GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | IL6 | affects response to substance | ISO | Il6 (Mus musculus) | 6480464 | CTD | IL6 protein affects the susceptibility to Methamphetamine | PMID:11093760 | IL6 | increases expression | ISO | Il6 (Mus musculus) | 6480464 | CTD | Methamphetamine results in increased expression of IL6 mRNA; Methamphetamine results in increased expression of IL6 protein | PMID:32569805 PMID:32768653 PMID:32916201 PMID:35688268 PMID:36720452 PMID:36914120 | IL6 | increases expression | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Methamphetamine results in increased expression of IL6 mRNA; Methamphetamine results in increased expression of IL6 protein | PMID:20374443 PMID:24533129 PMID:30450033 PMID:36914120 | IL6 | increases secretion | ISO | Il6 (Mus musculus) | 6480464 | CTD | Methamphetamine results in increased secretion of IL6 protein | PMID:21276779 PMID:32916201 | IL6 | increases secretion | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | Methamphetamine results in increased secretion of IL6 protein | PMID:24533129 | IL6 | multiple interactions | ISO | Il6 (Mus musculus) | 6480464 | CTD | [SNCA protein co-treated with Methamphetamine] results in increased expression of IL6 protein; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased expression of IL6 protein]; CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; Devazepide promotes the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]]; ethyl 6-(N-(2-chloro-4-fluorophenyl)sulfamoyl)cyclohex-1-ene-1-carboxylate inhibits the reaction [Methamphetamine results in increased expression of IL6 protein]; IL6 protein affects the reaction [Methamphetamine affects the expression of SLC6A4 protein]; IL6 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; L 365260 inhibits the reaction [CCK protein alternative form inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]]; Minocycline inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; obeticholic acid inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; PELI1 protein promotes the reaction [Methamphetamine results in increased expression of IL6 protein]; TICAM1 protein promotes the reaction [Methamphetamine results in increased expression of IL6 protein] | PMID:11093760 PMID:32569805 PMID:32768653 PMID:32916201 PMID:35688268 PMID:36720452 | IL6 | multiple interactions | ISO | Il6 (Rattus norvegicus) | 6480464 | CTD | GATA4 protein affects the reaction [Methamphetamine results in increased expression of IL6 mRNA]; GATA4 protein affects the reaction [Methamphetamine results in increased expression of IL6 protein]; Lactulose inhibits the reaction [Methamphetamine results in increased expression of IL6 protein]; margatoxin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA]; margatoxin inhibits the reaction [Methamphetamine results in increased secretion of IL6 protein]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of IL6 mRNA] | PMID:20374443 PMID:24533129 PMID:30450033 PMID:36914120 | | ||||||||||||||||||||||
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