Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352582
Species: Homo sapiens
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: CHEBI:8228
Term: pioglitazone
Definition: A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Chemical ID: MESH:C060836
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6affects expressionISOIl6 (Rattus norvegicus)6480464CTDpioglitazone affects the expression of IL6 proteinPMID:28744220
IL6increases expressionISOIl6 (Mus musculus)6480464CTDPioglitazone results in increased expression of IL6 proteinPMID:27918843
IL6multiple interactionsISOIl6 (Mus musculus)6480464CTD[Pioglitazone co-treated with Buthionine Sulfoximine] results in increased expression of IL6 mRNA; [Sodium Glutamate co-treated with Pioglitazone] results in decreased expression of IL6 protein; Pioglitazone inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Sodium Glutamate results in increased expression of IL6 mRNA]; Pioglitazone promotes the reaction [Plant Extracts results in increased expression of IL6 protein]PMID:18513333 PMID:27918843 PMID:28263783
IL6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[naringin co-treated with Pioglitazone] inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [propionic acid results in increased expression of IL6 protein]; Pioglitazone inhibits the reaction [Quinolinic Acid results in increased expression of IL6 mRNA]; Pioglitazone inhibits the reaction [Streptozocin results in increased expression of IL6 protein]PMID:29233026 PMID:30130594 PMID:31348919 PMID:37044004
Go Back to source page   Continue to Ontology report