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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pepstatin A
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Accession:CHEBI:7989 term browser browse the term
Definition:A pentapeptide isolated from Streptomyces testaceus. It is a potent inhibitor of aspartyl proteases.
Synonyms:exact_synonym: N-(3-methylbutanoyl)-L-valyl-N-[(3S,4S)-1-{[(2S)-1-{[(2S,3S)-1-carboxy-2-hydroxy-5-methylhexan-3-yl]amino}-1-oxopropan-2-yl]amino}-3-hydroxy-6-methyl-1-oxoheptan-4-yl]-L-valinamide
 related_synonym: (3S,4S)-3-hydroxy-4-[(2S)-2-[(3S,4S)-3-hydroxy-6-methyl-4-[(2S)-3-methyl-2-[(2S)-3-methyl-2-(3-methylbutanamido)butanamido]butanamido]heptanamido]propanamido]-6-methylheptanoic acid;   Formula=C34H63N5O9;   InChI=1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23?,24?,25?,26?,30-,31-/m0/s1;   InChIKey=FAXGPCHRFPCXOO-LXTPJMTPSA-N;   SMILES=CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)C[C@H](O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CC(C)C)C(C)C)C(C)C)[C@@H](O)CC(O)=O;   ahpatinin C;   pepsin inhibitor S 735A;   pepstatin;   pepstatina;   pepstatine;   pepstatinum;   procidin S 735A
 alt_id: CHEBI:43324
 xref: CAS:26305-03-3;   KEGG:C00773;   KEGG:D03818;   KNApSAcK:C00018785;   LINCS:LSM-2282
 xref_mesh: MESH:C031375
 xref: PDBeChem:IHN;   PMID:16633575;   PMID:16762607;   PMID:18675276;   PMID:19401235;   PMID:21344392;   PMID:22205353;   PMID:22384266;   PMID:22804908;   PMID:22890034;   PMID:26524537;   PMID:30408092;   PMID:30658511;   PMID:31130231;   PMID:31374272;   PMID:31718885;   PMID:4600212;   PMID:6115767;   Reaxys:2201362;   Wikipedia:Pepstatin


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pepstatin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP pepstatin inhibits the reaction [AKT1 protein modified form results in increased susceptibility to Etoposide] CTD PMID:17699715 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP pepstatin inhibits the reaction [Glucosamine results in decreased expression of BCL2L1 protein] CTD PMID:16850161 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BID BH3 interacting domain death agonist multiple interactions ISO pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; pepstatin inhibits the reaction [manganese chloride results in increased expression of BID protein]; pepstatin inhibits the reaction [thallium nitrate analog results in increased cleavage of BID protein] CTD PMID:22669516 PMID:28378122 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G CASP3 caspase 3 multiple interactions ISO
EXP
pepstatin affects the reaction [thallium nitrate results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; pepstatin inhibits the reaction [thallium nitrate analog results in increased activity of CASP3 protein]
[aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; pepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]
CTD PMID:22669516 PMID:26853465 PMID:28378122 PMID:31226464 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions ISO pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] CTD PMID:28378122 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions ISO
EXP
pepstatin inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein]
pepstatin inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]
CTD PMID:28378122 PMID:31226464 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CTSB cathepsin B multiple interactions EXP [aloxistatin co-treated with pepstatin] results in decreased expression of CTSB protein; [CA 074 methyl ester co-treated with pepstatin] results in decreased expression of CTSB protein CTD PMID:32186374 NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533
JBrowse link
G CTSD cathepsin D multiple interactions
decreases activity
EXP
ISO
[aloxistatin co-treated with pepstatin] results in decreased expression of CTSD protein; [CA 074 methyl ester co-treated with pepstatin] results in decreased expression of CTSD protein; pepstatin inhibits the reaction [Glucosamine results in decreased expression of CTSD protein alternative form]
pepstatin results in decreased activity of CTSD protein
CTD PMID:6497855 PMID:11423908 PMID:16850161 PMID:32186374 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,752...1,764,573
JBrowse link
G FASLG Fas ligand multiple interactions ISO pepstatin inhibits the reaction [manganese chloride results in increased expression of FASLG protein] CTD PMID:28378122 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G HMGA1 high mobility group AT-hook 1 multiple interactions EXP pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of HMGA1 mRNA] CTD PMID:20660070 NCBI chr 6:34,236,873...34,246,231
Ensembl chr 6:34,236,873...34,246,231
JBrowse link
G INHBA inhibin subunit beta A multiple interactions EXP pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of INHBA mRNA] CTD PMID:20660070 NCBI chr 7:41,685,101...41,710,532
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G LAMP2 lysosomal associated membrane protein 2 multiple interactions EXP [aloxistatin co-treated with pepstatin] results in increased expression of LAMP2 protein; [CA 074 methyl ester co-treated with pepstatin] results in increased expression of LAMP2 protein CTD PMID:32186374 NCBI chr  X:120,426,148...120,469,349
Ensembl chr  X:120,426,148...120,469,365
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP
ISO
[aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Biological Factors deficiency results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased degradation of MAP1LC3B protein modified form]; [aloxistatin co-treated with pepstatin] inhibits the reaction [Dronabinol results in increased lipidation of MAP1LC3B protein]; [aloxistatin co-treated with pepstatin] results in decreased degradation of MAP1LC3B protein modified form; pepstatin promotes the reaction [BO-1051 results in increased expression of MAP1LC3B protein modified form] CTD PMID:21184746 PMID:27635674 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP pepstatin inhibits the reaction [Glucosamine results in increased cleavage of PARP1 protein] CTD PMID:16850161 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP
ISO
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [CA 074 methyl ester co-treated with pepstatin] results in increased expression of SQSTM1 protein
[aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [Dronabinol co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein; [HU 211 co-treated with aloxistatin co-treated with pepstatin] results in increased expression of SQSTM1 protein
CTD PMID:32186374 PMID:32773031 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G STC1 stanniocalcin 1 multiple interactions EXP pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of STC1 mRNA] CTD PMID:20660070 NCBI chr 8:23,841,929...23,854,806
Ensembl chr 8:23,841,929...23,854,806
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP pepstatin inhibits the reaction [[Estradiol co-treated with Progesterone] results in decreased expression of TNFAIP6 mRNA] CTD PMID:20660070 NCBI chr 2:151,357,592...151,380,046
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 multiple interactions EXP pepstatin inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein] CTD PMID:31226464 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24775
    role 24693
      biological role 24662
        biochemical role 24079
          metabolite 24007
            prokaryotic metabolite 20892
              bacterial metabolite 20892
                pepstatin A 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 24775
    subatomic particle 24735
      composite particle 24735
        hadron 24735
          baryon 24735
            nucleon 24735
              atomic nucleus 24735
                atom 24735
                  main group element atom 24601
                    p-block element atom 24601
                      carbon group element atom 24393
                        carbon atom 24357
                          organic molecular entity 24357
                            organic group 22763
                              organic divalent group 22742
                                organodiyl group 22742
                                  carbonyl group 22729
                                    carbonyl compound 22729
                                      carboxylic acid 21798
                                        carboacyl group 19584
                                          univalent carboacyl group 19584
                                            carbamoyl group 19016
                                              carboxamide 19016
                                                peptide 9917
                                                  oligopeptide 1268
                                                    pentapeptide 22
                                                      pepstatin A 18
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