GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk3 | decreases phosphorylation | EXP | | 6480464 | CTD | Simvastatin results in decreased phosphorylation of MAPK3 protein | PMID:17169357 | Mapk3 | multiple interactions | EXP | | 6480464 | CTD | farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [IGF1 results in increased activity of MAPK3 protein]; Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]; Simvastatin results in increased phosphorylation of and results in increased activity of MAPK3 protein | PMID:17327694 PMID:17928392 PMID:18310456 PMID:20417880 | Mapk3 | decreases activity | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased activity of MAPK3 protein | PMID:19360310 | Mapk3 | decreases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in decreased phosphorylation of MAPK3 protein | PMID:17428261 PMID:20464445 | Mapk3 | increases phosphorylation | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | Simvastatin results in increased phosphorylation of MAPK3 protein | PMID:20594940 PMID:30513525 | Mapk3 | multiple interactions | ISO | Mapk3 (Rattus norvegicus) | 6480464 | CTD | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin inhibits the reaction [Smoke analog results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein | PMID:18047562 PMID:19299917 PMID:20359552 PMID:21080865 | Mapk3 | multiple interactions | ISO | MAPK3 (Homo sapiens) | 6480464 | CTD | [tipifarnib co-treated with Simvastatin] results in decreased phosphorylation of MAPK3 protein; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]; Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]; Simvastatin results in decreased phosphorylation of and results in decreased activity of MAPK3 protein | PMID:18625914 PMID:19383813 PMID:21910007 | | ||||||||||||||||||||||
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