GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | HIF1A | decreases expression | EXP | | 6480464 | CTD | Sirolimus results in decreased expression of HIF1A protein | PMID:15634505 | HIF1A | multiple interactions | EXP | | 6480464 | CTD | [Curcumin analog co-treated with Sirolimus] inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Oxygen deficiency inhibits the reaction [Sirolimus inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]]; Sirolimus inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; Sirolimus inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [sulprostone results in increased expression of HIF1A protein] | PMID:15050414 PMID:15297429 PMID:16682453 PMID:17968710 PMID:19640849 PMID:20335389 PMID:20554536 PMID:21984483 PMID:27286880 PMID:28574600 | HIF1A | decreases expression | ISO | Hif1a (Rattus norvegicus) | 6480464 | CTD | Sirolimus results in decreased expression of HIF1A mRNA | PMID:19335982 | HIF1A | multiple interactions | ISO | Hif1a (Mus musculus) | 6480464 | CTD | Sirolimus inhibits the reaction [cyanoginosin LR results in increased expression of HIF1A protein]; Sirolimus inhibits the reaction [Polystyrenes analog results in increased expression of HIF1A protein] | PMID:36115647 PMID:36709824 | | ||||||||||||||||||||||
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