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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736484
Species: Homo sapiens
RGD Object: Gene
Symbol: SQSTM1
Name: sequestosome 1
Acc ID: CHEBI:7989
Term: pepstatin A
Definition: A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.
Chemical ID: MESH:C031375
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SQSTM1multiple interactionsEXP 6480464CTD[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [CA 074 methyl ester co-treated with pepstatin] results in increased expression of SQSTM1 proteinPMID:32186374
SQSTM1multiple interactionsISOSqstm1 (Mus musculus)6480464CTD[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 proteinPMID:26483381 PMID:32773031
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