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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621676
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Acta2
Name: actin alpha 2, smooth muscle
Acc ID: CHEBI:7719
Term: ochratoxin A
Definition: A phenylalanine derivative resulting from the formal condensation of the amino group of L-phenylalanine with the carboxy group of (3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carboxylic acid (ochratoxin alpha). It is among the most widely occurring food-contaminating mycotoxins, produced by Aspergillus ochraceus, Aspergillus carbonarius and Penicillium verrucosum.
Chemical ID: MESH:C025589
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Acta2increases expressionEXP 6480464CTDochratoxin A results in increased expression of ACTA2 proteinPMID:16622519
Acta2multiple interactionsEXP 6480464CTDEthanol affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]PMID:16622519
Acta2increases expressionISOACTA2 (Homo sapiens)6480464CTDochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 proteinPMID:29673704 PMID:32617660 PMID:35543154
Acta2increases expressionISOActa2 (Mus musculus)6480464CTDochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 proteinPMID:32617660 PMID:33543323 PMID:35543154
Acta2multiple interactionsISOACTA2 (Homo sapiens)6480464CTD4-(4-(3-(pyridin-2-yl)-1H-pyrazol-4-yl)pyridin-2-yl)-N-(tetrahydro-2H-pyran-4-yl)benzamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 mRNA; [ochratoxin A co-treated with Citrinin] results in increased expression of ACTA2 protein; SMAD2 affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; SMAD2 affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; SMAD3 affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; SMAD3 affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]PMID:29673704 PMID:35543154
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