ISO [Carmustine results in decreased activity of GSR protein] which results in increased susceptibility to Streptozocin; [Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein; [Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein; [Streptozocin co-treated with Dietary Fats] results in decreased activity of GSR protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein; Acetylcysteine inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; arjunolic acid inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Bezafibrate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; caryophyllene inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Chromium inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; chromium tripicolinate inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Ellagic Acid inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased activity of GSR protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased activity of GSR protein]; geraniol inhibits the reaction [Streptozocin affects the activity of GSR protein]; Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein]; Glyburide inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; INS protein promotes the reaction [Streptozocin results in increased activity of GSR protein]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in decreased activity of GSR protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of GSR protein]; Sodium Selenite inhibits the reaction [Streptozocin results in decreased activity of GSR protein]; Zinc inhibits the reaction [Streptozocin results in decreased activity of GSR protein] CTD PMID:11424224, PMID:15720826, PMID:17145126, PMID:19682444, PMID:19840221, PMID:20053369, PMID:20307516, PMID:20620209, PMID:21439372, PMID:22476978, PMID:22940631, PMID:23122718, PMID:24752916, PMID:24877639, PMID:26341651, PMID:26748309, PMID:30817903, PMID:31009641 NCBI chr 8:33,653,238...33,698,162
Ensembl chr 8:33,652,523...33,698,163
JBrowse link
G Gsta1 glutathione S-transferase, alpha 1 (Ya) multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of GSTA5 mRNA
Streptozocin results in increased expression of GSTA5 mRNA
CTD PMID:25905778 NCBI chr 9:78,230,669...78,242,683
Ensembl chr 9:78,230,656...78,242,684
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) increases expression
multiple interactions
ISO Streptozocin results in increased expression of GSTA2 protein; Streptozocin results in increased expression of GSTA3 mRNA
Trientine inhibits the reaction [Streptozocin results in decreased expression of GSTA3 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of GSTA2 protein]; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTA3 mRNA]
CTD PMID:16684804, PMID:19634143 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Gsta4 glutathione S-transferase, alpha 4 increases expression ISO Streptozocin results in increased expression of GSTA4 protein CTD PMID:14693714 NCBI chr 9:78,191,966...78,209,349
Ensembl chr 9:78,182,774...78,209,349
JBrowse link
G Gstm2 glutathione S-transferase, mu 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of GSTM2 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTM2 mRNA]
CTD PMID:16684804 NCBI chr 3:107,981,702...107,986,420
Ensembl chr 3:107,981,702...107,986,453
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 multiple interactions ISO [Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA] CTD PMID:21439372 NCBI chr 3:107,895,854...107,898,685
Ensembl chr 3:107,895,821...107,898,686
JBrowse link
G Gstp1 glutathione S-transferase, pi 1 decreases expression ISO Streptozocin results in decreased expression of GSTP1 mRNA CTD PMID:25905778 NCBI chr19:4,035,411...4,037,912
Ensembl chr19:4,035,407...4,037,985
JBrowse link
G Gucy1b2 guanylate cyclase 1, soluble, beta 2 decreases expression ISO Streptozocin results in decreased expression of GUCY1B2 mRNA CTD PMID:25905778 NCBI chr14:62,372,935...62,456,291
Ensembl chr14:62,392,676...62,456,289
JBrowse link
G Gys1 glycogen synthase 1, muscle decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of GYS1 mRNA
Plant Extracts inhibits the reaction [Streptozocin results in decreased expression of GYS1 mRNA]
CTD PMID:27038876 NCBI chr 7:45,434,839...45,456,617
Ensembl chr 7:45,434,844...45,456,619
JBrowse link
G Gys2 glycogen synthase 2 multiple interactions ISO [Streptozocin co-treated with Niacinamide] affects the activity of GYS2 protein; resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] affects the activity of GYS2 protein] CTD PMID:19059388 NCBI chr 6:142,422,612...142,473,130
Ensembl chr 6:142,422,613...142,473,109
JBrowse link
G H2-DMa histocompatibility 2, class II, locus DMa multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of RT1-DMA mRNA CTD PMID:25905778 NCBI chr17:34,119,693...34,139,101
Ensembl chr17:34,119,541...34,139,101
JBrowse link
G H2-DMb2 histocompatibility 2, class II, locus Mb2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of RT1-DMB mRNA CTD PMID:25905778 NCBI chr17:34,143,229...34,151,553
Ensembl chr17:34,143,307...34,151,555
JBrowse link
G Hamp hepcidin antimicrobial peptide multiple interactions ISO [Streptozocin co-treated with iron pentacarbonyl] results in increased expression of HAMP mRNA CTD PMID:22170771 NCBI chr 7:30,942,368...30,944,029
Ensembl chr 7:30,942,368...30,944,032
JBrowse link
G Hao2 hydroxyacid oxidase 2 multiple interactions
decreases expression
ISO [resveratrol co-treated with Streptozocin] results in decreased expression of HAO2 mRNA; Trientine inhibits the reaction [Streptozocin results in decreased expression of HAO2 protein]
Streptozocin results in decreased expression of HAO2 mRNA; Streptozocin results in decreased expression of HAO2 protein
CTD PMID:19634143, PMID:25905778 NCBI chr 3:98,874,519...98,895,376
Ensembl chr 3:98,874,521...98,893,239
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 decreases expression
multiple interactions
EXP
ISO
Streptozocin results in decreased expression of HAVCR1 mRNA
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; [Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]
CTD PMID:19516248, PMID:30551545 NCBI chr11:46,739,822...46,779,578
Ensembl chr11:46,735,080...46,779,578
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 multiple interactions
increases glycation
ISO [Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein; coumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]
Streptozocin results in increased glycation of HBA1 protein
CTD PMID:19647726, PMID:21139377 NCBI chr11:32,296,492...32,297,310
Ensembl chr11:32,296,489...32,297,298
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of HBB-B1 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of HBB-B1 protein]
CTD PMID:19634143
G Hck hemopoietic cell kinase multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of HCK mRNA CTD PMID:25905778 NCBI chr 2:153,108,468...153,151,441
Ensembl chr 2:153,108,468...153,151,441
JBrowse link
G Hdac3 histone deacetylase 3 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of HDAC3 protein; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MIR10A mRNA]; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein]; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FN1 protein] CTD PMID:27292126 NCBI chr18:37,936,971...37,955,015
Ensembl chr18:37,935,844...37,955,016
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression EXP Streptozocin results in increased expression of HIF1A protein CTD PMID:26073000 NCBI chr12:73,901,324...73,947,554
Ensembl chr12:73,901,375...73,947,530
JBrowse link
G Hk1 hexokinase 1 decreases activity
multiple interactions
ISO Streptozocin results in decreased activity of HK1 protein
[homocastasterone analog co-treated with Streptozocin] results in increased expression of HK1 mRNA; plumbagin inhibits the reaction [Streptozocin results in decreased activity of HK1 protein]
CTD PMID:22960630, PMID:28822685 NCBI chr10:62,268,855...62,379,920
Ensembl chr10:62,268,855...62,379,908
JBrowse link
G Hmgb1 high mobility group box 1 increases expression
multiple interactions
EXP Streptozocin results in increased expression of HMGB1 mRNA
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Streptozocin results in increased expression of HMGB1 mRNA]
CTD PMID:19833897 NCBI chr 5:149,046,702...149,053,057
Ensembl chr 5:149,046,702...149,184,489
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-Coenzyme A reductase multiple interactions
increases expression
ISO [Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA; [Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein; [Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein; [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in increased activity of HMGCR protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in increased activity of HMGCR protein]; Warfarin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of HMGCR mRNA]
Streptozocin results in increased expression of HMGCR mRNA
CTD PMID:20696151, PMID:25240712, PMID:25905778, PMID:27488359 NCBI chr13:96,648,962...96,670,936
Ensembl chr13:96,648,967...96,670,936
JBrowse link
G Hmgcs2 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of HMGCS2 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of HMGCS2 mRNA]
CTD PMID:16684804 NCBI chr 3:98,280,431...98,310,738
Ensembl chr 3:98,280,435...98,310,738
JBrowse link
G Hmox1 heme oxygenase 1 decreases activity
decreases expression
multiple interactions
increases expression
ISO
EXP
Streptozocin results in decreased activity of HMOX1 protein
Streptozocin results in decreased expression of HMOX1 mRNA; Streptozocin results in decreased expression of HMOX1 protein
[Streptozocin co-treated with sulforafan] results in increased expression of HMOX1; sulforafan inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; sulforafan inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]
HMOX1 protein inhibits the reaction [Streptozocin results in decreased expression of SLC25A19 protein]
Streptozocin results in increased expression of HMOX1 mRNA; Streptozocin results in increased expression of HMOX1 protein
[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased activity of HMOX1 protein; [cobaltiprotoporphyrin co-treated with Streptozocin] results in increased expression of HMOX1 protein; [Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein; [Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein; caffeic acid phenethyl ester inhibits the reaction [Streptozocin results in increased expression of HMOX1 protein]; chromium mesoporphyrin inhibits the reaction [[Streptozocin co-treated with Hemin] results in increased activity of HMOX1 protein]; cobaltiprotoporphyrin inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of HMOX1 protein]; cobaltiprotoporphyrin promotes the reaction [Streptozocin results in increased expression of HMOX1 protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; diallyl trisulfide inhibits the reaction [Streptozocin results in decreased expression of HMOX1 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]; palbinone inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; Propofol inhibits the reaction [Streptozocin results in decreased activity of HMOX1 protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of HMOX1 protein]; Streptozocin results in decreased expression of and results in decreased activity of HMOX1 protein; Streptozocin results in increased expression of and results in decreased activity of HMOX1 protein; sulforafan inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; tin mesoporphyrin inhibits the reaction [[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased activity of HMOX1 protein]; tin mesoporphyrin inhibits the reaction [[cobaltiprotoporphyrin co-treated with Streptozocin] results in increased expression of HMOX1 protein]
CTD PMID:16309587, PMID:16595661, PMID:19019021, PMID:19190261, PMID:21439372, PMID:21457706, PMID:22023613, PMID:22531820, PMID:22675305, PMID:23453443, PMID:24508943, PMID:24810525, PMID:24967692, PMID:25541178, PMID:30817903, PMID:31173751, PMID:32202043 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hmox2 heme oxygenase 2 multiple interactions
increases response to substance
EXP cobaltiprotoporphyrin inhibits the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin]; tin mesoporphyrin promotes the reaction [HMOX2 gene mutant form results in increased susceptibility to Streptozocin] CTD PMID:16524951 NCBI chr16:4,726,361...4,766,742
Ensembl chr16:4,726,361...4,766,742
JBrowse link
G Hopx HOP homeobox multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of HOPX mRNA CTD PMID:25905778 NCBI chr 5:77,086,986...77,115,123
Ensembl chr 5:77,086,988...77,115,121
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of HSD17B10 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of HSD17B10 protein]
CTD PMID:21136691 NCBI chr  X:152,001,896...152,004,442
Ensembl chr  X:152,001,845...152,004,442
JBrowse link
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of HSD17B2 mRNA CTD PMID:25905778 NCBI chr 8:117,700,982...117,759,030
Ensembl chr 8:117,701,904...117,759,027
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects expression EXP Streptozocin affects the expression of HSD17B4 mRNA CTD PMID:18583417 NCBI chr18:50,128,201...50,196,270
Ensembl chr18:50,128,201...50,196,269
JBrowse link
G Hsd3b3 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 3 affects expression EXP Streptozocin affects the expression of HSD3B3 mRNA CTD PMID:18583417 NCBI chr 3:98,741,476...98,764,540
Ensembl chr 3:98,741,523...98,763,127
JBrowse link
G Hsd3b5 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of HSD3B5 mRNA CTD PMID:29127188 NCBI chr 3:98,618,636...98,645,534
Ensembl chr 3:98,618,634...98,630,252
JBrowse link
G Hsd3b6 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 6 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of HSD3B6 mRNA CTD PMID:29127188 NCBI chr 3:98,805,504...98,814,443
Ensembl chr 3:98,805,504...98,814,443
JBrowse link
G Hsp90b1 heat shock protein 90, beta (Grp94), member 1 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of HSP90B1 mRNA CTD PMID:26522834 NCBI chr10:86,690,841...86,705,444
Ensembl chr10:86,690,209...86,705,509
JBrowse link
G Hspa2 heat shock protein 2 affects expression EXP Streptozocin affects the expression of HSPA2 mRNA CTD PMID:18583417 NCBI chr12:76,403,812...76,406,938
Ensembl chr12:76,404,176...76,406,938
JBrowse link
G Hspa5 heat shock protein 5 multiple interactions
increases expression
decreases expression
ISO
EXP
4-phenylbutyric acid inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]; Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein]
[Streptozocin co-treated with Dietary Fats] results in increased expression of HSPA5 protein; sulforafan inhibits the reaction [Streptozocin results in increased expression of HSPA5 protein]
CTD PMID:19634143, PMID:24967692, PMID:26522834, PMID:30980806 NCBI chr 2:34,772,090...34,776,529
Ensembl chr 2:34,771,970...34,777,547
JBrowse link
G Hspa9 heat shock protein 9 decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of HSPA9 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA9 protein]
CTD PMID:19634143 NCBI chr18:34,937,414...34,954,351
Ensembl chr18:34,937,414...34,954,357
JBrowse link
G Hspb1 heat shock protein 1 multiple interactions ISO Curcumin inhibits the reaction [Streptozocin results in increased expression of HSPB1 protein] CTD PMID:18204486 NCBI chr 5:135,887,919...135,889,563
Ensembl chr 5:135,887,919...135,889,563
JBrowse link
G Hspd1 heat shock protein 1 (chaperonin) multiple interactions
decreases expression
increases expression
ISO Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPD1 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of HSPD1 protein] CTD PMID:19634143, PMID:21136691 NCBI chr 1:55,077,833...55,088,243
Ensembl chr 1:55,077,835...55,088,243
JBrowse link
G Hspe1 heat shock protein 1 (chaperonin 10) multiple interactions
decreases expression
ISO Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPE1 protein] CTD PMID:19634143 NCBI chr 1:55,088,148...55,091,317
Ensembl chr 1:55,088,132...55,091,307
JBrowse link
G Hspg2 perlecan (heparan sulfate proteoglycan 2) increases expression
multiple interactions
ISO Streptozocin results in increased expression of HSPG2 protein
Trientine inhibits the reaction [Streptozocin results in increased expression of HSPG2 protein]
CTD PMID:19634143 NCBI chr 4:137,468,751...137,570,630
Ensembl chr 4:137,468,769...137,570,630
JBrowse link
G Htr1a 5-hydroxytryptamine (serotonin) receptor 1A multiple interactions ISO Streptozocin inhibits the reaction [8-Hydroxy-2-(di-n-propylamino)tetralin results in increased activity of HTR1A protein] CTD PMID:18622176 NCBI chr13:105,443,693...105,448,133
Ensembl chr13:105,443,639...105,448,122
JBrowse link
G Htr2a 5-hydroxytryptamine (serotonin) receptor 2A multiple interactions ISO Streptozocin inhibits the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased activity of HTR2A protein] CTD PMID:18622176 NCBI chr14:74,640,874...74,706,859
Ensembl chr14:74,640,840...74,709,494
JBrowse link
G Iapp islet amyloid polypeptide multiple interactions
decreases expression
ISO
EXP
rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of IAPP mRNA]
[octylphenol co-treated with Streptozocin] results in decreased expression of IAPP mRNA; Streptozocin inhibits the reaction [Ethinyl Estradiol results in decreased expression of IAPP mRNA]
CTD PMID:18998217, PMID:29935216 NCBI chr 6:142,298,425...142,303,820
Ensembl chr 6:142,298,423...142,303,961
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions
increases expression
EXP
ISO
Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; dehydroxymethylepoxyquinomicin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; dehydroxymethylepoxyquinomicin inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; sulforafan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; telmisartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Valsartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]
Streptozocin results in increased expression of ICAM1 mRNA; Streptozocin results in increased expression of ICAM1 protein
[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; candesartan inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; cloricromen inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; fasudil inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Cholesterol, Dietary] results in increased expression of ICAM1 protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; Rosiglitazone inhibits the reaction [Streptozocin results in increased expression of ICAM1 mRNA]; Rosiglitazone inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]
CTD PMID:10485912, PMID:14871415, PMID:15892581, PMID:16129698, PMID:16139267, PMID:17589825, PMID:17724226, PMID:19246972, PMID:19279317, PMID:22058332, PMID:23376009, PMID:24513509, PMID:24967692, PMID:28700904 NCBI chr 9:21,015,940...21,028,814
Ensembl chr 9:21,015,985...21,028,817
JBrowse link
G Id2 inhibitor of DNA binding 2 decreases expression ISO Streptozocin results in decreased expression of ID2 mRNA CTD PMID:25905778 NCBI chr12:25,093,799...25,096,092
Ensembl chr12:25,093,799...25,097,140
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial affects expression EXP Streptozocin affects the expression of IDH2 mRNA CTD PMID:18583417 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of IFITM3 mRNA CTD PMID:25905778 NCBI chr 7:141,009,590...141,010,744
Ensembl chr 7:141,009,586...141,010,770
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
increases expression
EXP
ISO
Clodronic Acid inhibits the reaction [Streptozocin results in increased expression of IFNG protein]; Dronabinol inhibits the reaction [Streptozocin results in increased expression of IFNG mRNA]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein]; Sodium Selenite inhibits the reaction [Streptozocin results in increased expression of IFNG mRNA]
Streptozocin results in decreased expression of IFNG protein
arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IFNG protein]
Streptozocin results in increased expression of IFNG mRNA; Streptozocin results in increased expression of IFNG protein
CTD PMID:11357882, PMID:15862027, PMID:15892581, PMID:15975818, PMID:18789669, PMID:20053369, PMID:25541178 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions
decreases expression
increases expression
EXP
ISO
IGF1 protein inhibits the reaction [Streptozocin results in increased expression of AGT protein]; IGF1 protein inhibits the reaction [Streptozocin results in increased expression of BAX protein]; IGF1 protein inhibits the reaction [Streptozocin results in increased expression of TRP53 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]; puerarin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
Streptozocin results in increased expression of IGF1 protein
Streptozocin results in decreased expression of IGF1 mRNA; Streptozocin results in decreased expression of IGF1 protein
CTD PMID:7637645, PMID:9868179, PMID:11375343, PMID:23927877, PMID:25617479 NCBI chr10:87,858,265...87,937,047
Ensembl chr10:87,858,265...87,937,042
JBrowse link
G Igf1r insulin-like growth factor I receptor decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of IGF1R protein
xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of IGF1R protein]
CTD PMID:23562514 NCBI chr 7:67,952,257...68,233,668
Ensembl chr 7:67,952,827...68,233,668
JBrowse link
G Igf2bp3 insulin-like growth factor 2 mRNA binding protein 3 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of IGF2BP3 mRNA CTD PMID:25905778 NCBI chr 6:49,085,218...49,215,469
Ensembl chr 6:49,085,223...49,214,957
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of IGFBP2 mRNA CTD PMID:25905778 NCBI chr 1:72,824,480...72,852,474
Ensembl chr 1:72,824,503...72,852,474
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression
multiple interactions
EXP Streptozocin results in increased expression of IGFBP3 mRNA
2-amino-6-boronohexanoic acid inhibits the reaction [Streptozocin results in increased expression of IGFBP3 mRNA]
CTD PMID:29673160 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Igfbp7 insulin-like growth factor binding protein 7 increases expression EXP Streptozocin results in increased expression of IGFBP7 mRNA CTD PMID:29673160 NCBI chr 5:77,349,240...77,408,045
Ensembl chr 5:77,349,240...77,408,041
JBrowse link
G Igsf6 immunoglobulin superfamily, member 6 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of IGSF6 mRNA CTD PMID:25905778 NCBI chr 7:121,064,067...121,074,581
Ensembl chr 7:121,064,067...121,074,572
JBrowse link
G Il10 interleukin 10 decreases expression
multiple interactions
EXP
ISO
Streptozocin results in decreased expression of IL10 mRNA
[Vanadium co-treated with Selenium co-treated with Vitamin E co-treated with Chromium] inhibits the reaction [Streptozocin results in decreased expression of IL10 protein]
CTD PMID:15862027 NCBI chr 1:131,019,845...131,024,970
Ensembl chr 1:131,019,845...131,024,974
JBrowse link
G Il12b interleukin 12b increases expression
multiple interactions
EXP Streptozocin results in increased expression of IL12B mRNA
Dronabinol inhibits the reaction [Streptozocin results in increased expression of IL12B mRNA]
CTD PMID:11357882 NCBI chr11:44,400,063...44,414,677
Ensembl chr11:44,400,063...44,414,033
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
ISO stannous mesoporphyrin inhibits the reaction [4-(4-(3-adamantan-1-ylureido)cyclohexyloxy)benzoic acid inhibits the reaction [Streptozocin results in increased expression of IL17A protein]] CTD PMID:23611540 NCBI chr 1:20,730,905...20,734,496
Ensembl chr 1:20,730,905...20,734,496
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
ISO Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL18 protein]; nifuroxazide inhibits the reaction [Streptozocin results in increased expression of IL18 mRNA]; palbinone inhibits the reaction [Streptozocin results in increased expression of IL18 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of IL18 protein]
Streptozocin results in increased expression of IL18 mRNA; Streptozocin results in increased expression of IL18 protein
CTD PMID:23647015, PMID:29291386, PMID:32202043 NCBI chr 9:50,554,700...50,581,841
Ensembl chr 9:50,554,827...50,581,840
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [Streptozocin co-treated with bisphenol A] results in increased expression of IL1A mRNA; [Streptozocin co-treated with Ethinyl Estradiol] results in increased expression of IL1A mRNA; [Streptozocin co-treated with octylphenol] results in increased expression of IL1A mRNA CTD PMID:24781736 NCBI chr 2:129,299,609...129,310,186
Ensembl chr 2:129,299,610...129,309,972
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
decreases expression
ISO
EXP
PRDX4 protein inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Streptozocin results in increased expression of IL1B mRNA; Streptozocin results in increased expression of IL1B protein
Streptozocin results in decreased expression of IL1B protein
7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL1B protein; [Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein; [pimagedine co-treated with Fatty Acids, Omega-3] inhibits the reaction [Streptozocin results in increased expression of and results in increased secretion of IL1B protein]; [Resveratrol co-treated with Streptozocin] results in increased expression of IL1B mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein; [Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Atorvastatin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Curcumin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; palbinone inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; pinitol inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Plant Extracts inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL1B protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL1B protein]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; Streptozocin results in increased expression of and results in increased secretion of IL1B protein
Alendronate inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Ascorbic Acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Genistein inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; montelukast inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; Sodium Selenite inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
CTD PMID:12123627, PMID:16129698, PMID:17167242, PMID:17589825, PMID:18789669, PMID:20307516, PMID:20446767, PMID:20643114, PMID:21439372, PMID:23647015, PMID:24877639, PMID:25541178, PMID:25635252, PMID:25905778, PMID:26341651, PMID:27702591, PMID:28259689, PMID:30481507, PMID:30611788, PMID:30802477, PMID:30817903, PMID:31726037, PMID:32202043 NCBI chr 2:129,364,569...129,371,164
Ensembl chr 2:129,364,570...129,371,139
JBrowse link
G Il1rl1 interleukin 1 receptor-like 1 multiple interactions ISO 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA]; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL1RL1 mRNA CTD PMID:31726037 NCBI chr 1:40,404,864...40,465,418
Ensembl chr 1:40,429,570...40,465,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of IL1RN mRNA CTD PMID:29127188 NCBI chr 2:24,336,860...24,351,491
Ensembl chr 2:24,336,853...24,351,494
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO arjunolic acid inhibits the reaction [Streptozocin results in decreased expression of IL2 protein] CTD PMID:20053369 NCBI chr 3:37,120,713...37,125,954
Ensembl chr 3:37,120,523...37,125,959
JBrowse link
G Il22 interleukin 22 multiple interactions EXP IL22 protein inhibits the reaction [Streptozocin results in increased abundance of Glucose] CTD PMID:26064446 NCBI chr10:118,204,584...118,210,047
Ensembl chr10:118,204,942...118,210,047
JBrowse link
G Il33 interleukin 33 multiple interactions ISO 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL33 protein CTD PMID:31726037 NCBI chr19:29,925,113...29,960,718
Ensembl chr19:29,925,114...29,960,718
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO resveratrol inhibits the reaction [Streptozocin results in decreased expression of IL4] CTD PMID:25191525 NCBI chr11:53,612,460...53,618,665
Ensembl chr11:53,602,982...53,618,669
JBrowse link
G Il6 interleukin 6 increases expression
decreases expression
multiple interactions
increases secretion
ISO
EXP
Streptozocin results in increased expression of IL6 mRNA; Streptozocin results in increased expression of IL6 protein
Streptozocin results in decreased expression of IL6 protein
[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of IL6 protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein; Alendronate inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; asiatic acid promotes the reaction [Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Carnosine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Carnosine promotes the reaction [asiatic acid inhibits the reaction [Streptozocin results in increased expression of IL6 protein]]; Curcumin analog inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Donepezil inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 mRNA]; esculetin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of IL6 protein]
3,3',4,5'-tetrahydroxystilbene inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; 7,3'-dihydroxy-4'-methoxyisoflavone inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein]; [Dietary Fats co-treated with Streptozocin co-treated with Plant Extracts] affects the expression of IL6 protein; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of IL6 mRNA; [Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of IL6 protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of IL6 protein; [Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein; [Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein; Acetylcysteine inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Allopurinol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; caryophyllene inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; crocin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Curcumin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Ellagic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Enalapril inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Flavonoids inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Gallic Acid inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; Gliclazide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Glyburide inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; isoquercitrin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; pinitol inhibits the reaction [Streptozocin results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [[Niacinamide co-treated with Streptozocin] results in increased expression of IL6 protein]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of IL6 protein]; SMe1EC2 promotes the reaction [Streptozocin results in increased expression of IL6 protein]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL6 mRNA]; Streptozocin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL6 protein]
Streptozocin results in increased secretion of IL6 protein
CTD PMID:17167242, PMID:17854708, PMID:18999900, PMID:20307516, PMID:20643114, PMID:21439094, PMID:21439372, PMID:21457706, PMID:21912612, PMID:24760747, PMID:24877639, PMID:26341651, PMID:26748309, PMID:27769711, PMID:28700904, PMID:28904557, PMID:29409856, PMID:29988851, PMID:30481507, PMID:30611788, PMID:30802477, PMID:30817903, PMID:31323227, PMID:31696645, PMID:31726037, PMID:32554039 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Il6st interleukin 6 signal transducer affects expression EXP Streptozocin affects the expression of IL6ST mRNA CTD PMID:26073000 NCBI chr13:112,464,070...112,506,860
Ensembl chr13:112,464,070...112,510,086
JBrowse link
G Ilk integrin linked kinase multiple interactions
increases activity
ISO notoginsenoside R1 inhibits the reaction [Streptozocin results in increased activity of ILK protein] CTD PMID:25503068 NCBI chr 7:105,736,590...105,742,925
Ensembl chr 7:105,736,592...105,742,925
JBrowse link
G Impa2 inositol monophosphatase 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of IMPA2 mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of IMPA2 mRNA]
CTD PMID:16684804 NCBI chr18:67,289,247...67,319,216
Ensembl chr18:67,289,186...67,322,472
JBrowse link
G Inhbb inhibin beta-B multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of INHBB mRNA CTD PMID:29127188 NCBI chr 1:119,415,463...119,422,248
Ensembl chr 1:119,415,465...119,422,248
JBrowse link
G Ins1 insulin I multiple interactions
decreases secretion
decreases expression
EXP [1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein]; [Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of and results in decreased secretion of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INS1 protein; [Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein; [Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA; asiatic acid inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; bisphenol A inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Carnosine inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; Dronabinol inhibits the reaction [Streptozocin results in decreased expression of INS1]; Edaravone inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of INS1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; INS1 inhibits the reaction [[Streptozocin co-treated with APOE mutant form] results in increased abundance of Glucosamine]; INS1 protein affects the reaction [Streptozocin results in decreased methylation of PPP2CA protein]; INS1 protein inhibits the reaction [Streptozocin results in decreased expression of DNMT1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of POU1F1 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of POU1F1 protein]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of SLC20A2 mRNA]; INS1 protein inhibits the reaction [Streptozocin results in increased expression of SLC20A2 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; octylphenol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; PQQ Cofactor inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]; pterostilbene inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Resveratrol inhibits the reaction [Streptozocin results in decreased secretion of INS1 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of INS1 protein]; sulforafan inhibits the reaction [Streptozocin results in decreased expression of INS1 protein]
Streptozocin results in decreased expression of INS1; Streptozocin results in decreased expression of INS1 protein
CTD PMID:11357882, PMID:11766996, PMID:16380481, PMID:18291360, PMID:19071154, PMID:20711301, PMID:23884884, PMID:25362599, PMID:25446853, PMID:26064446, PMID:26343954, PMID:26522834, PMID:26700463, PMID:27542954, PMID:27769711, PMID:28422052, PMID:29216956, PMID:29935216, PMID:29988851, PMID:30802477 NCBI chr19:52,264,297...52,265,015
Ensembl chr19:52,264,297...52,265,476
JBrowse link
G Ins2 insulin II multiple interactions
decreases expression
ISO
EXP
ALPK1 protein promotes the reaction [Streptozocin results in decreased secretion of INS1 protein]; INS protein inhibits the reaction [Streptozocin results in decreased expression of NES mRNA]; resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]
INS protein inhibits the reaction [Streptozocin results in decreased expression of FASN mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased expression of POMC mRNA]; INS protein inhibits the reaction [Streptozocin results in decreased expression of SLC2A4 mRNA]; INS protein inhibits the reaction [Streptozocin results in increased expression of AGRP mRNA]; INS protein inhibits the reaction [Streptozocin results in increased expression of NPY mRNA]; INS protein promotes the reaction [Streptozocin results in decreased activity of SOD2 protein]; INS protein promotes the reaction [Streptozocin results in increased activity of GSR protein]; INS protein promotes the reaction [Streptozocin results in increased expression of PPARG mRNA]
Streptozocin results in decreased expression of INS protein
INS protein inhibits the reaction [Streptozocin results in decreased activity of SOD3 protein]; INS protein inhibits the reaction [Streptozocin results in decreased expression of ATP7A protein]
CTD PMID:11216864, PMID:19388005, PMID:20219977, PMID:22940631, PMID:23884884, PMID:25808216, PMID:27542954 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Insig2 insulin induced gene 2 decreases expression ISO Streptozocin results in decreased expression of INSIG2 mRNA CTD PMID:25905778 NCBI chr 1:121,304,353...121,332,662
Ensembl chr 1:121,304,353...121,332,589
JBrowse link
G Insr insulin receptor affects expression
multiple interactions
decreases expression
increases expression
decreases phosphorylation
ISO
EXP
Streptozocin affects the expression of INSR protein
[Dietary Fats co-treated with Streptozocin co-treated with Quercetin] affects the expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA; [Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein; Estradiol affects the reaction [Streptozocin affects the expression of INSR protein]; Melatonin inhibits the reaction [Streptozocin results in decreased expression of INSR protein]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR mRNA]; Plant Extracts inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of INSR protein]; Progesterone affects the reaction [Streptozocin affects the expression of INSR protein]; xanthoceraside inhibits the reaction [Streptozocin results in decreased expression of INSR protein]
resveratrol inhibits the reaction [Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Streptozocin inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]
Streptozocin results in decreased expression of INSR mRNA
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein]; [Dietary Fats co-treated with Streptozocin] results in increased expression of INSR protein; [Streptozocin co-treated with Dietary Fats] results in decreased phosphorylation of INSR protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]; puerarin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]
Streptozocin results in increased expression of INSR mRNA
Streptozocin results in decreased phosphorylation of INSR protein
CTD PMID:9243097, PMID:17068109, PMID:18331706, PMID:19705549, PMID:21439094, PMID:23562514, PMID:23927877, PMID:25446853, PMID:25808216, PMID:26522834, PMID:29614383 NCBI chr 8:3,150,922...3,279,649
Ensembl chr 8:3,122,061...3,279,617
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of IRF1 mRNA CTD PMID:25905778 NCBI chr11:53,770,014...53,778,374
Ensembl chr11:53,770,014...53,778,374
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions
decreases expression
EXP
ISO
[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein; [Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]; perilla seed oil inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] affects the phosphorylation of IRS1 protein]
Streptozocin results in decreased expression of IRS1 mRNA; Streptozocin results in decreased expression of IRS1 protein
[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS1 protein]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]
CTD PMID:23927877, PMID:24923654, PMID:26071184, PMID:26522834, PMID:31743741 NCBI chr 1:82,233,105...82,291,439
Ensembl chr 1:82,233,112...82,235,933
Ensembl chr 1:82,233,112...82,235,933
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions
decreases expression
ISO
EXP
[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased expression of IRS2 protein]; myrtenal inhibits the reaction [Streptozocin results in decreased expression of IRS2 protein]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of IRS2 mRNA]
[Streptozocin co-treated with bisphenol A] results in decreased expression of IRS2 mRNA; [Streptozocin co-treated with octylphenol] results in decreased expression of IRS2 mRNA
Streptozocin results in decreased expression of IRS2 mRNA; Streptozocin results in decreased expression of IRS2 protein
CTD PMID:24923654, PMID:26071184, PMID:27417257, PMID:29935216 NCBI chr 8:10,984,681...11,008,929
Ensembl chr 8:10,984,681...11,008,458
JBrowse link
G Itga3 integrin alpha 3 multiple interactions
decreases expression
EXP
ISO
notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGA3 protein]
Streptozocin results in decreased expression of ITGA3 mRNA; Streptozocin results in decreased expression of ITGA3 protein
CTD PMID:25503068 NCBI chr11:95,044,475...95,076,844
Ensembl chr11:95,044,474...95,076,801
JBrowse link
G Itgal integrin alpha L multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of ITGAL mRNA; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAL protein] CTD PMID:16129698, PMID:25905778 NCBI chr 7:127,296,139...127,335,137
Ensembl chr 7:127,296,260...127,335,138
JBrowse link
G Itgam integrin alpha M multiple interactions
increases expression
ISO Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Ibuprofen inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]; Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM mRNA]; Memantine inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]
Streptozocin results in increased expression of ITGAM mRNA; Streptozocin results in increased expression of ITGAM protein
CTD PMID:16129698, PMID:24333387 NCBI chr 7:128,062,640...128,118,491
Ensembl chr 7:128,062,640...128,118,491
JBrowse link
G Itgav integrin alpha V affects expression EXP Streptozocin affects the expression of ITGAV mRNA CTD PMID:26073000 NCBI chr 2:83,722,303...83,806,917
Ensembl chr 2:83,724,397...83,806,916
JBrowse link
G Itgb1 integrin beta 1 (fibronectin receptor beta) decreases expression
multiple interactions
ISO
EXP
Streptozocin results in decreased expression of ITGB1 mRNA; Streptozocin results in decreased expression of ITGB1 protein
notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 mRNA]; notoginsenoside R1 inhibits the reaction [Streptozocin results in decreased expression of ITGB1 protein]
CTD PMID:25503068 NCBI chr 8:128,685,654...128,733,579
Ensembl chr 8:128,685,654...128,733,200
JBrowse link
G Itgb2 integrin beta 2 multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of ITGB2 mRNA; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGB2 protein] CTD PMID:16129698, PMID:25905778 NCBI chr10:77,530,329...77,565,708
Ensembl chr10:77,530,252...77,565,708
JBrowse link
G Itpr3 inositol 1,4,5-triphosphate receptor 3 multiple interactions
increases expression
EXP [bisphenol A co-treated with Streptozocin] results in increased expression of ITPR3 mRNA; [octylphenol co-treated with Streptozocin] results in increased expression of ITPR3 mRNA
Streptozocin results in increased expression of ITPR3 mRNA
CTD PMID:29935216 NCBI chr17:27,057,002...27,122,223
Ensembl chr17:27,057,304...27,122,223
JBrowse link
G Jun jun proto-oncogene multiple interactions
increases expression
ISO
EXP
resveratrol inhibits the reaction [Streptozocin results in increased expression of JUN protein]
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Streptozocin promotes the reaction [JUN protein binds to MMP9 promoter]]; SIRT1 protein inhibits the reaction [Streptozocin promotes the reaction [JUN protein binds to PARP1 protein]]; Streptozocin promotes the reaction [JUN protein binds to MMP9 promoter]; Streptozocin promotes the reaction [JUN protein binds to PARP1 protein]
CTD PMID:26499206, PMID:28478229 NCBI chr 4:95,049,036...95,052,222
Ensembl chr 4:95,049,034...95,052,222
JBrowse link
G Kcnn2 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2 increases expression EXP Streptozocin results in increased expression of KCNN2 protein CTD PMID:30635400 NCBI chr18:45,268,750...45,685,887
Ensembl chr18:45,268,860...45,686,024
JBrowse link
G Kdr kinase insert domain protein receptor multiple interactions
increases expression
ISO
EXP
Simvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]; Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein
[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein; Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]
Streptozocin results in increased expression of KDR mRNA; Streptozocin results in increased expression of KDR protein
CTD PMID:15643138, PMID:20821229, PMID:27097221 NCBI chr 5:75,932,827...75,979,072
Ensembl chr 5:75,932,827...75,978,458
JBrowse link
G Keap1 kelch-like ECH-associated protein 1 multiple interactions
decreases expression
ISO [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA; [Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein]; Glyburide inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]; isoquercitrin inhibits the reaction [Streptozocin results in decreased expression of KEAP1 mRNA]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 mRNA]; Resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of KEAP1 protein] CTD PMID:21439372, PMID:30817903 NCBI chr 9:21,229,730...21,239,332
Ensembl chr 9:21,229,730...21,239,361
JBrowse link
G Kl klotho decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of KL
rosiglitazone inhibits the reaction [Streptozocin results in decreased expression of KL]
CTD PMID:24136780 NCBI chr 5:150,952,607...150,993,817
Ensembl chr 5:150,952,607...150,993,817
JBrowse link
G Klf4 Kruppel-like factor 4 (gut) multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of KLF4 mRNA CTD PMID:25905778 NCBI chr 4:55,527,137...55,532,475
Ensembl chr 4:55,527,143...55,532,466
JBrowse link
G Klk1 kallikrein 1 multiple interactions
increases expression
ISO
EXP
KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ICAM1 protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of IL1B protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAL protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGAM protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of ITGB2 protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of TNF protein]; KLK1 protein inhibits the reaction [Streptozocin results in increased expression of VCAM1 protein]
Streptozocin results in increased expression of KLK1 mRNA
CTD PMID:16129698, PMID:19516248 NCBI chr 7:44,225,360...44,229,622
Ensembl chr 7:44,225,360...44,229,618
JBrowse link
G Klk1b4 kallikrein 1-related pepidase b4 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of KLK1B4 mRNA CTD PMID:29127188 NCBI chr 7:44,207,433...44,211,754
Ensembl chr 7:44,207,435...44,211,754
JBrowse link
G Kng2 kininogen 2 multiple interactions
increases response to substance
ISO Streptozocin promotes the reaction [KNG1 protein modified form results in increased secretion of Dinoprostone]; Streptozocin promotes the reaction [KNG1 protein modified form results in increased secretion of TAC1 protein modified form]
Streptozocin results in increased susceptibility to KNG1 protein modified form
CTD PMID:20832942 NCBI chr16:22,985,852...23,029,101
Ensembl chr16:22,985,854...23,029,482
JBrowse link
G Krt19 keratin 19 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of KRT19 mRNA CTD PMID:25905778 NCBI chr11:100,140,810...100,145,926
Ensembl chr11:100,140,810...100,148,665
JBrowse link
G Kynu kynureninase multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of KYNU mRNA CTD PMID:25905778 NCBI chr 2:43,555,258...43,683,048
Ensembl chr 2:43,555,329...43,682,715
JBrowse link
G Lap3 leucine aminopeptidase 3 affects expression EXP Streptozocin affects the expression of LAP3 mRNA CTD PMID:18583417 NCBI chr 5:45,493,374...45,512,691
Ensembl chr 5:45,493,374...45,512,691
JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of LAPTM5 mRNA CTD PMID:25905778 NCBI chr 4:130,912,890...130,936,148
Ensembl chr 4:130,913,125...130,936,141
JBrowse link
G Lcat lecithin cholesterol acyltransferase multiple interactions ISO [Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein; [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LCAT protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LCAT protein] CTD PMID:20696151, PMID:25240712 NCBI chr 8:105,939,551...105,943,402
Ensembl chr 8:105,939,551...105,943,382
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; [Resveratrol co-treated with Streptozocin] results in increased expression of LCN2 mRNA; [Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein; [Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein]; palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of LCN2 protein] CTD PMID:25905778, PMID:26474837, PMID:30551545 NCBI chr 2:32,384,637...32,387,739
Ensembl chr 2:32,384,633...32,388,252
JBrowse link
G Ldhb lactate dehydrogenase B increases expression
multiple interactions
ISO Streptozocin results in increased expression of LDHB protein
Trientine inhibits the reaction [Streptozocin results in increased expression of LDHB protein]
CTD PMID:19634143, PMID:21136691 NCBI chr 6:142,490,249...142,507,957
Ensembl chr 6:142,490,249...142,507,957
JBrowse link
G Lep leptin multiple interactions ISO
EXP
[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein; morin analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]; Zinc Compounds inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of LEP protein]
[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein; Glucagon analog inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of and results in increased secretion of LEP protein]
CTD PMID:24854284, PMID:29988851 NCBI chr 6:29,060,221...29,073,876
Ensembl chr 6:29,060,220...29,073,877
JBrowse link
G Lepr leptin receptor multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of LEPR mRNA CTD PMID:29127188 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Lgals3 lectin, galactose binding, soluble 3 multiple interactions
increases expression
ISO [resveratrol co-treated with Streptozocin] results in increased expression of LGALS3 mRNA; vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LGALS3 mRNA] CTD PMID:16684804, PMID:25905778 NCBI chr14:47,373,860...47,386,167
Ensembl chr14:47,367,751...47,386,160
JBrowse link
G Lhb luteinizing hormone beta decreases expression
multiple interactions
ISO
EXP
Streptozocin results in decreased expression of LHB protein
Sildenafil Citrate inhibits the reaction [Streptozocin results in decreased expression of LHB protein]; vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein]
CTD PMID:19931367, PMID:30365938 NCBI chr 7:45,417,608...45,421,855
Ensembl chr 7:45,420,820...45,421,897
Ensembl chr 7:45,420,820...45,421,897
JBrowse link
G Limk2 LIM motif-containing protein kinase 2 multiple interactions
increases phosphorylation
ISO fasudil inhibits the reaction [Streptozocin results in increased phosphorylation of LIMK2 protein] CTD PMID:22062134 NCBI chr11:3,343,297...3,409,276
Ensembl chr11:3,344,256...3,409,189
JBrowse link
G Lipe lipase, hormone sensitive multiple interactions
increases expression
ISO vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LIPE mRNA] CTD PMID:16684804 NCBI chr 7:25,379,527...25,398,486
Ensembl chr 7:25,379,527...25,398,710
JBrowse link
G Litaf LPS-induced TN factor decreases expression ISO Streptozocin results in decreased expression of LITAF mRNA CTD PMID:25905778 NCBI chr16:10,959,273...10,993,121
Ensembl chr16:10,959,275...11,066,157
JBrowse link
G Lpin2 lipin 2 increases expression ISO Streptozocin results in increased expression of LPIN2 mRNA CTD PMID:25905778 NCBI chr17:71,183,532...71,249,818
Ensembl chr17:71,182,560...71,249,817
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO
EXP
[Streptozocin co-treated with Cadmium] results in decreased activity of LPL protein; [Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein; [tetrahydrocurcumin co-treated with Chlorogenic Acid] results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; Chlorogenic Acid results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]; myricetin inhibits the reaction [[Streptozocin co-treated with Cadmium] results in decreased activity of LPL protein]; tetrahydrocurcumin results in decreased susceptibility to [[Streptozocin co-treated with Niacinamide] results in decreased activity of LPL protein]
[1-Deoxynojirimycin co-treated with Polysaccharides] inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA]; [Dietary Fats co-treated with Streptozocin] results in decreased expression of LPL mRNA; [Streptozocin co-treated with Dietary Fats] results in increased expression of LPL mRNA
CTD PMID:20696151, PMID:25240712, PMID:25446853, PMID:29127188 NCBI chr 8:68,880,555...68,906,932
Ensembl chr 8:68,880,491...68,907,448
JBrowse link
G Lrp5 low density lipoprotein receptor-related protein 5 affects expression EXP Streptozocin affects the expression of LRP5 mRNA CTD PMID:18583417 NCBI chr19:3,584,825...3,686,585
Ensembl chr19:3,584,828...3,686,564
JBrowse link
G Lst1 leukocyte specific transcript 1 multiple interactions ISO [resveratrol co-treated with Streptozocin] results in increased expression of LST1 mRNA CTD PMID:25905778 NCBI chr17:35,185,095...35,188,440
Ensembl chr17:35,185,095...35,188,439
JBrowse link
G Lyz2 lysozyme 2 increases expression
multiple interactions
ISO Streptozocin results in increased expression of LYZ mRNA
vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of LYZ mRNA]
CTD PMID:16684804 NCBI chr10:117,277,541...117,282,272
Ensembl chr10:117,277,331...117,282,321
JBrowse link
G Mafa v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A (avian) multiple interactions
decreases expression
EXP octylphenol inhibits the reaction [Streptozocin results in decreased expression of MAFA mRNA] CTD PMID:24781736, PMID:29935216 NCBI chr15:75,745,501...75,748,321
Ensembl chr15:75,745,490...75,748,228
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions
decreases expression
EXP Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein]; Physostigmine inhibits the reaction [Streptozocin results in decreased expression of MAP2 protein] CTD PMID:28499986 NCBI chr 1:66,175,202...66,442,583
Ensembl chr 1:66,175,273...66,442,583
JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP2K4 protein] CTD PMID:26522834 NCBI chr11:65,688,244...65,788,359
Ensembl chr11:65,688,243...65,788,297
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Streptozocin results in increased expression of MAP2K6 mRNA CTD PMID:25905778 NCBI chr11:110,399,102...110,525,522
Ensembl chr11:110,399,122...110,525,522
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions
increases expression
EXP
ISO
[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAP3K5 protein]; Streptozocin promotes the reaction [MAP3K5 protein results in increased expression of SERPINE1 protein]
Streptozocin results in increased expression of MAP3K5 protein
resveratrol inhibits the reaction [Streptozocin results in increased expression of MAP3K5 protein]
CTD PMID:16731828, PMID:26499206, PMID:26522834 NCBI chr10:19,934,101...20,142,750
Ensembl chr10:19,934,472...20,142,753
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
increases expression
increases activity
ISO
EXP
arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; capsazepine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]; Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of MAPK1 mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; RN 1734 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; Streptozocin results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK1 protein]
[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of and results in decreased phosphorylation of MAPK1 protein; [Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK1 protein; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK1 protein]; Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK1 protein]
Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK1 protein]
Streptozocin results in increased expression of MAPK1 mRNA; Streptozocin results in increased expression of MAPK1 protein
Streptozocin results in increased activity of MAPK1 protein
CTD PMID:12642375, PMID:17063547, PMID:19002579, PMID:19133311, PMID:19682444, PMID:20053369, PMID:20474069, PMID:21300041, PMID:23562514, PMID:25541468, PMID:29059224, PMID:30583000, PMID:32303808 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk14 mitogen-activated protein kinase 14 increases phosphorylation
multiple interactions
EXP
ISO
Streptozocin results in increased phosphorylation of MAPK14 protein
Atorvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK14 protein]
CTD PMID:15232685, PMID:17589825 NCBI chr17:28,691,342...28,748,405
Ensembl chr17:28,691,329...28,748,406
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 increases activity
decreases phosphorylation
multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Streptozocin results in increased activity of MAPK3 protein
Streptozocin results in decreased phosphorylation of MAPK3 protein
[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK3 protein; Diethylhexyl Phthalate promotes the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Dietary Sugars] results in decreased phosphorylation of MAPK3 protein]; Streptozocin promotes the reaction [NTN1 protein results in increased phosphorylation of MAPK3 protein]
Streptozocin results in increased phosphorylation of MAPK3 protein
Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK3 protein]
arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; arjunolic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; Botulinum Toxins, Type A inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; capsazepine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; Donepezil inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein]; Memantine inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; RN 1734 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; Streptozocin results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; xanthoceraside inhibits the reaction [Streptozocin results in decreased phosphorylation of MAPK3 protein]
Streptozocin results in increased expression of MAPK3 mRNA
CTD PMID:12642375, PMID:19002579, PMID:19133311, PMID:19682444, PMID:20053369, PMID:20474069, PMID:21300041, PMID:23562514, PMID:25541468, PMID:29059224, PMID:30583000, PMID:32303808 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
ISO
EXP
Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK8 protein]
Streptozocin results in increased phosphorylation of MAPK8 protein
[Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Ramipril inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]
[Carnosine co-treated with asiatic acid] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; [Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK8 protein; asiatic acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Carnosine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK8 protein]
CTD PMID:25541468, PMID:26522834, PMID:30802477, PMID:31062909 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases expression
ISO
EXP
chromium mesoporphyrin inhibits the reaction [Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]]; Hemin inhibits the reaction [Streptozocin results in increased expression of MAPK9 mRNA]
[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK9 protein; Sodium Selenite promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased phosphorylation of MAPK9 protein]
Streptozocin inhibits the reaction [AKR1B1 protein results in increased phosphorylation of MAPK9 protein]
CTD PMID:19190261, PMID:25541468, PMID:26522834 NCBI chr11:49,846,728...49,886,421
Ensembl chr11:49,846,751...49,886,421
JBrowse link
G Mapkapk2 MAP kinase-activated protein kinase 2 multiple interactions
increases expression
EXP telmisartan inhibits the reaction [Streptozocin results in increased expression of MAPKAPK2 protein modified form] CTD PMID:21381899 NCBI chr 1:131,053,700...131,097,871
Ensembl chr 1:131,053,700...131,097,826
JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions
EXP
ISO
Streptozocin results in increased phosphorylation of MAPT protein
Melatonin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; Melatonin metabolite inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; N-acetyl-N-formyl-5-methoxykynurenamine inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]
Folic Acid inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]; SOD2 protein inhibits the reaction [Streptozocin results in increased phosphorylation of MAPT protein]
CTD PMID:20976160, PMID:28422052, PMID:31833155 NCBI chr11:104,229,409...104,332,090
Ensembl chr11:104,231,390...104,332,090
JBrowse link
G Mas1 MAS1 oncogene decreases expression
multiple interactions
EXP Streptozocin results in decreased expression of MAS1 protein
telmisartan inhibits the reaction [Streptozocin results in decreased expression of MAS1 protein]
CTD PMID:21381899 NCBI chr17:12,838,841...12,868,150
Ensembl chr17:12,841,079...12,868,143
JBrowse link
G Mat1a methionine adenosyltransferase I, alpha multiple interactions EXP [Streptozocin co-treated with Dietary Fats] affects the expression of MAT1A mRNA CTD PMID:29127188 NCBI chr14:41,105,012...41,124,428
Ensembl chr14:41,105,035...41,124,412
JBrowse link
G Mat2a methionine adenosyltransferase II, alpha multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of MAT2A mRNA CTD PMID:29127188 NCBI chr 6:72,432,796...72,439,556
Ensembl chr 6:72,432,799...72,439,558
JBrowse link
G Mbp myelin basic protein multiple interactions
decreases expression
ISO 20-alpha-Dihydroprogesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA]; Progesterone inhibits the reaction [Streptozocin results in decreased expression of MBP mRNA] CTD PMID:20349157 NCBI chr18:82,475,091...82,585,637
Ensembl chr18:82,475,146...82,585,637
JBrowse link
G Mdh1 malate dehydrogenase 1, NAD (soluble) multiple interactions
increases expression
ISO Trientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein] CTD PMID:21136691 NCBI chr11:21,556,692...21,571,934
Ensembl chr11:21,556,692...21,572,367
JBrowse link
G Mdh2 malate dehydrogenase 2, NAD (mitochondrial) decreases expression
multiple interactions
ISO Streptozocin results in decreased expression of MDH2 protein
Trientine inhibits the reaction [Streptozocin results in decreased expression of MDH2 protein]
CTD PMID:19634143 NCBI chr 5:135,778,649...135,790,386
Ensembl chr 5:135,778,480...135,790,398
JBrowse link
G Mecr mitochondrial trans-2-enoyl-CoA reductase increases expression ISO Streptozocin results in increased expression of MECR mRNA CTD PMID:25905778 NCBI chr 4:131,843,444...131,867,787
Ensembl chr 4:131,843,470...131,867,786
JBrowse link
G Mef2c myocyte enhancer factor 2C decreases expression
multiple interactions
EXP
ISO
Streptozocin results in decreased expression of MEF2C mRNA
SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of MEF2C mRNA]
CTD PMID:27629361 NCBI chr13:83,504,017...83,667,079
Ensembl chr13:83,504,034...83,667,080
JBrowse link
G Mep1a meprin 1 alpha multiple interactions ISO Streptozocin results in decreased activity of and results in decreased expression of MEP1A protein CTD PMID:15942051 NCBI chr17:43,474,324...43,504,143
Ensembl chr17:43,474,324...43,502,812
JBrowse link
G Mfn2 mitofusin 2 multiple interactions
decreases expression
ISO ferulic acid inhibits the reaction [Streptozocin results in decreased expression of MFN2 protein]; MFN2 protein mutant form inhibits the reaction [Streptozocin promotes the reaction [TFAP2A protein binds to COL4A1 promoter]]; MFN2 protein mutant form inhibits the reaction [Streptozocin results in increased expression of COL4A1 mRNA] CTD PMID:27997345, PMID:31029786 NCBI chr 4:147,873,586...147,904,909
Ensembl chr 4:147,873,599...147,904,704
JBrowse link
G Mgll monoglyceride lipase multiple interactions ISO [resveratrol co-treated with Streptozocin] results in decreased expression of MGLL mRNA CTD PMID:25905778 NCBI chr 6:88,724,412...88,828,360
Ensembl chr 6:88,724,412...88,828,360
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to Streptozocin CTD PMID:16039682 NCBI chr 7:136,894,463...137,128,193
Ensembl chr 7:136,894,614...137,130,266
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in increased expression of MGST2 mRNA CTD PMID:29127188 NCBI chr 3:51,636,912...51,682,675
Ensembl chr 3:51,660,360...51,682,677
JBrowse link
G Mir100 microRNA 100 decreases expression EXP Streptozocin results in decreased expression of MIR100 mRNA CTD PMID:27629361 NCBI chr 9:41,531,425...41,531,504
Ensembl chr 9:41,531,425...41,531,504
JBrowse link
G Mir101b microRNA 101b increases expression EXP Streptozocin results in increased expression of MIR101B mRNA CTD PMID:27629361 NCBI chr19:29,135,279...29,135,375
Ensembl chr19:29,135,279...29,135,375
JBrowse link
G Mir106a microRNA 106a increases expression EXP Streptozocin results in increased expression of MIR106A mRNA CTD PMID:27629361 NCBI chr  X:52,742,503...52,742,567
Ensembl chr  X:52,742,503...52,742,567
JBrowse link
G Mir10a microRNA 10a multiple interactions EXP [Streptozocin co-treated with Dietary Fats] results in decreased expression of MIR10A mRNA; HDAC3 protein affects the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of MIR10A mRNA]; MIR10A mRNA affects the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CREB1 protein] CTD PMID:27292126 NCBI chr11:96,317,165...96,317,274
Ensembl chr11:96,317,165...96,317,274
JBrowse link
G Mir1188 microRNA 1188 increases expression EXP Streptozocin results in increased expression of MIR1188 mRNA CTD PMID:27629361 NCBI chr12:109,611,822...109,611,941
Ensembl chr12:109,611,822...109,611,941
JBrowse link
G Mir1190 microRNA 1190 increases expression EXP Streptozocin results in increased expression of MIR1190 mRNA CTD PMID:27629361 NCBI chr12:101,021,673...101,021,768
Ensembl chr12:101,021,673...101,021,768
JBrowse link
G Mir1251 microRNA 1251 increases expression EXP Streptozocin results in increased expression of MIR1251 mRNA CTD PMID:27629361 NCBI chr10:92,137,140...92,137,223
Ensembl chr10:92,137,140...92,137,223
JBrowse link
G Mir125b-1 microRNA 125b-1 increases expression EXP Streptozocin results in increased expression of MIR125B-1 mRNA CTD PMID:27629361 NCBI chr 9:41,581,926...41,582,002
Ensembl chr 9:41,581,926...41,582,002
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP Streptozocin results in increased expression of MIR128-1 mRNA CTD PMID:27629361 NCBI chr 1:128,202,361...128,202,430
Ensembl chr 1:128,202,361...128,202,430
JBrowse link
G Mir1298 microRNA 1298 increases expression EXP Streptozocin results in increased expression of MIR1298 mRNA CTD PMID:27629361 NCBI chr  X:147,064,905...147,065,002
Ensembl chr  X:147,064,905...147,065,002
JBrowse link
G Mir1306 microRNA 1306 increases expression EXP Streptozocin results in increased expression of MIR1306 mRNA CTD PMID:27629361 NCBI chr16:18,284,239...18,284,317
Ensembl chr16:18,284,239...18,284,317
JBrowse link
G Mir132 microRNA 132 increases expression EXP Streptozocin results in increased expression of MIR132 mRNA CTD PMID:27629361 NCBI chr11:75,173,682...75,173,747
Ensembl chr11:75,173,682...75,173,747
JBrowse link
G Mir135a-2 microRNA 135a-2 increases expression EXP Streptozocin results in increased expression of MIR135A-2 mRNA CTD PMID:27629361 NCBI chr10:92,072,086...92,072,185
Ensembl chr10:92,072,086...92,072,185
JBrowse link
G Mir135b microRNA 135b increases expression EXP Streptozocin results in increased expression of MIR135B mRNA CTD PMID:27629361 NCBI chr 1:132,198,088...132,198,184
Ensembl chr 1:132,198,088...132,198,184
JBrowse link
G Mir142 microRNA 142 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of MIR142 mRNA
SOD1 protein inhibits the reaction [Streptozocin results in increased expression of MIR142 mRNA]
CTD PMID:27629361 NCBI chr11:87,756,864...87,756,927
Ensembl chr11:87,756,864...87,756,927
JBrowse link
G Mir144 microRNA 144 increases expression
multiple interactions
EXP
ISO
Streptozocin results in increased expression of MIR144 mRNA
SOD1 protein inhibits the reaction [Streptozocin results in increased expression of MIR144 mRNA]
CTD PMID:27629361 NCBI chr11:78,073,005...78,073,070
Ensembl chr11:78,073,005...78,073,070
JBrowse link
G Mir146b microRNA 146b increases expression EXP Streptozocin results in increased expression of MIR146B mRNA CTD PMID:27629361 NCBI chr19:46,342,762...46,342,870
Ensembl chr19:46,342,762...46,342,870
JBrowse link
G Mir155 microRNA 155 decreases expression EXP Streptozocin results in decreased expression of MIR155 mRNA CTD PMID:27629361 NCBI chr16:84,714,140...84,714,204
Ensembl chr16:84,714,140...84,714,204
JBrowse link
G Mir18 microRNA 18 decreases expression EXP Streptozocin results in decreased expression of MIR18 mRNA CTD PMID:27629361 NCBI chr14:115,043,851...115,043,946
Ensembl chr14:115,043,851...115,043,946
JBrowse link
G Mir184 microRNA 184 decreases expression EXP Streptozocin results in decreased expression of MIR184 mRNA CTD PMID:27629361 NCBI chr 9:89,802,260...89,802,328
Ensembl chr 9:89,802,260...89,802,328
JBrowse link
G Mir188 microRNA 188 increases expression EXP Streptozocin results in increased expression of MIR188 mRNA CTD PMID:27629361 NCBI chr  X:7,247,989...7,248,056
Ensembl chr  X:7,247,989...7,248,056
JBrowse link
G Mir1894 microRNA 1894 increases expression EXP Streptozocin results in increased expression of MIR1894 mRNA CTD PMID:27629361 NCBI chr17:35,917,889...35,917,969
Ensembl chr17:35,917,889...35,917,969
JBrowse link
G Mir1896 microRNA 1896 increases expression EXP Streptozocin results in increased expression of MIR1896 mRNA CTD PMID:27629361 NCBI chr13:21,445,160...21,445,240
Ensembl chr13:21,445,160...21,445,240
JBrowse link
G Mir1901 microRNA 1901 increases expression EXP Streptozocin results in increased expression of MIR1901 mRNA CTD PMID:27629361 NCBI chr18:11,840,361...11,840,438
Ensembl chr18:11,840,361...11,840,438
JBrowse link
G Mir191 microRNA 191 increases expression EXP Streptozocin results in increased expression of MIR191 mRNA CTD PMID:27629361 NCBI chr 9:108,568,319...108,568,392
Ensembl chr 9:108,568,319...108,568,392
JBrowse link
G Mir1930 microRNA 1930 increases expression EXP Streptozocin results in increased expression of MIR1930 mRNA CTD PMID:27629361 NCBI chr10:77,641,224...77,641,307
Ensembl chr10:77,641,224...77,641,307
JBrowse link
G Mir1934 microRNA 1934 increases expression EXP Streptozocin results in increased expression of MIR1934 mRNA CTD PMID:27629361 NCBI chr11:69,663,043...69,663,125
Ensembl chr11:69,663,043...69,663,125
JBrowse link
G Mir194-1 microRNA 194-1 increases expression EXP Streptozocin results in increased expression of MIR194-1 mRNA CTD PMID:27629361 NCBI chr 1:185,313,319...185,313,385
Ensembl chr 1:185,313,319...185,313,385
JBrowse link
G Mir1945 microRNA 1945 increases expression EXP Streptozocin results in increased expression of MIR1945 mRNA CTD PMID:27629361 NCBI chr16:11,254,368...11,254,445
Ensembl chr16:11,254,368...11,254,445
JBrowse link
G Mir1955 microRNA 1955 increases expression EXP Streptozocin results in increased expression of MIR1955 mRNA CTD PMID:27629361 NCBI chr 2:92,191,977...92,192,074
Ensembl chr 2:92,191,977...92,192,074
JBrowse link
G Mir1962 microRNA 1962 increases expression EXP Streptozocin results in increased expression of MIR1962 mRNA CTD PMID:27629361 NCBI chr 7:135,566,162...135,566,282
Ensembl chr 7:135,566,162...135,566,282
JBrowse link
G Mir196a-1 microRNA 196a-1 decreases expression EXP Streptozocin results in decreased expression of MIR196A-1 mRNA CTD PMID:27629361 NCBI chr11:96,265,164...96,265,265
Ensembl chr11:96,265,164...96,265,265
JBrowse link
G Mir1981 microRNA 1981 increases expression EXP Streptozocin results in increased expression of MIR1981 mRNA CTD PMID:27629361 NCBI chr 1:184,822,407...184,822,488
Ensembl chr 1:184,822,407...184,822,488
JBrowse link
G Mir1982 microRNA 1982 increases expression EXP Streptozocin results in increased expression of MIR1982 mRNA CTD PMID:27629361 NCBI chr10:80,828,797...80,828,870
Ensembl chr10:80,828,797...80,828,870
JBrowse link
G Mir1b microRNA 1b increases expression EXP Streptozocin results in increased expression of MIR1B mRNA CTD PMID:27629361 NCBI chr18:10,785,446...10,785,567
Ensembl chr18:10,785,446...10,785,567
JBrowse link
G Mir200a microRNA 200a increases expression EXP Streptozocin results in increased expression of MIR200A mRNA CTD PMID:27629361 NCBI chr 4:156,054,896...156,054,985
Ensembl chr 4:156,054,896...156,054,985
JBrowse link
G Mir203 microRNA 203 affects expression EXP Streptozocin affects the expression of MIR203 mRNA CTD PMID:27629361 NCBI chr12:112,130,880...112,130,955
Ensembl chr12:112,130,880...112,130,955
JBrowse link
G Mir205 microRNA 205 increases expression EXP Streptozocin results in increased expression of MIR205 mRNA CTD PMID:27629361 NCBI chr 1:193,507,463...193,507,530
Ensembl chr 1:193,507,463...193,507,530
JBrowse link
G Mir20b microRNA 20b decreases expression EXP Streptozocin results in decreased expression of MIR20B mRNA CTD PMID:27629361 NCBI chr  X:52,742,113...52,742,192
Ensembl chr  X:52,742,113...52,742,192
JBrowse link
G Mir2139 microRNA 2139 increases expression EXP Streptozocin results in increased expression of MIR2139 mRNA CTD PMID:27629361 NCBI chr 4:139,967,526...139,967,620
Ensembl chr 4:139,967,526...139,967,620
JBrowse link
G Mir216a microRNA 216a increases expression EXP Streptozocin results in increased expression of MIR216A mRNA CTD PMID:27629361 NCBI chr11:28,757,012...28,757,083
Ensembl chr11:28,757,012...28,757,083
JBrowse link
G Mir217 microRNA 217 increases expression EXP Streptozocin results in increased expression of MIR217 mRNA CTD PMID:27629361 NCBI chr11:28,763,728...28,763,835
Ensembl chr11:28,763,728...28,763,835
JBrowse link
G Mir218-2 microRNA 218-2 increases expression EXP Streptozocin results in increased expression of MIR218-2 mRNA CTD PMID:27629361 NCBI chr11:35,616,816...35,616,925
Ensembl chr11:35,616,816...35,616,925
JBrowse link
G Mir219a-1 microRNA 219a-1 increases expression EXP Streptozocin results in increased expression of MIR219A-1 mRNA CTD PMID:27629361 NCBI chr17:34,024,983...34,025,092
Ensembl chr17:34,024,983...34,025,092
JBrowse link
G Mir222 microRNA 222 increases expression EXP Streptozocin results in increased expression of MIR222 mRNA CTD PMID:27629361 NCBI chr  X:19,146,893...19,146,971
Ensembl chr  X:19,146,893...19,146,971
JBrowse link
G Mir27a microRNA 27a decreases expression
multiple interactions
EXP
ISO
Streptozocin results in decreased expression of MIR27A mRNA
SOD1 protein inhibits the reaction [Streptozocin results in decreased expression of MIR27A mRNA]
CTD PMID:27629361 NCBI chr 8:84,208,672...84,208,758
Ensembl chr 8:84,208,672...84,208,758
JBrowse link
G Mir28b microRNA 28b decreases expression EXP Streptozocin results in decreased expression of MIR28B mRNA CTD PMID:27629361 NCBI chr 8:73,016,512...73,016,591
Ensembl chr 8:73,016,512...73,016,591
JBrowse link
G Mir293 microRNA 293 increases expression EXP Streptozocin results in increased expression of MIR293 mRNA CTD PMID:27629361 NCBI chr 7:3,220,343...3,220,422
Ensembl chr 7:3,220,343...3,220,422
JBrowse link
G Mir298 microRNA 298 increases expression EXP Streptozocin results in increased expression of MIR298 mRNA CTD PMID:27629361 NCBI chr 2:174,267,504...174,267,585
Ensembl chr 2:174,267,504...174,267,585
JBrowse link
G Mir29c microRNA 29c increases expression EXP Streptozocin results in increased expression of MIR29C mRNA CTD PMID:27629361 NCBI chr 1:195,037,547...195,037,634
Ensembl chr 1:195,037,547...195,037,634
JBrowse link
G Mir302a microRNA 302a increases expression EXP Streptozocin results in increased expression of MIR302A mRNA CTD PMID:27629361 NCBI chr 3:127,545,496...127,545,564
Ensembl chr 3:127,545,496...127,545,564
JBrowse link
G Mir302c microRNA 302c increases expression EXP Streptozocin results in increased expression of MIR302C mRNA CTD PMID:27629361 NCBI chr 3:127,545,363...127,545,430
Ensembl chr 3:127,545,363...127,545,430
JBrowse link